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hypothetical protein GGI13_000022 [Coemansia sp. RSA 455]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
UPF0029 | pfam01205 | Uncharacterized protein family UPF0029; |
198-304 | 6.01e-34 | |||
Uncharacterized protein family UPF0029; : Pssm-ID: 460111 Cd Length: 105 Bit Score: 120.22 E-value: 6.01e-34
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RWD_IMPACT | cd23821 | RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene ... |
11-134 | 4.10e-20 | |||
RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene protein homolog, acts as a translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment, and glucose deprivation. It plays a role as a negative regulator of EIF2AK4/GCN2 kinase activity. It impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. IMPACT may be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, IMPACT plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. : Pssm-ID: 467657 Cd Length: 101 Bit Score: 83.44 E-value: 4.10e-20
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Name | Accession | Description | Interval | E-value | |||
UPF0029 | pfam01205 | Uncharacterized protein family UPF0029; |
198-304 | 6.01e-34 | |||
Uncharacterized protein family UPF0029; Pssm-ID: 460111 Cd Length: 105 Bit Score: 120.22 E-value: 6.01e-34
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RWD_IMPACT | cd23821 | RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene ... |
11-134 | 4.10e-20 | |||
RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene protein homolog, acts as a translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment, and glucose deprivation. It plays a role as a negative regulator of EIF2AK4/GCN2 kinase activity. It impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. IMPACT may be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, IMPACT plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. Pssm-ID: 467657 Cd Length: 101 Bit Score: 83.44 E-value: 4.10e-20
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YIH1 | COG1739 | Putative translation regulator, IMPACT (imprinted ancient) protein family [General function ... |
195-310 | 3.04e-12 | |||
Putative translation regulator, IMPACT (imprinted ancient) protein family [General function prediction only]; Pssm-ID: 441345 [Multi-domain] Cd Length: 198 Bit Score: 64.35 E-value: 3.04e-12
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RWD | pfam05773 | RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
8-134 | 3.17e-09 | |||
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices. Pssm-ID: 399058 Cd Length: 111 Bit Score: 53.87 E-value: 3.17e-09
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IMPACT_YIGZ | TIGR00257 | uncharacterized protein, YigZ family; This uncharacterized protein family includes YigZ, which ... |
196-289 | 6.96e-08 | |||
uncharacterized protein, YigZ family; This uncharacterized protein family includes YigZ, which has been crystallized, from E. coli. YigZ is homologous to the protein product of the mouse IMPACT gene. Crystallography shows a two-domain stucture, and the C-terminal domain is suggested to bind nucleic acids. The function is unknown. Note that the ortholog from E. coli was shown fused to the pepQ gene in GenBank entry X54687. This caused occasional misidentification of this protein as pepQ; this family is found in a number of species that lack pepQ. [Unknown function, General] Pssm-ID: 129359 [Multi-domain] Cd Length: 204 Bit Score: 52.11 E-value: 6.96e-08
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RWD | smart00591 | domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ... |
13-137 | 5.99e-07 | |||
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain; Pssm-ID: 214735 Cd Length: 107 Bit Score: 47.35 E-value: 5.99e-07
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Name | Accession | Description | Interval | E-value | |||
UPF0029 | pfam01205 | Uncharacterized protein family UPF0029; |
198-304 | 6.01e-34 | |||
Uncharacterized protein family UPF0029; Pssm-ID: 460111 Cd Length: 105 Bit Score: 120.22 E-value: 6.01e-34
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RWD_IMPACT | cd23821 | RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene ... |
11-134 | 4.10e-20 | |||
RWD domain of protein IMPACT and related proteins; IMPACT, also imprinted and ancient gene protein homolog, acts as a translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment, and glucose deprivation. It plays a role as a negative regulator of EIF2AK4/GCN2 kinase activity. It impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. IMPACT may be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, IMPACT plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. Pssm-ID: 467657 Cd Length: 101 Bit Score: 83.44 E-value: 4.10e-20
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YIH1 | COG1739 | Putative translation regulator, IMPACT (imprinted ancient) protein family [General function ... |
195-310 | 3.04e-12 | |||
Putative translation regulator, IMPACT (imprinted ancient) protein family [General function prediction only]; Pssm-ID: 441345 [Multi-domain] Cd Length: 198 Bit Score: 64.35 E-value: 3.04e-12
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RWD_RNF14 | cd23820 | RWD domain of RING finger protein 14 (RNF14) and related proteins; RNF14, also called androgen ... |
10-130 | 3.51e-10 | |||
RWD domain of RING finger protein 14 (RNF14) and related proteins; RNF14, also called androgen receptor (AR)-associated protein 54 (ARA54), HFB30, or Triad2 protein, is an RBR-type E3 ubiquitin-protein ligase (EC 2.3.2.31) that is highly expressed in the testis and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3). Its differential localization may play an important role in testicular development and spermatogenesis in humans. RNF14 functions as a transcriptional regulator of mitochondrial and immune function in muscles. It is a ligand-dependent AR co-activator that enhances AR-dependent transcriptional activation. It also may participate in enhancing cell cycle progression and cell proliferation via induction of cyclin D1. Moreover, RNF14 is crucial for colon cancer cell survival. It acts as a new enhancer of Wnt-dependent transcriptional outputs that act at the level of the T-cell factor/lymphoid enhancer factor (TCF/LEF)-beta-catenin complex. Pssm-ID: 467656 [Multi-domain] Cd Length: 125 Bit Score: 56.99 E-value: 3.51e-10
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RWD | pfam05773 | RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
8-134 | 3.17e-09 | |||
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices. Pssm-ID: 399058 Cd Length: 111 Bit Score: 53.87 E-value: 3.17e-09
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RWD_DRWD_ELF-like | cd11605 | RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF ... |
16-130 | 3.95e-08 | |||
RWD, DRWD, and ELF domain family; The family includes the RWD, double-RWD (DRWD), and ELF domains. They belong to the ubiquitin-conjugating (UBC) superfamily that represents a structural domain with an alpha-beta(4)-alpha(3) core fold. The RWD domain (named after three major RWD-containing proteins: RING finger, WD-repeat-containing proteins and DEXD-like helicases) mediates protein-protein interactions in a variety of pathways in eukaryotes. The DRWD domain is responsible for substrate binding. It is involved in interactions with other kinetochore proteins. The ELF (N-terminal E2-like fold) domain is found in all Fanconi anemia group L protein (FANCL) homologs. It is required to promote efficient DNA damage-induced FANCD2 (Fanconi anemia group D2 protein) monoubiquitination in vertebrate cells. Pssm-ID: 467641 Cd Length: 94 Bit Score: 50.26 E-value: 3.95e-08
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IMPACT_YIGZ | TIGR00257 | uncharacterized protein, YigZ family; This uncharacterized protein family includes YigZ, which ... |
196-289 | 6.96e-08 | |||
uncharacterized protein, YigZ family; This uncharacterized protein family includes YigZ, which has been crystallized, from E. coli. YigZ is homologous to the protein product of the mouse IMPACT gene. Crystallography shows a two-domain stucture, and the C-terminal domain is suggested to bind nucleic acids. The function is unknown. Note that the ortholog from E. coli was shown fused to the pepQ gene in GenBank entry X54687. This caused occasional misidentification of this protein as pepQ; this family is found in a number of species that lack pepQ. [Unknown function, General] Pssm-ID: 129359 [Multi-domain] Cd Length: 204 Bit Score: 52.11 E-value: 6.96e-08
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RWD_GCN2 | cd23823 | RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ... |
8-137 | 5.37e-07 | |||
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation. Pssm-ID: 467659 Cd Length: 117 Bit Score: 47.60 E-value: 5.37e-07
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RWD | smart00591 | domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily ... |
13-137 | 5.99e-07 | |||
domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain; Pssm-ID: 214735 Cd Length: 107 Bit Score: 47.35 E-value: 5.99e-07
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RWD_ScYIH1-like | cd23822 | RWD domain of Saccharomyces cerevisiae protein YIH1 and related proteins; YIH1, also called ... |
11-134 | 4.35e-03 | |||
RWD domain of Saccharomyces cerevisiae protein YIH1 and related proteins; YIH1, also called protein IMPACT homolog, is an actin-binding protein that acts as a translational regulator which ensures constant high levels of translation under amino acid starvation. It plays a role as a negative regulator of GCN2 kinase activity. It impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis. In normal conditions, it resides in an actin complex and has no activity. Pssm-ID: 467658 Cd Length: 97 Bit Score: 36.08 E-value: 4.35e-03
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Blast search parameters | ||||
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