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Conserved domains on  [gi|147900081|ref|NP_001090163|]
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protein fem-1 homolog C [Xenopus laevis]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-283 2.92e-41

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 2.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   1 MDLKTAVFNAARDGKLRLLSKLLENKAKDDVVLLMSEKTNGATPLLMAARYGHLDMVDYLLdqcsasveIGGSVNFDGET 80
Cdd:COG0666   13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLL--------LAAGADINAKD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  81 IEGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKG 160
Cdd:COG0666   85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 161 HKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGARME-KDGYGMTPLLSASVTGHTNIVDFLTQNPQT 239
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 147900081 240 SKNERINALELLGATFVDKKRDLLGALKYWKRAMDMRHSDRTNI 283
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-564 7.29e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.52  E-value: 7.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 478 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDST 557
Cdd:COG0666  116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182


                 ....*..
gi 147900081 558 NSHNQTA 564
Cdd:COG0666  183 DNDGETP 189
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-283 2.92e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 2.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   1 MDLKTAVFNAARDGKLRLLSKLLENKAKDDVVLLMSEKTNGATPLLMAARYGHLDMVDYLLdqcsasveIGGSVNFDGET 80
Cdd:COG0666   13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLL--------LAAGADINAKD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  81 IEGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKG 160
Cdd:COG0666   85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 161 HKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGARME-KDGYGMTPLLSASVTGHTNIVDFLTQNPQT 239
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 147900081 240 SKNERINALELLGATFVDKKRDLLGALKYWKRAMDMRHSDRTNI 283
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-178 1.04e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   87 LWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHkADLEVANrHGHTCLMISCYKGHKEIAQ 166
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 147900081  167 FLLEKGADVNRK 178
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-233 6.90e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 6.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  85 PPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGH-----LEIVKYLVEHKADLEVANRHGHTCLM--ISC 157
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLyaISK 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 158 YKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGS--LEIMQMLLKYGARM-----------------EKDGYGMTPL 218
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDInaknrvnyllsygvpinIKDVYGFTPL 196

                        170
                 ....*....|....*
gi 147900081 219 LSASVTGHTNIVDFL 233
Cdd:PHA03100 197 HYAVYNNNPEFVKYL 211
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-564 7.29e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.52  E-value: 7.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 478 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDST 557
Cdd:COG0666  116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182


                 ....*..
gi 147900081 558 NSHNQTA 564
Cdd:COG0666  183 DNDGETP 189
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-203 1.52e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 57.72  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   5 TAVFNAARDGKLRLLSKLLENKAKDdvvlLMSEKTNGATPLLMAARYGHLDMVDYLLDqcsasvEIGGSVN--FDGETIE 82
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCD----LFQRGALGETALHVAALYDNLEAAVVLME------AAPELVNepMTSDLYQ 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  83 GAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLR---------------AACFdGHLEIVKYLVEHKADLEVANR 147
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFFRPgpknliyygehplsfAACV-GNEEIVRLLIEHGADIRAQDS 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 147900081 148 HGHTCLMISCYKGHKEIA----QFLLEKGADVNRKSV------KGNTALHDCAESGSLEIMQMLLK 203
Cdd:cd22192  168 LGNTVLHILVLQPNKTFAcqmyDLILSYDKEDDLQPLdlvpnnQGLTPFKLAAKEGNIVMFQHLVQ 233
Ank_5 pfam13857
Ankyrin repeats (many copies);
514-567 1.58e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 1.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 147900081  514 LLECG-ADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQTACDL 567
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 478-552 2.55e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 2.55e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147900081 478 KGKNNFSPLHLAVDKNTTCVGRYpvckfpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGA 552
Cdd:PHA03100 188 KDVYGFTPLHYAVYNNNPEFVKY-------------LLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-176 1.21e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 1.21e-04
                           10        20
                   ....*....|....*....|....*....
gi 147900081   148 HGHTCLMISCYKGHKEIAQFLLEKGADVN 176
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 529-552 6.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.78e-03
                           10        20
                   ....*....|....*....|....
gi 147900081   529 NSPLHVAALNNHPDIMNLLVKSGA 552
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGA 26
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-283 2.92e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 151.26  E-value: 2.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   1 MDLKTAVFNAARDGKLRLLSKLLENKAKDDVVLLMSEKTNGATPLLMAARYGHLDMVDYLLdqcsasveIGGSVNFDGET 80
Cdd:COG0666   13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLL--------LAAGADINAKD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  81 IEGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKG 160
Cdd:COG0666   85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANG 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 161 HKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGARME-KDGYGMTPLLSASVTGHTNIVDFLTQNPQT 239
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNaKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 147900081 240 SKNERINALELLGATFVDKKRDLLGALKYWKRAMDMRHSDRTNI 283
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
5-186 1.71e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 95.02  E-value: 1.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   5 TAVFNAARDGKLRLLSKLLENKAKDDVVLlmsekTNGATPLLMAARYGHLDMVDYLLDQcsasveiGGSVNFdgETIEGA 84
Cdd:COG0666  122 TPLHLAAYNGNLEIVKLLLEAGADVNAQD-----NDGNTPLHLAAANGNLEIVKLLLEA-------GADVNA--RDNDGE 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  85 PPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEI 164
Cdd:COG0666  188 TPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALI 267

                        170       180
                 ....*....|....*....|..
gi 147900081 165 AQFLLEKGADVNRKSVKGNTAL 186
Cdd:COG0666  268 VKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
87-178 1.04e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 1.04e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   87 LWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHkADLEVANrHGHTCLMISCYKGHKEIAQ 166
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 147900081  167 FLLEKGADVNRK 178
Cdd:pfam12796  79 LLLEKGADINVK 90
Ank_2 pfam12796
Ankyrin repeats (3 copies);
120-206 2.55e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.86  E-value: 2.55e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  120 LRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKgADVNRKSvKGNTALHDCAESGSLEIMQ 199
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....*..
gi 147900081  200 MLLKYGA 206
Cdd:pfam12796  79 LLLEKGA 85
Ank_2 pfam12796
Ankyrin repeats (3 copies);
153-233 1.97e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 1.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  153 LMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYgARMEKDGYGMTPLLSASVTGHTNIVDF 232
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKL 79


                  .
gi 147900081  233 L 233
Cdd:pfam12796  80 L 80
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 85-233 6.90e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 80.09  E-value: 6.90e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  85 PPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGH-----LEIVKYLVEHKADLEVANRHGHTCLM--ISC 157
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNGITPLLyaISK 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 158 YKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGS--LEIMQMLLKYGARM-----------------EKDGYGMTPL 218
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDInaknrvnyllsygvpinIKDVYGFTPL 196

                        170
                 ....*....|....*
gi 147900081 219 LSASVTGHTNIVDFL 233
Cdd:PHA03100 197 HYAVYNNNPEFVKYL 211
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-146 8.09e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 8.09e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   45 LLMAARYGHLDMVDYLLDQcsasveiggSVNFDGETIEGAPPLWAASAAGHLKVVRSLLVHGASvnNTTLTNSTPLRAAC 124
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN---------GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|..
gi 147900081  125 FDGHLEIVKYLVEHKADLEVAN 146
Cdd:pfam12796  70 RSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 40-206 7.28e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.85  E-value: 7.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  40 NGATPLLMAA--RYGHLDMVDYLLDQcSASVEIggsVNFDGETIEgapPLWAASAAGHLKVVRSLLVHGASVNNTTltns 117
Cdd:PHA03100 105 NGITPLLYAIskKSNSYSIVEYLLDN-GANVNI---KNSDGENLL---HLYLESNKIDLKILKLLIDKGVDINAKN---- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 118 tplraacfdghleIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEI 197
Cdd:PHA03100 174 -------------RVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEI 240


                 ....*....
gi 147900081 198 MQMLLKYGA 206
Cdd:PHA03100 241 FKLLLNNGP 249
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 2-236 1.65e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 69.61  E-value: 1.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   2 DLKTAVFNaardGKLRLLSKLLENKAkdDVVLLMSEKTngATPLLMAARYGHLDMVDYLLDQcsasveiGGSVNFDGETI 81
Cdd:PHA02874   4 DLRMCIYS----GDIEAIEKIIKNKG--NCINISVDET--TTPLIDAIRSGDAKIVELFIKH-------GADINHINTKI 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  82 EGapPLWAASAAGHLKVVRSLLVHGasvnnttlTNSTPLRAACFDGhlEIVKYLVEHKADLEVANRHGHTCLMISCYKGH 161
Cdd:PHA02874  69 PH--PLLTAIKIGAHDIIKLLIDNG--------VDTSILPIPCIEK--DMIKTILDCGIDVNIKDAELKTFLHYAIKKGD 136

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 147900081 162 KEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGARME-KDGYGMTPLLSASVTGHTNIVDFLTQN 236
Cdd:PHA02874 137 LESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANvKDNNGESPLHNAAEYGDYACIKLLIDH 212
PHA03095 PHA03095
ankyrin-like protein; Provisional
 129-257 2.00e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 69.67  E-value: 2.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 129 LEIVKYLVEHKADLEVANRHG----HTCLMISCYKGhKEIAQFLLEKGADVNRKSVKGNTALHDCAESGS-LEIMQMLLK 203
Cdd:PHA03095  27 VEEVRRLLAAGADVNFRGEYGktplHLYLHYSSEKV-KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIK 105

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147900081 204 YGARM-EKDGYGMTPlLSASVTG---HTNIVDFLTQnpqtsKNERINALELLGATFVD 257
Cdd:PHA03095 106 AGADVnAKDKVGRTP-LHVYLSGfniNPKVIRLLLR-----KGADVNALDLYGMTPLA 157
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 4-206 6.64e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 67.71  E-value: 6.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   4 KTAVFNAARDGKLRLLSKLLENKAKDDVVLLmsektNGATPLLMAARYGHLDMVDYLL--------------DQCSASVE 69
Cdd:PHA02875   3 QVALCDAILFGELDIARRLLDIGINPNFEIY-----DGISPIKLAMKFRDSEAIKLLMkhgaipdvkypdieSELHDAVE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  70 IGGSV---------NFDGETI--EGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEH 138
Cdd:PHA02875  78 EGDVKaveelldlgKFADDVFykDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147900081 139 KADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGN-TALHDCAESGSLEIMQMLLKYGA 206
Cdd:PHA02875 158 KACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGA 226
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 7-203 7.05e-12

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 68.74  E-value: 7.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   7 VFNAARDGKLRLLSKLLENKAKDDVvllmsEKTNGATPLLMAARYGHLDMVDYLLDQcsasveiggSVNFDGETIEGAPP 86
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDI-----GDSKGRTPLHIAASKGYEDCVLVLLKH---------ACNVHIRDANGNTA 594

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  87 LWAASAAGHLKVVRsLLVHGASVNNTTlTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQ 166
Cdd:PLN03192 595 LWNAISAKHHKIFR-ILYHFASISDPH-AAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVR 672

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 147900081 167 FLLEKGADVNRKSvkgntaLHDcaESGSLEIMQMLLK 203
Cdd:PLN03192 673 LLIMNGADVDKAN------TDD--DFSPTELRELLQK 701
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-564 7.29e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 66.52  E-value: 7.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 478 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDST 557
Cdd:COG0666  116 RDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR 182


                 ....*..
gi 147900081 558 NSHNQTA 564
Cdd:COG0666  183 DNDGETP 189
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-110 9.13e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.29  E-value: 9.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   10 AARDGKLRLLSKLLENKAKDDVVLlmsekTNGATPLLMAARYGHLDMVDYLLDQCSAsveiggSVNFDGETiegapPLWA 89
Cdd:pfam12796   4 AAKNGNLELVKLLLENGADANLQD-----KNGRTALHLAAKNGHLEIVKLLLEHADV------NLKDNGRT-----ALHY 67

                          90       100
                  ....*....|....*....|.
gi 147900081   90 ASAAGHLKVVRSLLVHGASVN 110
Cdd:pfam12796  68 AARSGHLEIVKLLLEKGADIN 88
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
96-233 2.19e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 2.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  96 LKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADV 175
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 147900081 176 NRKSVKGNTALHDCAESGSLEIMQMLLKYGARME-KDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNaRDKDGETPLHLAAYNGNLEIVKLL 139
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-583 7.70e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.43  E-value: 7.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 478 KGKNNFSPLHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDST 557
Cdd:COG0666  149 QDNDGNTPLHLAAANG-------------NLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK 215

                         90       100
                 ....*....|....*....|....*.
gi 147900081 558 NSHNQTACDLLDEKEMAKNLIQPINH 583
Cdd:COG0666  216 DNDGKTALDLAAENGNLEIVKLLLEA 241
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 83-221 1.07e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 64.13  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  83 GAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISC-YKGH 161
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKD 247

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 147900081 162 KEIAQFLLEKGADVNRKS-VKGNTALHDCAESGslEIMQMLLKYGARMEK-DGYGMTPLLSA 221
Cdd:PHA02878 248 YDILKLLLEHGVDVNAKSyILGLTALHSSIKSE--RKLKLLLEYGADINSlNSYKLTPLSSA 307
PHA03095 PHA03095
ankyrin-like protein; Provisional
 19-233 1.22e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.89  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  19 LSKLLENKAKD--DVVLLMSEK--------TNGATPLLMAARYGH-LDMVDYLldqcsasVEIGGSVNFDGETieGAPPL 87
Cdd:PHA03095  51 LHLYLHYSSEKvkDIVRLLLEAgadvnapeRCGFTPLHLYLYNATtLDVIKLL-------IKAGADVNAKDKV--GRTPL 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  88 --WAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLraACF----DGHLEIVKYLVEHKADLEVANRHGHTCLMISC--YK 159
Cdd:PHA03095 122 hvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPL--AVLlksrNANVELLRLLIDAGADVYAVDDRFRSLLHHHLqsFK 199

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 147900081 160 GHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLE--IMQMLLKYGARM-EKDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:PHA03095 200 PRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISInARNRYGQTPLHYAAVFNNPRACRRL 276
Ank_4 pfam13637
Ankyrin repeats (many copies);
116-169 7.14e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 7.14e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 147900081  116 NSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLL 169
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
465-564 1.01e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.97  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 465 KKQNIYRFLKLHPKGKNNFSPLHLAVDKNTTcvgrypvckfpsfQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIM 544
Cdd:COG0666   70 ALLLLAAGADINAKDDGGNTLLHAAARNGDL-------------EIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                         90       100
                 ....*....|....*....|
gi 147900081 545 NLLVKSGAHFDSTNSHNQTA 564
Cdd:COG0666  137 KLLLEAGADVNAQDNDGNTP 156
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 48-251 8.37e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 58.08  E-value: 8.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  48 AARYGHLDMVDYLLDqcsasveIGGSVNFdgETIEGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDG 127
Cdd:PHA02875   9 AILFGELDIARRLLD-------IGINPNF--EIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 128 HLEIVKYLVE-HKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGA 206
Cdd:PHA02875  80 DVKAVEELLDlGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKA 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 147900081 207 RME-KDGYGMTPLLSASVTGHTNI----------VDFLTQNPQTS------KNERINALELL 251
Cdd:PHA02875 160 CLDiEDCCGCTPLIIAMAKGDIAIckmlldsganIDYFGKNGCVAalcyaiENNKIDIVRLF 221
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 5-203 1.52e-08

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 57.72  E-value: 1.52e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   5 TAVFNAARDGKLRLLSKLLENKAKDdvvlLMSEKTNGATPLLMAARYGHLDMVDYLLDqcsasvEIGGSVN--FDGETIE 82
Cdd:cd22192   19 SPLLLAAKENDVQAIKKLLKCPSCD----LFQRGALGETALHVAALYDNLEAAVVLME------AAPELVNepMTSDLYQ 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  83 GAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLR---------------AACFdGHLEIVKYLVEHKADLEVANR 147
Cdd:cd22192   89 GETALHIAVVNQNLNLVRELIARGADVVSPRATGTFFRPgpknliyygehplsfAACV-GNEEIVRLLIEHGADIRAQDS 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 147900081 148 HGHTCLMISCYKGHKEIA----QFLLEKGADVNRKSV------KGNTALHDCAESGSLEIMQMLLK 203
Cdd:cd22192  168 LGNTVLHILVLQPNKTFAcqmyDLILSYDKEDDLQPLdlvpnnQGLTPFKLAAKEGNIVMFQHLVQ 233
Ank_4 pfam13637
Ankyrin repeats (many copies);
149-202 1.67e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 1.67e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 147900081  149 GHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLL 202
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 5-218 7.43e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.97  E-value: 7.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081   5 TAVFNAARDGKLRLLSKLLENKAKDDVVllmseKTNGATPLLMAARYGHLDMVDYLLDQ----------------CSASV 68
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHI-----NTKIPHPLLTAIKIGAHDIIKLLIDNgvdtsilpipciekdmIKTIL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  69 EIGGSVNFdgETIEGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRH 148
Cdd:PHA02874 112 DCGIDVNI--KDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNN 189

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 149 GHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDcAESGSLEIMQMLLKYGARMEKDGYGMTPL 218
Cdd:PHA02874 190 GESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHN-AIIHNRSAIELLINNASINDQDIDGSTPL 258
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 97-221 7.50e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 7.50e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  97 KVVRSLLVHGASVNNTTL-TNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADV 175
Cdd:PHA02878 148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 147900081 176 NRKSVKGNTALHDCAES-GSLEIMQMLLKYGARMEKDGY--GMTPLLSA 221
Cdd:PHA02878 228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYilGLTALHSS 276
Ank_4 pfam13637
Ankyrin repeats (many copies);
85-136 8.82e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.81  E-value: 8.82e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 147900081   85 PPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLV 136
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 86-268 1.15e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.07  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  86 PLWAASAAGHL-KVVRSLLVHGASVNNTTLTNSTPLRAACFDGH-LEIVKYLVEHKADLEVANRHGHTCL-MISCYKGHK 162
Cdd:PHA02876 276 PLHHASQAPSLsRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLhQASTLDRNK 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 163 EIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGARMEKDGYGMTPLLSASVTGhtnivdfltQNPQTSKN 242
Cdd:PHA02876 356 DIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCG---------TNPYMSVK 426

                        170       180
                 ....*....|....*....|....*.
gi 147900081 243 ERINAlellGATFVDKKRDLLGALKY 268
Cdd:PHA02876 427 TLIDR----GANVNSKNKDLSTPLHY 448
PHA02798 PHA02798
ankyrin-like protein; Provisional
 96-205 1.76e-07

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 54.07  E-value: 1.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  96 LKVVRSLLVHGASVNNTTLTNSTPLraaC--------FDGHLEIVKYLVEHKADLEVANRHGHT---CLMISCYKGHKEI 164
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTPL---CtilsnikdYKHMLDIVKILIENGADINKKNSDGETplyCLLSNGYINNLEI 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 147900081 165 AQFLLEKGADVNRKSVKGNTALHDCAESG---SLEIMQMLLKYG 205
Cdd:PHA02798 128 LLFMIENGADTTLLDKDGFTMLQVYLQSNhhiDIEIIKLLLEKG 171
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 135-236 2.18e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 54.10  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 135 LVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDC------------------------- 189
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAisakhhkifrilyhfasisdphaag 623

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 147900081 190 ------AESGSLEIMQMLLKYGARME-KDGYGMTPLLSASVTGHTNIVDFLTQN 236
Cdd:PLN03192 624 dllctaAKRNDLTAMKELLKQGLNVDsEDHQGATALQVAMAEDHVDMVRLLIMN 677
Ank_4 pfam13637
Ankyrin repeats (many copies);
182-233 2.78e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 2.78e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 147900081  182 GNTALHDCAESGSLEIMQMLLKYGARM-EKDGYGMTPLLSASVTGHTNIVDFL 233
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADInAVDGNGETALHFAASNGNVEVLKLL 53
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 10-200 3.77e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.66  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  10 AARDGKLRLLSKLLENKAKDDVvllmsEKTNGATPLLMAARYGHLDMVDYLLDQCSasveiggsvNFDGETIEGAPPLwa 89
Cdd:PHA02874 164 AIKHNFFDIIKLLLEKGAYANV-----KDNNGESPLHNAAEYGDYACIKLLIDHGN---------HIMNKCKNGFTPL-- 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  90 ASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAAC-FDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKE----- 163
Cdd:PHA02874 228 HNAIIHNRSAIELLINNASINDQDIDGSTPLHHAInPPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDpvikd 307

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 147900081 164 -IAQFLLEKGAD-------VNRKSVKGNTALHDCAESGSLEIMQM 200
Cdd:PHA02874 308 iIANAVLIKEADklkdsdfLEHIEIKDNKEFSDFIKECNEEIEDM 352
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
478-578 6.46e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 51.49  E-value: 6.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 478 KGKNNFSPLHLAVDKnttcvGRYPVCKFpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDST 557
Cdd:COG0666  182 RDNDGETPLHLAAEN-----GHLEIVKL--------LLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAK 248

                         90       100
                 ....*....|....*....|.
gi 147900081 558 NSHNQTACDLLDEKEMAKNLI 578
Cdd:COG0666  249 DKDGLTALLLAAAAGAALIVK 269
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 86-236 6.48e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.19  E-value: 6.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  86 PLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGH-------------TC 152
Cdd:PHA02878  40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAikdafnnrnveifKI 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 153 LMISCYKGHK------------------EIAQFLLEKGADVNRKSV-KGNTALHDCAESGSLEIMQMLLKYGARME-KDG 212
Cdd:PHA02878 120 ILTNRYKNIQtidlvyidkkskddiieaEITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNiPDK 199

                        170       180
                 ....*....|....*....|....
gi 147900081 213 YGMTPLLSASVTGHTNIVDFLTQN 236
Cdd:PHA02878 200 TNNSPLHHAVKHYNKPIVHILLEN 223
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 91-169 7.06e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 7.06e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147900081  91 SAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLL 169
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 132-226 8.46e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 8.46e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 132 VKYLVEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKY------- 204
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHsqchfel 177

                         90       100
                 ....*....|....*....|....
gi 147900081 205 GARMEKDGYGMTP--LLSASVTGH 226
Cdd:PTZ00322 178 GANAKPDSFTGKPpsLEDSPISSH 201
Ank_5 pfam13857
Ankyrin repeats (many copies);
514-567 1.58e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 1.58e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 147900081  514 LLECG-ADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQTACDL 567
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDL 55
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 478-552 2.55e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 2.55e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 147900081 478 KGKNNFSPLHLAVDKNTTCVGRYpvckfpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGA 552
Cdd:PHA03100 188 KDVYGFTPLHYAVYNNNPEFVKY-------------LLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
PHA02798 PHA02798
ankyrin-like protein; Provisional
 96-187 2.87e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 50.22  E-value: 2.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  96 LKVVRSLLVHGASVNNTTLTNSTPLRAACFDGH---LEIVKYLVEHKADLEVANRHGHTCLMISCYKGHK---EIAQFLL 169
Cdd:PHA02798  89 LDIVKILIENGADINKKNSDGETPLYCLLSNGYinnLEILLFMIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLL 168

                         90
                 ....*....|....*....
gi 147900081 170 EKGADVNRKSVK-GNTALH 187
Cdd:PHA02798 169 EKGVDINTHNNKeKYDTLH 187
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-62 4.31e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 4.31e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 147900081    4 KTAVFNAARDGKLRLLSKLLENKAKDDvvllmseKTNGATPLLMAARYGHLDMVDYLLD 62
Cdd:pfam12796  31 RTALHLAAKNGHLEIVKLLLEHADVNL-------KDNGRTALHYAARSGHLEIVKLLLE 82
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 66-266 5.15e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 5.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  66 ASVEIGGSVNFDGETIEGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLeva 145
Cdd:PHA02876 161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNI--- 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 146 NRHGHTcLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSL-EIMQMLLKYGARME-KDGYGMTPLLSASV 223
Cdd:PHA02876 238 NKNDLS-LLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSLsRLVPKLLERGADVNaKNIKGETPLYLMAK 316

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 147900081 224 TGH--TNIVDFLTQNPQTSKNERINALELLGATFVDKKRDLLGAL 266
Cdd:PHA02876 317 NGYdtENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITL 361
Ank_2 pfam12796
Ankyrin repeats (3 copies);
480-558 8.29e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 8.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 147900081  480 KNNFSPLHLAvdknttcvgrypvCKFPSFQVTAILLECgADVNVRDaEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTN 558
Cdd:pfam12796  28 KNGRTALHLA-------------AKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_5 pfam13857
Ankyrin repeats (many copies);
135-187 9.51e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.10  E-value: 9.51e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 147900081  135 LVEHK-ADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALH 187
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
5-61 1.89e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 1.89e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 147900081    5 TAVFNAARDGKLRLLSKLLENKAKDDVVLLmsektNGATPLLMAARYGHLDMVDYLL 61
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDG-----NGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 480-579 2.41e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.97  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 480 KNNFSPLHLAVDK--NTTCVGRypvckfpsfqVTAILLECGADVNVRDAEQNSPLHVAALN--NHPDIMNLLVKSGAHFD 555
Cdd:PHA03100  66 KNNSTPLHYLSNIkyNLTDVKE----------IVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVN 135

                         90       100
                 ....*....|....*....|....*....
gi 147900081 556 STNSHNQTACDL-----LDEKEMAKNLIQ 579
Cdd:PHA03100 136 IKNSDGENLLHLylesnKIDLKILKLLID 164
PHA03095 PHA03095
ankyrin-like protein; Provisional
 483-568 2.44e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 47.33  E-value: 2.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 483 FSPLHLAVDKNTTcvgrYPVCKFpsfqvtaiLLECGADVNVRDAEQNSPLHV--AALNNHPDIMNLLVKSGAHFDSTNSH 560
Cdd:PHA03095  84 FTPLHLYLYNATT----LDVIKL--------LIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLY 151


                 ....*...
gi 147900081 561 NQTACDLL 568
Cdd:PHA03095 152 GMTPLAVL 159
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 486-588 2.53e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 46.88  E-value: 2.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 486 LHLAVDKNttcvgrypvckfpSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQT-- 563
Cdd:PHA02874 128 LHYAIKKG-------------DLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESpl 194

                         90       100
                 ....*....|....*....|....*..
gi 147900081 564 --ACDLLDEKEMaKNLIQPINHTTLQC 588
Cdd:PHA02874 195 hnAAEYGDYACI-KLLIDHGNHIMNKC 220
Ank_2 pfam12796
Ankyrin repeats (3 copies);
486-549 3.22e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.80  E-value: 3.22e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147900081  486 LHLAVDKnttcvGRYPVCKFpsfqvtaiLLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVK 549
Cdd:pfam12796   1 LHLAAKN-----GNLELVKL--------LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 164-554 6.06e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.21  E-value: 6.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 164 IAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGARMEKDGYGMTPLLSASVtgHTNIVDFLTQNPQTSKNE 243
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAV--DSKNIDTIKAIIDNRSNI 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 244 RINALELLGAtfvdkkrdllgalkywkramdmrhsdrtniVSKPEPQTLIMAYDYAREVNTAEELDNL-----IADPDEM 318
Cdd:PHA02876 238 NKNDLSLLKA------------------------------IRNEDLETSLLLYDAGFSVNSIDDCKNTplhhaSQAPSLS 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 319 RMQALLIR-------ERILGpshpDTSYYIRYRGAVyaDSGNFKRCINLwkyALDMQQNNLDPLSPM-TASSLLSFAELF 390
Cdd:PHA02876 288 RLVPKLLErgadvnaKNIKG----ETPLYLMAKNGY--DTENIRTLIML---GADVNAADRLYITPLhQASTLDRNKDIV 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 391 SFMLQdrakglLGTTVTFDDL-------MGILCKSVMEIDRAVKQTApppDQVQLNKALSIILHLICllekvpCSPDQDH 463
Cdd:PHA02876 359 ITLLE------LGANVNARDYcdktpihYAAVRNNVVIINTLLDYGA---DIEALSQKIGTALHFAL------CGTNPYM 423

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 464 FKKQNIYRFLKLHPKGKNNFSPLHLAVDKNttcvgrypvCKfpsFQVTAILLECGADVNVRDAEQNSPLHVaALNNHpDI 543
Cdd:PHA02876 424 SVKTLIDRGANVNSKNKDLSTPLHYACKKN---------CK---LDVIEMLLDNGADVNAINIQNQYPLLI-ALEYH-GI 489

                        410
                 ....*....|.
gi 147900081 544 MNLLVKSGAHF 554
Cdd:PHA02876 490 VNILLHYGAEL 500
Ank_4 pfam13637
Ankyrin repeats (many copies);
503-548 7.27e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.72  E-value: 7.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 147900081  503 CKFPSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLV 548
Cdd:pfam13637   9 AASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 17-242 8.77e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.44  E-value: 8.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  17 RLLSKLLENKAKddvvlLMSEKTNGATPLLMAARYGhldmvdYLLDQCSASVEIGGSVNfDGETIEGAPPLWAASAAGHL 96
Cdd:PHA02876 288 RLVPKLLERGAD-----VNAKNIKGETPLYLMAKNG------YDTENIRTLIMLGADVN-AADRLYITPLHQASTLDRNK 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  97 KVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEV-------------------------------- 144
Cdd:PHA02876 356 DIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEAlsqkigtalhfalcgtnpymsvktlidrganv 435

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 145 --ANRHGHTCLMISCYKGHK-EIAQFLLEKGADVNRKSVKGNTALHDCAESGSleIMQMLLKYGARMeKDGYGMTPLLSA 221
Cdd:PHA02876 436 nsKNKDLSTPLHYACKKNCKlDVIEMLLDNGADVNAINIQNQYPLLIALEYHG--IVNILLHYGAEL-RDSRVLHKSLND 512

                        250       260
                 ....*....|....*....|....*..
gi 147900081 222 S------VTGHTNIVDFLTQNPQTSKN 242
Cdd:PHA02876 513 NmfsfryIIAHICIQDFIRHDIRNEVN 539
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 148-176 1.21e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 1.21e-04
                           10        20
                   ....*....|....*....|....*....
gi 147900081   148 HGHTCLMISCYKGHKEIAQFLLEKGADVN 176
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 513-570 1.25e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 1.25e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 147900081 513 ILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQTACDLLDE 570
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEE 157
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 115-236 1.81e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 115 TNSTPLRAACFDGHLEIVKYLVE-HKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGAD-VNRKSV----KGNTALHD 188
Cdd:cd22192   16 ISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPElVNEPMTsdlyQGETALHI 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147900081 189 CAESGSLEIMQMLLKYGA------------RMEKDG---YGMTPLLSASVTGHTNIVDFLTQN 236
Cdd:cd22192   96 AVVNQNLNLVRELIARGAdvvspratgtffRPGPKNliyYGEHPLSFAACVGNEEIVRLLIEH 158
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 148-178 1.86e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.86e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 147900081  148 HGHTCLMISCYK-GHKEIAQFLLEKGADVNRK 178
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNAR 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 73-138 2.73e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 2.73e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 147900081  73 SVNFDGETiegapPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEH 138
Cdd:PTZ00322 110 CRDYDGRT-----PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
PHA02798 PHA02798
ankyrin-like protein; Provisional
 129-215 2.85e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.67  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 129 LEIVKYLVEHKADLEVANRHGHT--CLMISCYKGHK---EIAQFLLEKGADVNRKSVKGNTALHDCAESG---SLEIMQM 200
Cdd:PHA02798  51 TDIVKLFINLGANVNGLDNEYSTplCTILSNIKDYKhmlDIVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLF 130

                         90
                 ....*....|....*...
gi 147900081 201 LLKYGAR---MEKDGYGM 215
Cdd:PHA02798 131 MIENGADttlLDKDGFTM 148
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 19-235 3.43e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 43.72  E-value: 3.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  19 LSKLLENKAKDDVVLLMSEKTNGA---TPLLMAARY---GHLDMVDYLLDQCSASVEIGGSVN--FDGETIEGAPPLWAA 90
Cdd:cd21882    1 LEELLGLLECLRWYLTDSAYQRGAtgkTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELVNapCTDEFYQGQTALHIA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  91 SAAGHLKVVRSLLVHGASVN-------------NTTLTNSTPLRAACFDGHLEIVKYLVEHKADLevanrhghtclmisc 157
Cdd:cd21882   81 IENRNLNLVRLLVENGADVSaratgrffrkspgNLFYFGELPLSLAACTNQEEIVRLLLENGAQP--------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 158 ykghkeiaqfllekgADVNRKSVKGNTALH------DCAESGSLEIMQM---LLKYGARME--------KDGYGMTPLLS 220
Cdd:cd21882  146 ---------------AALEAQDSLGNTVLHalvlqaDNTPENSAFVCQMynlLLSYGAHLDptqqleeiPNHQGLTPLKL 210

                        250
                 ....*....|....*
gi 147900081 221 ASVTGHTNIVDFLTQ 235
Cdd:cd21882  211 AAVEGKIVMFQHILQ 225
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 40-210 3.83e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 43.70  E-value: 3.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  40 NGATPLLMAARYGHLDMVDYLLdQCSASVEIGGSvnfdgetiEGAPPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTP 119
Cdd:PLN03192 524 NMASNLLTVASTGNAALLEELL-KAKLDPDIGDS--------KGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA 594

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 120 LRAACFDGHLEIVKYLVEHKAdleVANRH-GHTCLMISCYKGHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIM 198
Cdd:PLN03192 595 LWNAISAKHHKIFRILYHFAS---ISDPHaAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMV 671

                        170
                 ....*....|..
gi 147900081 199 QMLLKYGARMEK 210
Cdd:PLN03192 672 RLLIMNGADVDK 683
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 468-563 4.76e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.12  E-value: 4.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 468 NIYRFLKLH-----PKGKNNFSPLHLAVDKNTTCVgryPVCKF---PSFQVTAI-----LLECGADVNVRDAEQNSPLHV 534
Cdd:PHA03100 122 SIVEYLLDNganvnIKNSDGENLLHLYLESNKIDL---KILKLlidKGVDINAKnrvnyLLSYGVPINIKDVYGFTPLHY 198

                         90       100
                 ....*....|....*....|....*....
gi 147900081 535 AALNNHPDIMNLLVKSGAHFDSTNSHNQT 563
Cdd:PHA03100 199 AVYNNNPEFVKYLLDLGANPNLVNKYGDT 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
510-579 5.07e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 42.63  E-value: 5.07e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147900081 510 VTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQTACDLL---DEKEMAKNLIQ 579
Cdd:COG0666   69 VALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAaynGNLEIVKLLLE 141
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 484-555 8.63e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.19  E-value: 8.63e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 147900081 484 SPLHLAvdknttcvgrypvCKFPSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVK-SGAHFD 555
Cdd:PTZ00322 117 TPLHIA-------------CANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRhSQCHFE 176
TRPV1 cd22196
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 ...
 149-254 1.00e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 1; Vanilloid receptor 1 (TRPV1), a capsaicin (vanilloid) receptor, is the founding member of the vanilloid TRP subfamily (TRPV). In humans, it is expressed in the brain, kidney, pancreas, testis, uterus, spleen, stomach, small intestine, lung and liver. TRPV1 has been implicated to have function in thermo-sensation (heat), autonomic thermoregulation, nociception, food intake regulation, and multiple functions in the gastrointestinal (GI) tract. The receptor has also been involved in growth cone guidance, long-term depression, endocannabinoid signaling and osmosensing in the central nervous system. TRPV1 is up regulated in several human pathological conditions including vulvodynia, GI inflammation, Crohn's disease and ulcerative colitis. TRPV1 knock-out mice exhibit impaired sensation to thermal-mechanical acute pain. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411980 [Multi-domain]  Cd Length: 649  Bit Score: 42.10  E-value: 1.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 149 GHTCL---MISCYKGHKEIAQFLL---EKG--------ADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGARM------ 208
Cdd:cd22196   47 GKTCLlkaMLNLHNGQNDTISLLLdiaEKTgnlkefvnAAYTDSYYKGQTALHIAIERRNMHLVELLVQNGADVharasg 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 147900081 209 -------EKDGY--GMTPLLSASVTGHTNIVDFLTQNPQTSKNerINALELLGAT 254
Cdd:cd22196  127 effkkkkGGPGFyfGELPLSLAACTNQLDIVKFLLENPHSPAD--ISARDSMGNT 179
Ank_5 pfam13857
Ankyrin repeats (many copies);
168-218 1.20e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 1.20e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 147900081  168 LLEKG-ADVNRKSVKGNTALHDCAESGSLEIMQMLLKYGA-RMEKDGYGMTPL 218
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVdLNLKDEEGLTAL 53
Ank_4 pfam13637
Ankyrin repeats (many copies);
43-103 1.20e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 1.20e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 147900081   43 TPLLMAARYGHLDMVDYLLDQcsasveiggSVNFDGETIEGAPPLWAASAAGHLKVVRSLL 103
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK---------GADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 14-200 1.33e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 41.57  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  14 GKLRLLSKLLENKAKDDVVllmseKTNGATPLLMAARYGH--LDMVDYLLDQcSASVEIGGSVNF--------DGETIEG 83
Cdd:PHA03100 119 NSYSIVEYLLDNGANVNIK-----NSDGENLLHLYLESNKidLKILKLLIDK-GVDINAKNRVNYllsygvpiNIKDVYG 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  84 APPLWAASAAGHLKVVRSLLVHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRH--------GHTCLMI 155
Cdd:PHA03100 193 FTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIETllyfkdkdLNTITKI 272

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 147900081 156 SCYKgHKEIAQFLLEKGADVNRKSVKGNTALHDCAESGSLEIMQM 200
Cdd:PHA03100 273 KMLK-KSIMYMFLLDPGFYKNRKLIENSKSLKDVINECEKEIERM 316
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 148-176 1.89e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*....
gi 147900081  148 HGHTCLMISCYKGHKEIAQFLLEKGADVN 176
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
102-151 2.30e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 2.30e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 147900081  102 LLVHG-ASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVANRHGHT 151
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLT 51
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 484-563 2.86e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.63  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 484 SPLHLAVDKnttcvgrypvckfPSFQVTAILLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQT 563
Cdd:PHA02878 170 TALHYATEN-------------KDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNT 236
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 514-564 3.09e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 3.09e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 147900081 514 LLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQTA 564
Cdd:PHA02876 361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTA 411
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 40-62 3.73e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 3.73e-03
                          10        20
                  ....*....|....*....|...
gi 147900081   40 NGATPLLMAARYGHLDMVDYLLD 62
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLE 23
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 181-206 3.91e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 3.91e-03
                           10        20
                   ....*....|....*....|....*.
gi 147900081   181 KGNTALHDCAESGSLEIMQMLLKYGA 206
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 509-563 4.01e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.25  E-value: 4.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 147900081 509 QVTAILLECGADVNVRDAEQ-NSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQT 563
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNS 203
PHA02741 PHA02741
hypothetical protein; Provisional
 121-187 4.16e-03

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 38.49  E-value: 4.16e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 147900081 121 RAACFDGHLEIVKYLVE--HKADLEVANRHGHTCLMISCYKGHK----EIAQFLLEKGADVN-RKSVKGNTALH 187
Cdd:PHA02741  30 RCGCFDIIARFTPFIRGdcHAAALNATDDAGQMCIHIAAEKHEAqlaaEIIDHLIELGADINaQEMLEGDTALH 103
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 140-239 4.26e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 40.13  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 140 ADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGADVNRKSvKGNTalhdcaesgsleimqmllkYGARMEKDG--YGMTP 217
Cdd:cd22194  132 AEYTEEAYEGQTALNIAIERRQGDIVKLLIAKGADVNAHA-KGVF-------------------FNPKYKHEGfyFGETP 191

                         90       100
                 ....*....|....*....|..
gi 147900081 218 LLSASVTGHTNIVDFLTQNPQT 239
Cdd:cd22194  192 LALAACTNQPEIVQLLMEKEST 213
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 118-147 4.46e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.96  E-value: 4.46e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 147900081  118 TPL-RAACFDGHLEIVKYLVEHKADLEVANR 147
Cdd:pfam00023   4 TPLhLAAGRRGNLEIVKLLLSKGADVNARDK 34
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 109-235 5.24e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 38.65  E-value: 5.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081 109 VNNTTLTNSTPLRAaCFDG---HLEIVKYLVEHKADLEVANRHGHTCLMISCYKGHK----EIAQFLLEKGADVNRKSVK 181
Cdd:PHA02859  44 VNDCNDLYETPIFS-CLEKdkvNVEILKFLIENGADVNFKTRDNNLSALHHYLSFNKnvepEILKILIDSGSSITEEDED 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 147900081 182 GNTALHD--CAESGSLEIMQMLLKYGAR-MEKDGYGmTPLLSASVTGHTN--IVDFLTQ 235
Cdd:PHA02859 123 GKNLLHMymCNFNVRINVIKLLIDSGVSfLNKDFDN-NNILYSYILFHSDkkIFDFLTS 180
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 514-580 5.72e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 39.85  E-value: 5.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 147900081 514 LLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGAHFDSTNSHNQ----TACDLLDEKEMAKNLIQP 580
Cdd:PLN03192 641 LLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDDfsptELRELLQKRELGHSITIV 711
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 529-552 6.78e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 6.78e-03
                           10        20
                   ....*....|....*....|....
gi 147900081   529 NSPLHVAALNNHPDIMNLLVKSGA 552
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGA 26
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 514-552 8.03e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 39.18  E-value: 8.03e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 147900081 514 LLECGADVNVRDAEQNSPLHVAALNNHPDIMNLLVKSGA 552
Cdd:PHA02874 110 ILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGA 148
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 529-555 8.77e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 8.77e-03
                          10        20
                  ....*....|....*....|....*..
gi 147900081  529 NSPLHVAALNNHPDIMNLLVKSGAHFD 555
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADIN 29
PHA03095 PHA03095
ankyrin-like protein; Provisional
 97-186 9.73e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 38.85  E-value: 9.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 147900081  97 KVVRSLLVHGASVNNTTLTNSTPLRAA---CFDGHLEIVKYLvEHKADLEVANRHGHTCLMISCYKGHKEIAQFLLEKGA 173
Cdd:PHA03095 203 RIVRELIRAGCDPAATDMLGNTPLHSMatgSSCKRSLVLPLL-IAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281

                         90
                 ....*....|...
gi 147900081 174 DVNRKSVKGNTAL 186
Cdd:PHA03095 282 DINAVSSDGNTPL 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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