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Conserved domains on  [gi|525507110|ref|NP_001265875|]
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protein SEC13 homolog isoform 5 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-129 1.19e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREEngTWEKSHEHAGHDS 104
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPD--GYLLASGSEDGTIRVWDLR--TGECVQTLSGHTN 262

                         90       100
                 ....*....|....*....|....*
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAI 129
Cdd:cd00200  263 SVTSLAWSPD--GKRLASGSADGTI 285
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-129 1.19e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREEngTWEKSHEHAGHDS 104
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPD--GYLLASGSEDGTIRVWDLR--TGECVQTLSGHTN 262

                         90       100
                 ....*....|....*....|....*
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAI 129
Cdd:cd00200  263 SVTSLAWSPD--GKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
25-131 1.35e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 1.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDS 104
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                         90       100
                 ....*....|....*....|....*..
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:COG2319  248 SVRSVAFSPD--GRLLASGSADGTVRL 272
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-86 8.16e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 8.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 525507110    49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 11-90 2.98e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 525507110  84 IIWREEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
49-86 1.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 525507110   49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-129 1.19e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.23  E-value: 1.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREEngTWEKSHEHAGHDS 104
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPD--GYLLASGSEDGTIRVWDLR--TGECVQTLSGHTN 262

                         90       100
                 ....*....|....*....|....*
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAI 129
Cdd:cd00200  263 SVTSLAWSPD--GKRLASGSADGTI 285
WD40 COG2319
WD40 repeat [General function prediction only];
25-131 1.35e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 1.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDS 104
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                         90       100
                 ....*....|....*....|....*..
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:COG2319  248 SVRSVAFSPD--GRLLASGSADGTVRL 272
WD40 COG2319
WD40 repeat [General function prediction only];
25-131 3.19e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 3.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWReeNGTWEKSHEHAGHDS 104
Cdd:COG2319  216 GKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRLWD--LATGELLRTLTGHSG 289

                         90       100
                 ....*....|....*....|....*..
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:COG2319  290 GVNSVAFSPD--GKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
25-131 6.65e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 6.65e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                         90       100
                 ....*....|....*....|....*..
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:COG2319  206 AVRSVAFSPD--GKLLASGSADGTVRL 230
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-129 9.79e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 9.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 89
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 525507110  90 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAI 129
Cdd:cd00200   82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTI 117
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-129 4.10e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.99  E-value: 4.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIWreE 89
Cdd:cd00200  132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLW--D 205

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 525507110  90 NGTWEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAI 129
Cdd:cd00200  206 LSTGKCLGTLRGHENGVNSVAFSPDGY--LLASGSEDGTI 243
WD40 COG2319
WD40 repeat [General function prediction only];
25-131 7.10e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.26  E-value: 7.10e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPmYGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAF-SP-DGKTLASGSDDGTVRLWDLATG--ELLRTLTGHTG 373

                         90       100
                 ....*....|....*....|....*..
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:COG2319  374 AVTSVAFSPD--GRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-131 9.51e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 9.51e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110   7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIW 86
Cdd:cd00200   45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 525507110  87 REENGtwEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:cd00200  121 DVETG--KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKL 161
WD40 COG2319
WD40 repeat [General function prediction only];
10-131 3.79e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 3.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREE 89
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLA 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 525507110  90 NGtwEKSHEHAGHDSSVNSVCWAPhDyGLILACGSSDGAISL 131
Cdd:COG2319  151 TG--KLLRTLTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRL 188
WD40 COG2319
WD40 repeat [General function prediction only];
10-87 2.65e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 2.65e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 525507110  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWR 87
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-131 2.25e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 2.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  49 LIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDSSVNSV-CWAPHDYgliLACGSSDG 127
Cdd:cd00200    1 LRRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVaASADGTY---LASGSSDK 73


                 ....
gi 525507110 128 AISL 131
Cdd:cd00200   74 TIRL 77
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-87 3.84e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 3.84e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  28 LATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIWR 87
Cdd:cd00200  234 LASGSEDGTIRVWDLRTGE--CVQTLSGHTNSVTSLAW-SPD-GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-131 2.75e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEksHEHAGHDS 104
Cdd:COG2319   48 GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWDLATGLLL--RTLTGHTG 121

                         90       100
                 ....*....|....*....|....*..
gi 525507110 105 SVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:COG2319  122 AVRSVAFSPD--GKTLASGSADGTVRL 146
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-86 8.16e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 8.16e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 525507110    49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 11-90 2.98e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 525507110  84 IIWREEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
49-86 1.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 1.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 525507110   49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 9.10e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 9.10e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 525507110    92 TWEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
PTZ00420 PTZ00420
coronin; Provisional
 53-131 1.69e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.39  E-value: 1.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 525507110  53 LRGHEGPVWQVAWaHPMYGNILASCSYDRKVIIWR----EENGTWEKSHE--HAGHDSSVNSVCWAPHDYgLILACGSSD 126
Cdd:PTZ00420  70 LKGHTSSILDLQF-NPCFSEILASGSEDLTIRVWEiphnDESVKEIKDPQciLKGHKKKISIIDWNPMNY-YIMCSSGFD 147


                 ....*
gi 525507110 127 GAISL 131
Cdd:PTZ00420 148 SFVNI 152
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 10-41 7.97e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.05  E-value: 7.97e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 525507110    10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFD 41
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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