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Conserved domains on  [gi|301069351|ref|NP_001180270|]
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radial spoke head protein 9 homolog isoform 2 [Homo sapiens]

Protein Classification

radial spoke head family protein( domain architecture ID 10758)

radial spoke head family proteins (RSPHs) are located in the radial spokes which are involved in the structure and function of cilia and flagella.

Gene Ontology:  GO:0035082

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Radial_spoke super family cl04698
Radial spokehead-like protein; This family includes the radial spoke head proteins RSP4 and ...
 17-106 3.94e-05

Radial spokehead-like protein; This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologs, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.


The actual alignment was detected with superfamily member pfam04712:

Pssm-ID: 461405 [Multi-domain]  Cd Length: 406  Bit Score: 44.95  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069351   17 GQGLSPDRRASLLTSLMLVKRDYRYDRVLFWGRILGLVADYYIAQG-LSED--QLAPRKTLYSLNC--TEWSLLPPATEE 91
Cdd:pfam04712 121 GVGLGREEIFRIFLALKQLVDSQPLATVRFWGKILGTEANYYIAEAeFKEEngTGANKKVYFVCNEpgEPWVRLPDVTPA 200

                          90
                  ....*....|....*
gi 301069351   92 MVAQSSVVKGRFMGD 106
Cdd:pfam04712 201 QIVVARQIKKFFTGD 215
 
Name Accession Description Interval E-value
Radial_spoke pfam04712
Radial spokehead-like protein; This family includes the radial spoke head proteins RSP4 and ...
 17-106 3.94e-05

Radial spokehead-like protein; This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologs, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.


Pssm-ID: 461405 [Multi-domain]  Cd Length: 406  Bit Score: 44.95  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069351   17 GQGLSPDRRASLLTSLMLVKRDYRYDRVLFWGRILGLVADYYIAQG-LSED--QLAPRKTLYSLNC--TEWSLLPPATEE 91
Cdd:pfam04712 121 GVGLGREEIFRIFLALKQLVDSQPLATVRFWGKILGTEANYYIAEAeFKEEngTGANKKVYFVCNEpgEPWVRLPDVTPA 200

                          90
                  ....*....|....*
gi 301069351   92 MVAQSSVVKGRFMGD 106
Cdd:pfam04712 201 QIVVARQIKKFFTGD 215
 
Name Accession Description Interval E-value
Radial_spoke pfam04712
Radial spokehead-like protein; This family includes the radial spoke head proteins RSP4 and ...
 17-106 3.94e-05

Radial spokehead-like protein; This family includes the radial spoke head proteins RSP4 and RSP6 from Chlamydomonas reinhardtii, and several eukaryotic homologs, including mammalian RSHL1, the protein product of a familial ciliary dyskinesia candidate gene.


Pssm-ID: 461405 [Multi-domain]  Cd Length: 406  Bit Score: 44.95  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 301069351   17 GQGLSPDRRASLLTSLMLVKRDYRYDRVLFWGRILGLVADYYIAQG-LSED--QLAPRKTLYSLNC--TEWSLLPPATEE 91
Cdd:pfam04712 121 GVGLGREEIFRIFLALKQLVDSQPLATVRFWGKILGTEANYYIAEAeFKEEngTGANKKVYFVCNEpgEPWVRLPDVTPA 200

                          90
                  ....*....|....*
gi 301069351   92 MVAQSSVVKGRFMGD 106
Cdd:pfam04712 201 QIVVARQIKKFFTGD 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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