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Conserved domains on  [gi|34577063|ref|NP_001117|]
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adenylosuccinate synthetase isozyme 2 isoform 1 [Homo sapiens]

Protein Classification

adenylosuccinate synthetase( domain architecture ID 10464973)

GTP-dependent adenylosuccinate synthetase catalyzes the formation of adenylosuccinate from L-aspartate and IMP, the first step in the de novo biosynthesis of AMP

CATH:  1.10.300.10
EC:  6.3.4.4
Gene Ontology:  GO:0004019|GO:0005525|GO:0003688|GO:0000287
PubMed:  6347525|10218106
SCOP:  4003995

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
32-453 0e+00

Adenylosuccinate synthetase;


:

Pssm-ID: 459912  Cd Length: 417  Bit Score: 748.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   112 KNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDGF 191
Cdd:pfam00709  81 EL--EERGID-VPDRLFISDRAHLILPYHKALDGLREEAR---GKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   192 SERFKVLANQYKSIYPTL---EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYPF 268
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPY 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:pfam00709 233 VTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   349 AHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNY 428
Cdd:pfam00709 313 AVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKY 392

                         410       420
                  ....*....|....*....|....*
gi 34577063   429 VRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:pfam00709 393 VEFIEELLGVPIKIISVGPDREQTI 417
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
32-453 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 748.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   112 KNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDGF 191
Cdd:pfam00709  81 EL--EERGID-VPDRLFISDRAHLILPYHKALDGLREEAR---GKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   192 SERFKVLANQYKSIYPTL---EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYPF 268
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPY 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:pfam00709 233 VTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   349 AHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNY 428
Cdd:pfam00709 313 AVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKY 392

                         410       420
                  ....*....|....*....|....*
gi 34577063   429 VRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:pfam00709 393 VEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 30-453 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 664.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063     30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    110 AEKNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQqrqeqagKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:smart00788  81 IEEL--EAKGVD-VKDRLFISDRAHLILPYHIALDKAREK-------ARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGT 265
Cdd:smart00788 150 VLREKLEELLDYKnfllKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:smart00788 229 YPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNA 425
Cdd:smart00788 309 LRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENA 388

                          410       420
                   ....*....|....*....|....*...
gi 34577063    426 QNYVRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:smart00788 389 KKYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 27-453 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 632.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   27 GNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGL 106
Cdd:PTZ00350  11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  107 FEEAEKNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQQRQEQaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVs 186
Cdd:PTZ00350  91 LEEIEQLTKKGINLLG---RLYISDRAHLVFDLHQAIDGIQESEKGKG-GTQIGTTKRGIGPCYSTKASRTGLRVGDLL- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  187 DFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTY 266
Cdd:PTZ00350 166 NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTY 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  267 PFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLL 346
Cdd:PTZ00350 245 PYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPAL 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  347 KYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGE--IIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVN 424
Cdd:PTZ00350 325 RYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPEN 404

                        410       420
                 ....*....|....*....|....*....
gi 34577063  425 AQNYVRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:PTZ00350 405 AQKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 30-455 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 629.35  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:COG0104   1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 110 AEKNVQKGKGLEgweKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:COG0104  81 IDGLEARGVDVR---SRLRISERAHLILPYHRALDKAREEAR---GKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALH-GppKKILVEGANAALLDIDFG 264
Cdd:COG0104 154 VLREKLEELLEYKnfllEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHG 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 265 TYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLV 344
Cdd:COG0104 232 TYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAV 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 345 LLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVN 424
Cdd:COG0104 312 ALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPEN 391

                       410       420       430
                ....*....|....*....|....*....|.
gi 34577063 425 AQNYVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:COG0104 392 ARAYVERIEELLGVPISIVSVGPDREQTIVR 422
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 29-453 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 535.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  29 RVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:cd03108   1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 109 EAEKNVQKGkglEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQeqaGKNLGTTKKGIGPVYSSKAARSGLRMCDlvsdf 188
Cdd:cd03108  81 EIEELEKKG---IDVKGRLLISDRAHLVFPYHQELDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD----- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 189 dgfserfkvlanqyksiyptleidiegelqklkgymekikPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTYPF 268
Cdd:cd03108 150 ----------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPY 188

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:cd03108 189 VTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRY 268

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 349 AHMINGFTALALTKLDildmfteikvgvaykldgeiiphipanqevlnkvevqyktlpgwntdisnarafkelpVNAQNY 428
Cdd:cd03108 269 AVRINGLTELALTKLD----------------------------------------------------------VNAQKY 290

                       410       420
                ....*....|....*....|....*
gi 34577063 429 VRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:cd03108 291 IERIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 32-455 7.04e-180

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 509.39  E-value: 7.04e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   112 knvQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQrqeQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfDGF 191
Cdd:TIGR00184  81 ---YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKS---KLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDD-EAF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   192 SERFK----VLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYP 267
Cdd:TIGR00184 154 AEKAKnileYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   268 FVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLK 347
Cdd:TIGR00184 233 YVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAAR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   348 YAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQN 427
Cdd:TIGR00184 313 YACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKK 392

                         410       420
                  ....*....|....*....|....*...
gi 34577063   428 YVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:TIGR00184 393 YIERIEELTGVPVTIISTGPEREQTIDL 420
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
30-354 9.07e-29

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 114.77  E-value: 9.07e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQ-GGNNAGHTVVVD-SVEYDFHLLPSGIINPNVTA-FIGNGVVIHLPGL 106
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIVSPPLKQvLIGPGSEIDLEVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  107 FEEAEKNVQKGkglEGWEKRLIIsdrahivfdfHQAADGIQEQQRQEQAGK---NLGTTKKGIGPVYSSKAARSGLRMCD 183
Cdd:NF038379  81 REEIEELEDAG---HDVGKRLLI----------HEQATVIELHKHVEEEAGpmtKIGSTKKGIGAARAAKIRRNPSTLGD 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  184 LVSDFDGFSERFKvlanqyksiypTLEIDiegelqklkgymekikpmVRDGVYFLYEALHGPPKKILVEGANAALLDIDF 263
Cdd:NF038379 148 AEGDFGEGAVRDQ-----------PWEIA------------------ERVVDNALYDFALQAAERIQIEGTQGYSLGLHA 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  264 GTYPFVTSSNCTVGGVCTGLGMPPQNVGE--VYGVVKAYTTRVGIGAFPTEQDNEigellQTRGREFGVT------TGRK 335
Cdd:NF038379 199 GFYPYCTSRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAGWSGNSYPDQG-----ETTWEELGLPeelttvTKKV 273

                        330
                 ....*....|....*....
gi 34577063  336 RRCGWLDLVLLKYAHMING 354
Cdd:NF038379 274 RRVGTFSAEQVREAVQANG 292
 
Name Accession Description Interval E-value
Adenylsucc_synt pfam00709
Adenylosuccinate synthetase;
32-453 0e+00

Adenylosuccinate synthetase;


Pssm-ID: 459912  Cd Length: 417  Bit Score: 748.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:pfam00709   1 VVVGAQWGDEGKGKIVDLLAEDADVVVRFQGGNNAGHTVVVDGKKYKLHLLPSGILNPGKTNVIGNGVVIDPPALLEEIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   112 KNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDGF 191
Cdd:pfam00709  81 EL--EERGID-VPDRLFISDRAHLILPYHKALDGLREEAR---GKKKIGTTGRGIGPAYSDKAARRGIRVGDLL-DPEVF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   192 SERFKVLANQYKSIYPTL---EIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYPF 268
Cdd:pfam00709 154 REKLEALLELKNKLLEKLygePLDVEEELEELLEYAERLKPYVVDTSYFLNKALKEG-KKILFEGAQGTLLDIDHGTYPY 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:pfam00709 233 VTSSNTTAGGACTGLGIGPTKIDEVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGATTGRPRRCGWLDLVALRY 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   349 AHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQNY 428
Cdd:pfam00709 313 AVRINGVTGLALTKLDVLDGLDEIKVCVAYELDGKRIDYFPADLEDLEKVEPVYETLPGWKEDISGVRSFEDLPENARKY 392

                         410       420
                  ....*....|....*....|....*
gi 34577063   429 VRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:pfam00709 393 VEFIEELLGVPIKIISVGPDREQTI 417
Adenylsucc_synt smart00788
Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine ...
 30-453 0e+00

Adenylosuccinate synthetase; Adenylosuccinate synthetase plays an important role in purine biosynthesis, by catalyzing the GTP-dependent conversion of IMP and aspartic acid to AMP. Adenylosuccinate synthetase has been characterized from various sources ranging from Escherichia coli (gene purA) to vertebrate tissues. In vertebrates, two isozymes are present - one involved in purine biosynthesis and the other in the purine nucleotide cycle. The crystal structure of adenylosuccinate synthetase from E. coli reveals that the dominant structural element of each monomer of the homodimer is a central beta-sheet of 10 strands. The first nine strands of the sheet are mutually parallel with right-handed crossover connections between the strands. The 10th strand is antiparallel with respect to the first nine strands. In addition, the enzyme has two antiparallel beta-sheets, comprised of two strands and three strands each, 11 alpha-helices and two short 3/10-helices. Further, it has been suggested that the similarities in the GTP-binding domains of the synthetase and the p21ras protein are an example of convergent evolution of two distinct families of GTP-binding proteins. Structures of adenylosuccinate synthetase from Triticum aestivum and Arabidopsis thaliana when compared with the known structures from E. coli reveals that the overall fold is very similar to that of the E. coli protein.


Pssm-ID: 197875  Cd Length: 417  Bit Score: 664.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063     30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:smart00788   1 VVVVVGAQWGDEGKGKIVDYLAEKADVVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNKKNVIGNGVVIDPEALFKE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    110 AEKNvqKGKGLEgWEKRLIISDRAHIVFDFHQAADGIQEQqrqeqagKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:smart00788  81 IEEL--EAKGVD-VKDRLFISDRAHLILPYHIALDKAREK-------ARIGTTGRGIGPAYEDKVARRGIRVGDLF-DEE 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGT 265
Cdd:smart00788 150 VLREKLEELLDYKnfllKKLYGAEPVDVEEILEELLEYAERLRPYVTDVSELLNEALKAG-KKVLFEGAQGTLLDIDHGT 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:smart00788 229 YPYVTSSNTTAGGAATGAGIGPTRIDRVIGVVKAYTTRVGEGPFPTELFDETGEKLRERGHEFGTTTGRPRRCGWFDAVL 308

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNA 425
Cdd:smart00788 309 LRYAVRINGITGLALTKLDVLDGLDEIKVCVAYKLDGKIIDYFPADLEDLERCEPIYEELPGWKEDTTGVRSYEDLPENA 388

                          410       420
                   ....*....|....*....|....*...
gi 34577063    426 QNYVRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:smart00788 389 KKYIERIEELVGVPVSIISTGPDREQTI 416
PTZ00350 PTZ00350
adenylosuccinate synthetase; Provisional
 27-453 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 240376  Cd Length: 436  Bit Score: 632.45  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   27 GNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGL 106
Cdd:PTZ00350  11 KSKVVVILGAQWGDEGKGKLVDILSEKADIVARFNGGANAGHTIVVDGKKYALHLLPCGILYPNCINVLGNGVVIHLPSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  107 FEEAEKNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQQRQEQaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVs 186
Cdd:PTZ00350  91 LEEIEQLTKKGINLLG---RLYISDRAHLVFDLHQAIDGIQESEKGKG-GTQIGTTKRGIGPCYSTKASRTGLRVGDLL- 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  187 DFDGFSERFKVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTY 266
Cdd:PTZ00350 166 NFETFEKKYRKLVEKLQEQYNIEEYDAEEELERYKGYAEKLKDMIVDTVYFMNKAIK-EGKRVLVEGANATMLDIDFGTY 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  267 PFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLL 346
Cdd:PTZ00350 245 PYVTSSNTTVGGVCTGLGIPPNAIILVIGVVKAYTTRVGEGPFPTELFDENGDYLRKKGHEYGTTTGRPRRCGWLDIPAL 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  347 KYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGE--IIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVN 424
Cdd:PTZ00350 325 RYVQMINGFDSINLTKLDVLSGLKEIKICVNYKNKGTglEIGRYPSSIEELEEYEPVYETMPGWKTDISKCKTFEELPEN 404

                        410       420
                 ....*....|....*....|....*....
gi 34577063  425 AQNYVRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:PTZ00350 405 AQKYVLFIEELLGVPIVWIGVGPNRENMI 433
PurA COG0104
Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is ...
 30-455 0e+00

Adenylosuccinate synthase [Nucleotide transport and metabolism]; Adenylosuccinate synthase is part of the Pathway/BioSystem: Purine biosynthesis


Pssm-ID: 439874  Cd Length: 423  Bit Score: 629.35  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEE 109
Cdd:COG0104   1 NVVVVGAQWGDEGKGKIVDLLAERADVVVRFQGGNNAGHTVVVGGKKFKLHLIPSGILRPGKTCVIGNGVVLDPEALLEE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 110 AEKNVQKGKGLEgweKRLIISDRAHIVFDFHQAADGIQEQQRqeqAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:COG0104  81 IDGLEARGVDVR---SRLRISERAHLILPYHRALDKAREEAR---GKKKIGTTGRGIGPAYEDKVARRGIRVGDLL-DPE 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 190 GFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALH-GppKKILVEGANAALLDIDFG 264
Cdd:COG0104 154 VLREKLEELLEYKnfllEKLYGAEPLDFEELLEEYLEYAERLKPYVADTSELLNEALKaG--KKVLFEGAQGTLLDIDHG 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 265 TYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLV 344
Cdd:COG0104 232 TYPYVTSSNTTAGGACTGSGVGPTKIDRVIGVVKAYTTRVGEGPFPTELFDETGERLRERGHEFGTTTGRPRRCGWLDAV 311

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 345 LLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVN 424
Cdd:COG0104 312 ALRYAVRINGLTGLALTKLDVLDGLDEIKVCVAYELDGERIDEFPASLEDLARCEPVYEELPGWKEDISGIRSFEDLPEN 391

                       410       420       430
                ....*....|....*....|....*....|.
gi 34577063 425 AQNYVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:COG0104 392 ARAYVERIEELLGVPISIVSVGPDREQTIVR 422
PRK01117 PRK01117
adenylosuccinate synthetase; Provisional
 29-455 0e+00

adenylosuccinate synthetase; Provisional


Pssm-ID: 234904  Cd Length: 430  Bit Score: 609.74  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   29 RVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:PRK01117   2 KNVVVVGTQWGDEGKGKIVDLLSERADVVVRFQGGHNAGHTLVIDGKKYKLHLIPSGILRPGKTCVIGNGVVLDPEALLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  109 EAEKnvQKGKGLEGwEKRLIISDRAHIVFDFHQAADGIQEQQRqeqaGKN-LGTTKKGIGPVYSSKAARSGLRMCDLVsD 187
Cdd:PRK01117  82 EIDE--LEARGVDV-RERLRISERAHLILPYHRALDKAREKAR----GKKkIGTTGRGIGPAYEDKVARRGIRVGDLL-D 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  188 FDGFSERFKVLANQY----KSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALH-GppKKILVEGANAALLDID 262
Cdd:PRK01117 154 PETFAEKLEENLEYKnfllTKYYGAEAVDFEEILDEYLEYAERLKPYVTDTSLLLNDALKaG--KRVLFEGAQGTLLDID 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  263 FGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLD 342
Cdd:PRK01117 232 HGTYPFVTSSNTTAGGAATGSGVGPTKIDYVLGIAKAYTTRVGSGPFPTELFDEVGEHLRERGHEFGTTTGRPRRCGWFD 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  343 LVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELP 422
Cdd:PRK01117 312 AVALRYAVRVNGLTGLALTKLDVLDGLEEIKICVAYELDGKRIDYFPASLEDLARCEPIYEELPGWSESTTGVRSFDDLP 391

                        410       420       430
                 ....*....|....*....|....*....|...
gi 34577063  423 VNAQNYVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:PRK01117 392 ENARKYIKRIEELTGVPISIISTGPDRDQTIIL 424
PLN02513 PLN02513
adenylosuccinate synthase
 30-453 0e+00

adenylosuccinate synthase


Pssm-ID: 178129  Cd Length: 427  Bit Score: 580.06  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVV-VDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:PLN02513   4 VSAVLGTQWGDEGKGKLVDILAQHFDIVARCQGGANAGHTIYnDEGKKFALHLVPSGILNEKTTCVIGNGVVVHLPGLFE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  109 EAEKNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQqrqEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLvSDF 188
Cdd:PLN02513  84 EIDGLESNGVSCEG---RLLVSDRAHLLFDFHQEVDGLREA---ELAGSKIGTTKRGIGPAYSSKATRNGLRVGDL-RHM 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  189 DGFSERFKVLANQYKSIYPTLEID---IEGELQKLKGYMEKIKPMVRDGVYFLYEAlHGPPKKILVEGANAALLDIDFGT 265
Cdd:PLN02513 157 DTFAEKLRELLADAAARFEGFEYDasmVEEEVEAYKKFAERLEPFITDTVHYLNEA-IQAGKKILVEGAQATMLDIDFGT 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:PLN02513 236 YPFVTSSNPSAGGICTGLGIAPRKLGDIIGVVKAYTTRVGSGPFPTELFGELGDLLREAGQEFGTTTGRPRRCGWLDIVA 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKL-DGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVN 424
Cdd:PLN02513 316 LKYSCQINGFTSLNLTKLDVLSGLPEIKIGVAYKTpDGKVVKSFPADLDTLEQVEVVYEVLPGWQEDISSVRNYDDLPAA 395

                        410       420
                 ....*....|....*....|....*....
gi 34577063  425 AQNYVRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:PLN02513 396 AQAYVERIEELVGVPVHYIGVGPGRDALI 424
AdSS cd03108
adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in ...
 29-453 0e+00

adenylosuccinate synthetase; Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-phosphate group of GTP is transferred to the 6-oxygen atom of IMP. An aspartate then displaces this 6-phosphate group to form the product adenylosuccinate. Because of its critical role in purine biosynthesis, AdSS is a target of antibiotics, herbicides and antitumor drugs.


Pssm-ID: 349762  Cd Length: 316  Bit Score: 535.54  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  29 RVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFE 108
Cdd:cd03108   1 KVTVVVGAQWGDEGKGKIVDYLAEKADIVVRFQGGNNAGHTVVVNGKKYKLHLLPSGILNPNATCVIGNGVVIDPPALFE 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 109 EAEKNVQKGkglEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQeqaGKNLGTTKKGIGPVYSSKAARSGLRMCDlvsdf 188
Cdd:cd03108  81 EIEELEKKG---IDVKGRLLISDRAHLVFPYHQELDGLEEKERG---GKKIGTTKRGIGPAYADKAARTGIRVGD----- 149

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 189 dgfserfkvlanqyksiyptleidiegelqklkgymekikPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTYPF 268
Cdd:cd03108 150 ----------------------------------------PYVVDTVELLNEALK-AGKKVLFEGAQGTLLDIDFGTYPY 188

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 269 VTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKY 348
Cdd:cd03108 189 VTSSNTTAGGVCTGLGIPPRRVDRVIGVVKAYTTRVGSGPFPTELFDEEGEKLRELGHEYGTTTGRPRRCGWLDLVALRY 268

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063 349 AHMINGFTALALTKLDildmfteikvgvaykldgeiiphipanqevlnkvevqyktlpgwntdisnarafkelpVNAQNY 428
Cdd:cd03108 269 AVRINGLTELALTKLD----------------------------------------------------------VNAQKY 290

                       410       420
                ....*....|....*....|....*
gi 34577063 429 VRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:cd03108 291 IERIEELLGVPITYISVGPDREQTI 315
purA TIGR00184
adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, ...
 32-455 7.04e-180

adenylosuccinate synthase; Alternate name IMP--aspartate ligase. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 272949  Cd Length: 425  Bit Score: 509.39  E-value: 7.04e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063    32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:TIGR00184   1 VVVGGQWGDEGKGKIVDLLADKPDIVARYQGGHNAGHTIVIDGVKYGLHLIPSGFLYPDAKLLIGNGVVVDPEVLLKEME 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   112 knvQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQrqeQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfDGF 191
Cdd:TIGR00184  81 ---YLEKRGISVRDRLFVSYRCHLILPYHKKLDKAREKS---KLAKKIGTTGKGIGPAYEDKVARSGLRVGDLLDD-EAF 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   192 SERFK----VLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYP 267
Cdd:TIGR00184 154 AEKAKnileYLNEQLVKYYKDEGVDYEKKLDEYMKYAEELKPFVVDVSVELNEALDEG-EKVLFEGAQGTMLDIDYGTYP 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   268 FVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLK 347
Cdd:TIGR00184 233 YVTSSNTTAGGVATGVGIGPTKVDEVIGVFKAYTTRVGAGPFPTELSDEEGEKLGTKGAEFGTTTGRRRRCGWFDLVAAR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   348 YAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQN 427
Cdd:TIGR00184 313 YACRLNGATQLALTKLDVLDGIDEIKVCVAYRMKGEILELFPLDLKDLKGVEPIYETLPGWDKECTGVTEYSDLPENAKK 392

                         410       420
                  ....*....|....*....|....*...
gi 34577063   428 YVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:TIGR00184 393 YIERIEELTGVPVTIISTGPEREQTIDL 420
PRK13783 PRK13783
adenylosuccinate synthetase; Provisional
 32-455 8.51e-125

adenylosuccinate synthetase; Provisional


Pssm-ID: 237505  Cd Length: 404  Bit Score: 368.28  E-value: 8.51e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:PRK13783   4 VIVGLQWGDEGKGKVVTYLSRYYDIVVRYSGGANAGHTVNYGDFKVVHHLLPSADFKKNVGAAIGNGVVLDLEVLVEELE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  112 KNVQKGKGLEGwekRLIISDRAHIVFDFHQAADGIQEQQRqeqaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfDGF 191
Cdd:PRK13783  84 ELKEKFPDYSG---RIFISELAHVVLPVHKELDEIIESVR----KNAIGTTKRGIGPAYADKVMRVGVRLADLFDE-EKL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  192 SERFKVLANQYKSIYpTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEALHgppKKILVEGANAALLDIDFGTYPFVTS 271
Cdd:PRK13783 156 REFLEKILSLYKKLY-GIEFDVEKMMEDLLTFYEKIKDLVVSPVEIKRILEE---KSVLFEGTQGVLLDLDVGTYPYVTS 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  272 SNCTVGGVCTGLGMPPQnVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLLKYAHM 351
Cdd:PRK13783 232 SNCSTTGVSAGMGFPVK-VDEVIGVFKAYTTRVGEGPFPTELFGEEGEKLRKAGHEYGATTGRPRRCGWLDLPLLRYAIE 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  352 INGFTALALTKLDILDMFTEIKVGVAYKLDGEIIpHIPANQEVLNKVEVQYKTLPGWNTDISnarafkelpVNAQNYVRF 431
Cdd:PRK13783 311 VSGVDSLVMTKADVLNGFEKIKVCVRYEIGGKEV-RDPSSLRDLEKAEPVYEEFDGWKSLED---------KNFLKFVDF 380

                        410       420
                 ....*....|....*....|....
gi 34577063  432 IEDELQIPVKWIGVGKSRESMIQL 455
Cdd:PRK13783 381 IERETGRKIAYISTGPKIEEIVEV 404
PRK13786 PRK13786
adenylosuccinate synthetase; Provisional
 31-454 1.37e-121

adenylosuccinate synthetase; Provisional


Pssm-ID: 184325  Cd Length: 424  Bit Score: 361.04  E-value: 1.37e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   31 TVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIInPNVTAFIGNGVVIHLPGLFEEA 110
Cdd:PRK13786   3 TIITGAQFGDEGKGKIVDLLAKDYDIVARFQGGDNAGHTVKVGDEVYKLHLIPSGFL-LDARVLIGPGVVLNPEVLAEEI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  111 EknVQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQagknLGTTKKGIGPVYSSKAARSGLRMCDLVsDFDG 190
Cdd:PRK13786  82 D--MLEKHGVKVDAEKLGIDAKTSIIMPYHIELDGLRESARTEK----IGTTKRGIGFAYIDKIARDEVRMSDLV-DKER 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  191 FSERFKVLANQYKSIYPTLEID--IEGELQKLKGYME---KIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGT 265
Cdd:PRK13786 155 LMRRLEELAPQKEKEIKELGGDpsIVRDEALIDKYLElgrQLAPYITDVSYEINKALD-EGKSVLAEGAQGTHLDVIHGT 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  266 YPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVL 345
Cdd:PRK13786 234 QKFVTSSSTIAGSACANLGVGPTRVDNVLGIVKAYITRVGEGPLPTELKDEAGEHLQDVGGEFGTTTGRPRRCGWFDLPL 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEVQYKTLPGWNTDISNARAFKELPVNA 425
Cdd:PRK13786 314 LKKAIYLNGYTEIALTKLDVLTGLDPIKICVGYELDGEILDYPPELTSDLARCVPVYEELEGWSTDLTEVKAYEDLPENA 393

                        410       420
                 ....*....|....*....|....*....
gi 34577063  426 QNYVRFIEDELQIPVKWIGVGKSRESMIQ 454
Cdd:PRK13786 394 RNYVERLEELMGVPIKYISVGPGREQTFK 422
PRK13788 PRK13788
adenylosuccinate synthetase; Provisional
 33-450 9.24e-118

adenylosuccinate synthetase; Provisional


Pssm-ID: 184326 [Multi-domain]  Cd Length: 404  Bit Score: 350.65  E-value: 9.24e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   33 VLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHlPGLFEEAEK 112
Cdd:PRK13788   6 IIGAQWGDEGKGKVVDALAPEADFVVRYQGGANAGHTVVAKGKTFKLNLLPSGVLHPHATSVLGDGMVID-PFRFAEERE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  113 NVQKGkgleGWEKRLIISDRAHIVFDFHQAADGiqeqqrqeqaGKN-LGTTKKGIGPVYSSKAARSGLRMCDLvSDFDGF 191
Cdd:PRK13788  85 NLRAG----GLNPKLLISERAHLVLPHHKYVDG----------RKNfVGTTGRGIGPAYSDRARRVGIRFGDL-LDEAVL 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  192 SERF-KVLANQYKSIYPTLEIDIEGELQKLKGYMEKIKPMVRDGVYFLYEAL-HGppKKILVEGANAALLDIDFGTYPFV 269
Cdd:PRK13788 150 RERVeRLLEAKPNSTREAGWDTVEKALADLAPMREILLPFIADTGSLLREAIrEG--KRVLFEGAQATLLDLNYGTYPYV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  270 TSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRG----REFGVTTGRKRRCGWLDLVL 345
Cdd:PRK13788 228 TSSHPTVGGILVGAGVNHKAINKVYGVAKAFTTRVGHGPFPTEVFGEMAIRLRGKGgnpwDEFGTTTGRARRVGWLDLVL 307

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  346 LKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGeiiphipanqevlnkvEVQYKTLPGWNtDISNARAFKELPVNA 425
Cdd:PRK13788 308 LKYACEVNGFDGLVLTKLDVLSGLEKVKVCVEYDDDG----------------QPVYKELPGWG-DLDGVKSREALPKEA 370

                        410       420
                 ....*....|....*....|....*
gi 34577063  426 QNYVRFIEDELQIPVKWIGVGKSRE 450
Cdd:PRK13788 371 QAYLELIEETTGVPVVMFSTSPRRE 395
PRK13787 PRK13787
adenylosuccinate synthetase; Provisional
 31-455 1.53e-115

adenylosuccinate synthetase; Provisional


Pssm-ID: 172324  Cd Length: 423  Bit Score: 345.40  E-value: 1.53e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   31 TVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHlPGLFEEA 110
Cdd:PRK13787   4 SLVVGTQWGDEGKAKVIDFLSKDTDIIVRYQGGANAGHTVVVHGKKYVFHLVPSGVIYDQTICVIGNGVVLD-PLFFIEE 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  111 EKNVQKgKGLEGWEKrLIISDRAHIVFDFHQAADGIQEQQRQEQagKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDfdG 190
Cdd:PRK13787  83 CDRLQK-EGFPVKDK-LLLSDACHLLFPYHSQIDSARETTSSQE--HKIGTTKKGIGICYADKMMRTGLRVGDLLDK--S 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  191 FSERFKVL---ANQYKSIYPTLEIDIEGELQK-LKGYMEKIKPMVRDGVYFLYEALHgPPKKILVEGANAALLDIDFGTY 266
Cdd:PRK13787 157 YKRRLKHLvdeKNRELDKLYGMPPVSYNDINDgLKFFLSKVGKNIINTAYYLDTELK-KGKRVLLEGAQGTGLDVDFGTY 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  267 PFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVLL 346
Cdd:PRK13787 236 PYVTSSNPTTGGALIGTGISFQHLKHVIGITKAYTTRVGEGPFPTELLGEAGEVLRQKGGEFGATTGRPRRCGWFDVEML 315

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  347 KYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPAnqEVLNKVEVQYKTLPGWNTDISNARAFKELPVNAQ 426
Cdd:PRK13787 316 KHSVRINGITSIALTKIDILSDYDTIPVAVGYKLNGKTLDCFPS--QGLEKVEPLYEEFPGWKDDISGINEFQKLPEKCK 393

                        410       420
                 ....*....|....*....|....*....
gi 34577063  427 NYVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:PRK13787 394 NYISALEKWIGVKINLVSTGPDRKDTIIG 422
PRK13785 PRK13785
adenylosuccinate synthetase; Provisional
 30-455 4.31e-110

adenylosuccinate synthetase; Provisional


Pssm-ID: 237506  Cd Length: 454  Bit Score: 332.49  E-value: 4.31e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   30 VTVVlGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVtAFIGNGVVIHLPGLFEE 109
Cdd:PRK13785   3 VTIV-GSQLGDEGKGGVVDLYGDAADVVVRYQGGDNAGHTVVHGGEEYKLSLVPSGAVRGKI-GVLGNGCVVNPETLFDE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  110 AEKNVQKGkglegWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQaGKNLGTTKKGIGPVYSSKAARSGLRMCDLVsDFD 189
Cdd:PRK13785  81 IDALRERG-----LDPDVRVAERAHVILPYHRVLDGIEEEAKSDS-DLEVGTTGRGIGPTYEDKAGRRGVRVGDLL-DPD 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  190 GFSERFKVLANQYKSIYPTL----------EIDIEGELQKLKGYMEKIKP--MVRDGVYFLYEALHGPpKKILVEGANAA 257
Cdd:PRK13785 154 VLRDRLEYVVPQKRALAEDVygldasetpeAFDVDALFEEYREYGERLAEedMTVNAGDFLAERIDDG-DNVMLEGAQGT 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  258 LLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNV--GEVYGVVKAYTTRVGIGAFPTE---------------QDNEIGEL 320
Cdd:PRK13785 233 SIDIDHGNYPYVTSSNPTAGGAATGTGLGPTVVgqGEVVGIVKAYLSRVGSGPLPTElggvegdtpdeggrpDEEELATY 312

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  321 LQTRGREFGVTTGRKRRCGWLDLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGEIIPHIPANQEVLNKVEV 400
Cdd:PRK13785 313 IREEGGEYGTVTGRPRRVGWLDMPMLRHAARASGFTGLAINHIDVLAGLDEVKVGHSYELDGEELLTMPATTERWARCEP 392

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 34577063  401 QYKTLPGWNTDISNARA---FKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:PRK13785 393 NFRSFDGWPEVDWAAVAeegYDALPENARTYLEYVSDELDTPIYAVGVGPGREETVVL 450
PRK13784 PRK13784
adenylosuccinate synthetase; Provisional
 32-453 1.06e-90

adenylosuccinate synthetase; Provisional


Pssm-ID: 172322  Cd Length: 428  Bit Score: 281.91  E-value: 1.06e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   32 VVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAE 111
Cdd:PRK13784   5 VIVGAQWGDEGKGKIADTLAEKADLVVRYQGGNNAGHTLVVNGKKTFLHLIPSGVLHQHTKCVIGHGVVLDPVALDEEIT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  112 KnvQKGKGLEGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQagknLGTTKKGIGPVYSSKAARSGLRMCDLvsdFD-- 189
Cdd:PRK13784  85 R--LQAKGIAISAENLFVSESCTIITSYHKLLDAVRESNTSEK----IGTTGKGIGPAYEDKVSRKGIKFKHL---FDkd 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  190 --------GFSERFKVLANQYKSIYPTLEidieGELQKLKGYMEKIKPMVRDGVYFLYEALhGPPKKILVEGANAALLDI 261
Cdd:PRK13784 156 llrsrlaiSLAEKETLFRDLYKVEYPTLE----QEFDKLFALGQKLKQYAADTFSIIDQAI-AAGKNVVYEGAQGVLLDV 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  262 DFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWL 341
Cdd:PRK13784 231 DYGTYPFVTSSNTSVAGVYSGATTAGHGLDHVIGITKAYTTRVGEGPFPTELFDDVGKFIQHKGGEIGVTTGRIRRCGWL 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  342 DLVLLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDG-EIIPHIPANQevLNKVEVQYKTLPGWNTDISNARafKE 420
Cdd:PRK13784 311 DLPLLKYSAKCSNLTSIALTKVDVLSDMDTLKVCIGYKYEGkEIYCAYPGID--LYKVEPILVEMEPFSIDETVTK--DN 386

                        410       420       430
                 ....*....|....*....|....*....|...
gi 34577063  421 LPVNAQNYVRFIEDELQIPVKWIGVGKSRESMI 453
Cdd:PRK13784 387 MPAALKTYLKTIENHVGIPISSLAYGPSREQIL 419
PRK04293 PRK04293
adenylosuccinate synthetase; Provisional
 30-455 1.38e-62

adenylosuccinate synthetase; Provisional


Pssm-ID: 179812  Cd Length: 333  Bit Score: 205.89  E-value: 1.38e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   30 VTVVLGAQWGDEGKGKVVDLLAQ--DADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLF 107
Cdd:PRK04293   3 CTIVVGGFFGDEGKGKIIAYLALkdKPSIIARGGVGPNAGHTVEYNGKKYGLRMIPSGFVNKDAKLAIGAGVLVDPEVLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  108 EEAEKNVQKGkglegwekRLIISDRAHIVFDFHqaadgIQEQQRQEQAGKNLGTTKKGIGPVYSSKAarsgLRMCDLVSD 187
Cdd:PRK04293  83 KEVEELNVGG--------RVFVDYRCGIIEEKH-----VEEDRSDEHLSKKIGSTGTGCGPANADRV----LRRLKLAKD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  188 FdgfserfkvlanqyksiyptleidiegelqklkgymEKIKPMVRDGVYFLYEALHGPpKKILVEGANAALLDIDFGTYP 267
Cdd:PRK04293 146 V------------------------------------EELEKYLTDVPEEVNEALDRG-ENVLIEGTQGFGLSLYYGTYP 188

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  268 FVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGEllqTRG-REFGVTTGRKRRCGWLDLVLL 346
Cdd:PRK04293 189 YVTSKDTTASGIASDVGVGPTKVDEVIVVFKSYPTRVGEGPFPTELSLEEAE---KLGlVEYGTVTGRRRRVGPFDFELA 265

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  347 KYAHMINGFTALALTKLDILDmfteikvgvaykldgeiiphipanqevlnkvevqyktlpgwnTDISNARAFKELPVNAQ 426
Cdd:PRK04293 266 RRAARINGATQIAITKLDKLD------------------------------------------KEAYGVTEYDKLPPEAK 303

                        410       420
                 ....*....|....*....|....*....
gi 34577063  427 NYVRFIEDELQIPVKWIGVGKSRESMIQL 455
Cdd:PRK04293 304 KFIEEIEEELGVPVTLISTGPELEDTIDL 332
amino_Aden_PurZ NF038379
succino-amino-deoxyadenylate synthase PurZ;
30-354 9.07e-29

succino-amino-deoxyadenylate synthase PurZ;


Pssm-ID: 468496  Cd Length: 292  Bit Score: 114.77  E-value: 9.07e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   30 VTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQ-GGNNAGHTVVVD-SVEYDFHLLPSGIINPNVTA-FIGNGVVIHLPGL 106
Cdd:NF038379   1 VDVVVDGQFGSTGKGLIAGYLAERAAPDVVVRaAGPNAGHTYIDDeGRKFVHRMLPNGIVSPPLKQvLIGPGSEIDLEVL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  107 FEEAEKNVQKGkglEGWEKRLIIsdrahivfdfHQAADGIQEQQRQEQAGK---NLGTTKKGIGPVYSSKAARSGLRMCD 183
Cdd:NF038379  81 REEIEELEDAG---HDVGKRLLI----------HEQATVIELHKHVEEEAGpmtKIGSTKKGIGAARAAKIRRNPSTLGD 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  184 LVSDFDGFSERFKvlanqyksiypTLEIDiegelqklkgymekikpmVRDGVYFLYEALHGPPKKILVEGANAALLDIDF 263
Cdd:NF038379 148 AEGDFGEGAVRDQ-----------PWEIA------------------ERVVDNALYDFALQAAERIQIEGTQGYSLGLHA 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  264 GTYPFVTSSNCTVGGVCTGLGMPPQNVGE--VYGVVKAYTTRVGIGAFPTEQDNEigellQTRGREFGVT------TGRK 335
Cdd:NF038379 199 GFYPYCTSRDCTPADFLADAGIPLPNVDAfkVVGTARTYPIRVAGWSGNSYPDQG-----ETTWEELGLPeelttvTKKV 273

                        330
                 ....*....|....*....
gi 34577063  336 RRCGWLDLVLLKYAHMING 354
Cdd:NF038379 274 RRVGTFSAEQVREAVQANG 292
PTZ00351 PTZ00351
adenylosuccinate synthetase; Provisional
 30-311 5.39e-13

adenylosuccinate synthetase; Provisional


Pssm-ID: 173544  Cd Length: 710  Bit Score: 71.24  E-value: 5.39e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063   30 VTVVLGAQWGDEGKGKVVDLLAQDADIVC--RCQGGNNAGHTVVVDS-VEYDFHLLPSGIINPNVTAFIGNGVVIHlPGL 106
Cdd:PTZ00351 171 VIMVAGAFFGDEGKGKTVDAVAHHPLCTCiaRVNSGENAGHTVYDKAgRKFVFNLAPSGLLLPGKRNYIGPECVMD-PVS 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  107 FEEAEKNVQKGKGLEgWEKRLIISDRAhIVFDFHQAADGIQEQQRQeqagknlgTTKKGIGPVYSSKAARSGLRMCDLVS 186
Cdd:PTZ00351 250 FMEKEIIQLIDAGID-YRDRLFIGNVC-IVTPYHKLLDLLGSAANS--------STLKGMAPVHGSKVMKRGIRLDHIFN 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  187 DFDGFSERFKVLANQYKSIY-------------------------PTLEIDIEGELQKLKGYMEKIKPMVR--------- 232
Cdd:PTZ00351 320 DDETLRKRLEKDMDTYLGLLkvknlsdadvvrlcreensdgvvrvPDYVIAFAQAKDKVEFLVKLYRDRVRhnpdfparc 399

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34577063  233 DGVYFLYEA-LHGppKKILVEGANAALL-DIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGE-VYGVVKAY-TTRVGIGA 308
Cdd:PTZ00351 400 DVTYELHAAvLRG--EKVLLEGPQSYWLsNARTKFWESTTSADTTAAGLLAASQLNFQKFKSvVLNVHKAPgSSRVGIGA 477


                 ...
gi 34577063  309 FPT 311
Cdd:PTZ00351 478 CPS 480
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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