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Conserved domains on  [gi|209180455|ref|NP_001129203|]
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zinc finger matrin-type protein 4 isoform b [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10583776)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003676|GO:0008270
PubMed:  11179890|11361095|10940247|22803940|12665246
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 72-106 2.34e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


:

Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.85  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 209180455    72 DKNKCCTLCNMSFTSAVVADSHYQGKIHAKRLKLL 106
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
TUTase super family cl41074
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
 122-153 5.03e-03

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


The actual alignment was detected with superfamily member pfam19088:

Pssm-ID: 465974  Cd Length: 218  Bit Score: 35.88  E-value: 5.03e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 209180455  122 YRCTICSVSLNSIEQYHAHLKGSKHQTNLKNK 153
Cdd:pfam19088  51 YLCKLCSVHIENIQGAHKHIKEKRHKKNIMEK 82
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 15-38 9.94e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


:

Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 32.08  E-value: 9.94e-03
                          10        20
                  ....*....|....*....|....
gi 209180455   15 YCKVCSAQLISESQRVAHYESRKH 38
Cdd:pfam12874   2 YCELCNVTFNSESQLKSHLQGKKH 25
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 72-106 2.34e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.85  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 209180455    72 DKNKCCTLCNMSFTSAVVADSHYQGKIHAKRLKLL 106
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 77-99 3.77e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.93  E-value: 3.77e-04
                          10        20
                  ....*....|....*....|...
gi 209180455   77 CTLCNMSFTSAVVADSHYQGKIH 99
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
 122-153 5.03e-03

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


Pssm-ID: 465974  Cd Length: 218  Bit Score: 35.88  E-value: 5.03e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 209180455  122 YRCTICSVSLNSIEQYHAHLKGSKHQTNLKNK 153
Cdd:pfam19088  51 YLCKLCSVHIENIQGAHKHIKEKRHKKNIMEK 82
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 15-38 9.94e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 32.08  E-value: 9.94e-03
                          10        20
                  ....*....|....*....|....
gi 209180455   15 YCKVCSAQLISESQRVAHYESRKH 38
Cdd:pfam12874   2 YCELCNVTFNSESQLKSHLQGKKH 25
 
Name Accession Description Interval E-value
ZnF_U1 smart00451
U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ...
 72-106 2.34e-04

U1-like zinc finger; Family of C2H2-type zinc fingers, present in matrin, U1 small nuclear ribonucleoprotein C and other RNA-binding proteins.


Pssm-ID: 197732 [Multi-domain]  Cd Length: 35  Bit Score: 36.85  E-value: 2.34e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 209180455    72 DKNKCCTLCNMSFTSAVVADSHYQGKIHAKRLKLL 106
Cdd:smart00451   1 TGGFYCKLCNVTFTDEISVEAHLKGKKHKKNVKKR 35
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 77-99 3.77e-04

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 35.93  E-value: 3.77e-04
                          10        20
                  ....*....|....*....|...
gi 209180455   77 CTLCNMSFTSAVVADSHYQGKIH 99
Cdd:pfam12874   3 CELCNVTFNSESQLKSHLQGKKH 25
TUTase pfam19088
TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase ...
 122-153 5.03e-03

TUTase nucleotidyltransferase domain; This nucleotidyltransferase domain is found in TUTase enzymes. Terminal uridyltransferases (TUTases) execute 3' RNA uridylation across protists, fungi, metazoan and plant species.


Pssm-ID: 465974  Cd Length: 218  Bit Score: 35.88  E-value: 5.03e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 209180455  122 YRCTICSVSLNSIEQYHAHLKGSKHQTNLKNK 153
Cdd:pfam19088  51 YLCKLCSVHIENIQGAHKHIKEKRHKKNIMEK 82
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 122-146 8.03e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 32.47  E-value: 8.03e-03
                          10        20
                  ....*....|....*....|....*
gi 209180455  122 YRCTICSVSLNSIEQYHAHLKGSKH 146
Cdd:pfam12874   1 FYCELCNVTFNSESQLKSHLQGKKH 25
zf-met pfam12874
Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found ...
 15-38 9.94e-03

Zinc-finger of C2H2 type; This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.


Pssm-ID: 463736 [Multi-domain]  Cd Length: 25  Bit Score: 32.08  E-value: 9.94e-03
                          10        20
                  ....*....|....*....|....
gi 209180455   15 YCKVCSAQLISESQRVAHYESRKH 38
Cdd:pfam12874   2 YCELCNVTFNSESQLKSHLQGKKH 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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