NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|634352411|gb|KDE07539|]
View 

hypothetical protein MVLG_02210 [Microbotryum lychnidis-dioicae p1A1 Lamole]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MPC pfam03650
Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, ...
 248-350 2.83e-49

Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologs. They mediate the uptake of pyruvate into mitochondria. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions. Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.


:

Pssm-ID: 427425  Cd Length: 110  Bit Score: 161.64  E-value: 2.83e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 634352411  248 KLEHKLNE--GPKTVFFWAPVFKWGLVVAGLKDLSRPADKISIPQNLALTATGLIWVRYSFVITPVNYSLAAVNAFVGAT 325
Cdd:pfam03650   1 AFQRFWNSetGPKTVHFWAPVMKWGLVIAGISDLKRPPEKISGPQNLALLATGAIWTRWSLVIKPKNYLLASVNFFLGCV 80

                          90       100
                  ....*....|....*....|....*
gi 634352411  326 GIASLSRAFAWKYMTPEEQMKVRAE 350
Cdd:pfam03650  81 GLYQVSRILNYRYSQGDSKSQAKKY 105
DUF2470 pfam10615
Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron ...
 9-86 1.28e-15

Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron utilization proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts.


:

Pssm-ID: 431396  Cd Length: 73  Bit Score: 71.09  E-value: 1.28e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 634352411    9 ASRIISHMNADHAPSLSHYLEHFAHAPARVAAlapRIIEFSTDEMAIEYGpqvQRRTWHYTFDPPMY-AGQARKRLEAM 86
Cdd:pfam10615   1 SARIIAHMNADHADALLLYARHYGGVPDATAA---RMTDIDRDGMDLRVT---GDVTVRIPFDPPLTdREEARARLVEM 73
 
Name Accession Description Interval E-value
MPC pfam03650
Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, ...
 248-350 2.83e-49

Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologs. They mediate the uptake of pyruvate into mitochondria. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions. Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.


Pssm-ID: 427425  Cd Length: 110  Bit Score: 161.64  E-value: 2.83e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 634352411  248 KLEHKLNE--GPKTVFFWAPVFKWGLVVAGLKDLSRPADKISIPQNLALTATGLIWVRYSFVITPVNYSLAAVNAFVGAT 325
Cdd:pfam03650   1 AFQRFWNSetGPKTVHFWAPVMKWGLVIAGISDLKRPPEKISGPQNLALLATGAIWTRWSLVIKPKNYLLASVNFFLGCV 80

                          90       100
                  ....*....|....*....|....*
gi 634352411  326 GIASLSRAFAWKYMTPEEQMKVRAE 350
Cdd:pfam03650  81 GLYQVSRILNYRYSQGDSKSQAKKY 105
DUF2470 pfam10615
Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron ...
 9-86 1.28e-15

Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron utilization proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts.


Pssm-ID: 431396  Cd Length: 73  Bit Score: 71.09  E-value: 1.28e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 634352411    9 ASRIISHMNADHAPSLSHYLEHFAHAPARVAAlapRIIEFSTDEMAIEYGpqvQRRTWHYTFDPPMY-AGQARKRLEAM 86
Cdd:pfam10615   1 SARIIAHMNADHADALLLYARHYGGVPDATAA---RMTDIDRDGMDLRVT---GDVTVRIPFDPPLTdREEARARLVEM 73
 
Name Accession Description Interval E-value
MPC pfam03650
Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, ...
 248-350 2.83e-49

Mitochondrial pyruvate carriers; This family includes mitochondrial pyruvate carrier proteins, such as Mpc 1/2 and their homologs. They mediate the uptake of pyruvate into mitochondria. In humans, Mpc1 and Mpc2 associate to form an ~150-kilodalton complex in the inner mitochondrial membrane. MPC1 contains two predicted transmembrane regions. MPC2 contains three predicted transmembrane regions. Several studies have demonstrated MPC involvement in the control of cell fate in cancer and gluconeogenesis in models of type 2 diabetes.


Pssm-ID: 427425  Cd Length: 110  Bit Score: 161.64  E-value: 2.83e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 634352411  248 KLEHKLNE--GPKTVFFWAPVFKWGLVVAGLKDLSRPADKISIPQNLALTATGLIWVRYSFVITPVNYSLAAVNAFVGAT 325
Cdd:pfam03650   1 AFQRFWNSetGPKTVHFWAPVMKWGLVIAGISDLKRPPEKISGPQNLALLATGAIWTRWSLVIKPKNYLLASVNFFLGCV 80

                          90       100
                  ....*....|....*....|....*
gi 634352411  326 GIASLSRAFAWKYMTPEEQMKVRAE 350
Cdd:pfam03650  81 GLYQVSRILNYRYSQGDSKSQAKKY 105
DUF2470 pfam10615
Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron ...
 9-86 1.28e-15

Domain of unknown function (DUF2470); This domain is found in a group of putative heme-iron utilization proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts.


Pssm-ID: 431396  Cd Length: 73  Bit Score: 71.09  E-value: 1.28e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 634352411    9 ASRIISHMNADHAPSLSHYLEHFAHAPARVAAlapRIIEFSTDEMAIEYGpqvQRRTWHYTFDPPMY-AGQARKRLEAM 86
Cdd:pfam10615   1 SARIIAHMNADHADALLLYARHYGGVPDATAA---RMTDIDRDGMDLRVT---GDVTVRIPFDPPLTdREEARARLVEM 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH