|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
42-452 |
0e+00 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 604.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 42 LAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHT------------------------ 97
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETgkkydwdaetqgwilgsffygyii 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 --IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTI 175
Cdd:cd17381 81 tqIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 176 SYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvp 255
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 256 wgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTI 335
Cdd:cd17381 208 -------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFSTV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 336 SVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGP 415
Cdd:cd17381 281 CVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGP 360
|
410 420 430
....*....|....*....|....*....|....*..
gi 451172071 416 IIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 452
Cdd:cd17381 361 VIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
43-452 |
6.61e-158 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 452.46 E-value: 6.61e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 43 AILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHT------------------IPGGYIA 104
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDTLPVEAPEFDWSEktqgiilssffygyiltqIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 105 SRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGT 184
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 185 VISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishyekeyivsslknqlssqkvvpwgsilksLP 264
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV----------------------------------------LP 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 265 LWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTISVRRIFSLV 344
Cdd:cd17318 201 VWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTSI 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 345 GMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPD 424
Cdd:cd17318 281 GFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVKN 360
|
410 420
....*....|....*....|....*....
gi 451172071 425 N-TIREWQTVFCIAAAINVFGAIFFTLFA 452
Cdd:cd17318 361 DqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
43-452 |
5.57e-109 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 327.76 E-value: 5.57e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 43 AILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAE-HSAPIKVHHNHT----------IPGGYIASRVGGKL 111
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEfNWTPETVGLIESsffwgylvtqIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 112 LLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLS 191
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 192 GIICYYMNWTYVFYLFGIVGIVWFILWMWIvsdtpethktishyekeyivsslknqlssqkvvpwgsilkSLPLWAIVVA 271
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLV----------------------------------------SMPVYAIIVA 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 272 HFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAV 351
Cdd:cd17382 201 NFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFGMEAT 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 352 FLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQ 431
Cdd:cd17382 281 FLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQ 359
|
410 420
....*....|....*....|.
gi 451172071 432 TVFCIAAAINVFGAIFFTLFA 452
Cdd:cd17382 360 YVFLIASLVHFFGVIFYAIFA 380
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-465 |
1.24e-103 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 317.07 E-value: 1.24e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 30 EAAPVCCSARYNLAILAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVH-------------HNH 96
Cdd:TIGR00894 8 TKLPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKNPNFkwsgalqglilssHFY 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 97 -----TIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSK 171
Cdd:TIGR00894 88 gqiiiQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 172 LLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQ-LS 249
Cdd:TIGR00894 168 LLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQkGS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 250 SQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVK 329
Cdd:TIGR00894 248 TRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSS 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 330 WNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATI 409
Cdd:TIGR00894 328 KTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFI 407
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 451172071 410 PGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHH 465
Cdd:TIGR00894 408 GGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
44-452 |
1.15e-87 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 272.12 E-value: 1.15e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 44 ILAFCGFFVLYALRVNLSVALVDMVDSNT-----------------TLTDnrtskecaehsapikvhhnhtIPGGYIASR 106
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGwsktdqglvlssffwgyALTQ---------------------VLGGYLADR 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 107 VGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVI 186
Cdd:cd17380 61 FGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLL 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 187 SLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSdtpethktishyekeyivsslknqlssqkvvpwgsilkslPLW 266
Cdd:cd17380 141 GGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP----------------------------------------PVW 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 267 AIVVAHFSYNWSFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwNFSTISVRRIFSLVGM 346
Cdd:cd17380 181 AIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISR-GWTVTSVRKLMQSIGF 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 347 VGPAVFLVAAGFIgCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTpdNT 426
Cdd:cd17380 259 LGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL--EA 335
|
410 420
....*....|....*....|....*.
gi 451172071 427 IREWQTVFCIAAAINVFGAIFFTLFA 452
Cdd:cd17380 336 TGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
39-446 |
1.99e-36 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 137.70 E-value: 1.99e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 39 RYNLAILAFCGFFVLYALRVNLSVALVDMVDS---NTTLTDNRTSkecaehsAPIKVHHNHTIPGGYIASRVGGKLLLGL 115
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDlglSPTQYGLIAS-------AFFLGYALFQVPGGWLLDRFGARKVLAV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 116 GILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC 195
Cdd:cd17319 74 SMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 196 YYMNWTYVFYLFGIVGIVWFILWMWIVSDtpethktishyekeyivsslknqlssqkvvpwgsilkslpLWAIVVAHFSY 275
Cdd:cd17319 152 LLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------------------------------------VWGLALGYFGI 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 276 NWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwnfstisVRRIFSLVGMVGPAVFLVA 355
Cdd:cd17319 192 NYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRG-------ARRLVIIIGLLLAAVGLLL 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 356 AGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAP-SYAGILLGITNTFATIPGMTGPIIAKSLTpdNTIREWQTVF 434
Cdd:cd17319 265 AYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAF 341
|
410
....*....|..
gi 451172071 435 CIAAAINVFGAI 446
Cdd:cd17319 342 LFLAAVALLAAL 353
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
98-448 |
5.99e-33 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 128.31 E-value: 5.99e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGvvTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 177
Cdd:cd06174 49 PLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW--LLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQ 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 178 AGAQLGTVISLPLSGIICYY--MNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKtishyekeyivSSLKNQLSSQKVVP 255
Cdd:cd06174 127 AFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESAR-----------AKNEEASSKSVLKL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 256 WGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfsti 335
Cdd:cd06174 196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI-------- 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 336 sVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGP 415
Cdd:cd06174 268 -GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGP 346
|
330 340 350
....*....|....*....|....*....|...
gi 451172071 416 IIAKSLTPDNTIreWQTVFCIAAAINVFGAIFF 448
Cdd:cd06174 347 LLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
98-453 |
1.25e-30 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 121.52 E-value: 1.25e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 177
Cdd:COG2271 63 IPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFN 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 178 AGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIlwmwivsdtpethktishyekeyivsslknqlssqkvvpwg 257
Cdd:COG2271 141 AGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL----------------------------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 258 silksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLrvkwnfstISV 337
Cdd:COG2271 180 -----LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL--------GRR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 338 RRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPII 417
Cdd:COG2271 247 RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLL 326
|
330 340 350
....*....|....*....|....*....|....*.
gi 451172071 418 AKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLFAK 453
Cdd:COG2271 327 VGYLL---DATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-415 |
2.05e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 106.73 E-value: 2.05e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAAdlGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 177
Cdd:pfam07690 50 PLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 178 AGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILwmWIVSDTPETHKTISHYEKEYIVSslknqlssqkVVPWG 257
Cdd:pfam07690 128 AGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKRPKPAEEARLSL----------IVAWK 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 258 SILKSLPLWAIVVAhFSYNWSFYTLLTLLPTYMkEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwnfstisV 337
Cdd:pfam07690 196 ALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR-------R 266
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 451172071 338 RRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGP 415
Cdd:pfam07690 267 RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
97-452 |
8.34e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 96.49 E-value: 8.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 97 TIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 176
Cdd:cd17325 48 SPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIF 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 177 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivsslKNQLSSQKVVPW 256
Cdd:cd17325 126 SSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK-------------RAVSAARLRSGL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 257 GSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstis 336
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG--------- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 337 vRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPI 416
Cdd:cd17325 264 -RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPL 342
|
330 340 350
....*....|....*....|....*....|....*.
gi 451172071 417 IAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLFA 452
Cdd:cd17325 343 LGGFLY---DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
98-451 |
2.03e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 95.72 E-value: 2.03e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 177
Cdd:COG2223 58 IPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWL--LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAA 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 178 AGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEthktishyekeyivssLKNQLSSQKVVPWG 257
Cdd:COG2223 136 GGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA----------------GAAAAAKASLRDQL 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 258 SILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYlrvkwnfstISV 337
Cdd:COG2223 200 EALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDR---------IGG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 338 RRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPII 417
Cdd:COG2223 271 RRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLL 350
|
330 340 350
....*....|....*....|....*....|....
gi 451172071 418 AKSLTpdNTIREWQTVFCIAAAINVFGAIFFTLF 451
Cdd:COG2223 351 FGALL--DATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
97-409 |
1.30e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 86.95 E-value: 1.30e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 97 TIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 176
Cdd:COG2814 62 APLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWL--LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 177 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV-WFILWMWIVSDTPETHKTISHyekeyivsslknqlssqkvvP 255
Cdd:COG2814 140 GAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARARLRG--------------------S 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 256 WGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfsti 335
Cdd:COG2814 200 LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG-------- 271
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 451172071 336 svRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATI 409
Cdd:COG2814 272 --RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
100-421 |
2.59e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 71.23 E-value: 2.59e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 100 GGYIASRVGGKLLLGLGILGTSVFTLFTPLAADlgVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAG 179
Cdd:TIGR00895 72 FGPLADRIGRRRVLLWSILLFSVFTLLCALATN--VTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCG 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 180 AQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWM--------WIVSDTPETHKTISHYEKEYIVSSLKNQLSSQ 251
Cdd:TIGR00895 150 YPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETVRRIVNAIAPQMQAEAQSALPEQ 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 252 KVVP--WGSILK----------SLPLWaivVAHFSYNWSFYTLLTLLPTYMKEiLRFNVQENGFLSALPYFGCWLCMILC 319
Cdd:TIGR00895 230 KSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPKLMVE-LGFSLSLAATGGALFNFGGVIGSIIF 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 320 GQAADYLRVKwnfstisVRRIFSLVGmvgpAVFLVAAGFigcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA--- 396
Cdd:TIGR00895 306 GWLADRLGPR-------VTALLLLLG----AVFAVLVGS---TLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPtai 371
|
330 340 350
....*....|....*....|....*....|
gi 451172071 397 -----GILLGITNTFATIpgmtGPIIAKSL 421
Cdd:TIGR00895 372 ratgvGWAIGIGRLGAII----GPILAGYL 397
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
98-417 |
2.05e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 68.56 E-value: 2.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 IPGGYIASRVGGKLLLGLGILGTSVFTLFtpLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 177
Cdd:TIGR00881 48 FVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWN 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 178 AGAQLGTVISLPLSGI-ICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIS-----HYEKEYIVSSLKNQLSSQ 251
Cdd:TIGR00881 126 CSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeempNEEPDGDAEKKEEELTKK 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 252 KVVPWgSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLrvkwn 331
Cdd:TIGR00881 206 QIFLQ-YVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKL----- 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 332 fstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF----SINHLDIAPSYA-GILLGITNTF 406
Cdd:TIGR00881 280 -----FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIASELAPKKAaGTAAGFVGFF 354
|
330
....*....|.
gi 451172071 407 ATIPGMTGPII 417
Cdd:TIGR00881 355 AYLGGILAGLP 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
138-420 |
1.38e-11 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 66.12 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 138 LVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVislpLSGII---CYYM-------NWTYVFYLF 207
Cdd:cd17327 97 LIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSI----FGGLLaygVFKIlgvgglaGWRWLFIIE 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 208 GIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLK-NQ--LSSQKVVP--WGSILKSLPLWAIVVAHFSYNWSFYTL 282
Cdd:cd17327 173 GLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRaNQtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGI 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 283 LTLLPTYMKEILRFNVQENGFLSALPYFGCwLCMILCGQAADYLRVKWNFSTisvrrIFSLVGMVGPAVflvaagFIGCD 362
Cdd:cd17327 253 SNFLPLILKSLGFYSLQTNLLSVPIGALGA-VSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII------LLAAP 320
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 451172071 363 YSLAVAFLTISTTLGGFASSGFSINHL-DIAPSYAG--ILLGITNTFATIPGMTGPIIAKS 420
Cdd:cd17327 321 NPPGAYFAAYILGGGSYAGFPILLSWIsSNCAGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
137-402 |
6.61e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 60.66 E-value: 6.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 137 TLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYyMNWTYVFYLFGiVGIVWFI 216
Cdd:cd17473 90 ALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLI 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 217 LWMWIVSDTPETHKTISHYEKEyivsslknqlsSQKVVPWGSIlkslplWAIVVAHFSYNWSFYTLLTLLPTYMKEILRF 296
Cdd:cd17473 168 LVLLFLPEPARKSKSAASPGAA-----------TAAALPWKRV------LPIYFLAFLAMLLFYVIPIQLPFLLQERGGG 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 297 NVQENGFLSAlpyfgcwlcmilcgqaadylrvkwnfstisvrrIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTL 376
Cdd:cd17473 231 SAALIGLALA---------------------------------IASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
250 260
....*....|....*....|....*.
gi 451172071 377 GGFAssgfsinhldIAPSYAGILLGI 402
Cdd:cd17473 278 LLLA----------LASGLWVVLLGA 293
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
137-451 |
3.21e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 3.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 137 TLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFI 216
Cdd:cd17474 89 LLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFL 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 217 LWMWIVSDTPEThktishyekeyivsslKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRF 296
Cdd:cd17474 168 AILFLLPEPKEK----------------AKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGI 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 297 NVQENGFLSALPYFGcwlcmilcGQAADYLRVKWNFSTISVRRIFsLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTL 376
Cdd:cd17474 232 SPIIIGLLFAGWSVL--------LALGSLFVGRLLKKRFGARRIL-VIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLG 301
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 451172071 377 GGFASSGFSINHLDIAPSYA-GILLGITNTFATIPGMTGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLF 451
Cdd:cd17474 302 LGLNLPLLTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
121-449 |
8.40e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.17 E-value: 8.40e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 121 SVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNW 200
Cdd:cd17324 75 ILGNLLAALAPSFAL--LLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGW 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 201 TYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivsslknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFY 280
Cdd:cd17324 153 RAAFLAIAVLALLAALLLWRLLPSLPPKKPG-----------------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFF 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 281 TLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADylrvkwnfsTISVRRIFSLVGMVgpAVFLVAAGFIG 360
Cdd:cd17324 216 ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLAD---------RGGRRALLIALLLL--AAALLLLTLLG 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 361 CDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAkSLTPDNTirEWQTVFCIAAAI 440
Cdd:cd17324 285 PSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALG-GLVLDHG--GWAGVGWVGAAL 361
|
....*....
gi 451172071 441 NVFGAIFFT 449
Cdd:cd17324 362 LLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
168-451 |
1.13e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.22 E-value: 1.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 168 ERSKLLTISYAGAQLGTVISLPLSGIICYYM------NWTYVFYLFGIVGIVWFILWMWIVSDTPETHKtishyEKEYIV 241
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFFGTKERPVPEE-----EKVSLK 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 242 SSLKnqlssqkvvpwgSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQ 321
Cdd:COG2211 219 ESLK------------ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 322 AADYlrvkwnfstISVRRIFsLVGMVGPAVFLVAAGFIGcdySLAVAFLTISTTLGGFASSGFSINHL----DIAP---- 393
Cdd:COG2211 287 LAKR---------FGKKKAF-IIGLLLAALGLLLLFFLG---PGNLWLLLVLAALAGIGLGAILVLPWamlaDVVDydew 353
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 451172071 394 ----SYAGILLGITNTFATIPGMTGPII-----------AKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLF 451
Cdd:COG2211 354 ktgrRREGLYFGIFTFAIKLGQALAGALaglllalfgyvAGAAQSPSALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
98-448 |
2.08e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 53.07 E-value: 2.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISY 177
Cdd:cd17371 52 ILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ--LLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 178 AGAQLG----TVISLPLSGIICYYMNWTYVFYLfgivGIVWFILWMWIVSDTPEThktishyeKEYIVSSLKNQLSSQKV 253
Cdd:cd17371 130 SGWAVGwllaTLLAALLFPLLPPEIAWRVLFLL----GALPALLVLFIRRFVKEP--------PQWQAARAARRHFADRP 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 254 VPWG---SILKSLPLWAIVVAHFSYnWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKW 330
Cdd:cd17371 198 SLRElfsPPLLRTTLLASLLATGAL-GGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRN 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 331 NFstisvrRIFSLVGmvgpAVFLVAAGFIGCDYSLavaFLTISTTLGGFASSGFSINHLDIAPSYA----GILLGITNTF 406
Cdd:cd17371 277 NF------ALFALGS----AISILLYFFLPLSPTL---ILILGFPLGFFASGPFSGMGAYLTELFPtavrATAQGFCYNV 343
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 451172071 407 ATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFF 448
Cdd:cd17371 344 GRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
268-451 |
1.61e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.11 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 268 IVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMV 347
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 348 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTpdnTI 427
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SL 147
|
170 180
....*....|....*....|....
gi 451172071 428 REWQTVFCIAAAINVFGAIFFTLF 451
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
127-451 |
1.85e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 49.93 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 127 TPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM---NWTYV 203
Cdd:cd17345 87 FVPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGA 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 204 FYLFGIVGIVWFILWMWIVSDTPET------HKTISHYEKEYIVSSLKNQLSSQKVVpWGSILKSLPLWAIVVAHFSYNW 277
Cdd:cd17345 167 FIFPAIIAIIVAVIVLFLGKDTPESeglppiEEYKGDYPEEADGEEEEQELSAWEIF-VKYVLKNKLLWYIAIANVFVYL 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 278 SFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLrvkwnfstISVRRifSLVGMVgpAVFLVAAG 357
Cdd:cd17345 246 VRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL--------FKGRR--APTGII--FMILVIVA 313
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 358 FIGCDYSLAVAFLTISTTLGGFASSG----FSINHLDIAPSYA-GILLGITNTFATIPGMTGPIIAKSLTPDNTirEWQT 432
Cdd:cd17345 314 LIVYWLAPNVLVDLIALIALGFLIYGpvmlIGLQALELVPKKAaGTAAGLTGLFGYLGGSVLATALIGIIVDHF--GWNG 391
|
330
....*....|....*....
gi 451172071 433 VFcIAAAINVFGAIFFTLF 451
Cdd:cd17345 392 GF-IVLLASCILAIIFLAL 409
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
122-217 |
1.86e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.88 E-value: 1.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 122 VFTLFTPLAA---DLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM 198
Cdd:cd17503 70 LFTLGSLLCGlapNLAS--LIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNL 147
|
90
....*....|....*....
gi 451172071 199 NWTYVFYLFGIVGIVWFIL 217
Cdd:cd17503 148 SWRWIFYINLPIGILALLL 166
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
122-217 |
1.92e-06 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 49.42 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 122 VFTLFTPLAADL-GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNW 200
Cdd:COG0477 88 LFGLASLLCGLApSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGW 167
|
90
....*....|....*..
gi 451172071 201 TYVFYLFGIVGIVWFIL 217
Cdd:COG0477 168 RWIFLINAPLGLLALVL 184
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
134-458 |
2.11e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.87 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 134 GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPpLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV 213
Cdd:COG2807 105 SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALL 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 214 WFILWMWIVSDTPETHKtishyekeyivsslknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEi 293
Cdd:COG2807 184 ALLLWLPLLRRRPAAAA------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD- 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 294 LRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKWNFSTisvrrIFSLVGMVGPAVFLVAAGFigcdySLAVAFLTIS 373
Cdd:COG2807 245 AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL-----LLGLLGLAGLLGLLLAPGS-----LPWLWAVLLG 314
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 374 TTLGGFASSGFS-INHLDIAPSYAGILLGITNTFATIPGMTGPIIA---KSLTPDntireWQTVFCIAAAINVFGAIFFT 449
Cdd:COG2807 315 LGQGGLFPLALTlIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVgalHDATGS-----WTAALLLLAALAVLMLVAGL 389
|
....*....
gi 451172071 450 LFAKGEVQS 458
Cdd:COG2807 390 LAGRPYVED 398
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
126-417 |
3.06e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.15 E-value: 3.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 126 FTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFY 205
Cdd:cd17329 79 FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIG-PLLGGLLLLYSFRLLFL 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 206 LFGIVGIVWFILWMWIVSDTPETHktishyekeyivsslKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTL 285
Cdd:cd17329 158 AAAVLFLLAALVLLFLLPETRPKR---------------RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQLEST 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 286 LPTYMKEILRFNVQENGFLSALPyfgcwLCMILCGQaadYLRVKWnFSTISVRRIFsLVGMVGPAVFLVAAGFIGCDYSL 365
Cdd:cd17329 223 LPVYVVEILGLGESLLGLLLALN-----ALLIVLLQ---FPVARL-VERFRLRKIL-MIGILLFAIGFAVLAFANTLAVL 292
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 451172071 366 --AVAFLTISTTLGGFASSGFsINHLdIAPSYAGILLGITNTFATIPGMTGPII 417
Cdd:cd17329 293 ilAMIVLTLGEMLVFPAVQTL-VAAL-APPDKRGSYMGFYALAWGLGRAIGPLV 344
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
121-417 |
1.50e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 46.85 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 121 SVFTLFTPLAADL-----GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC 195
Cdd:cd17475 65 AVGLLLMGAAALLmalvgSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 196 YYMNWTYVFYLFGIVGIVWFIL-WMWIvsdtpethktishyeKEYIVSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFS 274
Cdd:cd17475 145 LHYGWRAAFVVAGLVSILAAVLfWLFY---------------REPPAASAATESASTLLRSLKEVLRNRDVWLIAIAGAL 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 275 YNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRVKwnfstisvRRIFSLVGMVGPAVfLV 354
Cdd:cd17475 210 LVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGG--------RRRPVLVITAAIAA-AA 280
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 451172071 355 AAGFIGCDYSLAVAFLTISTTLGGFASSGF-SINHLDIA----PSYAGILLGITNTFATIPGMTGPII 417
Cdd:cd17475 281 LLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesagPEQAGTALGLANTINFIGIAIGPPL 348
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
120-451 |
2.10e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 120 TSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMN 199
Cdd:cd06173 77 LAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 200 WTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekeyivSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSF 279
Cdd:cd06173 157 PGGAFAINALSFLLSALLLLFIRRPPPAA-------------PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 280 YT-LLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGF 358
Cdd:cd06173 224 GGaLTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR----------RGRLLLIGALLLGLALLVLGL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 359 IGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIRewqTVFCIAA 438
Cdd:cd06173 294 SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLS---AVFLLAG 370
|
330
....*....|...
gi 451172071 439 AINVFGAIFFTLF 451
Cdd:cd06173 371 ALLLLAALLLLLL 383
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
123-226 |
2.73e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.10 E-value: 2.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 123 FTLFTPLAA-DLGVVTLVVLRALEGLGEGVTFP-AMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNW 200
Cdd:cd17476 73 FAIWSLIAGfSPNFIFFIICRALQGLGPAFLLPnAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWW 152
|
90 100
....*....|....*....|....*..
gi 451172071 201 TYVFYLFGIVGIVWFIL-WMWIVSDTP 226
Cdd:cd17476 153 PWIFWFLAILAAIVAVAaIFWTSPSFI 179
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
121-217 |
6.59e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 44.88 E-value: 6.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 121 SVFTLFTPLAADlgVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNW 200
Cdd:cd17365 75 GLFTLLTAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGW 152
|
90
....*....|....*..
gi 451172071 201 TYVFYLFGIVGIVWFIL 217
Cdd:cd17365 153 RSVFLLGGVPPLILLPL 169
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
138-451 |
7.37e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 44.96 E-value: 7.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 138 LVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL 217
Cdd:cd17312 94 FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAII 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 218 WMWIVSDTPEThktishyekeyivsslknqlssqkvvpwgsilkslpLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFN 297
Cdd:cd17312 174 LFFFLRDSPPY------------------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYS 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 298 VQENGFLSALPYFGCWLCMILCGQAADYLrvkWNFSTISVRRIFSLVGMVGPAVFLVAAGFIgcdYSLAVAFLTISTTLG 377
Cdd:cd17312 218 LIDAGWFSSLYEVGGIAGTILAGLLSDKL---FGGRRAPIAVIYMLLMTLSLALFWFFPHNK---LLSIVLLFLIGFFVG 291
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 451172071 378 GFASSGFSINHLDIAPSYA-GILLGITNTFATIPGMTGPIIAKSLTPDNTireWQTVFCIAAAINVFGAIFFTLF 451
Cdd:cd17312 292 GPINLIGGAAAQDIGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYG---WSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
121-372 |
8.71e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 44.53 E-value: 8.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 121 SVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMN 199
Cdd:cd17328 75 SAATLLSSFAPNFWQ--LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAqATGG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 200 WTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNqlssqkvvpWGSILKSLPLWAIVVAHFSYNWSF 279
Cdd:cd17328 153 WRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD---------LKALAKNPSFILSTLGFTAVSFVT 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 280 YTLLTLLPTYMKEILRFNVQENGFLSAlpYFGCWLCM------ILCGQAADYLRVKwnfsTISVRRIFSLVGMVGPAVFL 353
Cdd:cd17328 224 GALAFWAPTFFLRAFGVGDLSSADVGL--IFGAITCIagvlgvLLGGILADRLRRK----TPRADPLVCAVGLLAAAPFL 297
|
250
....*....|....*....
gi 451172071 354 VAAgFIGCDYSLAVAFLTI 372
Cdd:cd17328 298 FLA-LVLALSNLLLAWVLL 315
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
122-226 |
9.38e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 44.57 E-value: 9.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 122 VFTLFTPLAADLGvvTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWT 201
Cdd:PRK11551 92 LFSLATAQAWDFP--SLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWR 169
|
90 100
....*....|....*....|....*
gi 451172071 202 YVFYLFGIVGIVWFILWMWIVSDTP 226
Cdd:PRK11551 170 HIFYVGGVGPLLLVPLLMRWLPESR 194
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
134-447 |
1.25e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.09 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 134 GVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIV 213
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 214 WFILwmwivsdtpethktishyekeyivsslknqlssqkvvpwgsilkSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEI 293
Cdd:cd17321 163 ALLL--------------------------------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGV 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 294 LRFNVQENGFLSaLPYFgcwLCMILCGQAADYLRVKWNFstisvrRIFSLVGMVGPAVFLVAAGFIGCDYS---LAVAFL 370
Cdd:cd17321 199 LGYSPLQAGLAL-LPLA---LAMLVAAPLAGRLADRFGP------RLVLVAGLLLTAVGLLLLALLGADSSvwlLLPGLV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 371 TISTTLGGFASSGFSINHLDIAPSYAGILLGITNT--------------------FATIPGMTGPIIAKSLTPDNTIREW 430
Cdd:cd17321 269 LLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTarqlggalgvallgalltagLSANLGDSGVAALLSAAAAAFAAGF 348
|
330
....*....|....*..
gi 451172071 431 QTVFCIAAAINVFGAIF 447
Cdd:cd17321 349 HLAFLVAAALALLAALL 365
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
120-417 |
2.55e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 42.97 E-value: 2.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 120 TSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM- 198
Cdd:cd17316 76 FGLATLLIGLLPTPIL--LLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLs 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 199 ---NWTYVFYLFGIVGIVWFILWMWIvsdtpethktishyekeyivsslknqlssqkvvpwgsilkslplWAIVVAHFSY 275
Cdd:cd17316 154 gdwGWRILFLIGALPALLALLLRRRT--------------------------------------------LLLILLWFFI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 276 NWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMVGPAVFLVA 355
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALP 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 451172071 356 AGFIGCDYSLAVAFLTIstTLGGFASSGFSINHLDIAPSYA----GILLGITNTFATIPGMTGPII 417
Cdd:cd17316 260 LFYLLSGSPTLLLLLLF--ILSFFVGGVWGALYAYLAELFPtevrATGVGLSYNLGRLGGGGAPPL 323
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
265-452 |
4.61e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.16 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 265 LWAIVVAHFSYNWSFYTLLTLLPTYMKEiLRFNVQENGFLSALPYFGCWLCMILCGQAADylrvKWNfstisvRRIFSLV 344
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAPPLQAD-LGLSAAQLGLLASAFFLGYALGQIPAGLLAD----RFG------RRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 345 GMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPD 424
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180
....*....|....*....|....*...
gi 451172071 425 NTireWQTVFCIAAAINVFGAIFFTLFA 452
Cdd:COG2271 161 FG---WRAAFLILGLPGLLLALLRFWLL 185
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
137-448 |
5.15e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 5.15e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 137 TLVVLRALEGLGeGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVIS----LPLSGIICY---YMNWTYVFYLFGI 209
Cdd:cd17341 90 GLLVLGFLLGFA-GANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllaPLIAGAIVFdggFVGWRNAFFVPGI 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 210 VGIVWFILwMWIVSDTPETHKtishyekEYIVSSLKNQLSsqkvvpwgsILKSLPLWAIVVAHFSYNWSFYTLLTLLPTY 289
Cdd:cd17341 169 LLAIAAVL-VLLFGDDLPTGK-------ASALEFLKVQLA---------VLKNYRTWILSLLYGVTFGSFVGFSNVLPTY 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 290 MKEILRFNVQENGFLSALPYFGCWLCMILCGQAADylrvKWNFStisVRRIFSLVGMVGPAVFLVAAGFIgcDYSLAVAF 369
Cdd:cd17341 232 FKTRFGLPLVTAGILAALFPLAGALARPAGGWLSD----RFGGR---RRLWWLFIVMTIGAALLSLSLPT--SGTNLVLF 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 370 LTISTTLGGFASSGF-SINHL--DIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAI 446
Cdd:cd17341 303 LALFVALGLGAGAGNgSVFRMvpFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLV 382
|
..
gi 451172071 447 FF 448
Cdd:cd17341 383 WL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
101-419 |
7.28e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 7.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 101 GYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVlrALEGLGEGVTFPAMHAMWSSWAPPlERSKLLTISYAGA 180
Cdd:cd17478 52 GYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV--ALAGIGSAAFHPEGARLASQAAGG-RRGLAMSIFSVGG 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 181 QLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIshyekeyivsslKNQLSSQKVVPWGSIL 260
Cdd:cd17478 129 NLGFALG-PLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKK------------AAAKSSARSTLKGVWR 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 261 KSLPLWAIVvahFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALpYFGCWLCMILCGQAADYlrvkwnfstISVRRI 340
Cdd:cd17478 196 ALLLLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF-LFAGAIGTLIGGPLSDR---------FGRRRV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 341 FsLVGMVGPAVFLVAAGFIGCDYSLAVAFLTisttlGGFASSGFSINHL---DIAPSYAGILLGITNTFA-TIPGMTGPI 416
Cdd:cd17478 263 I-IASLLLAAPFLLLFLLTPGIWSYILLVLA-----GFLLFASFPVTVVlaqELLPGNVGLASGLMMGLSfGLGGIGAPV 336
|
...
gi 451172071 417 IAK 419
Cdd:cd17478 337 LGA 339
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
261-451 |
1.46e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 261 KSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEiLRFNVQENGFLSALPYFGCWLCMILCGQAADylrvkwnfsTISVRRI 340
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLAD---------RFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 341 FsLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKS 420
Cdd:COG2814 78 L-LLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
170 180 190
....*....|....*....|....*....|.
gi 451172071 421 LTpdnTIREWQTVFCIAAAINVFGAIFFTLF 451
Cdd:COG2814 157 LA---DLFGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
268-451 |
1.55e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 40.87 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 268 IVVAHFSYNWSFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMV 347
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFG-LSASQLGLLFALFSLGYALLQPLAGLLADRFG----------RRPVLLLGLL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 348 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAkSLTPDNTI 427
Cdd:cd06174 70 LFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLG-GILASSLG 148
|
170 180
....*....|....*....|....
gi 451172071 428 REWQTVFCIAAAINVFGAIFFTLF 451
Cdd:cd06174 149 FGWRAVFLIAAALALLAAILLLLV 172
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
97-227 |
2.65e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.85 E-value: 2.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 97 TIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTIS 176
Cdd:COG2271 233 SLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLV 312
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 451172071 177 YAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPE 227
Cdd:COG2271 313 NTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
98-417 |
5.21e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.07 E-value: 5.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 98 IPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLGVvtLVVLRALEGLGEGVTFPAMHAMwSSWAPPLERSKLLTISY 177
Cdd:COG0738 61 LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPL--LLLALFLLGLGLGLLDVAANPY-VAALGPETAASRLNLLH 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 178 AGAQLGTVISlPLSGIICYYMN----WTYVFYLFGIVGIVWFILWMWivSDTPETHKTISHyekeyivsslknqlSSQKV 253
Cdd:COG0738 138 AFFSLGALLG-PLLGGLLILLGlslsWHLPYLILAVLLLLLALLFLR--SKLPEIEEEEEE--------------AAGSA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 254 VPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQEngflSALPYFGCWLCMILCGQAADYLRVKWNFS 333
Cdd:COG0738 201 ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEAT----AALGLSLFWGGMTIGRFLGGFLLKRFGPV 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 334 TisVRRIFSLVGMVGPAVFLVAAGFIgcdysLAVAFLTIsttLGGFASSGFS-INHL--DIAPSYAGILLGITNTFATIP 410
Cdd:COG0738 277 R--LLRLSALLAAVGLLLALLAPGPW-----LALIGLAL---VGLGLSLMFPtIFSLalDGLGKRTAAAVSAVLIMGIVG 346
|
....*..
gi 451172071 411 GMTGPII 417
Cdd:COG0738 347 GAIGPPL 353
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
129-222 |
7.73e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.34 E-value: 7.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 451172071 129 LAADLGVVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFG 208
Cdd:cd17489 274 LSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAA 353
|
90
....*....|....
gi 451172071 209 IVGIVWFILWMWIV 222
Cdd:cd17489 354 VVVLLALVLYIFLL 367
|
|
| |
