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Conserved domains on  [gi|83716019|ref|NP_001032902|]
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zinc finger protein 284 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 1.31e-23

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 94.20  E-value: 1.31e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 83716019      8 VTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLSVGHQLS-HRDTFHFQREEKFWI 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPkPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-554 1.38e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 209 SKAFSQNSQ--LQTHQRIHTGE----KPFKCEQCGKSFSRRSGMYVHCKLHTGEKPHIC--EECGKAFIHNSQLREHQRI 280
Cdd:COG5048   6 SQSSSSNNSvlSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 281 HTGEKPFKCYICGKSFHSRSNLNRHSMVHMQEKSFrCDTCSNSFGQRSALNSHCMDHTKEKLYKCEE--CGRSFtcrqdl 358
Cdd:COG5048  86 HHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDN-NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgNNSSS------ 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 359 ckHQMDHTGDKPYNCNVCGKGFRWSSCLSR--HQRVHNGETTFKCDGCGKRFYMNSQGHSHQRAYREEELYKCQKCgkGY 436
Cdd:COG5048 159 --VNTPQSNSLHPPLPANSLSKDPSSNLSLliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQ 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 437 ISKFNLDLHQRVHTGErPYNCKECGKSFR---------WASGILRHKRLHTG-EKPFKCEECGKRFTENSKLRFHQR--I 504
Cdd:COG5048 235 LSPKSLLSQSPSSLSS-SDSSSSASESPRsslptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvN 313

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 83716019 505 HTGE--KPYKCEE--CGKGFRWASTHLTHQRLHSREKLFQCEDCGKSSEHSSCL 554
Cdd:COG5048 314 HSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 1.31e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 94.20  E-value: 1.31e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 83716019      8 VTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLSVGHQLS-HRDTFHFQREEKFWI 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPkPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 1.07e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 1.07e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 83716019     8 VTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLSVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 6.37e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.43  E-value: 6.37e-16
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 83716019   8 VTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLS 46
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-554 1.38e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 209 SKAFSQNSQ--LQTHQRIHTGE----KPFKCEQCGKSFSRRSGMYVHCKLHTGEKPHIC--EECGKAFIHNSQLREHQRI 280
Cdd:COG5048   6 SQSSSSNNSvlSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 281 HTGEKPFKCYICGKSFHSRSNLNRHSMVHMQEKSFrCDTCSNSFGQRSALNSHCMDHTKEKLYKCEE--CGRSFtcrqdl 358
Cdd:COG5048  86 HHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDN-NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgNNSSS------ 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 359 ckHQMDHTGDKPYNCNVCGKGFRWSSCLSR--HQRVHNGETTFKCDGCGKRFYMNSQGHSHQRAYREEELYKCQKCgkGY 436
Cdd:COG5048 159 --VNTPQSNSLHPPLPANSLSKDPSSNLSLliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQ 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 437 ISKFNLDLHQRVHTGErPYNCKECGKSFR---------WASGILRHKRLHTG-EKPFKCEECGKRFTENSKLRFHQR--I 504
Cdd:COG5048 235 LSPKSLLSQSPSSLSS-SDSSSSASESPRsslptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvN 313

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 83716019 505 HTGE--KPYKCEE--CGKGFRWASTHLTHQRLHSREKLFQCEDCGKSSEHSSCL 554
Cdd:COG5048 314 HSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-242 1.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....*
gi 83716019   218 LQTHQRIHTGEKPFKCEQCGKSFSR 242
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 204-250 3.56e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 3.56e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 83716019 204 KCDVCSKAFSQNSQLQTHQRIHTgekpFKCEQCGKSFSRRSGMYVHC 250
Cdd:cd20908   3 WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-306 3.04e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 111 LTRPQDSISSSQFSTQGDVPSQVDAGLSIIHIGETPSE-HGKCKKFFSDVSILDLHQQLHSGKISHTCNeyrkrfcyssa 189
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpYSLCGKLFSRNDALKRHILLHTSISPAKEK----------- 355

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 190 LCLHQKVHMGEKRYKcdvcskafsqNSQLQTHQRIHTGEKPFKCE--QCGKSFSRRSGMYVHCKLHTGEKPH--ICEECG 265
Cdd:COG5048 356 LLNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCS 425

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 83716019 266 KAFIHNSQLREHQRIHTGEKPFkCYICGKSFHSRSNLNRHS 306
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHG 465
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
8-67 1.31e-23

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 94.20  E-value: 1.31e-23
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 83716019      8 VTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLSVGHQLS-HRDTFHFQREEKFWI 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPkPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 8-48 1.07e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 1.07e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 83716019     8 VTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLSVG 48
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-46 6.37e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.43  E-value: 6.37e-16
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 83716019   8 VTFKDVAVVFTEEELGLLDVSQRKLYRDVMLENFRNLLS 46
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-554 1.38e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.38e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 209 SKAFSQNSQ--LQTHQRIHTGE----KPFKCEQCGKSFSRRSGMYVHCKLHTGEKPHIC--EECGKAFIHNSQLREHQRI 280
Cdd:COG5048   6 SQSSSSNNSvlSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 281 HTGEKPFKCYICGKSFHSRSNLNRHSMVHMQEKSFrCDTCSNSFGQRSALNSHCMDHTKEKLYKCEE--CGRSFtcrqdl 358
Cdd:COG5048  86 HHNNPSDLNSKSLPLSNSKASSSSLSSSSSNSNDN-NLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgNNSSS------ 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 359 ckHQMDHTGDKPYNCNVCGKGFRWSSCLSR--HQRVHNGETTFKCDGCGKRFYMNSQGHSHQRAYREEELYKCQKCgkGY 436
Cdd:COG5048 159 --VNTPQSNSLHPPLPANSLSKDPSSNLSLliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQ 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 437 ISKFNLDLHQRVHTGErPYNCKECGKSFR---------WASGILRHKRLHTG-EKPFKCEECGKRFTENSKLRFHQR--I 504
Cdd:COG5048 235 LSPKSLLSQSPSSLSS-SDSSSSASESPRsslptassqSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvN 313

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....
gi 83716019 505 HTGE--KPYKCEE--CGKGFRWASTHLTHQRLHSREKLFQCEDCGKSSEHSSCL 554
Cdd:COG5048 314 HSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
203-553 2.80e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 2.80e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 203 YKCDVCSKAFSQNSQLQTHQRIHTGEKPFKC--EQCGKSFSRRSGMYVHCKLHTGEKPHicEECGKAFIHNSQLREHQRI 280
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 281 HTGEKPFKCYIC-----GKSFHSRSNLNRHSMVHMQEK-------SFRCDTCSNSFGQRSALNSHCMDHTKEKLYKCEE- 347
Cdd:COG5048 112 SSSSNSNDNNLLsshslPPSSRDPQLPDLLSISNLRNNplpgnnsSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSn 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 348 ------------CGRSFTCRQDLCKHQMDHTGDKPYNCNVCGKGFRWSSCLSRHQRVHNGETTFKCDGCGKRF--YMNSQ 413
Cdd:COG5048 192 vstsipsssensPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 414 GHSHQRAYREEE-----LYKCQKCGKGYISKFNLDLHQR--VHTGE--RPYNCKE--CGKSFRWASGILRHKRLHTGEKP 482
Cdd:COG5048 272 SSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 483 FKC--EECGKRFTENSKLRFHQRIHT-------------------------------------GEKPYKCEECGKGFRWA 523
Cdd:COG5048 352 AKEklLNSSSKFSPLLNNEPPQSLQQykdlkndkksetlsnscirnfkrdsnlslhiithlsfRPYNCKNPPCSKSFNRH 431

                       410       420       430
                ....*....|....*....|....*....|
gi 83716019 524 STHLTHQRLHSREKLFQCEDCGKSSEHSSC 553
Cdd:COG5048 432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-242 1.58e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|....*
gi 83716019   218 LQTHQRIHTGEKPFKCEQCGKSFSR 242
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 204-250 3.56e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.46  E-value: 3.56e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 83716019 204 KCDVCSKAFSQNSQLQTHQRIHTgekpFKCEQCGKSFSRRSGMYVHC 250
Cdd:cd20908   3 WCYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
274-296 4.68e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.68e-04
                          10        20
                  ....*....|....*....|...
gi 83716019   274 LREHQRIHTGEKPFKCYICGKSF 296
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
498-520 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|...
gi 83716019   498 LRFHQRIHTGEKPYKCEECGKGF 520
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
472-493 1.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.20e-03
                          10        20
                  ....*....|....*....|..
gi 83716019   472 RHKRLHTGEKPFKCEECGKRFT 493
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 451-529 1.77e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 451 GERPYNCK--ECGKSFRWASGiLRHKRLHTgekpfkceECGKRFTENSKLRFHQRIHTGEKPYKCEECGK------GFRW 522
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNG-LKYHMLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKryknlnGLKY 416


                ....*..
gi 83716019 523 ASTHLTH 529
Cdd:COG5189 417 HRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
441-464 3.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|....
gi 83716019   441 NLDLHQRVHTGERPYNCKECGKSF 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-306 3.04e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 111 LTRPQDSISSSQFSTQGDVPSQVDAGLSIIHIGETPSE-HGKCKKFFSDVSILDLHQQLHSGKISHTCNeyrkrfcyssa 189
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpYSLCGKLFSRNDALKRHILLHTSISPAKEK----------- 355

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 190 LCLHQKVHMGEKRYKcdvcskafsqNSQLQTHQRIHTGEKPFKCE--QCGKSFSRRSGMYVHCKLHTGEKPH--ICEECG 265
Cdd:COG5048 356 LLNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCS 425

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 83716019 266 KAFIHNSQLREHQRIHTGEKPFkCYICGKSFHSRSNLNRHS 306
Cdd:COG5048 426 KSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHG 465
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 227-305 3.25e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 83716019 227 GEKPFKCE--QCGKSFSRRSGMYVHcKLHTGEKPHICEecgkafihNSQLREHQRIHTGEKPFKCYICGKSFHSRSNLNR 304
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHE--------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 83716019 305 H 305
Cdd:COG5189 417 H 417
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 285-342 3.85e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.85e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 83716019 285 KPFkCYICGKSFHSRSNLnrhsMVHMQEKSFRCDTCSNSFGQRSALNSHCMDHTKEKL 342
Cdd:cd20908   1 KPW-CYYCDREFDDEKIL----IQHQKAKHFKCHICHKKLYTAGGLAVHCLQVHKETL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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