![](files/infoQ.gif)
protein mono-ADP-ribosyltransferase TIPARP [Homo sapiens]
WWE and TCCD_inducible_PARP_like domain-containing protein( domain architecture ID 11137801)
WWE and TCCD_inducible_PARP_like domain-containing protein
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | |||
TCCD_inducible_PARP_like | cd01439 | Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to ... |
529-648 | 5.91e-62 | |||
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes pleotropic effects in mammalian species through modulating gene expression. TCCD indicible PARP (TiPARP) is a target of TCDD that may contribute to multiple responses to TCDD by modulating protein function through poly ADP-ribosylation : Pssm-ID: 238719 [Multi-domain] Cd Length: 121 Bit Score: 201.78 E-value: 5.91e-62
|
|||||||
WWE | pfam02825 | WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
346-401 | 1.48e-04 | |||
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems. : Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 40.36 E-value: 1.48e-04
|
|||||||
Name | Accession | Description | Interval | E-value | ||||
TCCD_inducible_PARP_like | cd01439 | Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to ... |
529-648 | 5.91e-62 | ||||
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes pleotropic effects in mammalian species through modulating gene expression. TCCD indicible PARP (TiPARP) is a target of TCDD that may contribute to multiple responses to TCDD by modulating protein function through poly ADP-ribosylation Pssm-ID: 238719 [Multi-domain] Cd Length: 121 Bit Score: 201.78 E-value: 5.91e-62
|
||||||||
PARP | pfam00644 | Poly(ADP-ribose) polymerase catalytic domain; Poly(ADP-ribose) polymerase catalyzes the ... |
474-648 | 2.28e-33 | ||||
Poly(ADP-ribose) polymerase catalytic domain; Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active. Pssm-ID: 395519 [Multi-domain] Cd Length: 195 Bit Score: 126.68 E-value: 2.28e-33
|
||||||||
WWE | pfam02825 | WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
346-401 | 1.48e-04 | ||||
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems. Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 40.36 E-value: 1.48e-04
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
TCCD_inducible_PARP_like | cd01439 | Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to ... |
529-648 | 5.91e-62 | ||||
Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) causes pleotropic effects in mammalian species through modulating gene expression. TCCD indicible PARP (TiPARP) is a target of TCDD that may contribute to multiple responses to TCDD by modulating protein function through poly ADP-ribosylation Pssm-ID: 238719 [Multi-domain] Cd Length: 121 Bit Score: 201.78 E-value: 5.91e-62
|
||||||||
PARP | pfam00644 | Poly(ADP-ribose) polymerase catalytic domain; Poly(ADP-ribose) polymerase catalyzes the ... |
474-648 | 2.28e-33 | ||||
Poly(ADP-ribose) polymerase catalytic domain; Poly(ADP-ribose) polymerase catalyzes the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active. Pssm-ID: 395519 [Multi-domain] Cd Length: 195 Bit Score: 126.68 E-value: 2.28e-33
|
||||||||
ADP_ribosyl | cd01341 | ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. ... |
529-644 | 1.79e-22 | ||||
ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. Poly(ADP-ribose) polymerases (PARPS 1-3, VPARP, tankyrase) catalyze the addition of up to 100 ADP_ribose units from NAD+. PARPs 1 and 2 are localized in the nucleaus, bind DNA, and are activated by DNA damage. VPARP is part of the vault ribonucleoprotein complex. Tankyrases regulates telomere length in part through poy(ADP_ribosylation) of telomere repeat binding factor 1 (TRF1). Poly(ADP-ribose) polymerase catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active. Pssm-ID: 238651 [Multi-domain] Cd Length: 137 Bit Score: 93.78 E-value: 1.79e-22
|
||||||||
tankyrase_like | cd01438 | Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 ... |
489-649 | 4.33e-07 | ||||
Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin repeats that mediate protein-protein interaction (binding TRF1 and insulin-responsive aminopeptidase) and may function as a complex. Overexpression of Tank1 promotes increased telomere length when overexpressed, while overexpressed Tank2 has been shown to promote PARP cleavage- independent cell death (necrosis). Pssm-ID: 238718 [Multi-domain] Cd Length: 223 Bit Score: 51.44 E-value: 4.33e-07
|
||||||||
WWE | pfam02825 | WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ... |
346-401 | 1.48e-04 | ||||
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems. Pssm-ID: 460715 [Multi-domain] Cd Length: 66 Bit Score: 40.36 E-value: 1.48e-04
|
||||||||
parp_like | cd01437 | Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ... |
466-595 | 2.43e-04 | ||||
Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component induced by DNA damage. The carboxyl-terminal region is the most highly conserved region of the protein. Experiments have shown that a carboxyl 40 kDa fragment is still catalytically active. Poly(ADP-ribose)-like polymerases (PARPS 1-3, VPARP, tankyrase) catalyze the addition of up to 100 ADP_ribose units from NAD+. PARPs 1 and 2 are localized in the nucleaus, bind DNA, and are activated by DNA damage. VPARP is part of the vault ribonucleoprotein complex. Tankyrases regulates telomere length through interactions with telomere repeat binding factor 1. Pssm-ID: 238717 [Multi-domain] Cd Length: 347 Bit Score: 43.80 E-value: 2.43e-04
|
||||||||
Blast search parameters | ||||
|