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Conserved domains on  [gi|4506913|ref|NP_000223|]
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beta-sarcoglycan [Homo sapiens]

Protein Classification

sarcoglycan( domain architecture ID 10521547)

sarcoglycan beta/delta/gamma/zeta is a component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sarcoglycan_1 pfam04790
Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a ...
54-303 1.69e-65

Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.


:

Pssm-ID: 461428  Cd Length: 255  Bit Score: 206.32  E-value: 1.69e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913     54 KTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGlLRF-KQVSDMGvihPLYKSTVGGRRN 132
Cdd:pfam04790   1 KTGIYGWRKRCLYLLVLLLLILAVVNLALTIWILKVLRFSSNGMGSLEITPDG-VRFeGESEFLD---PLYAKEIHSFKD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913    133 ENLVITGNNQPIVFQ-----QGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGvKSLNV-QKASTE 206
Cdd:pfam04790  77 SPLSITSDRNVVLNArnengSVTSQLVVGPDGAVEASVNRFEVKDPDGGKTLFSADRPEVTVGADKG-KKLRVtGSVETP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913    207 RITSNATSDLNIKVDGRAI-VRGNEGVFIMGKTIEFHMGGNMELK---AENSIILNGSVMVSTTRLPSSSSGDQLGSGDw 282
Cdd:pfam04790 156 RIRSPPDEDLRLESPTRSLsLRAPEGVHIEARAGNISATSLKDIKlrsTNGSIVLDASGIFLPNLRPVSSSSGSSQTVS- 234
                         250       260
                  ....*....|....*....|.
gi 4506913    283 VRYKLCMCADGTLFKVQVTSQ 303
Cdd:pfam04790 235 TQYKLCVCPNGKLFLVPANAG 255
 
Name Accession Description Interval E-value
Sarcoglycan_1 pfam04790
Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a ...
54-303 1.69e-65

Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.


Pssm-ID: 461428  Cd Length: 255  Bit Score: 206.32  E-value: 1.69e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913     54 KTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGlLRF-KQVSDMGvihPLYKSTVGGRRN 132
Cdd:pfam04790   1 KTGIYGWRKRCLYLLVLLLLILAVVNLALTIWILKVLRFSSNGMGSLEITPDG-VRFeGESEFLD---PLYAKEIHSFKD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913    133 ENLVITGNNQPIVFQ-----QGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGvKSLNV-QKASTE 206
Cdd:pfam04790  77 SPLSITSDRNVVLNArnengSVTSQLVVGPDGAVEASVNRFEVKDPDGGKTLFSADRPEVTVGADKG-KKLRVtGSVETP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913    207 RITSNATSDLNIKVDGRAI-VRGNEGVFIMGKTIEFHMGGNMELK---AENSIILNGSVMVSTTRLPSSSSGDQLGSGDw 282
Cdd:pfam04790 156 RIRSPPDEDLRLESPTRSLsLRAPEGVHIEARAGNISATSLKDIKlrsTNGSIVLDASGIFLPNLRPVSSSSGSSQTVS- 234
                         250       260
                  ....*....|....*....|.
gi 4506913    283 VRYKLCMCADGTLFKVQVTSQ 303
Cdd:pfam04790 235 TQYKLCVCPNGKLFLVPANAG 255
 
Name Accession Description Interval E-value
Sarcoglycan_1 pfam04790
Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a ...
54-303 1.69e-65

Sarcoglycan complex subunit protein; The dystrophin glycoprotein complex (DGC) is a membrane-spanning complex that links the interior cytoskeleton to the extracellular matrix in muscle. The sarcoglycan complex is a subcomplex within the DGC and is composed of several muscle-specific, transmembrane proteins (alpha-, beta-, gamma-, delta- and zeta-sarcoglycan). The sarcoglycans are asparagine-linked glycosylated proteins with single transmembrane domains. This family contains beta, gamma and delta members.


Pssm-ID: 461428  Cd Length: 255  Bit Score: 206.32  E-value: 1.69e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913     54 KTGLRGRKGNLAICVIILLFILAVINLIITLVIWAVIRIGPNGCDSMEFHESGlLRF-KQVSDMGvihPLYKSTVGGRRN 132
Cdd:pfam04790   1 KTGIYGWRKRCLYLLVLLLLILAVVNLALTIWILKVLRFSSNGMGSLEITPDG-VRFeGESEFLD---PLYAKEIHSFKD 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913    133 ENLVITGNNQPIVFQ-----QGTTKLSVENNKTSITSDIGMQFFDPRTQNILFSTDYETHEFHLPSGvKSLNV-QKASTE 206
Cdd:pfam04790  77 SPLSITSDRNVVLNArnengSVTSQLVVGPDGAVEASVNRFEVKDPDGGKTLFSADRPEVTVGADKG-KKLRVtGSVETP 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506913    207 RITSNATSDLNIKVDGRAI-VRGNEGVFIMGKTIEFHMGGNMELK---AENSIILNGSVMVSTTRLPSSSSGDQLGSGDw 282
Cdd:pfam04790 156 RIRSPPDEDLRLESPTRSLsLRAPEGVHIEARAGNISATSLKDIKlrsTNGSIVLDASGIFLPNLRPVSSSSGSSQTVS- 234
                         250       260
                  ....*....|....*....|.
gi 4506913    283 VRYKLCMCADGTLFKVQVTSQ 303
Cdd:pfam04790 235 TQYKLCVCPNGKLFLVPANAG 255
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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