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Conserved domains on  [gi|679186507|gb|KFW77599|]
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Doublecortin domain-containing protein 2, partial [Manacus vitellinus]

Protein Classification

DCX1_DCDC2 and DCX2_DCDC2 domain-containing protein( domain architecture ID 13019570)

protein containing domains DCX1_DCDC2, DCX2_DCDC2, and 2A1904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 17-96 1.10e-53

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


:

Pssm-ID: 340669  Cd Length: 80  Bit Score: 171.11  E-value: 1.10e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17149    1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 137-216 3.26e-53

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


:

Pssm-ID: 340672  Cd Length: 80  Bit Score: 169.60  E-value: 3.26e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVGREKFKK 216
Cdd:cd17152    1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFKK 80
 
Name Accession Description Interval E-value
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 17-96 1.10e-53

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 171.11  E-value: 1.10e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17149    1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 137-216 3.26e-53

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 169.60  E-value: 3.26e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVGREKFKK 216
Cdd:cd17152    1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFKK 80
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 133-220 1.92e-27

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 103.11  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507   133 PLQEPYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSG-AVHRLYTSDGKLVQNGSELENGQIYVAVGR 211
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGT 80


                   ....*....
gi 679186507   212 EKFKKLPYG 220
Cdd:smart00537  81 EAFKKVDYG 89
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 12-100 1.59e-26

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 100.80  E-value: 1.59e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507    12 SQPTVKSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFG-AVRNIYTPRgGHRVRQLEELQSGEQYVAGG 90
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLD-GKKVTSLDELEDGGSYVASG 79

                           90
                   ....*....|
gi 679186507    91 REAFKKLNYL 100
Cdd:smart00537  80 TEAFKKVDYG 89
DCX pfam03607
Doublecortin;
156-214 1.03e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 81.34  E-value: 1.03e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  156 LIPRKTLNHWDHILEMVTGKV-TLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVGREKF 214
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVvKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX pfam03607
Doublecortin;
35-94 1.45e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 80.95  E-value: 1.45e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 679186507   35 VIHEKKVSNFDVFLKEVT-SGVKAPFGAVRNIYTPRGgHRVRQLEELQSGEQYVAGGREAF 94
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTeKVVKLPFGAVRKLYTLDG-KRVTSLDELEDGGVYVAAGREKF 60
 
Name Accession Description Interval E-value
DCX1_DCDC2 cd17149
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 17-96 1.10e-53

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340669  Cd Length: 80  Bit Score: 171.11  E-value: 1.10e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17149    1 KNVLVYRNGDPFYAGRRLVINEKRVSSFEVFLKEVTGGVQAPFGAVRNIYTPRGGHRVRSLEQLQSGEQYVAAGRERFKK 80
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 137-216 3.26e-53

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 169.60  E-value: 3.26e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVGREKFKK 216
Cdd:cd17152    1 PCTIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYTLDGKLINDGSELENGQFYVAVGREKFKK 80
DCX1_DCDC2_like cd17071
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and ...
 17-96 6.08e-43

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2 (DCDC2) and similar proteins; DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340591  Cd Length: 80  Bit Score: 143.13  E-value: 6.08e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17071    1 KIIVVYKNGDPFFPGKKFVVNERQVRTFDAFLNEVTSGIKAPFGAVRSIYTPTGGHRVKDLDSLQNGGVYVAAGSERFKK 80
DCX1_DCDC2B cd17150
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 17-96 2.15e-34

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340670  Cd Length: 79  Bit Score: 121.06  E-value: 2.15e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFgAVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17150    1 KNVVVYRNGDPFFTGRKFVVNQRQFLTFEAFLNEVTSNIQAPV-AVRNLYTPREGHRVTELGDLQNGGHYVAAGFERFKK 79
DCX1_DCDC2C cd17151
Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 17-96 4.00e-30

Dublecortin-like domain 1 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of ubiquitin-like tertiary fold. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340671  Cd Length: 79  Bit Score: 109.88  E-value: 4.00e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17151    1 KTILVYRNGDPFYQAHKVVIHRRRVKTFDALLRQLTETVKVPFG-VRCLYTPRNGHRVKGLDDLQGGGKYVAAGRERFKK 79
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 137-216 1.30e-27

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 103.29  E-value: 1.30e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVGREKFKK 216
Cdd:cd17153    1 PCIIHVFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTGAVRKLCTLDGVPLSSGKELVSGQYYVAVGSEKFKD 80
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 133-220 1.92e-27

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 103.11  E-value: 1.92e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507   133 PLQEPYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSG-AVHRLYTSDGKLVQNGSELENGQIYVAVGR 211
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLDGKKVTSLDELEDGGSYVASGT 80


                   ....*....
gi 679186507   212 EKFKKLPYG 220
Cdd:smart00537  81 EAFKKVDYG 89
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 137-210 2.95e-27

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 101.88  E-value: 2.95e-27
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVG 210
Cdd:cd16113    1 PKTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTGAVRKLYTLDGKRISDPDELVNGGQYVAVG 74
DCX smart00537
Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the ...
 12-100 1.59e-26

Domain in the Doublecortin (DCX) gene product; Tandemly-repeated domain in doublin, the Doublecortin gene product. Proposed to bind tubulin. Doublecortin (DCX) is mutated in human X-linked neuronal migration defects.


Pssm-ID: 214711  Cd Length: 89  Bit Score: 100.80  E-value: 1.59e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507    12 SQPTVKSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFG-AVRNIYTPRgGHRVRQLEELQSGEQYVAGG 90
Cdd:smart00537   1 SLVKPKRIRFYRNGDRFFKGVRLVVNRKRFKSFEALLQDLTEVVKLDLPhGVRKLYTLD-GKKVTSLDELEDGGSYVASG 79

                           90
                   ....*....|
gi 679186507    91 REAFKKLNYL 100
Cdd:smart00537  80 TEAFKKVDYG 89
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 137-215 2.00e-21

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 86.79  E-value: 2.00e-21
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVGREKFK 215
Cdd:cd17154    1 SRTINVFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTGGVFRLCTLNGHPVSDSTELEDNHYYVAVGSEKFK 79
DCX pfam03607
Doublecortin;
156-214 1.03e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 81.34  E-value: 1.03e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  156 LIPRKTLNHWDHILEMVTGKV-TLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVGREKF 214
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTEKVvKLPFGAVRKLYTLDGKRVTSLDELEDGGVYVAAGREKF 60
DCX pfam03607
Doublecortin;
35-94 1.45e-19

Doublecortin;


Pssm-ID: 460986  Cd Length: 60  Bit Score: 80.95  E-value: 1.45e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 679186507   35 VIHEKKVSNFDVFLKEVT-SGVKAPFGAVRNIYTPRGgHRVRQLEELQSGEQYVAGGREAF 94
Cdd:pfam03607   1 VVNKRRFRSFDALLDELTeKVVKLPFGAVRKLYTLDG-KRVTSLDELEDGGVYVAAGREKF 60
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 17-90 1.79e-19

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 81.12  E-value: 1.79e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTPRgGHRVRQLEELQSGEQYVAGG 90
Cdd:cd01617    1 KRITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTGGVRKLYTPS-GKLVKSLSDLEDGESYVVCG 73
DCX1_RP_like cd16110
Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 17-88 9.03e-19

Doublecortin-like domain 1 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) family. It has double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340527  Cd Length: 75  Bit Score: 79.26  E-value: 9.03e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVA 88
Cdd:cd16110    1 KNVTFYKDGDVHFSGVRVAINPRRYRTFDALLDELSRKVPLPFG-VRSITTPRGRHSITSLEQLEDGGKYVC 71
DCX cd01617
Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin ...
 139-210 2.54e-17

Dublecortin-like domain structurally similar to a beta-grasp ubiquitin-like fold; Dublecortin (DCX) is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of the cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its DCX protein domains can occur in double tandem or as single DCX repeats. Proteins with DCX tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK). Single DCX repeat proteins are normally localized to actin-rich subcellular structures, or the nucleus such as DCDC2. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340456  Cd Length: 73  Bit Score: 75.34  E-value: 2.54e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 679186507 139 TIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSELENGQIYVAVG 210
Cdd:cd01617    2 RITVFRNGDKNFKGVKVLVKPRRFRTFDQLLDELTEKLGLPTGGVRKLYTPSGKLVKSLSDLEDGESYVVCG 73
DCX2_DCDC2_like cd16113
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 17-90 3.67e-15

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340530  Cd Length: 74  Bit Score: 69.53  E-value: 3.67e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTpRGGHRVRQLEELQSGEQYVAGG 90
Cdd:cd16113    2 KTIHVFPNGDLLHPPSKVLLTKRRLPNWDTVLEEVTEKVKLQTGAVRKLYT-LDGKRISDPDELVNGGQYVAVG 74
DCX1_RP1 cd17145
Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also ...
 17-95 3.90e-15

Doublecortin-like domain 1 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors and is required for correct stacking of outer segment discs. It interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340665  Cd Length: 79  Bit Score: 69.46  E-value: 3.90e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFK 95
Cdd:cd17145    1 KRVCFYKSGDPQFGGLRMVVNSRSFKTFDALLDNLSKKVPLPFG-VRNITTPRGVHHITSLEDLEDGKSYICSHQKKVK 78
DCX1 cd16109
Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are ...
 17-96 9.63e-15

Dublecortin-like domain 1; Members of the doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or single repeats. The family represents the first repeat of the DCX domain which has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340526  Cd Length: 85  Bit Score: 68.48  E-value: 9.63e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTS----GVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVAGGRE 92
Cdd:cd16109    3 KKVRFYRNGDRFFKGIVYAVSSERFRSFEALLADLTRslsdNVNLPQG-VRTIFTIDGSRKITSLDELEDGESYVCASTD 81


                 ....
gi 679186507  93 AFKK 96
Cdd:cd16109   82 AFKK 85
DCX1_RP1L1 cd17146
Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a ...
 17-95 6.14e-13

Doublecortin-like domain 1 found in retinitis pigmentosa 1-like 1 (RP1L1) protein; RP1L1 is a member of the doublecortin (DCX) family. Its DCX domains occur in double tandem repeats. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX-domain of RP1L1 localizes to the photoreceptor and is genetically associated with retinitis pigmentosa.


Pssm-ID: 340666  Cd Length: 79  Bit Score: 63.31  E-value: 6.14e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVAGGREAFK 95
Cdd:cd17146    1 KKITFYKSGDPQFGGVKMAVNKRTFKSFSALLDDLSQRVPLPFG-VRTITTPRGTHSISRLEQLEDGGCYLCSDKKYVK 78
DCX1_DCLK2 cd17141
Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 17-96 1.15e-12

Dublecortin-like domain 1 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier (Ubiquitination) in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. Molecular actions of DCX members are less well characterized and it shows that DCLK2 members regulate cyclic AMP signaling. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340661  Cd Length: 85  Bit Score: 63.00  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVT----SGVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVAGGRE 92
Cdd:cd17141    3 KKVRFYRNGDRYFKGLVYAVSSDRFRSFDALLMELTrslsDNVNLPQG-VRTIYTIDGSKKITSLDELLEGESYVCASNE 81


                 ....
gi 679186507  93 AFKK 96
Cdd:cd17141   82 PFRK 85
DCX1_DCLK1 cd17140
Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 17-99 1.50e-12

Dublecortin-like domain 1 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein superfamily that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule-binding domains, DCLK encodes a serine/threonine kinase domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, this DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340660  Cd Length: 89  Bit Score: 62.71  E-value: 1.50e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVT----SGVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVAGGRE 92
Cdd:cd17140    3 KKVRFYRNGDRYFKGIVYAISPDRFRSFEALLADLTrtlsDNVNLPQG-VRTIYTIDGLKKISSLDQLVEGESYVCGSIE 81


                 ....*..
gi 679186507  93 AFKKLNY 99
Cdd:cd17140   82 PFKKLEY 88
DCX2_DCDC2 cd17152
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is ...
 18-96 1.30e-11

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340672  Cd Length: 80  Bit Score: 59.81  E-value: 1.30e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 679186507  18 SVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTpRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17152    3 TIFVVANGDLLNPAVRLLIPRKTLNQWEKILEMITEKVTLRTGAVRRLYT-LDGKLINDGSELENGQFYVAVGREKFKK 80
DCX1_DCX cd16112
Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 17-99 8.76e-11

Dublecortin-like domain 1 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of structure, it also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340529  Cd Length: 89  Bit Score: 57.62  E-value: 8.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVT----SGVKAPFGaVRNIYTPRGGHRVRQLEELQSGEQYVAGGRE 92
Cdd:cd16112    3 KKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTrslsDNINLPQG-VRYIYTIDGSRKIGSMDELEEGESYVCSSDN 81


                 ....*..
gi 679186507  93 AFKKLNY 99
Cdd:cd16112   82 FFKKVEY 88
DCX2_DCDC2B cd17153
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 ...
 21-96 1.25e-09

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2B (DCDC2B); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340673  Cd Length: 80  Bit Score: 54.37  E-value: 1.25e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 679186507  21 VYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTpRGGHRVRQLEELQSGEQYVAGGREAFKK 96
Cdd:cd17153    6 VFRNGDLLSPPFRLLIPKHMLQDWETILSLLTEKANLRTGAVRKLCT-LDGVPLSSGKELVSGQYYVAVGSEKFKD 80
DCX2 cd17069
Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are ...
 137-214 2.34e-09

Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or as a single repeat. The first repeat of DCX domain has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340589  Cd Length: 84  Bit Score: 53.54  E-value: 2.34e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSEL-ENGQIYVAVGREKF 214
Cdd:cd17069    4 PKLVTVIRNGTKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGAVRKLFTLDGRQVTCLQDFfGDDDVFIAYGPEKF 82
DCX2_RP1 cd17147
Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed ...
 17-95 3.52e-08

Dublecortin-like domain 2 found in retinitis pigmentosa 1 (RP1)-like protein; RP1, also termed oxygen-regulated protein 1, is a member of doublecortin (DCX) superfamily that contains double tandem repeats of the DCX domains. RP1 is associated with retinitis pigmentosa, which is a type of inherited blindness. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The RP1 protein is expressed in photoreceptors that is required for correct stacking of outer segment discs. RP1 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340667  Cd Length: 76  Bit Score: 50.14  E-value: 3.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507  17 KSVLVYRNGDPFFPgRRIVIHEKKVSNFDVFLKEVTSGVKAPfgaVRNIYTPrGGHRVRQLEEL-QSGEQYVAGGREAFK 95
Cdd:cd17147    1 RKLIVFKNGDPGFK-HTLILNKKTTQSFEALLDHVSELMQFP---VVKLYTT-DGRRVDSLQALiLSSGAVVAAGREPFK 75
DCX2_DCLK1 cd17143
Dublecortin-like domain 2 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of ...
 136-215 5.07e-07

Dublecortin-like domain 2 found in doublecortin-like kinase 1 (DCLK1); DCLK1 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK1 appears to regulate cyclic AMP signaling and is involved in neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340663  Cd Length: 84  Bit Score: 46.87  E-value: 5.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507 136 EPYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSE-LENGQIYVAVGREKF 214
Cdd:cd17143    3 RPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDfFGDDDIFIACGPEKF 82


                 .
gi 679186507 215 K 215
Cdd:cd17143   83 R 83
DCX2_DCDC2C cd17154
Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 ...
 21-95 6.32e-07

Doublecortin-like domain 2 found in doublecortin domain-containing protein 2C (DCDC2C); DCDC2 is a member of the doublecortin (DCX) family. It is a microtubule-associated protein (MAP) with stable double tandem DCX repeats of a ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. DCDC2 genetic variation in humans is associated with reading disability, attention deficit hyperactivity disorder (ADHD), and difficulties in mathematics. A genetic variant of DCDC2 associates with dyslexia, a common neurobehavioral disorder of reading. DCDC2 protein interacts with many of the same cytoskeleton related proteins that other members of the DCX family interact with.


Pssm-ID: 340674  Cd Length: 80  Bit Score: 46.73  E-value: 6.32e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 679186507  21 VYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTpRGGHRVRQLEELQSGEQYVAGGREAFK 95
Cdd:cd17154    6 VFTNGEVLVPPAKIIIPKFTLRSWENVLAMITEKAFLRTGGVFRLCT-LNGHPVSDSTELEDNHYYVAVGSEKFK 79
DCX2_DCX cd17142
Dublecortin-like domain 2 found in neuronal migration protein doublecortin (DCX); DCX, also ...
 137-215 2.13e-06

Dublecortin-like domain 2 found in neuronal migration protein doublecortin (DCX); DCX, also termed doublin or lissencephalin-X (Lis-XDCX), is a microtubule-associated protein (MAP). It belongs to the doublecortin (DCX) family, has double tandem DCX repeats, and is expressed in migrating neurons. Structure studies show that the N-terminal DCX domain has a stable ubiquitin-like fold. DCX is not only a unique MAP in terms of its structure, but also interacts with multiple additional proteins. Mutations in the human DCX genes are associated with abnormal neuronal migration, epilepsy, and mental retardation.


Pssm-ID: 340662  Cd Length: 84  Bit Score: 45.04  E-value: 2.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507 137 PYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSE-LENGQIYVAVGREKFK 215
Cdd:cd17142    4 PKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDfFGDDDVFIACGPEKFR 83
DCX2_DCLK2 cd17144
Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of ...
 136-215 6.78e-06

Dublecortin-like domain 2 found in doublecortin-like kinase 2 (DCLK2); DCLK2 is a member of doublecortin (DCX) protein family that functions as a microtubule-associated protein (MAP), and contains two conserved tubulin binding domains, which typically occur in double tandem. The DCX domain has a stable ubiquitin-like tertiary fold. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. In addition to microtubule binding domains, DCLK encodes a serine/threonine kinase-domain that is similar to Ca/calmodulin-dependent (Cam) protein kinases. DCLK2 members regulate cyclic AMP signaling. Unlike DCX, the DCLK has varying levels of expression throughout embryonic and adult life.


Pssm-ID: 340664  Cd Length: 84  Bit Score: 43.86  E-value: 6.78e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 679186507 136 EPYTIFLVANGDLISPAVRLLIPRKTLNHWDHILEMVTGKVTLRSGAVHRLYTSDGKLVQNGSE-LENGQIYVAVGREKF 214
Cdd:cd17144    3 KPKLVTVIRSGVKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGVVKRLCTLDGKQVTCLQDfFGDDDVFIACGPEKY 82


                 .
gi 679186507 215 K 215
Cdd:cd17144   83 R 83
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 17-88 4.21e-05

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 41.08  E-value: 4.21e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 679186507  17 KSVLVYRNGDPFFPgRRIVIHEKKVSNFDVFLKEVTSGVKAPfgaVRNIYTpRGGHRVRQLEEL-QSGEQYVA 88
Cdd:cd17070    1 KVITVISNGDPHSR-HTILLNRRTTQSFEQVLQDLSELLKGP---VRKLYT-TDGKKVESLSALfHGPDEYVA 68
DCX2 cd17069
Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are ...
 17-94 2.12e-03

Dublecortin-like domain 2; Members in doublecortin (DCX) gene family are microtubule-associated proteins (MAPs). Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. The DCX gene family consists of eleven paralogs in human and mouse, and its protein domains can occur in double tandem or as a single repeat. The first repeat of DCX domain has a stable ubiquitin-like tertiary fold. Proteins with DCX double tandem domains in general have roles in microtubule (MT) regulation and signal transduction such as X-linked doublecortin (DCX), retinitis pigmentosa-1 (RP1) and doublecortin-like kinase (DCLK).


Pssm-ID: 340589  Cd Length: 84  Bit Score: 36.59  E-value: 2.12e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 679186507  17 KSVLVYRNGDPFFPGRRIVIHEKKVSNFDVFLKEVTSGVKAPFGAVRNIYTpRGGHRVRQLEEL-QSGEQYVAGGREAF 94
Cdd:cd17069    5 KLVTVIRNGTKPRKAVRILLNKKTAHSFEQVLTDITEAIKLDSGAVRKLFT-LDGRQVTCLQDFfGDDDVFIAYGPEKF 82
DCX2_RP_like cd17070
Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein ...
 140-209 8.50e-03

Dublecortin-like domain 2 found in retinitis pigmentosa (RP)-like protein; RP-like protein family is part of doublecortin (DCX) superfamily with double tandem DCX repeats that are associated with retinitis pigmentosa. DCX is a microtubule-associated protein (MAP) with a stable ubiquitin-like tertiary fold. Microtubules are key components of cytoskeleton that are involved in cell movement, shape determination, division and transport. RP-like proteins are colocalized to the photoreceptor and share a function in outer segment disc morphogenesis.


Pssm-ID: 340590  Cd Length: 69  Bit Score: 34.53  E-value: 8.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 679186507 140 IFLVANGDLiSPAVRLLIPRKTLNHWDHILEMVTgkVTLRsGAVHRLYTSDGKLVQNGSELENGQ-IYVAV 209
Cdd:cd17070    3 ITVISNGDP-HSRHTILLNRRTTQSFEQVLQDLS--ELLK-GPVRKLYTTDGKKVESLSALFHGPdEYVAA 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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