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Conserved domains on  [gi|226371633|ref|NP_001139759|]
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CDK5 and ABL1 enzyme substrate 1 isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 463-594 1.24e-93

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


:

Pssm-ID: 410305  Cd Length: 132  Bit Score: 283.09  E-value: 1.24e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 463 FKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHE 542
Cdd:cd20602    1 FKEKFPHIKLTLSKIRSLKREMRKLAQEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 226371633 543 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQSS 594
Cdd:cd20602   81 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQNS 132
 
Name Accession Description Interval E-value
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 463-594 1.24e-93

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410305  Cd Length: 132  Bit Score: 283.09  E-value: 1.24e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 463 FKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHE 542
Cdd:cd20602    1 FKEKFPHIKLTLSKIRSLKREMRKLAQEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 226371633 543 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQSS 594
Cdd:cd20602   81 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQNS 132
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 468-579 7.64e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 41.64  E-value: 7.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 468 PHIKLTLSKIRSLKreMRKLAQEDC---GFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVK 544
Cdd:COG5333   34 PELTLEKELNLVIY--YLKLIMDLCtrlNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDISIE 111

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 226371633 545 HLI--DKLEEKFRLNRRELIAFEFPVLVALEFALHLP 579
Cdd:COG5333  112 SFEarDLWSEEPKSSRERILEYEFELLEALDFDLHVH 148
 
Name Accession Description Interval E-value
CYCLIN_CABLES1 cd20602
cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called ...
 463-594 1.24e-93

cyclin box found in CDK5 and ABL1 enzyme substrate 1 (CABLES1); CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410305  Cd Length: 132  Bit Score: 283.09  E-value: 1.24e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 463 FKEKFPHIKLTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHE 542
Cdd:cd20602    1 FKEKFPHIKLTLSKIRSLKREMRKLAQEECGYEEPTVAMAFVYFEKLALKGKLNKQNRKLCAGACVLLAAKIGSDLKKHE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 226371633 543 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQSS 594
Cdd:cd20602   81 VKHLIDKLEEKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLVQNS 132
CYCLIN_CABLES2 cd20603
cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called ...
 472-592 3.72e-70

cyclin box found in CDK5 and ABL1 enzyme substrate 2 (CABLES2); CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. CABLES2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410306  Cd Length: 121  Bit Score: 222.07  E-value: 3.72e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 472 LTLSKIRSLKREMRKLAqEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLE 551
Cdd:cd20603    1 LTLSKIRSLKREMRNVA-EECNLEPVTVAMAYVYFEKLVLQGKLNKQNRKLCAGACVLLAAKISSDLKKHEVKHLIDKLE 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 226371633 552 EKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRLIQ 592
Cdd:cd20603   80 ERFRLNRRELISFEFTVLVALELALYLPENQVLPHYRRLTQ 120
CYCLIN_CABLES cd20556
cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes ...
 472-590 3.64e-67

cyclin box found in CDK5 and ABL1 enzyme substrate (CABLES) family; The CABLES family includes CABLES1 and CABLES2. CABLES1, also called interactor with CDK3 1 (Ik3-1), is a cyclin-dependent kinase binding protein that enhances cyclin-dependent kinase tyrosine phosphorylation by non-receptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. CABLES2, also called interactor with CDK3 2 (Ik3-2), acts as a proapoptotic factor involved in both p53-mediated and p53-independent apoptotic pathways. Both, CABLES1 and CABLES2, contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410259  Cd Length: 119  Bit Score: 213.97  E-value: 3.64e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 472 LTLSKIRSLKREMRKLAQEDCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVKHLIDKLE 551
Cdd:cd20556    1 LTLSKLRSLKREMLKIALKLCGLDVSTVALAYVYFEKLVLKGLVNKSNRKLIAGACLLLAAKFNDDVKKEDLKSLLEEIE 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 226371633 552 EKFRLNRRELIAFEFPVLVALEFALHLPEHEVMPHYRRL 590
Cdd:cd20556   81 DVFRLTRKELIAFEFPVLVALEFSLHVPDEEILPHLQRL 119
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 479-565 3.77e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 47.79  E-value: 3.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 479 SLKREMRKLAQEdCGFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVgsdlrkHEVKHLIDKLEEKFRLNR 558
Cdd:cd00043    1 KAVDFIRRLCSK-LGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKL------EELPRTLKEIAKVSGVSE 73


                 ....*..
gi 226371633 559 RELIAFE 565
Cdd:cd00043   74 KELRKAE 80
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 468-579 7.64e-04

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 41.64  E-value: 7.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 468 PHIKLTLSKIRSLKreMRKLAQEDC---GFEEPTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRKHEVK 544
Cdd:COG5333   34 PELTLEKELNLVIY--YLKLIMDLCtrlNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDISIE 111

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 226371633 545 HLI--DKLEEKFRLNRRELIAFEFPVLVALEFALHLP 579
Cdd:COG5333  112 SFEarDLWSEEPKSSRERILEYEFELLEALDFDLHVH 148
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 497-574 9.90e-03

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 36.44  E-value: 9.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 226371633 497 PTVAMAFVYFEKLALRGKLNKQNRKLCAGACVLLAAKVGSDLRK--------HEVKHLIDkLEEKFRLNRRELIAFEFPV 568
Cdd:cd20530   30 DTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKVEETPKKckdiiktaRSLLNDKQ-FAQFGDDPKEEVMVLERIL 108


                 ....*.
gi 226371633 569 LVALEF 574
Cdd:cd20530  109 LQTIKF 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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