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Conserved domains on  [gi|285002204|ref|NP_001165442|]
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cadherin-related family member 1 isoform 2 precursor [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 4.83e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 4.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 216
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 285002204 217 GRlhgadvVFSATTTVTVNVEDVQD 241
Cdd:cd11304   79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-572 1.08e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 555
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 285002204 556 --KYSVAEVFITLLDVNDH 572
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-349 5.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 5.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 250 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 325
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....
gi 285002204 326 spaGSPAAQATVPVTIRIVDLNNH 349
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-679 2.60e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 666
Cdd:cd11304   13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                         90
                 ....*....|...
gi 285002204 667 STTALLKIDITDA 679
Cdd:cd11304   83 SSTATVTITVLDV 95
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-468 2.81e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 2.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 363 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 440
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 285002204 441 LLAVEVNTPeKFSSTADVVIQLLDTNDN 468
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 7.03e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*
gi 285002204 119 E---KVVILVTDAND 130
Cdd:cd11304   83 SstaTVTITVLDVND 97
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 4.83e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 4.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 216
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 285002204 217 GRlhgadvVFSATTTVTVNVEDVQD 241
Cdd:cd11304   79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-572 1.08e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 555
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 285002204 556 --KYSVAEVFITLLDVNDH 572
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-349 5.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 5.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 250 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 325
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....
gi 285002204 326 spaGSPAAQATVPVTIRIVDLNNH 349
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
477-567 6.10e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 6.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 553
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 285002204  554 EGKYSVAEVFITLL 567
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-574 5.77e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 5.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   495 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 571
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 285002204   572 HPP 574
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-244 1.07e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   158 HAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAgaTLDYERSRTHYITVVAKDGGGRLHgadvvfSATTTVTVN 235
Cdd:smart00112   1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 285002204   236 VEDVQDMAP 244
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
140-237 3.17e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  140 YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP--FAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGGG 217
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 285002204  218 RlhgadvVFSATTTVTVNVE 237
Cdd:pfam00028  79 P------PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-679 2.60e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 666
Cdd:cd11304   13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                         90
                 ....*....|...
gi 285002204 667 STTALLKIDITDA 679
Cdd:cd11304   83 SSTATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 269-351 2.14e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 2.14e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   269 VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIV 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 285002204   345 DLNNHPP 351
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
251-343 1.74e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  251 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQspaQLQREV---YELHVQVTEms 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTK---PLDRESigeYELTVEATD-- 75

                          90
                  ....*....|....*..
gi 285002204  327 pAGSPAAQATVPVTIRI 343
Cdd:pfam00028  76 -SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-468 2.81e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 2.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 363 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 440
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 285002204 441 LLAVEVNTPeKFSSTADVVIQLLDTNDN 468
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 7.03e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*
gi 285002204 119 E---KVVILVTDAND 130
Cdd:cd11304   83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-678 1.32e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   595 AIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDalhnitpgRDCL--WSLEVQAKDRGSPSFSTTALL 672
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT---KPLD--------REEQpeYTLTVEATDGGGPPLSSTATV 69


                   ....*.
gi 285002204   673 KIDITD 678
Cdd:smart00112  70 TITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 383-470 3.78e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 3.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   383 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 460
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 285002204   461 QLLDTNDNVP 470
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
588-677 6.10e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLD----ALHNITpgrdclwsleVQAKDRG 662
Cdd:pfam00028  12 GTEVlTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDresiGEYELT----------VEATDSG 77

                          90
                  ....*....|....*
gi 285002204  663 SPSFSTTALLKIDIT 677
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 2.50e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 37.67  E-value: 2.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 285002204   42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPTFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 5.96e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.17  E-value: 5.96e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 285002204    61 DPEGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-241 4.83e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 4.83e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 139 PYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGG 216
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGG 78

                         90       100
                 ....*....|....*....|....*
gi 285002204 217 GRlhgadvVFSATTTVTVNVEDVQD 241
Cdd:cd11304   79 GP------PLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-572 1.08e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 104.32  E-value: 1.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG 555
Cdd:cd11304    2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSiVSGNEDGLFSIDPSTGEITTA--KPLDREEQSSYTLTVTATDGGG 79

                         90
                 ....*....|....*....
gi 285002204 556 --KYSVAEVFITLLDVNDH 572
Cdd:cd11304   80 ppLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 250-349 5.45e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 5.45e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 250 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSpaqLQRE---VYELHVQVTEM 325
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKP---LDREeqsSYTLTVTATDG 77

                         90       100
                 ....*....|....*....|....
gi 285002204 326 spaGSPAAQATVPVTIRIVDLNNH 349
Cdd:cd11304   78 ---GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
477-567 6.10e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 6.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  477 YVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDM-- 553
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSgg 78

                          90
                  ....*....|....
gi 285002204  554 EGKYSVAEVFITLL 567
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-574 5.77e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 5.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   495 TAVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGLIYTQpwASLDAEATARYNFYVKAEDMEG--KYSVAEVFITLLDVND 571
Cdd:smart00112   1 SATDADSGENGKVTYSiLSGNDDGLFSIDPETGEITTT--KPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVND 78


                   ...
gi 285002204   572 HPP 574
Cdd:smart00112  79 NAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 158-244 1.07e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.46  E-value: 1.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   158 HAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAgaTLDYERSRTHYITVVAKDGGGRLHgadvvfSATTTVTVN 235
Cdd:smart00112   1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTK--PLDREEQPEYTLTVEATDGGGPPL------SSTATVTIT 72


                   ....*....
gi 285002204   236 VEDVQDMAP 244
Cdd:smart00112  73 VLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
140-237 3.17e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 3.17e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  140 YVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP--FAVDRHSGVLRLQagATLDYERSRTHYITVVAKDGGG 217
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgnFRIDPDTGDISTT--KPLDRESIGEYELTVEATDSGG 78

                          90       100
                  ....*....|....*....|
gi 285002204  218 RlhgadvVFSATTTVTVNVE 237
Cdd:pfam00028  79 P------PLSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 588-679 2.60e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 71.96  E-value: 2.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDALHNitpgrdCLWSLEVQAKDRGSPSF 666
Cdd:cd11304   13 GTVVlTVSATDPD-SGENGEVTYSIVSGNEDGLFSIDPSTGEITTA---KPLDREEQ------SSYTLTVTATDGGGPPL 82

                         90
                 ....*....|...
gi 285002204 667 STTALLKIDITDA 679
Cdd:cd11304   83 SSTATVTITVLDV 95
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 269-351 2.14e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.14  E-value: 2.14e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   269 VAMDGDRGKPNRILYSLVNGND-GAFEINETSGAISITqspAQLQRE---VYELHVQVTEMspaGSPAAQATVPVTIRIV 344
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdGLFSIDPETGEITTT---KPLDREeqpEYTLTVEATDG---GGPPLSSTATVTITVL 74


                   ....*..
gi 285002204   345 DLNNHPP 351
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
251-343 1.74e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 1.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  251 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQspaQLQREV---YELHVQVTEms 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpGGNFRIDPDTGDISTTK---PLDRESigeYELTVEATD-- 75

                          90
                  ....*....|....*..
gi 285002204  327 pAGSPAAQATVPVTIRI 343
Cdd:pfam00028  76 -SGGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 363-468 2.81e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 2.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204 363 FELSMNEHPPQGEILrgLKITVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneAQVTIIvensAAIDFEKSKVLTFK 440
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGENGEVTYSIVSgnEDGLFSIDPST----GEITTA----KPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*...
gi 285002204 441 LLAVEVNTPeKFSSTADVVIQLLDTNDN 468
Cdd:cd11304   72 VTATDGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 42-130 7.03e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  42 FSLPEDTPVGSHVYTLNGTDP---EGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVA 118
Cdd:cd11304    4 VSVPENAPPGTVVLTVSATDPdsgENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                         90
                 ....*....|....*
gi 285002204 119 E---KVVILVTDAND 130
Cdd:cd11304   83 SstaTVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 595-678 1.32e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 55.05  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   595 AIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLDalhnitpgRDCL--WSLEVQAKDRGSPSFSTTALL 672
Cdd:smart00112   2 ATDAD-SGENGKVTYSILSGNDDGLFSIDPETGEITTT---KPLD--------REEQpeYTLTVEATDGGGPPLSSTATV 69


                   ....*.
gi 285002204   673 KIDITD 678
Cdd:smart00112  70 TITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 383-470 3.78e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 53.89  E-value: 3.78e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204   383 TVNDSDQGANAKFNLQLVG--PRGIFRVVPQTvlneaqvtIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKfSSTADVVI 460
Cdd:smart00112   1 SATDADSGENGKVTYSILSgnDDGLFSIDPET--------GEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTI 71

                           90
                   ....*....|
gi 285002204   461 QLLDTNDNVP 470
Cdd:smart00112  72 TVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
588-677 6.10e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 48.07  E-value: 6.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 285002204  588 GTPV-KIEAIDEDaEEPNNLVDYSITHAEPANVFDINSHTGEIWLKnsiRSLD----ALHNITpgrdclwsleVQAKDRG 662
Cdd:pfam00028  12 GTEVlTVTATDPD-LGPNGRIFYSILGGGPGGNFRIDPDTGDISTT---KPLDresiGEYELT----------VEATDSG 77

                          90
                  ....*....|....*
gi 285002204  663 SPSFSTTALLKIDIT 677
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
42-95 2.50e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 37.67  E-value: 2.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 285002204   42 FSLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSvFSVDPTFGNITLVEE 95
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLGPngrIFYSILGGGPGGN-FRIDPDTGDISTTKP 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 61-133 5.96e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.17  E-value: 5.96e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 285002204    61 DPEGDPISYHISfDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG--LNLVAE-KVVILVTDANDEAP 133
Cdd:smart00112   7 SGENGKVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggPPLSSTaTVTITVLDVNDNAP 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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