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Conserved domains on  [gi|113682095|ref|NP_001038496|]
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uncharacterized protein LOC563854 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-315 1.81e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 1.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 137 LRALEGH-SDIITCAVAVDN-LVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLCAPPPescrrlarafdladkERFV 214
Cdd:cd00200   86 VRTLTGHtSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---------------GTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 215 LSGSTDCCVKIWALSSGQCVKSIYTFN-AVTSLCFIPEGEGFIVTGSDaGKLQVWSWSSLENWLSVNAHLDAVTTLQSHG 293
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTgEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                        170       180
                 ....*....|....*....|....
gi 113682095 294 P--LVFSGSAEGSVCVWEVCDEGP 315
Cdd:cd00200  230 DgyLLASGSEDGTIRVWDLRTGEC 253
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-315 1.81e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 1.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 137 LRALEGH-SDIITCAVAVDN-LVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLCAPPPescrrlarafdladkERFV 214
Cdd:cd00200   86 VRTLTGHtSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---------------GTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 215 LSGSTDCCVKIWALSSGQCVKSIYTFN-AVTSLCFIPEGEGFIVTGSDaGKLQVWSWSSLENWLSVNAHLDAVTTLQSHG 293
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTgEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                        170       180
                 ....*....|....*....|....
gi 113682095 294 P--LVFSGSAEGSVCVWEVCDEGP 315
Cdd:cd00200  230 DgyLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
137-412 9.47e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 9.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 137 LRALEGHSDIITcAVAVD---NLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLcapppescrrlarAFDlADkERF 213
Cdd:COG2319  155 LRTLTGHSGAVT-SVAFSpdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-------------AFS-PD-GKL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 214 VLSGSTDCCVKIWALSSGQCVKSIYTF-NAVTSLCFIPEGEgFIVTGSDAGKLQVWSWSSLENWLSVNAHLDAVTTLQSH 292
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHsGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 293 --GPLVFSGSAEGSVCVWEVcdEGPEPLRRLHlwgpevtgcgGEDGLNGRLVLSPRGDRVFLSCGKASIRILNWRTG-VM 369
Cdd:COG2319  298 pdGKLLASGSDDGTVRLWDL--ATGKLLRTLT----------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGeLL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 113682095 370 TRLANHssTAGVTDCVNQIPGLLIAScfdlANGESTINLFSLP 412
Cdd:COG2319  366 RTLTGH--TGAVTSVAFSPDGRTLAS----GSADGTVRLWDLA 402
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 143-237 2.01e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.60  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095  143 HSDIITC-AVAVD-NLVISGSRDTTVKVWHV--PTATEQRN---------------------LGGHSGGVTCLCApppes 197
Cdd:pfam20426 123 HKDVVSCvAVTSDgSILATGSYDTTVMVWEVlrGRSSEKRSrntqtefprkdhviaetpfhiLCGHDDIITCLYV----- 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 113682095  198 crrlARAFDLadkerfVLSGSTDCCVKIWALSSGQCVKSI 237
Cdd:pfam20426 198 ----SVELDI------VISGSKDGTCIFHTLREGRYVRSI 227
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-170 1.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 113682095   137 LRALEGHSDIITCaVAVD---NLVISGSRDTTVKVWH 170
Cdd:smart00320   5 LKTLKGHTGPVTS-VAFSpdgKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-315 1.81e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.74  E-value: 1.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 137 LRALEGH-SDIITCAVAVDN-LVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLCAPPPescrrlarafdladkERFV 214
Cdd:cd00200   86 VRTLTGHtSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD---------------GTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 215 LSGSTDCCVKIWALSSGQCVKSIYTFN-AVTSLCFIPEGEGFIVTGSDaGKLQVWSWSSLENWLSVNAHLDAVTTLQSHG 293
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTgEVNSVAFSPDGEKLLSSSSD-GTIKLWDLSTGKCLGTLRGHENGVNSVAFSP 229

                        170       180
                 ....*....|....*....|....
gi 113682095 294 P--LVFSGSAEGSVCVWEVCDEGP 315
Cdd:cd00200  230 DgyLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
137-412 9.47e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 9.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 137 LRALEGHSDIITcAVAVD---NLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLcapppescrrlarAFDlADkERF 213
Cdd:COG2319  155 LRTLTGHSGAVT-SVAFSpdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV-------------AFS-PD-GKL 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 214 VLSGSTDCCVKIWALSSGQCVKSIYTF-NAVTSLCFIPEGEgFIVTGSDAGKLQVWSWSSLENWLSVNAHLDAVTTLQSH 292
Cdd:COG2319  219 LASGSADGTVRLWDLATGKLLRTLTGHsGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 293 --GPLVFSGSAEGSVCVWEVcdEGPEPLRRLHlwgpevtgcgGEDGLNGRLVLSPRGDRVFLSCGKASIRILNWRTG-VM 369
Cdd:COG2319  298 pdGKLLASGSDDGTVRLWDL--ATGKLLRTLT----------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGeLL 365

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 113682095 370 TRLANHssTAGVTDCVNQIPGLLIAScfdlANGESTINLFSLP 412
Cdd:COG2319  366 RTLTGH--TGAVTSVAFSPDGRTLAS----GSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
136-453 3.76e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 3.76e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 136 RLRALEGHSDIITcAVAVD---NLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLcapppescrrlarAFDlADkER 212
Cdd:COG2319  112 LLRTLTGHTGAVR-SVAFSpdgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV-------------AFS-PD-GK 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 213 FVLSGSTDCCVKIWALSSGQCVKSIYTF-NAVTSLCFIPEGEgFIVTGSDAGKLQVWSWSSLENWLSVNAHLDAVTTL-- 289
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHtGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVaf 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 290 QSHGPLVFSGSAEGSVCVWEVcdEGPEPLRRLHLWGPEVTGcggedglngrLVLSPRGDRVFLSCGKASIRILNWRTGvm 369
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNS----------VAFSPDGKLLASGSDDGTVRLWDLATG-- 320

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 370 TRLANHSSTAGVTDCVNQIP-GLLIAScfdlANGESTINLFSLPQCKYLVSLTSsdlprilcFAAWLTA---SGDHRW-V 444
Cdd:COG2319  321 KLLRTLTGHTGAVRSVAFSPdGKTLAS----GSDDGTVRLWDLATGELLRTLTG--------HTGAVTSvafSPDGRTlA 388

                        330
                 ....*....|.
gi 113682095 445 TGGRD--LIVW 453
Cdd:COG2319  389 SGSADgtVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 137-442 1.10e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 109.35  E-value: 1.10e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 137 LRALEGHSDIITCA--VAVDNLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLcapppescrrLARAFDladkeRFV 214
Cdd:cd00200    2 RRTLKGHTGGVTCVafSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDV----------AASADG-----TYL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 215 LSGSTDCCVKIWALSSGQCVKSIYTF-NAVTSLCFIPEGEgFIVTGSDAGKLQVWSWSSLENWLSVNAHLDAVTTLQSH- 292
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHtSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSp 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 293 -GPLVFSGSAEGSVCVWEVcdEGPEPLRRLHlwgpevtgcGGEDGLNGrLVLSPRGDRVFLSCGKASIRILNWRTGVMTR 371
Cdd:cd00200  146 dGTFVASSSQDGTIKLWDL--RTGKCVATLT---------GHTGEVNS-VAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG 213

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113682095 372 LaNHSSTAGVTDCVNQIPGLLIASCfdlaNGESTINLFSLPQCKYLVSLTSSDlPRILCFAAW------LTASGDHR 442
Cdd:cd00200  214 T-LRGHENGVNSVAFSPDGYLLASG----SEDGTIRVWDLRTGECVQTLSGHT-NSVTSLAWSpdgkrlASGSADGT 284
WD40 COG2319
WD40 repeat [General function prediction only];
136-366 3.56e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 3.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 136 RLRALEGHSDIITC-AVAVD-NLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLcapppescrrlarAFdlADKERF 213
Cdd:COG2319  196 LLRTLTGHTGAVRSvAFSPDgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV-------------AF--SPDGRL 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 214 VLSGSTDCCVKIWALSSGQCVKSI-YTFNAVTSLCFIPEGEgFIVTGSDAGKLQVWSWSSLENWLSVNAHLDAVTTLQ-- 290
Cdd:COG2319  261 LASGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfs 339

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113682095 291 SHGPLVFSGSAEGSVCVWEVcdEGPEPLRRLHlwgpevtgcGGEDGLNGrLVLSPRGDRVFLSCGKASIRILNWRT 366
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDL--ATGELLRTLT---------GHTGAVTS-VAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
120-454 6.28e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 6.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 120 DAEFRSRKQTWEKAKFRLRALEGHSDIITCAVA--VDNLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLcapppes 197
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSV------- 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 198 crrlarAFDlADkERFVLSGSTDCCVKIWALSSGQCVKSIYTF-NAVTSLCFIPEGEgFIVTGSDAGKLQVWSWSSLENW 276
Cdd:COG2319  127 ------AFS-PD-GKTLASGSADGTVRLWDLATGKLLRTLTGHsGAVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLL 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 277 LSVNAHLDAVTTLQ--SHGPLVFSGSAEGSVCVWEVcdEGPEPLRRLHLWGPEVTGcggedglngrLVLSPRGDRVFLSC 354
Cdd:COG2319  198 RTLTGHTGAVRSVAfsPDGKLLASGSADGTVRLWDL--ATGKLLRTLTGHSGSVRS----------VAFSPDGRLLASGS 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 355 GKASIRILNWRTG-VMTRLANHSSTagvtdcVNQI---P-GLLIAScfdlANGESTINLFSLPQCKYLVSLT-SSDLPRI 428
Cdd:COG2319  266 ADGTVRLWDLATGeLLRTLTGHSGG------VNSVafsPdGKLLAS----GSDDGTVRLWDLATGKLLRTLTgHTGAVRS 335

                        330       340
                 ....*....|....*....|....*....
gi 113682095 429 LCFaawltaSGDHRW-VTGGRD--LIVWE 454
Cdd:COG2319  336 VAF------SPDGKTlASGSDDgtVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 130-227 1.50e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 61.97  E-value: 1.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 130 WEKAKFRLRA-LEGHSDIITCaVAVD---NLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLCapppescrrlaraf 205
Cdd:cd00200  204 WDLSTGKCLGtLRGHENGVNS-VAFSpdgYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA-------------- 268

                         90       100
                 ....*....|....*....|..
gi 113682095 206 dLADKERFVLSGSTDCCVKIWA 227
Cdd:cd00200  269 -WSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
150-453 1.50e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 150 AVAVDNLVISGSRDTTVKVWHVPTATEQRNLGGHSGGVTCLCAPPPESCRRLARAFDLadkerfvlsgstdccVKIWALS 229
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLT---------------LLLLDAA 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 230 SGQCVKS-IYTFNAVTSLCFIPEGeGFIVTGSDAGKLQVWSWSSLENWLSVNAHLDAVTTLQ--SHGPLVFSGSAEGSVC 306
Cdd:COG2319   67 AGALLATlLGHTAAVLSVAFSPDG-RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAfsPDGKTLASGSADGTVR 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095 307 VWEVcdEGPEPLRRLHLWGPEVTGcggedglngrLVLSPRGDRVFLSCGKASIRILNWRTG-VMTRLANHsstagvTDCV 385
Cdd:COG2319  146 LWDL--ATGKLLRTLTGHSGAVTS----------VAFSPDGKLLASGSDDGTVRLWDLATGkLLRTLTGH------TGAV 207

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113682095 386 NQI---P-GLLIAScfdlANGESTINLFSLPQCKYLVSLTSSDlPRILCfAAWltaSGDHRW-VTGGRD--LIVW 453
Cdd:COG2319  208 RSVafsPdGKLLAS----GSADGTVRLWDLATGKLLRTLTGHS-GSVRS-VAF---SPDGRLlASGSADgtVRLW 273
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 143-237 2.01e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.60  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113682095  143 HSDIITC-AVAVD-NLVISGSRDTTVKVWHV--PTATEQRN---------------------LGGHSGGVTCLCApppes 197
Cdd:pfam20426 123 HKDVVSCvAVTSDgSILATGSYDTTVMVWEVlrGRSSEKRSrntqtefprkdhviaetpfhiLCGHDDIITCLYV----- 197

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 113682095  198 crrlARAFDLadkerfVLSGSTDCCVKIWALSSGQCVKSI 237
Cdd:pfam20426 198 ----SVELDI------VISGSKDGTCIFHTLREGRYVRSI 227
WD40 pfam00400
WD domain, G-beta repeat;
137-169 8.66e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.66e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 113682095  137 LRALEGHSDIITCaVAVD---NLVISGSRDTTVKVW 169
Cdd:pfam00400   4 LKTLEGHTGSVTS-LAFSpdgKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-170 1.82e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 113682095   137 LRALEGHSDIITCaVAVD---NLVISGSRDTTVKVWH 170
Cdd:smart00320   5 LKTLKGHTGPVTS-VAFSpdgKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
175-226 2.41e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 2.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 113682095  175 TEQRNLGGHSGGVTCLCAPPpescrrlarafdladKERFVLSGSTDCCVKIW 226
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP---------------DGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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