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Conserved domains on  [gi|156139133|ref|NP_001095837|]
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D-glutamate cyclase, mitochondrial isoform a precursor [Homo sapiens]

Protein Classification

DUF4392 domain-containing protein; putative hydro-lyase( domain architecture ID 10538093)

DUF4392 domain-containing protein similar to Thermococcus onnurineus TON_0340; putative hydro-lyase belonging to the D-glutamate cyclase family (formerly called DUF1445); similar to Bacillus subtilis putative hydro-lyase YcsI

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
298-609 5.50e-143

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


:

Pssm-ID: 464140  Cd Length: 291  Bit Score: 416.30  E-value: 5.50e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  298 LESMIGIDPGNRGIGHLLCKDELLKASLSLSHAR-SVLITTGFPTHFNHepPEETDGPPGAVALVAFLQALEKEVAIIVD 376
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPLSHAAgSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  377 qrawNLHQKIVEDAVEQGVLKTQIPIlTYQGGSVEAAQAFLCKNGDPQ---------TPRFDHLVAIERAGRAADGNYYN 447
Cdd:pfam14336  79 ----ELNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAeaqaeelleKYKPDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  448 ARKMNIKHLVDPIDDLFLAAKKIpGISSTGVGDGGNELGMGKVKEAVRRHIRHGDVIACDVEADFAVIAGVSNWGGYALA 527
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGIGDGGNELGMGNVKEAVKKHVPNGEKIACVVAADFLITAGVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  528 CALYILYSCAvhsqylrkavgpsrapgdqawtQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHnTHAEMIQK 607
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 156139133  608 LV 609
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
118-255 4.38e-70

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


:

Pssm-ID: 462133  Cd Length: 143  Bit Score: 223.10  E-value: 4.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  118 VAFFLGCSFSLEEALEKAGLPRRDPAGHS-----QTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLGGEQGQPV 192
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRnvpmyRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPAVHGAPV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156139133  193 HMGDPELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTD 255
Cdd:pfam07286  81 HIGDPALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFVTD 143
 
Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
298-609 5.50e-143

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


Pssm-ID: 464140  Cd Length: 291  Bit Score: 416.30  E-value: 5.50e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  298 LESMIGIDPGNRGIGHLLCKDELLKASLSLSHAR-SVLITTGFPTHFNHepPEETDGPPGAVALVAFLQALEKEVAIIVD 376
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPLSHAAgSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  377 qrawNLHQKIVEDAVEQGVLKTQIPIlTYQGGSVEAAQAFLCKNGDPQ---------TPRFDHLVAIERAGRAADGNYYN 447
Cdd:pfam14336  79 ----ELNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAeaqaeelleKYKPDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  448 ARKMNIKHLVDPIDDLFLAAKKIpGISSTGVGDGGNELGMGKVKEAVRRHIRHGDVIACDVEADFAVIAGVSNWGGYALA 527
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGIGDGGNELGMGNVKEAVKKHVPNGEKIACVVAADFLITAGVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  528 CALYILYSCAvhsqylrkavgpsrapgdqawtQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHnTHAEMIQK 607
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 156139133  608 LV 609
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
118-255 4.38e-70

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


Pssm-ID: 462133  Cd Length: 143  Bit Score: 223.10  E-value: 4.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  118 VAFFLGCSFSLEEALEKAGLPRRDPAGHS-----QTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLGGEQGQPV 192
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRnvpmyRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPAVHGAPV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156139133  193 HMGDPELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTD 255
Cdd:pfam07286  81 HIGDPALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFVTD 143
PRK05463 PRK05463
putative hydro-lyase;
12-259 4.38e-51

putative hydro-lyase;


Pssm-ID: 180100  Cd Length: 262  Bit Score: 176.94  E-value: 4.38e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  12 PSAIRSLIlQKKPNIRNTSSMAGELRPASLVVLPRSLAPAFERFCQVNTGPLPLLGQSEPEKWMLPPQGAISETRMGHPQ 91
Cdd:PRK05463   8 PAEARQAI-RAGELTGPTAGLAPGYAQANLVILPKDWAYDFLLFCQRNPKPCPLLDVTEPGSPELPLLGPDADIRTDVPR 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  92 FWKYEFGACTGSLASLEQYSEqlKDMVAFFLGCSFSLEEALEKAGLP-RRDPAGHS----QTTVPCVTHAGFCCPLVVTM 166
Cdd:PRK05463  87 YRVYRDGELVEEVTDITDLWR--DDLVTFLIGCSFSFEHALLEAGIPvRHIEEGRNvpmyRTNIPCRPAGRFSGPMVVSM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133 167 RPIPKDKLeglVRACcslggeQ---------GQPVHMGDPELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSS 237
Cdd:PRK05463 165 RPIPAADA---IRAV------QitsrfpavhGAPVHIGDPAAIGIADLARPDFGDAVEIEPGEIPVFWACGVTPQAVVMA 235
                        250       260
                 ....*....|....*....|..
gi 156139133 238 CETPLAFASIPGCTVMTDLKDA 259
Cdd:PRK05463 236 AKPPFAITHAPGHMLITDLPDS 257
 
Name Accession Description Interval E-value
DUF4392 pfam14336
Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea ...
298-609 5.50e-143

Domain of unknown function (DUF4392); This family of proteins is found in bacteria, archaea and eukaryotes. Proteins in this family are typically between 282 and 585 amino acids in length. There are two completely conserved G residues that may be functionally important.


Pssm-ID: 464140  Cd Length: 291  Bit Score: 416.30  E-value: 5.50e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  298 LESMIGIDPGNRGIGHLLCKDELLKASLSLSHAR-SVLITTGFPTHFNHepPEETDGPPGAVALVAFLQALEKEVAIIVD 376
Cdd:pfam14336   1 LETLIARDPGGRGIKALLYPGELLKAALPLSHAAgSVLITTGFPVPPTH--PAETDGPPGAIALARALQALGKKVVIVTD 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  377 qrawNLHQKIVEDAVEQGVLKTQIPIlTYQGGSVEAAQAFLCKNGDPQ---------TPRFDHLVAIERAGRAADGNYYN 447
Cdd:pfam14336  79 ----ELNEKAVEAAVEVGVLKTPVPI-TYQDGSREAAVVFLTKDGDGAeaqaeelleKYKPDHLIAIERPGRAADGNYHN 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  448 ARKMNIKHLVDPIDDLFLAAKKIpGISSTGVGDGGNELGMGKVKEAVRRHIRHGDVIACDVEADFAVIAGVSNWGGYALA 527
Cdd:pfam14336 154 MRGINITHLVAPLDDLFLLAKKI-GIPTIGIGDGGNELGMGNVKEAVKKHVPNGEKIACVVAADFLITAGVSNWGGYALA 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  528 CALYILYSCAvhsqylrkavgpsrapgdqawtQALPSVIKEEKMLGILVQHKVRSGVSGIVGMEVDGLPFHnTHAEMIQK 607
Cdd:pfam14336 233 AALSLLSGCP----------------------SLLPSVEKEEEMLEALVEAGAVDGVTGELEPSVDGLPFE-EHAEILKE 289

                  ..
gi 156139133  608 LV 609
Cdd:pfam14336 290 LR 291
D-Glu_cyclase pfam07286
D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts ...
118-255 4.38e-70

D-glutamate cyclase; This family includes mitochondrial D-glutamate cyclase which converts D-glutamate to 5-oxo-D-proline. This family also includes numerous uncharacterized proteins from bacteria.


Pssm-ID: 462133  Cd Length: 143  Bit Score: 223.10  E-value: 4.38e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  118 VAFFLGCSFSLEEALEKAGLPRRDPAGHS-----QTTVPCVTHAGFCCPLVVTMRPIPKDKLEGLVRACCSLGGEQGQPV 192
Cdd:pfam07286   1 VTFLIGCSFSFEEALLEAGIPVRHIEQGRnvpmyRTNIPCCPAGPFSGPMVVSMRPIPKDKVERAVQITSRFPAVHGAPV 80
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 156139133  193 HMGDPELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSSCETPLAFASIPGCTVMTD 255
Cdd:pfam07286  81 HIGDPALIGIKDLSKPDYGDPVEIQPGEVPVFWACGVTPQEAVMSAKPPLAITHAPGHMFVTD 143
PRK05463 PRK05463
putative hydro-lyase;
12-259 4.38e-51

putative hydro-lyase;


Pssm-ID: 180100  Cd Length: 262  Bit Score: 176.94  E-value: 4.38e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  12 PSAIRSLIlQKKPNIRNTSSMAGELRPASLVVLPRSLAPAFERFCQVNTGPLPLLGQSEPEKWMLPPQGAISETRMGHPQ 91
Cdd:PRK05463   8 PAEARQAI-RAGELTGPTAGLAPGYAQANLVILPKDWAYDFLLFCQRNPKPCPLLDVTEPGSPELPLLGPDADIRTDVPR 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133  92 FWKYEFGACTGSLASLEQYSEqlKDMVAFFLGCSFSLEEALEKAGLP-RRDPAGHS----QTTVPCVTHAGFCCPLVVTM 166
Cdd:PRK05463  87 YRVYRDGELVEEVTDITDLWR--DDLVTFLIGCSFSFEHALLEAGIPvRHIEEGRNvpmyRTNIPCRPAGRFSGPMVVSM 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156139133 167 RPIPKDKLeglVRACcslggeQ---------GQPVHMGDPELLGIKELSKPAYGDAMVCPPGEVPVFWPSPLTSLGAVSS 237
Cdd:PRK05463 165 RPIPAADA---IRAV------QitsrfpavhGAPVHIGDPAAIGIADLARPDFGDAVEIEPGEIPVFWACGVTPQAVVMA 235
                        250       260
                 ....*....|....*....|..
gi 156139133 238 CETPLAFASIPGCTVMTDLKDA 259
Cdd:PRK05463 236 AKPPFAITHAPGHMLITDLPDS 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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