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Conserved domains on  [gi|298676433|ref|NP_001177325|]
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st3Gal-III protein [Xenopus laevis]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 141-347 1.40e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467709  Cd Length: 207  Bit Score: 457.85  E-value: 1.40e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 141 NCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQD 220
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 221 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 300
Cdd:cd23981   81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 298676433 301 EVAVAGFGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKEFLKKL 347
Cdd:cd23981  161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 141-347 1.40e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 457.85  E-value: 1.40e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 141 NCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQD 220
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 221 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 300
Cdd:cd23981   81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 298676433 301 EVAVAGFGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKEFLKKL 347
Cdd:cd23981  161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 101-352 1.12e-83

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 254.45  E-value: 1.12e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  101 KWAKIREYVPPFgiKGQDNLIKAILAATKeyrlkpaLDSLNCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGF 180
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  181 EKDVGSKTTLRITYPEGAIQKL-------EQYEKDSIFVLAGFKWQDFKWLKYIVYKEKVSAS---DGFWKSVatRVPRE 250
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSKygnlgfsHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  251 PHEIRILNPYFIQEAAFSFIGLPFNNglmgrGNIPTLGSVAITMALHNCDEVAVAGFGYDMNLPNAPLHYYETIKMAAIK 330
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 298676433  331 ESWTHNIQKEKEFLKKLVKARV 352
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 141-347 1.40e-164

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 457.85  E-value: 1.40e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 141 NCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQD 220
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 221 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 300
Cdd:cd23981   81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 298676433 301 EVAVAGFGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKEFLKKL 347
Cdd:cd23981  161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 142-347 7.49e-121

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 346.97  E-value: 7.49e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQDF 221
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 222 KWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNglMGRGNIPTLGSVAITMALHNCDE 301
Cdd:cd23967   82 LWLQAVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCDE 159

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 298676433 302 VAVAGFGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKEFLKKL 347
Cdd:cd23967  160 VDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 142-347 2.70e-85

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 256.97  E-value: 2.70e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQDF 221
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 222 KWLKYIVYKEKVSASDG--FWKSVATRVPREPHEIRILNPYFIQEAAFSFIGL--PFNNGLMGRGNIPTLGSVAITMALH 297
Cdd:cd23983   82 AWLKAMVKKEPLSFWSRlfFWKEVADSIPLKPSQFRILNPLIIKETALDILQYpePQSRLWGWDKNVPTLGVTAVVLATH 161

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 298676433 298 NCDEVAVAGFGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKEFLKKL 347
Cdd:cd23983  162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 101-352 1.12e-83

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 254.45  E-value: 1.12e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  101 KWAKIREYVPPFgiKGQDNLIKAILAATKeyrlkpaLDSLNCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGF 180
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  181 EKDVGSKTTLRITYPEGAIQKL-------EQYEKDSIFVLAGFKWQDFKWLKYIVYKEKVSAS---DGFWKSVatRVPRE 250
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSKygnlgfsHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  251 PHEIRILNPYFIQEAAFSFIGLPFNNglmgrGNIPTLGSVAITMALHNCDEVAVAGFGYDMNLPNAPLHYYETIKMAAIK 330
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 298676433  331 ESWTHNIQKEKEFLKKLVKARV 352
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 142-347 1.09e-76

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 235.03  E-value: 1.09e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQDF 221
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 222 KWLKYIVYKEKVSASdGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDE 301
Cdd:cd23984   82 RWLLDLLMGKKVSAK-GFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 298676433 302 VAVAGFGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKEFLKKL 347
Cdd:cd23984  161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 142-347 3.72e-72

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 223.39  E-value: 3.72e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGA-IQKLEQYEKDSIFVLAGFKWQD 220
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAqFDPGIENDPDTLLVLVPFKPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 221 FKWLKYIVYKEKVSAsDGFWKsvatRVPRE----PHEIRILNPYFIQEAAFSFIGLPfnnGLMGRGNIPTLGSVAITMAL 296
Cdd:cd23982   82 FYWLYEILSNEKRVR-KGFWK----QPPRIwdanPKQIRILNPYYTYVAATKLLQVP---GQRKKKQKPTTGLLAITLAL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 298676433 297 HNCDEVAVAGFGY-DMNLPNAPLHYYETIKMAAIKESwTHNIQKEKEFLKKL 347
Cdd:cd23982  154 HLCDEVHIAGFGYpDNGNSNQPIHYYNQITLKSMANS-GHNLNAEAQAIQRL 204
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 145-347 3.03e-46

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 155.98  E-value: 3.03e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 145 CIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLE---------QYEKDSIFVLAG 215
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRgprcgchplPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 216 FKWQDFKWLKYIVYKEKVSASdgFWKSVAtrvprepheirilnPYFIQEAAFSFIGLpfNNGLMGRGNIPTLGSVAITMA 295
Cdd:cd19952   81 AAAADFKRLKRRKKRHDNAVL--LLTDPA--------------PDLLSYVRKRLEKL--GLKSFFGGNAPSSGLLAVLLA 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 298676433 296 LHNCDEVAVAGFGYDMNL-PNAPLHYYETIKMAAikESWTHNIQKEKEFLKKL 347
Cdd:cd19952  143 LQLCDSVDLYGFGVDSGHaPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 92-354 3.85e-41

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 145.86  E-value: 3.85e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  92 PMFLDDS---FRKWAKIREYVPPFGIKGQDNLIKAILAATKEYRLKPALDSLN-----CRRCIIVGNGGVLANKSLGSKI 163
Cdd:cd23964   24 KVLLDSEdfnPEEYNRLSHYKLPFGWGGLNREVVERLLRNLNLTSSRYMFVLRggrprCIRCAVVGNGGILNGSGKGKEI 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 164 DEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQY---EKDSIFVLAGFKWQDFKWLKYIVYKEKVSASDGFW 240
Cdd:cd23964  104 DAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKHvpqDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKG 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 241 KSV-ATRVPR-EPHEIRILNPYFIQEAAFSFIglpfNNGLMGRgniPTLGSVAITMALHNCDEVAVAGFGYDmnlPNAPL 318
Cdd:cd23964  184 KRPpPLFGPKlNATNVRLLHPDFIRYLFNRWL----NSSTSYR---PTTGALMLLTALHTCDQVSVYGFGYD---PRFSL 253

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 298676433 319 HYYETIKMAAIKESWTHNIQKEKEFLKKLVKARVIN 354
Cdd:cd23964  254 HYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 142-353 8.00e-38

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 136.64  E-value: 8.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIqkleQYEKDSIFVLAGFKWQDF 221
Cdd:cd23966   77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAV----DLDPGVHLVLVPFKVLDL 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 222 KWLKyivykekvSA-SDGFWKSVATRVPR----EPHEIRILNPYFIQEAAFSFIGlpfnnglmGRGNIPTLGSVAITMAL 296
Cdd:cd23966  153 QWLI--------SAlTTGEITRTYTPVKRfikaDKDKVLVINPAFIKYVHDNWTE--------HHGRYPSTGFLALIFAL 216

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 298676433 297 HNCDEVAVAGFGYDmNLPNAPlHYYETiKMAAIKESWT--HNIQKEKEFLKKLVKARVI 353
Cdd:cd23966  217 HICDEVSVFGFGAD-SKGNWH-HYWEK-NRSAGAFRKTgvHDADFESDIIKKLAKEGKI 272
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 139-310 5.75e-27

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 107.66  E-value: 5.75e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 139 SLNCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEgAIQKLEQyekDSIFVLAGFKW 218
Cdd:cd23980   78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE-SFRELAQ---NVSMILVPFKT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 219 QDFKWLKYIVYKEKVSASdgfWKSVATRVPREPHEIRILNPyfiqeaafSFIGLPFNNGLMGRGNIPTLGSVAITMALHN 298
Cdd:cd23980  154 LDLEWVISATTTGTISHT---YVPVPRKIKVKKEKILIYHP--------AFIKYVFDRWLQGHGRYPSTGILSVIFSLHV 222

                        170
                 ....*....|..
gi 298676433 299 CDEVAVAGFGYD 310
Cdd:cd23980  223 CDEVDLYGFGAD 234
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 138-353 9.26e-25

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 101.87  E-value: 9.26e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 138 DSLNCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAiqklEQYEKDSIFVLAGFK 217
Cdd:cd23979   76 DPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA----KNLPANVSFVLVPFK 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 218 WQDFKWLKYIVYKEKVSASDGFWKSVaTRVPREphEIRILNPYFiqeaaFSFIglpFNNGLMGRGNIPTLGSVAITMALH 297
Cdd:cd23979  152 TLDLLWITSALSTGQIRFTYAPVKQF-LRVDKD--KVQIYNPAF-----FKYI---HDRWTEHHGRYPSTGMLVLFFALH 220

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 298676433 298 NCDEVAVAGFGYDmNLPNAPlHYYETIKMAA-IKESWTHNIQKEKEFLKKLVKARVI 353
Cdd:cd23979  221 VCDEVNVYGFGAD-SRGNWH-HYWENNRYAGeFRKTGVHDADFEAHIIDMLAKAGKI 275
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 93-354 3.95e-23

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 97.90  E-value: 3.95e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433  93 MFLDD---SFRKWAKIREYVPPFGIKGQD-NLIKAI---LAATKEYRLKPALDSLN--CRRCIIVGNGGVLANKSLGSKI 163
Cdd:cd23973   25 LFLDKdhfNMSEWDRLEHFNPPFGFMGLNyTLVKEVvelIPKPKEQQLLALSPPGGdgCIRCAVVGNGGILNGSKMGQEI 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 164 DEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQY----------EKDSIFVLAGFKWQDFKWLKYIVYKEKV 233
Cdd:cd23973  105 DSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILqkrgfknipqDKDIKYILFPEGPRDYQWLEALLKNKTI 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 234 saSDGFWKSvatRVPRE-------PHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDEVAVAG 306
Cdd:cd23973  185 --PSGAYYG---RRPRSyfsgdftEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSAYG 259

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 298676433 307 F---GYDmnlpNAPLHYYETiKMAAIKESWTHNIQKEKEFLKKLVKARVIN 354
Cdd:cd23973  260 FiteDYR----KYPDHYYDK-KKTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 143-347 4.51e-22

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 93.87  E-value: 4.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRI------TYPEGAIQKLEQYEKDSIFV---- 212
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLinsqilSKPEFNFLTDPLYRNVTLLVwdps 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 213 ------LAGFKWQDFKWL-KYIVYKEkvsasdgfwksvatRVPREPheIRILNPYF-------IQEaafsfiglpfNNGL 278
Cdd:cd23968  126 synvnlEKWYKKPDFDFFpNYIKYRR--------------RHPEEP--FYLIDPRFlwrlwdiLQE----------YTPE 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 298676433 279 MGRGNIPTLGSVAITMALHNCDEVAVAGFgydmnLPNAPL----HYYET-IKMAAIKESWtHNIQKEKEFLKKL 347
Cdd:cd23968  180 KIKPNPPSSGFIGIVLMLHLCDWVDVYEY-----VPSVRQtdrcHYYDVeKDLACTLGAW-HPLAAEKLLVRHL 247
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 102-353 1.98e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 90.27  E-value: 1.98e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 102 WAKIREYVPPFGIKGqdnLIKAILAATkeyrLKPALDSLN------------CRRCIIVGNGGVLANKSLGSKIDEYEVV 169
Cdd:cd23972   37 WDRLSQRKVPYGWKG---LSHQVVAST----LSLLNDSANaklffprdtpgkCIRCAVVGNGGILNGSRQGRAIDAHDYV 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 170 VRLNSAPVKGFEKDVGSKTTLR-----------ITYPEGAIQKLEQyEKDSIFVLAGFKWQDFKWLKYIVYKEKV-SASD 237
Cdd:cd23972  110 FRLNGAVIKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPQ-GQDLQYIFIPSDIRDYVMLRSAILGVPVpEGLD 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 238 GFWKSVATRVPR-EPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCDEVAVAGFGYDmNLPNA 316
Cdd:cd23972  189 KGDRPHKYFGPEaSAKKFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGFITS-NYWKF 267

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 298676433 317 PLHYYETIKMAAIKESwTHNIQKEKEFLKKLVKARVI 353
Cdd:cd23972  268 SDHYYERKKKPLVFYA-NHDMLLEAALWRRLHKAGIL 303
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 143-354 4.92e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 88.47  E-value: 4.92e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKT--------TLRITY--------PEGAIQKLEQYe 206
Cdd:cd23963   64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRRYnslkknrdRDKFLNRLKEY- 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 207 KDSIFVLAGFKWQdfkwlkyiVYKEKVsasdgfwKSVATRVPREPHEIRIL--NPYFIqEAAFSFiglpfnNGLMGRGNI 284
Cdd:cd23963  143 NGSILWYPKFSFK--------SSTNLL-------LKAARALKKNGLNLTVVysNPEHF-LAVQKF------WKRRGLEKR 200

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 298676433 285 PTLGSVAITMALHNCDEVAVAGF---GYDMNLPNAPLHYYEtiKMAAIKESWTHNIQKEKEFLKKLVKARVIN 354
Cdd:cd23963  201 PSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYD--DLSPSTKNKVHNMPEEFKLLRELHKKGVLK 271
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 142-323 1.76e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 85.76  E-value: 1.76e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRI----TYPEGAIQKLEQYEKDS---IFVLa 214
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVvshsSLPRLLRNAILLLAGTRaptVVVF- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 215 gfkwqdfkWLKYIVYKEKVSASDGFWKSVATRVPRepheiriLNPYFIQEAAFSFIGLPFNN--GL--MGRGNIPTLGSV 290
Cdd:cd23965   80 --------WGPETKMNKDGAGKYNLLRSLSKKYPD-------VEFYSLTPEKMDYADELFEKetGKsrIKSGTWLSTGWF 144

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 298676433 291 AITMALHNCDEVAVAGF---GYDMNLPN--APLHYYET 323
Cdd:cd23965  145 TMLLALDVCDEIKVYGMvpeNYCREHPNskVPYHYYEP 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 141-353 5.10e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 77.49  E-value: 5.10e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 141 NCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIFVLAGFKWQD 220
Cdd:cd23974   83 PCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSKETR 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 221 FKWL-----KYIVYKEKVS---------ASDGFWKSVATRVPREphEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPT 286
Cdd:cd23974  163 YIFLpdhdrDYLLVKAALThtpidrgrdKSKRPSKYFGKDVTAE--KFKIYHPDFIRYLRNRFLWSPILNTKQRDIYRPS 240

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 287 LGSVAITMALHNCDEVAVAGFgydMNlPNAPL---HYYETIKMAAIKESwTHNIQKEKEFLKKLVKARVI 353
Cdd:cd23974  241 TGAVMLLAALHTCDQVSAYGF---MT-PDYGKysdHYYDKTYHKVVFYA-NHDLRLEMQLWQKLHKAGLI 305
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 143-347 2.12e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 75.53  E-value: 2.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYP----------------EGAIQKLEQYE 206
Cdd:cd23969   65 RTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPsviphaygdlvnatdkEKFVERLRQLG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 207 kDSIFVLAGF--KW--QDFKWLKYIVYKEKVSAS------------DGFWKSVATRVPRepheirilnpyfiqeaafsfi 270
Cdd:cd23969  145 -DSILWIPAFvsKGgeEHVQWTNEIILKHKLNVKtaypplrlnhaiRGYWLTTKFRIKR--------------------- 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 271 glpfnnglmgrgniPTLGSVAITMALHNCDEVAVAG---FGYDMNLPNAPLHYYETIKMAAikESWTHNIQKEKEFLKKL 347
Cdd:cd23969  203 --------------PSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLT--TARPHKMPEEFRALRSL 266
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 143-349 3.45e-15

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 74.87  E-value: 3.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRI------TYPEGAIQKLEQYeKDSIFVL--- 213
Cdd:cd23986   50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIinsqilTNPNHHFIDSSLY-KDVILVAwdp 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 214 AGFKWQDFKWLK---------YIVYKEkvsasdgfwksvatRVPREPheIRILNPYF-------IQEaafsfiglpfNNG 277
Cdd:cd23986  129 APYSANLHKWYKkpdynlftpYVQYRK--------------RNPNQP--FYILHPKFiwqlwdiIQE----------NTQ 182

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 298676433 278 LMGRGNIPTLGSVAITMALHNCDEVAVagFGYDMNLPNAPL-HYYETIKMAAIKESWTHNIQKEKEFLKKLVK 349
Cdd:cd23986  183 EKIQPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLcHYHERYYDAACTLGAYHPLLYEKLLIQRMNK 253
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 143-347 3.76e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 74.36  E-value: 3.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQYEKDSIF---VL-----A 214
Cdd:cd23985   46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQLVTTEKHKFLKDSLYnegILivwdpA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 215 GFKWQDFKWLKYIVYK--EKvsasdgfWKSVATRVPREPheIRILNPYF-------IQEAAFSFIGL-PFNNGLMGrgni 284
Cdd:cd23985  126 PYHSDIPEWYKNPDYNffEN-------YKTYRRLNPNQP--FYILHPQMqwelwdiIQENSPEEIQPnPPSSGMLG---- 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 298676433 285 ptlgsVAITMALhnCDEVAVAGFgydmnLPNAP----LHYYETIKMAAIKESWTHNIQKEKEFLKKL 347
Cdd:cd23985  193 -----IILMMTL--CDQVDVYEF-----LPSKRktdvCHYYQKFFDRACTMGAYHPLLYEKNLVKHL 247
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 142-322 6.44e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 72.97  E-value: 6.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKLEQY------EKDSIFVLAG 215
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQgyffqqSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 216 FKWQDFKWLKYIVYKEKVsasdgfwkSVATRVPRepheiriLNPYFIQEAAFSFIGLPFNN----GLMGRGNIPTLGSVA 291
Cdd:cd23977   81 PERNMDRDGGGKTYRALL--------TLAKMYPH-------LQVYTLTEEKMAYCDGVFQNetgkNRMKSGSFLSTGWFT 145

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 298676433 292 ITMALHNCDEVAVAG-----FGYDMNLPNAPLHYYE 322
Cdd:cd23977  146 MILALELCEEILVYGmvsdsYCRNKNHSSVPYHYYE 181
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 131-347 3.54e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 71.89  E-value: 3.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 131 YRLKPALDSLNCRR---CIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRI--------------- 192
Cdd:cd23987   50 YELLPRTSPLKNKHfktCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTmnpsvvqrafedlvn 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 193 -TYPEGAIQKLEQYeKDSIFVLAGFKWQDFK----WLKYIVYKEKVsasdgfwkSVATRVP--REPHEIRilnPYFIQea 265
Cdd:cd23987  130 eTWKEKFLQRLQSL-NGSILWIPAFMAKGGEerveWVNDLILKHHI--------NVRTAYPslRLLHAVR---GYWLT-- 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 266 afsfiglpfNNGLMGRgniPTLGSVAITMALHNCDEVAVAG---FGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKEKE 342
Cdd:cd23987  196 ---------NKVHIKR---PTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263


                 ....*
gi 298676433 343 FLKKL 347
Cdd:cd23987  264 ALKNL 268
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 131-347 5.81e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 68.44  E-value: 5.81e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 131 YRLKPALDSLNCRR---CIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITYPE------GAIQK 201
Cdd:cd23988   50 HSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafGGFRN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 202 LEQYEK---------DSIFVLAGFK----WQDFKWLKYIVYKEKVsasdgfwkSVATRVP--REPHEIR---ILNPYFIQ 263
Cdd:cd23988  130 ESDREKfvhrlsmlnDSVLWIPAFMvkggEKHVEWVNALILKNKL--------KVRTAYPslRLIHAVRgywLTNKVNIK 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 264 EaafsfiglpfnnglmgrgniPTLGSVAITMALHNCDEVAVAG---FGYDMNLPNAPLHYYETIKMAAIKESWTHNIQKE 340
Cdd:cd23988  202 R--------------------PSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLE 261


                 ....*..
gi 298676433 341 KEFLKKL 347
Cdd:cd23988  262 FKTLNVL 268
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 143-201 1.36e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 67.42  E-value: 1.36e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLrITYPEGAIQK 201
Cdd:cd23970   69 NTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL-TTFNPSILEK 126
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 140-322 3.34e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 65.66  E-value: 3.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 140 LNCRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRITyPEGAIQKL--EQYE-----KDSIFV 212
Cdd:cd23976   13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRIlrNRNEllnvsQGTVFI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 213 L-----------AGFKWQDFKWLKYIVYKEKVsasdgfwkSVATRvprepHEIRILNPYFIQEAAFSfigLPFNNGLMgr 281
Cdd:cd23976   92 FwgpsnymrrdgKGLVYNNLQLMNQILPKLKV--------YTITR-----HKMLQFDELFKRETGKD---RKISNTWL-- 153

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 298676433 282 gnipTLGSVAITMALHNCDEVAVAG-----FGYDMNLPNAPLHYYE 322
Cdd:cd23976  154 ----STGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 142-192 9.33e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 64.11  E-value: 9.33e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRI 192
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 143-324 1.12e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 61.31  E-value: 1.12e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKG-FEKDVGSKTTLRITYPEGAIQKLEQYEK-------------D 208
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLVTANPSIISIKYAKLNErrkpfletvsvygD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 209 SIFVLAGFKW--------------QDFKW-LKYIVYKEKVSASDG-FWKSVATRVPRepheirilnpyfiqeaafsfigl 272
Cdd:cd23991  145 AFLLLPAFSYrsntalsfkvyytlEDFKAkQKVIFFHPIYLKHLAqFWRSKGVQVYR----------------------- 201

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 298676433 273 pFNNGLMgrgniptlgsvAITMALHNCDEVAVAGF-GYDMNLPNAPL--HYYETI 324
Cdd:cd23991  202 -LSTGLM-----------ITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDNQ 244
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 144-325 1.13e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 61.50  E-value: 1.13e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 144 RCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKgFEKDVGSKTTLRITYPEGAIQK--------------LEQYEkDS 209
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLVTANPSILREKfhnlkkrrrpfverMKVYG-NA 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 210 IFVLAGFKW--------------QDFKWLKYIVY--KEKVSASDGFWKSvatrvpREPHEIRIlnpyfiqeaafsfiglp 273
Cdd:cd23971  144 LLLLPAFSYtsntepslralytlEDFGSPQKVLFfnPEYLRNLSRYWKS------KGLKARRL----------------- 200

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 298676433 274 fNNGLMgrgniptLGSVAITMalhnCDEVAVAGF-GYDMNLPNAPL--HYYETIK 325
Cdd:cd23971  201 -STGLM-------LVSAALEL----CENVHLYGFwPFSTDLDGNPIshHYYDNVL 243
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 142-192 1.80e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 57.25  E-value: 1.80e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 298676433 142 CRRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPVKGFEKDVGSKTTLRI 192
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRV 51
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 143-324 2.17e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 57.53  E-value: 2.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPV-KGFEKDVGSKTTLrITYPEGAIQKLEQYE--KDSIFVlAGFKWQ 219
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQL-VTANPSIIDKRFQNLlwSRKSFV-ESMKVY 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 220 DFKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEaafsfIGLPFNNGLMGRGNIPTlGSVAITMALHNC 299
Cdd:cd23989  142 GRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRN-----VGKFWKSKGVHAKRLST-GLFLVSAALGLC 215

                        170       180
                 ....*....|....*....|....*...
gi 298676433 300 DEVAVAGF-GYDMNLPNAPL--HYYETI 324
Cdd:cd23989  216 EEVTIYGFwPFSVDLDERTIshHYYDNV 243
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 143-325 5.07e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 53.69  E-value: 5.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 143 RRCIIVGNGGVLANKSLGSKIDEYEVVVRLNSAPV-KGFEKDVGSKTTLRITYPE---GAIQKLEQYEKDSIFVLAgfkw 218
Cdd:cd23990   65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSiitERFHKLEKWRRPFYEVLQ---- 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 298676433 219 qdfkwlkyiVYKEKVSASDGFWKSVATRVprephEIRI---LNPYFIQEAAFSFIGLPFNN-----GLMG-RGNIPTLGS 289
Cdd:cd23990  141 ---------VYENASVVLPAFYNTRNTDV-----SIRVkyvLDDFESQQAVYYFHPQYLLNvsrfwLRQGvRAKRISSGL 206

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 298676433 290 VAITMALHNCDEVAVAGF-GYDMNlPNAPL---HYYETIK 325
Cdd:cd23990  207 MLVTAALELCEEVHLYGFwAFPMN-PSGIFithHYYDNVK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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