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Conserved domains on  [gi|122114567|ref|NP_001073651|]
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aquaporin-8a.2 [Danio rerio]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 239)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  8849412|11473620|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP super family cl00200
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-246 3.78e-50

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


The actual alignment was detected with superfamily member cd00333:

Pssm-ID: 444743  Cd Length: 228  Bit Score: 163.96  E-value: 3.78e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  36 CIAELVGTTFFVFIGCVSVI----ENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVVPY 111
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLavklAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 112 LISQLIGGVLGAAMSKVMTSDENYANATGAAFAVLKSDEQL------GKVVFAEMAMTCLVTLVVLMGAV--NGKSKSPM 183
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPspgvsnGNAFFVEFIGTFILVLVVFATTDdpNGPPPGGL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122114567 184 VPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVAN---HWTYHWVYWVGPLGGGLVAAALMRLL 246
Cdd:cd00333  163 APLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-246 3.78e-50

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 163.96  E-value: 3.78e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  36 CIAELVGTTFFVFIGCVSVI----ENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVVPY 111
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLavklAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 112 LISQLIGGVLGAAMSKVMTSDENYANATGAAFAVLKSDEQL------GKVVFAEMAMTCLVTLVVLMGAV--NGKSKSPM 183
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPspgvsnGNAFFVEFIGTFILVLVVFATTDdpNGPPPGGL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122114567 184 VPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVAN---HWTYHWVYWVGPLGGGLVAAALMRLL 246
Cdd:cd00333  163 APLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 36-240 1.65e-49

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 162.10  E-value: 1.65e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567   36 CIAELVGTTFFVFIGCVSVI------ENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVV 109
Cdd:pfam00230  11 VIAEFLATLLFVFFGVGSALgvkklvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLRAI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  110 PYLISQLIGGVLGAAMSKVMTSdeNYANATGAAfAVLKSDEQLGKVVFAEMAMTCLVTLVVLMGAVNGK--SKSPMVPFM 187
Cdd:pfam00230  91 FYIVAQLLGAIAGAALLYGVTV--GLQRAGLFA-NTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRngSLGTVAPLA 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 122114567  188 VGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAA 240
Cdd:pfam00230 168 IGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGA 220
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 33-248 7.17e-45

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 150.66  E-value: 7.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  33 FQPCIAELVGTTFFVFIGCVSVI---ENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVV 109
Cdd:COG0580    3 MKRLLAEFLGTFILVLLGCGVVAvlaGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 110 PYLISQLIGGVLGAAMSKVMTSD----ENYANATGAAFAVLKSDEQ-LGKVVFAEMAMTCLVTLVVLMGAVNGKSKSPMV 184
Cdd:COG0580   83 PYIIAQLLGAFLGAALVYLIYGGhfdaTEDGGAKLGVFATSPAIGYsLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 185 PFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVA------NHWTYHWVYWVGPLGGGLVAAALMRLLLG 248
Cdd:COG0580  163 PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 38-240 4.29e-43

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 145.52  E-value: 4.29e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567   38 AELVGTTFFVFIGCVSVIENVEAAG--------RLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVV 109
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAygavgggqFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  110 PYLISQLIGGVLGAAMSKVMTSDENYANATGAAFAVLKSDeqLGKVVFAEMAMTCLVTLVVLMGAV--NGKSKSPMVPFM 187
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVS--SGQAFFVEFIGTAILVLVIFATTDdrNRVPRGGFAPLA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 122114567  188 VGCTVIVNILAGGDVSGTCLNPARAFGPALVANH--WTYHWVYWVGPLGGGLVAA 240
Cdd:TIGR00861 159 IGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGA 213
PLN00184 PLN00184
aquaporin NIP1; Provisional
 23-257 4.31e-31

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 116.66  E-value: 4.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  23 PKPQSKYERIF-------QPCIAELVGTTFFVFIGCVSVIENVE---AAGRLQPALVHGLAVAVLVACMAEISGSHFNPP 92
Cdd:PLN00184  37 PKPLKKQDSLLsvsvpflQKLIAEVLGTYFLVFTGCASVVVNMQndnVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  93 FTIAIWLCGGMQLTMVVPYLISQLIGGVLGAAMSKVMTS-DENYANATGAAF-AVLKSDEQLGKVVFaEMAMTCLVTLVV 170
Cdd:PLN00184 117 VTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGlDHDVCSGKHDVFiGSSPVGSDLQAFVM-EFIVTFYLMFII 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 171 LMGAVNGKSKSPMVPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAAALMRLL-LGD 249
Cdd:PLN00184 196 SGVATDNRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVrYTD 275


                 ....*...
gi 122114567 250 EKLRVVMK 257
Cdd:PLN00184 276 KPLREITK 283
 
Name Accession Description Interval E-value
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 36-246 3.78e-50

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 163.96  E-value: 3.78e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  36 CIAELVGTTFFVFIGCVSVI----ENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVVPY 111
Cdd:cd00333    3 YLAEFLGTFLLVFFGCGSVLavklAGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIPY 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 112 LISQLIGGVLGAAMSKVMTSDENYANATGAAFAVLKSDEQL------GKVVFAEMAMTCLVTLVVLMGAV--NGKSKSPM 183
Cdd:cd00333   83 IIAQLLGAILGAALLYGLYYGLYLEFLGANNIVAGIFGTYPspgvsnGNAFFVEFIGTFILVLVVFATTDdpNGPPPGGL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 122114567 184 VPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVAN---HWTYHWVYWVGPLGGGLVAAALMRLL 246
Cdd:cd00333  163 APLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGlarHWHYFWVYWVGPLIGAIAGALVYDYV 228
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 36-240 1.65e-49

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 162.10  E-value: 1.65e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567   36 CIAELVGTTFFVFIGCVSVI------ENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVV 109
Cdd:pfam00230  11 VIAEFLATLLFVFFGVGSALgvkklvSSLAVSGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLVGRRFSLLRAI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  110 PYLISQLIGGVLGAAMSKVMTSdeNYANATGAAfAVLKSDEQLGKVVFAEMAMTCLVTLVVLMGAVNGK--SKSPMVPFM 187
Cdd:pfam00230  91 FYIVAQLLGAIAGAALLYGVTV--GLQRAGLFA-NTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRngSLGTVAPLA 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 122114567  188 VGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAA 240
Cdd:pfam00230 168 IGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKWDDHWVYWVGPFIGAALGA 220
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 33-248 7.17e-45

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 150.66  E-value: 7.17e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  33 FQPCIAELVGTTFFVFIGCVSVI---ENVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVV 109
Cdd:COG0580    3 MKRLLAEFLGTFILVLLGCGVVAvlaGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 110 PYLISQLIGGVLGAAMSKVMTSD----ENYANATGAAFAVLKSDEQ-LGKVVFAEMAMTCLVTLVVLMGAVNGKSKSPMV 184
Cdd:COG0580   83 PYIIAQLLGAFLGAALVYLIYGGhfdaTEDGGAKLGVFATSPAIGYsLGAAFLTEIIGTFVLVFVILGITDKRAAPGGLA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 185 PFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVA------NHWTYHWVYWVGPLGGGLVAAALMRLLLG 248
Cdd:COG0580  163 PLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHalgkggSDWGYLWVPIVAPILGAALAALLYRALFG 232
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 38-240 4.29e-43

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 145.52  E-value: 4.29e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567   38 AELVGTTFFVFIGCVSVIENVEAAG--------RLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVV 109
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGAygavgggqFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  110 PYLISQLIGGVLGAAMSKVMTSDENYANATGAAFAVLKSDeqLGKVVFAEMAMTCLVTLVVLMGAV--NGKSKSPMVPFM 187
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSASAGVS--SGQAFFVEFIGTAILVLVIFATTDdrNRVPRGGFAPLA 158

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 122114567  188 VGCTVIVNILAGGDVSGTCLNPARAFGPALVANH--WTYHWVYWVGPLGGGLVAA 240
Cdd:TIGR00861 159 IGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLagWGNHWVYWVGPIIGAILGA 213
PLN00184 PLN00184
aquaporin NIP1; Provisional
 23-257 4.31e-31

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 116.66  E-value: 4.31e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  23 PKPQSKYERIF-------QPCIAELVGTTFFVFIGCVSVIENVE---AAGRLQPALVHGLAVAVLVACMAEISGSHFNPP 92
Cdd:PLN00184  37 PKPLKKQDSLLsvsvpflQKLIAEVLGTYFLVFTGCASVVVNMQndnVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPA 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  93 FTIAIWLCGGMQLTMVVPYLISQLIGGVLGAAMSKVMTS-DENYANATGAAF-AVLKSDEQLGKVVFaEMAMTCLVTLVV 170
Cdd:PLN00184 117 VTIAFASCGRFPLKQVPAYVISQVIGSTLAAATLRLLFGlDHDVCSGKHDVFiGSSPVGSDLQAFVM-EFIVTFYLMFII 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 171 LMGAVNGKSKSPMVPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAAALMRLL-LGD 249
Cdd:PLN00184 196 SGVATDNRAIGELAGLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYKGIWIYIVAPTLGAIAGAWVYNTVrYTD 275


                 ....*...
gi 122114567 250 EKLRVVMK 257
Cdd:PLN00184 276 KPLREITK 283
PLN00027 PLN00027
aquaporin TIP; Provisional
 33-240 9.94e-29

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 109.11  E-value: 9.94e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  33 FQPCIAELVGTTFFVFIGCVSVIE--------NVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQ 104
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSGMAfnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 105 LTMVVPYLISQLIGGVLGAAMSKVMTsdenyANATGAAFAVLKSDEQLGKVVFaEMAMTCLVTLVVLMGAVNGKSKSPMV 184
Cdd:PLN00027 100 LLRGILYWIAQLLGSVVACLLLKFST-----GGLETSAFSLSSGVGVWNAFVF-EIVMTFGLVYTVYATAVDPKKGDLGI 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 122114567 185 --PFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAA 240
Cdd:PLN00027 174 iaPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWTNHWVYWAGPLIGGGIAG 231
PRK05420 PRK05420
aquaporin Z; Provisional
 32-251 1.61e-27

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 105.43  E-value: 1.61e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  32 IFQPCIAELVGTTFFVFIGCVSVienVEAA-------GRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQ 104
Cdd:PRK05420   1 MFKKLAAEFFGTFWLVFGGCGSA---VLAAafpelgiGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 105 LTMVVPYLISQLIGGVLGAAMSKVMTSDENYANATGAAFAVLKSDEQ------LGKVVFAEMAMTcLVTLVVLMGAVNGK 178
Cdd:PRK05420  78 AKELVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFASNGYGEHspggysLLAALVCEVVLT-AFFLLVILGATDKR 156

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 122114567 179 SKSPMVPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYH--WVYWVGPLGGGLVAAALMRLLLGDEK 251
Cdd:PRK05420 157 APAGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEqlWLFWVAPIVGAIIGGLIYRLLLEKDD 231
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 32-257 6.32e-27

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 105.38  E-value: 6.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  32 IFQPCIAELVGTTFFVFIGCVSVIENVEAAGRLQ-PAL--VHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMV 108
Cdd:PLN00182  41 LTQKLIAEMIGTYFIIFSGCGVVVVNVLYGGTITfPGIcvTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQV 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 109 VPYLISQLIGGVLGAAMSKVMTsdenyaNATGAAFAVLKSDEQLGKVVFAEMAMTCLVTLVVLMGAVNGKSKSPMVPFMV 188
Cdd:PLN00182 121 PLYIGAQLTGSLLASLTLRLMF------NVTPEAFFGTTPTDSSGQALVAEIIISFLLMFVISGVATDSRAVGELAGIAV 194

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 189 GCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAAALMRLL-LGDEKLRVVMK 257
Cdd:PLN00182 195 GMTIILNVFVAGPISGASMNPARSLGPAIVMGRYKGIWVYIVGPFVGIIAGGFVYNLIrFTDKPLRELTK 264
PLN00166 PLN00166
aquaporin TIP2; Provisional
 37-249 2.74e-24

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 97.70  E-value: 2.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  37 IAELVGTTFFVFIGCVSVIE--------NVEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMV 108
Cdd:PLN00166  22 LSEFIATLLFVFAGVGSAIAfakltsdaALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITIITG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 109 VPYLISQLIGGVLGAAMSKVMTSDENYANATGAAfavlksdeQLGKV--VFAEMAMTCLVTLVVLMGAVNGKSKS--PMV 184
Cdd:PLN00166 102 FFYWIAQCLGSIVACLLLVFVTNGESVPTHGVAA--------GLGAIegVVMEIVVTFALVYTVYATAADPKKGSlgTIA 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 122114567 185 PFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGlvaaALMRLLLGD 249
Cdd:PLN00166 174 PIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFSQIWIYWVGPLVGG----ALAGLIYGD 234
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 37-246 3.80e-19

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 84.14  E-value: 3.80e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  37 IAELVGTtfFVFIGCVSVIENVEA-----AGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVVPY 111
Cdd:PLN00183  49 LAEMVGT--FILMFCVCGIIASTQlsggeVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLY 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 112 LISQLIGGVLGAAMSKVMTsdenyanATGAAFAVLKSDEQLGKVVFAEMAMTCLVTLVVLMGAVNGKSKSPMVPFMVGCT 191
Cdd:PLN00183 127 ITAQTVGSVLATYVGVSVY-------GVKADLMTTKPAQGCSSAFWVEFIATFIVMFLAASLTSQPQSLGHLSGFVIGIA 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 122114567 192 VIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAAALMRLL 246
Cdd:PLN00183 200 IGLAVLITGPVSGGSMNPARSLGPAIVSWDFKDIWIYITAPTIGAVAGALMFHLL 254
PLN00167 PLN00167
aquaporin TIP5; Provisional
 37-242 3.95e-18

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 81.10  E-value: 3.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  37 IAELVGTTFFVFIGCVSVIEN--------VEAAGRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMV 108
Cdd:PLN00167  26 LAEFISTFFFVFAAVGSAMSSrklmpdaaSDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 109 VPYLISQLIGGVLGAAMSKVMTSDENYAnatgaAFAVLKSDEQLGKVVFAEMAMTCLVTLVVLMGAVNGKSKSPMVPFMV 188
Cdd:PLN00167 106 MFYWISQMLASVMACLFLKVTTVGQHVP-----TYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRGLLGAIGPLAI 180

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 122114567 189 GCTVIVNILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAAAL 242
Cdd:PLN00167 181 GLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFKNQAVYWVGPLLGGAVAGLL 234
PLN00026 PLN00026
aquaporin NIP; Provisional
 38-241 2.32e-17

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 79.52  E-value: 2.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  38 AELVGTTFFVFIGCVSVIENVEAAGRLQP---ALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVVPYLIS 114
Cdd:PLN00026  76 AEFVGTFILIFAATAGPIVNQKYDGAETLignAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAYIAA 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 115 QLIGGVLGAAMSKVMTSDENYANATGAAFAvlksdeqLGKVVFAEMAMTCLVTLVVLMGAVNGKSKSPMVPFMVGCTVIV 194
Cdd:PLN00026 156 QVSASICASFALKGVFHPFMSGGVTVPSVS-------TGQAFALEFIITFNLLFVVTAVATDTRAVGELAGIAVGATVML 228

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 122114567 195 NILAGGDVSGTCLNPARAFGPALVANHWTYHWVYWVGPLGGGLVAAA 241
Cdd:PLN00026 229 NILVAGPSTGGSMNPVRTLGPAVAAGNYRAIWIYLVAPTLGALAGAG 275
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 36-248 1.56e-14

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 71.70  E-value: 1.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567  36 CIAELVGTTFFVFIGCVSVIENVEAA---GRLQPALVHGLAVAVLVACMAEISGSHFNPPFTIAIWLCGGMQLTMVVPYL 112
Cdd:PTZ00016  53 YVAEFLGTFVLLFFGEGVVATTHTVGnngDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGYF 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 113 ISQLIGGVLGAAMSKVMTSD------------ENYANATGAAFAVLKSDEQLGkVVFAEMAMTCLVTLVVLmgAVNGKSK 180
Cdd:PTZ00016 133 VAQLLGAFVGAACVYGLYYGffkdhgipelpwETMANGFAGVFATYPREGNFY-AIFSELILTAILLLVIL--AITDPNN 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 181 SPMV---PFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVA----------NHWTYHWVYWVGPLGGGLVAAALMRLLL 247
Cdd:PTZ00016 210 CPAFnylPVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSailwgsevftKDNYYFWVPLVAPFVGAVLGMFLYDKFI 289


                 .
gi 122114567 248 G 248
Cdd:PTZ00016 290 P 290
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 152-249 3.32e-03

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 37.80  E-value: 3.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122114567 152 LGKVVFAEMAMT-CLVTLVVLMGAVNGKSKSP----MVPFMVGCTVIVNILAGGDVSGTCLNPARAFGPALVANH-WTYH 225
Cdd:COG0580    2 LMKRLLAEFLGTfILVLLGCGVVAVLAGTKGGigwlGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFpWKDV 81

                         90       100
                 ....*....|....*....|....
gi 122114567 226 WVYWVGPLGGGLVAAALMRLLLGD 249
Cdd:COG0580   82 LPYIIAQLLGAFLGAALVYLIYGG 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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