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Conserved domains on  [gi|118600995|ref|NP_001072998|]
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cryptic family protein 1B precursor [Homo sapiens]

Protein Classification

EGF_CA and CFC domain-containing protein( domain architecture ID 10042993)

EGF_CA and CFC domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CFC pfam09443
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ...
 123-157 6.62e-12

Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.


:

Pssm-ID: 462800  Cd Length: 35  Bit Score: 58.05  E-value: 6.62e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 118600995  123 CGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRC 157
Cdd:pfam09443   1 CGSVPHGAWVPKGCSLCRCGYGTLHCLPQQTLPGC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 91-115 6.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.04e-04
                         10        20
                 ....*....|....*....|....*...
gi 118600995  91 CRNGGTCV--LGSF-CVCPAHFTGRYCE 115
Cdd:cd00054   11 CQNGGTCVntVGSYrCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
CFC pfam09443
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ...
 123-157 6.62e-12

Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.


Pssm-ID: 462800  Cd Length: 35  Bit Score: 58.05  E-value: 6.62e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 118600995  123 CGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRC 157
Cdd:pfam09443   1 CGSVPHGAWVPKGCSLCRCGYGTLHCLPQQTLPGC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 91-115 6.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.04e-04
                         10        20
                 ....*....|....*....|....*...
gi 118600995  91 CRNGGTCV--LGSF-CVCPAHFTGRYCE 115
Cdd:cd00054   11 CQNGGTCVntVGSYrCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
CFC pfam09443
Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein ...
 123-157 6.62e-12

Cripto_Frl-1_Cryptic (CFC); CFC domain is one half of the membrane protein Cripto, a protein overexpressed in many tumours and structurally similar to the C-terminal extracellular portions of Jagged 1 and Jagged 2. CFC is approx 40-residues long, compacted by three internal disulphide bridges, and binds Alk4 via a hydrophobic patch. CFC is structurally homologous to the VWFC-like domain.


Pssm-ID: 462800  Cd Length: 35  Bit Score: 58.05  E-value: 6.62e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 118600995  123 CGALEHGAWTLRACHLCRCIFGALHCLPLQTPDRC 157
Cdd:pfam09443   1 CGSVPHGAWVPKGCSLCRCGYGTLHCLPQQTLPGC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 91-115 6.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.04e-04
                         10        20
                 ....*....|....*....|....*...
gi 118600995  91 CRNGGTCV--LGSF-CVCPAHFTGRYCE 115
Cdd:cd00054   11 CQNGGTCVntVGSYrCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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