NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|646701961|gb|KDR11428|]
View 

Hermansky-Pudlak syndrome 1 protein-like protein [Zootermopsis nevadensis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 2-146 1.48e-24

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465953  Cd Length: 125  Bit Score: 99.21  E-value: 1.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646701961    2 KCILVFDHLNDVLYAKYNKKfskhvrklsreqgfmpdgkdddelSNSVLIQHFSPIVTSLQLMNCQFgNSYTSVQCKDgT 81
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDE------------------------DESLLFSLFGPLNGSISFMQTQD-DTLTSITCEN-T 54

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 646701961   82 NVVFNQYMGCLFVHIGLNN--VNWLQRTLGIFITVVKHLCG-PNVSILKRNKS---RAFLLSRLLDTWMQL 146
Cdd:pfam19036  55 KVVFLEKGPLLLVAISRSGesEQQLRRQLDVVYNQILSLLGlPQLTRIFNRRPnedLRRLLSGLEDLLDSL 125
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 505-651 3.92e-22

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465955  Cd Length: 103  Bit Score: 91.55  E-value: 3.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646701961  505 GLVHFLYIDRFNHRITAPSLDFSSEETTSLTKKKIWAMVEFSRAHLQE--GHTAIMWKDTTfSYAYFLWFEDssasplkp 582
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSLPTDPPYTTEQRRRRLRSFYQLLHSTLHSpsGPLKLLYKVSD-YESLLAWFTD-------- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 646701961  583 kifptaalknfprpgilcgdfyqklaefcfpktslckvhCYELYCVHLGLATSSCVLEQSRRLAATIWE 651
Cdd:pfam19038  72 ---------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKK 101
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 188-229 7.84e-08

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465954  Cd Length: 98  Bit Score: 50.69  E-value: 7.84e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 646701961  188 FSRIHAMLLVENKFLSLYSSRGAqELSAGDIMFLSLMCEAFY 229
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWA-SLHPSDLLLLFLLVQSSS 41
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 2-146 1.48e-24

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 99.21  E-value: 1.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646701961    2 KCILVFDHLNDVLYAKYNKKfskhvrklsreqgfmpdgkdddelSNSVLIQHFSPIVTSLQLMNCQFgNSYTSVQCKDgT 81
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDE------------------------DESLLFSLFGPLNGSISFMQTQD-DTLTSITCEN-T 54

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 646701961   82 NVVFNQYMGCLFVHIGLNN--VNWLQRTLGIFITVVKHLCG-PNVSILKRNKS---RAFLLSRLLDTWMQL 146
Cdd:pfam19036  55 KVVFLEKGPLLLVAISRSGesEQQLRRQLDVVYNQILSLLGlPQLTRIFNRRPnedLRRLLSGLEDLLDSL 125
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 505-651 3.92e-22

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 91.55  E-value: 3.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646701961  505 GLVHFLYIDRFNHRITAPSLDFSSEETTSLTKKKIWAMVEFSRAHLQE--GHTAIMWKDTTfSYAYFLWFEDssasplkp 582
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSLPTDPPYTTEQRRRRLRSFYQLLHSTLHSpsGPLKLLYKVSD-YESLLAWFTD-------- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 646701961  583 kifptaalknfprpgilcgdfyqklaefcfpktslckvhCYELYCVHLGLATSSCVLEQSRRLAATIWE 651
Cdd:pfam19038  72 ---------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKK 101
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 188-229 7.84e-08

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 50.69  E-value: 7.84e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 646701961  188 FSRIHAMLLVENKFLSLYSSRGAqELSAGDIMFLSLMCEAFY 229
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWA-SLHPSDLLLLFLLVQSSS 41
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 2-146 1.48e-24

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 99.21  E-value: 1.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646701961    2 KCILVFDHLNDVLYAKYNKKfskhvrklsreqgfmpdgkdddelSNSVLIQHFSPIVTSLQLMNCQFgNSYTSVQCKDgT 81
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDE------------------------DESLLFSLFGPLNGSISFMQTQD-DTLTSITCEN-T 54

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 646701961   82 NVVFNQYMGCLFVHIGLNN--VNWLQRTLGIFITVVKHLCG-PNVSILKRNKS---RAFLLSRLLDTWMQL 146
Cdd:pfam19036  55 KVVFLEKGPLLLVAISRSGesEQQLRRQLDVVYNQILSLLGlPQLTRIFNRRPnedLRRLLSGLEDLLDSL 125
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 505-651 3.92e-22

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 91.55  E-value: 3.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646701961  505 GLVHFLYIDRFNHRITAPSLDFSSEETTSLTKKKIWAMVEFSRAHLQE--GHTAIMWKDTTfSYAYFLWFEDssasplkp 582
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSLPTDPPYTTEQRRRRLRSFYQLLHSTLHSpsGPLKLLYKVSD-YESLLAWFTD-------- 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 646701961  583 kifptaalknfprpgilcgdfyqklaefcfpktslckvhCYELYCVHLGLATSSCVLEQSRRLAATIWE 651
Cdd:pfam19038  72 ---------------------------------------CFELYVLFSPLVPKHALRSSANKLLKWIKK 101
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 188-229 7.84e-08

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 50.69  E-value: 7.84e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 646701961  188 FSRIHAMLLVENKFLSLYSSRGAqELSAGDIMFLSLMCEAFY 229
Cdd:pfam19037   1 KSLLFALLLVGGKLVAAYRPRWA-SLHPSDLLLLFLLVQSSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH