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Conserved domains on  [gi|333440451|ref|NP_001193973|]
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CLIP-associating protein 2 isoform 2 [Homo sapiens]

Protein Classification

CLASP domain-containing protein( domain architecture ID 139677)

CLASP (CLIP-associated protein) domain-containing protein similar to Mus musculus CLIP-associating protein 2 and Arabidopsis thaliana protein MOR1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CLASP_N super family cl20455
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
93-305 4.00e-28

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


The actual alignment was detected with superfamily member pfam12348:

Pssm-ID: 432496  Cd Length: 227  Bit Score: 113.84  E-value: 4.00e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440451    93 NKIREILS--DDK---HDWDQRANALKKIRSLLVAGAAQ--YDCFFQHLR-LLDGALKlSAKDLRSQVVREACITVAHLS 164
Cdd:pfam12348    3 DKFRELLPafEGKeteLNWDAREKNITKLRSLIKGNAPEdfPPEFFEGLKsLLDGILK-AVLSLRTTLSSTGCHLLKELA 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440451   165 TVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRH-THVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEW 243
Cdd:pfam12348   82 IQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNaSYTPRILQHISAASQDKNVQPREYSAIWLKILLRRH 161
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 333440451   244 QTH--SLERHAAV--LVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQ 305
Cdd:pfam12348  162 GHHksHIEHSGGLrlIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLSTLDPNVRKALE 227
 
Name Accession Description Interval E-value
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
93-305 4.00e-28

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 113.84  E-value: 4.00e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440451    93 NKIREILS--DDK---HDWDQRANALKKIRSLLVAGAAQ--YDCFFQHLR-LLDGALKlSAKDLRSQVVREACITVAHLS 164
Cdd:pfam12348    3 DKFRELLPafEGKeteLNWDAREKNITKLRSLIKGNAPEdfPPEFFEGLKsLLDGILK-AVLSLRTTLSSTGCHLLKELA 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440451   165 TVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRH-THVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEW 243
Cdd:pfam12348   82 IQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNaSYTPRILQHISAASQDKNVQPREYSAIWLKILLRRH 161
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 333440451   244 QTH--SLERHAAV--LVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQ 305
Cdd:pfam12348  162 GHHksHIEHSGGLrlIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLSTLDPNVRKALE 227
 
Name Accession Description Interval E-value
CLASP_N pfam12348
CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). ...
93-305 4.00e-28

CLASP N terminal; This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1.


Pssm-ID: 432496  Cd Length: 227  Bit Score: 113.84  E-value: 4.00e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440451    93 NKIREILS--DDK---HDWDQRANALKKIRSLLVAGAAQ--YDCFFQHLR-LLDGALKlSAKDLRSQVVREACITVAHLS 164
Cdd:pfam12348    3 DKFRELLPafEGKeteLNWDAREKNITKLRSLIKGNAPEdfPPEFFEGLKsLLDGILK-AVLSLRTTLSSTGCHLLKELA 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 333440451   165 TVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRH-THVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEW 243
Cdd:pfam12348   82 IQLGHHIDPMAEILLPTLLKLCGDTKKITSQNANQAVAAILSNaSYTPRILQHISAASQDKNVQPREYSAIWLKILLRRH 161
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 333440451   244 QTH--SLERHAAV--LVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQ 305
Cdd:pfam12348  162 GHHksHIEHSGGLrlIEKSLKKGLEDANPGVRETARSTFWEFFKVWPSRAKSLLSTLDPNVRKALE 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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