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early growth response protein 3 isoform 2 [Homo sapiens]
DUF3446 and COG5048 domain-containing protein( domain architecture ID 12112506)
DUF3446 and COG5048 domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
DUF3446 | pfam11928 | Early growth response N-terminal domain; Proteins containing this domain include early growth ... |
49-135 | 4.86e-10 | |||
Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096. : Pssm-ID: 463400 Cd Length: 104 Bit Score: 56.00 E-value: 4.86e-10
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COG5048 | COG5048 | FOG: Zn-finger [General function prediction only]; |
265-338 | 1.63e-06 | |||
FOG: Zn-finger [General function prediction only]; : Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 49.69 E-value: 1.63e-06
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COG5048 super family | cl34881 | FOG: Zn-finger [General function prediction only]; |
231-295 | 5.95e-04 | |||
FOG: Zn-finger [General function prediction only]; The actual alignment was detected with superfamily member COG5048: Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 41.61 E-value: 5.95e-04
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Name | Accession | Description | Interval | E-value | |||
DUF3446 | pfam11928 | Early growth response N-terminal domain; Proteins containing this domain include early growth ... |
49-135 | 4.86e-10 | |||
Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096. Pssm-ID: 463400 Cd Length: 104 Bit Score: 56.00 E-value: 4.86e-10
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COG5048 | COG5048 | FOG: Zn-finger [General function prediction only]; |
265-338 | 1.63e-06 | |||
FOG: Zn-finger [General function prediction only]; Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 49.69 E-value: 1.63e-06
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
281-306 | 2.23e-06 | |||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 43.51 E-value: 2.23e-06
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COG5048 | COG5048 | FOG: Zn-finger [General function prediction only]; |
231-295 | 5.95e-04 | |||
FOG: Zn-finger [General function prediction only]; Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 41.61 E-value: 5.95e-04
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zf-C2H2 | pfam00096 | Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ... |
237-261 | 2.05e-03 | |||
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter. Pssm-ID: 395048 [Multi-domain] Cd Length: 23 Bit Score: 34.97 E-value: 2.05e-03
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PHA00733 | PHA00733 | hypothetical protein |
266-313 | 7.20e-03 | |||
hypothetical protein Pssm-ID: 177301 Cd Length: 128 Bit Score: 36.39 E-value: 7.20e-03
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ZnF_C2H2 | smart00355 | zinc finger; |
267-289 | 9.12e-03 | |||
zinc finger; Pssm-ID: 197676 Cd Length: 23 Bit Score: 33.21 E-value: 9.12e-03
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Name | Accession | Description | Interval | E-value | |||
DUF3446 | pfam11928 | Early growth response N-terminal domain; Proteins containing this domain include early growth ... |
49-135 | 4.86e-10 | |||
Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096. Pssm-ID: 463400 Cd Length: 104 Bit Score: 56.00 E-value: 4.86e-10
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COG5048 | COG5048 | FOG: Zn-finger [General function prediction only]; |
265-338 | 1.63e-06 | |||
FOG: Zn-finger [General function prediction only]; Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 49.69 E-value: 1.63e-06
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
281-306 | 2.23e-06 | |||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 43.51 E-value: 2.23e-06
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SFP1 | COG5189 | Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
222-315 | 1.00e-05 | |||
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]; Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 47.02 E-value: 1.00e-05
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zf-H2C2_2 | pfam13465 | Zinc-finger double domain; |
253-278 | 1.10e-05 | |||
Zinc-finger double domain; Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 41.59 E-value: 1.10e-05
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zf-C2H2 | pfam00096 | Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ... |
267-289 | 3.17e-04 | |||
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter. Pssm-ID: 395048 [Multi-domain] Cd Length: 23 Bit Score: 37.28 E-value: 3.17e-04
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COG5048 | COG5048 | FOG: Zn-finger [General function prediction only]; |
231-295 | 5.95e-04 | |||
FOG: Zn-finger [General function prediction only]; Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 41.61 E-value: 5.95e-04
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COG5048 | COG5048 | FOG: Zn-finger [General function prediction only]; |
244-340 | 8.02e-04 | |||
FOG: Zn-finger [General function prediction only]; Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 41.22 E-value: 8.02e-04
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zf-C2H2_4 | pfam13894 | C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers. |
267-289 | 2.02e-03 | |||
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers. Pssm-ID: 464025 Cd Length: 24 Bit Score: 35.31 E-value: 2.02e-03
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zf-C2H2 | pfam00096 | Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ... |
237-261 | 2.05e-03 | |||
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter. Pssm-ID: 395048 [Multi-domain] Cd Length: 23 Bit Score: 34.97 E-value: 2.05e-03
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COG5236 | COG5236 | Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; |
239-318 | 2.06e-03 | |||
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Pssm-ID: 227561 [Multi-domain] Cd Length: 493 Bit Score: 40.00 E-value: 2.06e-03
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PHA00733 | PHA00733 | hypothetical protein |
266-313 | 7.20e-03 | |||
hypothetical protein Pssm-ID: 177301 Cd Length: 128 Bit Score: 36.39 E-value: 7.20e-03
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ZnF_C2H2 | smart00355 | zinc finger; |
267-289 | 9.12e-03 | |||
zinc finger; Pssm-ID: 197676 Cd Length: 23 Bit Score: 33.21 E-value: 9.12e-03
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Blast search parameters | ||||
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