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Conserved domains on  [gi|985671752|gb|KXB02539|]
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hypothetical protein AKJ44_00030 [candidate division MSBL1 archaeon SCGC-AAA261F17]

Protein Classification

translation initiation factor eIF-1A( domain architecture ID 10012115)

translation initiation factor eIF-1A (aIF-1A) is thought to be required for maximal rate of protein biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04012 PRK04012
translation initiation factor IF-1A; Provisional
 1-86 2.49e-43

translation initiation factor IF-1A; Provisional


:

Pssm-ID: 179708  Cd Length: 100  Bit Score: 135.85  E-value: 2.49e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752   1 MARLRLPKDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVK 80
Cdd:PRK04012  12 RVRLPMPEEGEVFGVVEQMLGANRVRVRCMDGVERMGRIPGKMKKRMWIREGDVVIVAPWDFQ-DEKADIIWRYTKPQVD 90


                 ....*.
gi 985671752  81 WLSQKG 86
Cdd:PRK04012  91 WLRRKG 96
 
Name Accession Description Interval E-value
PRK04012 PRK04012
translation initiation factor IF-1A; Provisional
 1-86 2.49e-43

translation initiation factor IF-1A; Provisional


Pssm-ID: 179708  Cd Length: 100  Bit Score: 135.85  E-value: 2.49e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752   1 MARLRLPKDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVK 80
Cdd:PRK04012  12 RVRLPMPEEGEVFGVVEQMLGANRVRVRCMDGVERMGRIPGKMKKRMWIREGDVVIVAPWDFQ-DEKADIIWRYTKPQVD 90


                 ....*.
gi 985671752  81 WLSQKG 86
Cdd:PRK04012  91 WLRRKG 96
eIF1a smart00652
eukaryotic translation initiation factor 1A;
7-88 2.37e-34

eukaryotic translation initiation factor 1A;


Pssm-ID: 128900  Cd Length: 83  Bit Score: 112.73  E-value: 2.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752    7 PKDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVKWLSQKG 86
Cdd:smart00652  2 KEDGQEIAQVVKMLGNGRLEVMCADGKERLARIPGKMRKKVWIRRGDIVLVDPWDFQ-DVKADIIYKYTKDEVRWLKKEG 80


                  ..
gi 985671752   87 IW 88
Cdd:smart00652 81 EL 82
S1_IF1A cd05793
S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A ...
 11-87 9.42e-34

S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A in archaea, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. IF1A is essential for translation initiation. eIF1A acts synergistically with eIF1 to mediate assembly of ribosomal initiation complexes at the initiation codon and maintain the accuracy of this process by recognizing and destabilizing aberrant preinitiation complexes from the mRNA. Without eIF1A and eIF1, 43S ribosomal preinitiation complexes can bind to the cap-proximal region, but are unable to reach the initiation codon. eIF1a also enhances the formation of 5'-terminal complexes in the presence of other translation initiation factors. This protein family is only found in eukaryotes and archaea.


Pssm-ID: 240219  Cd Length: 77  Bit Score: 110.69  E-value: 9.42e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985671752 11 EVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVKWLSQKGI 87
Cdd:cd05793   1 EEYGQVEKMLGNGRLEVRCFDGKKRLCRIRGKMRKRVWINEGDIVLVAPWDFQ-DDKADIIYKYTPDEVRWLKRKGE 76
eIF-1A TIGR00523
eukaryotic/archaeal initiation factor 1A; Recommended nomenclature: eIF-1A for eukaryotes, ...
 3-86 5.29e-33

eukaryotic/archaeal initiation factor 1A; Recommended nomenclature: eIF-1A for eukaryotes, aIF-1A for Archaea. Also called eIF-4C [Protein synthesis, Translation factors]


Pssm-ID: 273118  Cd Length: 98  Bit Score: 109.57  E-value: 5.29e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752   3 RLRLP--KDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVK 80
Cdd:TIGR00523 10 RVRLPykEEGEIYGVITQMLGAGRVKVRCFDGNKRLARIPGKLRKKIWIREGDVVLVKPWEFQ-DDKCDIVWRYTLTEVE 88


                 ....*.
gi 985671752  81 WLSQKG 86
Cdd:TIGR00523 89 WLKRKG 94
InfA COG0361
Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; ...
 9-75 1.08e-26

Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; Translation initiation factor IF-1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440130  Cd Length: 73  Bit Score: 92.86  E-value: 1.08e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985671752  9 DNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRK-RTWIREGDVVIVEPWQVQsDEKADIVYRYT 75
Cdd:COG0361   7 LIEVEGVVEEVLPNARFRVRLENGHERLARISGKMRKnRIRILPGDRVLVEPSPYD-LTKGRIVYRYK 73
eIF-1a pfam01176
Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation ...
 11-73 2.97e-22

Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.


Pssm-ID: 460099  Cd Length: 62  Bit Score: 81.28  E-value: 2.97e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 985671752  11 EVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYR 73
Cdd:pfam01176  1 EVIGKVVEALGNNLFEVELDNGHTRLAHIPGKMRNRIWIKRGDYVLVEPSPYD-LTKGRIVYR 62
 
Name Accession Description Interval E-value
PRK04012 PRK04012
translation initiation factor IF-1A; Provisional
 1-86 2.49e-43

translation initiation factor IF-1A; Provisional


Pssm-ID: 179708  Cd Length: 100  Bit Score: 135.85  E-value: 2.49e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752   1 MARLRLPKDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVK 80
Cdd:PRK04012  12 RVRLPMPEEGEVFGVVEQMLGANRVRVRCMDGVERMGRIPGKMKKRMWIREGDVVIVAPWDFQ-DEKADIIWRYTKPQVD 90


                 ....*.
gi 985671752  81 WLSQKG 86
Cdd:PRK04012  91 WLRRKG 96
eIF1a smart00652
eukaryotic translation initiation factor 1A;
7-88 2.37e-34

eukaryotic translation initiation factor 1A;


Pssm-ID: 128900  Cd Length: 83  Bit Score: 112.73  E-value: 2.37e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752    7 PKDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVKWLSQKG 86
Cdd:smart00652  2 KEDGQEIAQVVKMLGNGRLEVMCADGKERLARIPGKMRKKVWIRRGDIVLVDPWDFQ-DVKADIIYKYTKDEVRWLKKEG 80


                  ..
gi 985671752   87 IW 88
Cdd:smart00652 81 EL 82
S1_IF1A cd05793
S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A ...
 11-87 9.42e-34

S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A in archaea, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. IF1A is essential for translation initiation. eIF1A acts synergistically with eIF1 to mediate assembly of ribosomal initiation complexes at the initiation codon and maintain the accuracy of this process by recognizing and destabilizing aberrant preinitiation complexes from the mRNA. Without eIF1A and eIF1, 43S ribosomal preinitiation complexes can bind to the cap-proximal region, but are unable to reach the initiation codon. eIF1a also enhances the formation of 5'-terminal complexes in the presence of other translation initiation factors. This protein family is only found in eukaryotes and archaea.


Pssm-ID: 240219  Cd Length: 77  Bit Score: 110.69  E-value: 9.42e-34
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985671752 11 EVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVKWLSQKGI 87
Cdd:cd05793   1 EEYGQVEKMLGNGRLEVRCFDGKKRLCRIRGKMRKRVWINEGDIVLVAPWDFQ-DDKADIIYKYTPDEVRWLKRKGE 76
eIF-1A TIGR00523
eukaryotic/archaeal initiation factor 1A; Recommended nomenclature: eIF-1A for eukaryotes, ...
 3-86 5.29e-33

eukaryotic/archaeal initiation factor 1A; Recommended nomenclature: eIF-1A for eukaryotes, aIF-1A for Archaea. Also called eIF-4C [Protein synthesis, Translation factors]


Pssm-ID: 273118  Cd Length: 98  Bit Score: 109.57  E-value: 5.29e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752   3 RLRLP--KDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVK 80
Cdd:TIGR00523 10 RVRLPykEEGEIYGVITQMLGAGRVKVRCFDGNKRLARIPGKLRKKIWIREGDVVLVKPWEFQ-DDKCDIVWRYTLTEVE 88


                 ....*.
gi 985671752  81 WLSQKG 86
Cdd:TIGR00523 89 WLKRKG 94
S1_IF1A_like cd04456
S1_IF1A_like: Translation initiation factor IF1A-like, S1-like RNA-binding domain. IF1A is ...
 11-88 3.37e-28

S1_IF1A_like: Translation initiation factor IF1A-like, S1-like RNA-binding domain. IF1A is also referred to as eIF1A in eukaryotes and aIF1A in archaea. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. IF1A is essential for translation initiation. eIF1A acts synergistically with eIF1 to mediate assembly of ribosomal initiation complexes at the initiation codon and maintain the accuracy of this process by recognizing and destabilizing aberrant preinitiation complexes from the mRNA. Without eIF1A and eIF1, 43S ribosomal preinitiation complexes can bind to the cap-proximal region, but are unable to reach the initiation codon. eIF1a also enhances the formation of 5'-terminal complexes in the presence of other translation initiation factors. This protein family is only found in eukaryotes and archaea.


Pssm-ID: 239903  Cd Length: 78  Bit Score: 96.85  E-value: 3.37e-28
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985671752 11 EVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQSDEKADIVYRYTRTQVKWLSQKGIW 88
Cdd:cd04456   1 QQIVRVLRMLGNNRHEVECADGQRRLVSIPGKLRKNIWIKRGDFLIVDPIEEGEDVKADIIFVYCKDHVRSLKKEGFL 78
InfA COG0361
Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; ...
 9-75 1.08e-26

Translation initiation factor IF-1 [Translation, ribosomal structure and biogenesis]; Translation initiation factor IF-1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440130  Cd Length: 73  Bit Score: 92.86  E-value: 1.08e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985671752  9 DNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRK-RTWIREGDVVIVEPWQVQsDEKADIVYRYT 75
Cdd:COG0361   7 LIEVEGVVEEVLPNARFRVRLENGHERLARISGKMRKnRIRILPGDRVLVEPSPYD-LTKGRIVYRYK 73
eIF-1a pfam01176
Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation ...
 11-73 2.97e-22

Translation initiation factor 1A / IF-1; This family includes both the eukaryotic translation factor eIF-1A and the bacterial translation initiation factor IF-1.


Pssm-ID: 460099  Cd Length: 62  Bit Score: 81.28  E-value: 2.97e-22
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 985671752  11 EVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYR 73
Cdd:pfam01176  1 EVIGKVVEALGNNLFEVELDNGHTRLAHIPGKMRNRIWIKRGDYVLVEPSPYD-LTKGRIVYR 62
PLN00208 PLN00208
translation initiation factor (eIF); Provisional
 9-86 1.95e-16

translation initiation factor (eIF); Provisional


Pssm-ID: 177798  Cd Length: 145  Bit Score: 69.06  E-value: 1.95e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 985671752   9 DNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVKWLSQKG 86
Cdd:PLN00208  31 DGQEYAQVLRMLGNGRCEALCIDGTKRLCHIRGKMRKKVWIAAGDIILVGLRDYQ-DDKADVILKYMPDEARLLKAYG 107
PTZ00329 PTZ00329
eukaryotic translation initiation factor 1A; Provisional
 4-86 4.92e-15

eukaryotic translation initiation factor 1A; Provisional


Pssm-ID: 185558  Cd Length: 155  Bit Score: 65.60  E-value: 4.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985671752   4 LRLPKDNEVLGLVEKTFGSGHLRVRCKDGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQsDEKADIVYRYTRTQVKWLS 83
Cdd:PTZ00329  26 LVFKEEGQEYAQVLRMLGNGRLEAYCFDGVKRLCHIRGKMRKRVWINIGDIILVSLRDFQ-DSKADVILKYTPDEARALK 104


                 ...
gi 985671752  84 QKG 86
Cdd:PTZ00329 105 QHG 107
S1_eIF1AD_like cd05792
S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD) ...
 31-88 5.47e-10

S1_eIF1AD_like: eukaryotic translation initiation factor 1A domain containing protein (eIF1AD)-like, S1-like RNA-binding domain. eIF1AD is also known as MGC11102 protein. Little is known about the function of eIF1AD. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins, including translation initiation factor IF1A (also referred to as eIF1A in eukaryotes). eIF1A is essential for translation initiation. eIF1A acts synergistically with eIF1 to mediate assembly of ribosomal initiation complexes at the initiation codon and maintain the accuracy of this process by recognizing and destabilizing aberrant preinitiation complexes from the mRNA. Without eIF1A and eIF1, 43S ribosomal preinitiation complexes can bind to the cap-proximal region, but are unable to reach the initiation codon. eIF1a also enhances the formation of 5'-terminal complexes in the presence of other translation initiation factors.


Pssm-ID: 240218  Cd Length: 78  Bit Score: 50.51  E-value: 5.47e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 985671752 31 DGLTRMCRIPGRMRKRTWIREGDVVIVEPWQVQSDEKADIVYRYTRTQVKWLSQKGIW 88
Cdd:cd05792  21 NGSRYLVSMPTKFRKNIWIKRGDFVLVEPIEEGDKVKAEIVKILTRDHVKYIKEEGLW 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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