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Conserved domains on  [gi|382545139|ref|NP_001244258|]
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beta-arrestin-2 isoform 4 [Homo sapiens]

Protein Classification

arrestin family protein( domain architecture ID 10432337)

arrestin family protein with both N-terminal and C-terminal Ig-like beta-sandwich domains found in arrestin (S antigen)

CATH:  2.60.40.840
PubMed:  7720881|7833798
SCOP:  4007521

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arrestin_N super family cl22903
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 19-175 9.61e-36

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


The actual alignment was detected with superfamily member pfam00339:

Pssm-ID: 451447  Cd Length: 148  Bit Score: 126.64  E-value: 9.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139   19 LTVYLGKRDFVDHLDkvDPVDGVVLVDPDYLKD-RKVFVTLTCAFRYGREDLDVL--GLSFRKDLFIATYQAFPPVPNPP 95
Cdd:pfam00339   1 FTIEFDKPDGVYFPG--ETVTGRVLLENEEPKKaRAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTETSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139   96 -RPPTRLQDRLLRklGQHAHPFFFTIPQNLPCSVtlqpgpedTGKACGVDFEIRAFCAKSleEKSHKR-NSVRLVIRKVQ 173
Cdd:pfam00339  79 wGSKTGGQNKLPA--GTHTFPFSFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP--WKFNKSfRRVFTVIPKLD 146


                  ..
gi 382545139  174 FA 175
Cdd:pfam00339 147 LN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 194-264 2.39e-15

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


:

Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 71.99  E-value: 2.39e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 382545139   194 SDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLfstaqYKCPVAQLEQDDQRE 264
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVS-----SDGPVKRSLAEKSKE 66
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 19-175 9.61e-36

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 126.64  E-value: 9.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139   19 LTVYLGKRDFVDHLDkvDPVDGVVLVDPDYLKD-RKVFVTLTCAFRYGREDLDVL--GLSFRKDLFIATYQAFPPVPNPP 95
Cdd:pfam00339   1 FTIEFDKPDGVYFPG--ETVTGRVLLENEEPKKaRAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTETSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139   96 -RPPTRLQDRLLRklGQHAHPFFFTIPQNLPCSVtlqpgpedTGKACGVDFEIRAFCAKSleEKSHKR-NSVRLVIRKVQ 173
Cdd:pfam00339  79 wGSKTGGQNKLPA--GTHTFPFSFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP--WKFNKSfRRVFTVIPKLD 146


                  ..
gi 382545139  174 FA 175
Cdd:pfam00339 147 LN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 194-264 2.39e-15

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 71.99  E-value: 2.39e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 382545139   194 SDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLfstaqYKCPVAQLEQDDQRE 264
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVS-----SDGPVKRSLAEKSKE 66
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 194-269 2.70e-12

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 63.11  E-value: 2.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139  194 SDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFS----TAQYKCPVAQLEQDDQREGGCQQ 269
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKTplgeSKREERVVAKEKNPGVAPGSKDK 80
 
Name Accession Description Interval E-value
Arrestin_N pfam00339
Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 19-175 9.61e-36

Arrestin (or S-antigen), N-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with C-terminal domain.


Pssm-ID: 425619  Cd Length: 148  Bit Score: 126.64  E-value: 9.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139   19 LTVYLGKRDFVDHLDkvDPVDGVVLVDPDYLKD-RKVFVTLTCAFRYGREDLDVL--GLSFRKDLFIATYQAFPPVPNPP 95
Cdd:pfam00339   1 FTIEFDKPDGVYFPG--ETVTGRVLLENEEPKKaRAVKIELRGKARTGWEESEVRkeGLTFRKDLYYKGTEVYLPTETSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139   96 -RPPTRLQDRLLRklGQHAHPFFFTIPQNLPCSVtlqpgpedTGKACGVDFEIRAFCAKSleEKSHKR-NSVRLVIRKVQ 173
Cdd:pfam00339  79 wGSKTGGQNKLPA--GTHTFPFSFTLPPNCPSSF--------EGKHGGIRYEVKVTLDRP--WKFNKSfRRVFTVIPKLD 146


                  ..
gi 382545139  174 FA 175
Cdd:pfam00339 147 LN 148
Arrestin_C smart01017
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 194-264 2.39e-15

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X). which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction.


Pssm-ID: 214976 [Multi-domain]  Cd Length: 142  Bit Score: 71.99  E-value: 2.39e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 382545139   194 SDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLfstaqYKCPVAQLEQDDQRE 264
Cdd:smart01017   1 WSGPLSLEVSLPKKGYVPGETIPVTIKITNLSKKTVKKIKVSLVQTVTYVS-----SDGPVKRSLAEKSKE 66
Arrestin_C pfam02752
Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports ...
 194-269 2.70e-12

Arrestin (or S-antigen), C-terminal domain; Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain.


Pssm-ID: 460676  Cd Length: 135  Bit Score: 63.11  E-value: 2.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 382545139  194 SDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFS----TAQYKCPVAQLEQDDQREGGCQQ 269
Cdd:pfam02752   1 WSGKVSYSVSLPKKGYVPGETIPVTIEIDNQSKKKIKKIKISLVQQLTYKAKTplgeSKREERVVAKEKNPGVAPGSKDK 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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