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Conserved domains on  [gi|545746355|ref|NP_001271135|]
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DDB1- and CUL4-associated factor 5 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
49-361 2.99e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 2.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWHMEQAihsrvKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILH 128
Cdd:COG2319  116 LTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATG-----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 129 DVES-ETLDVF-AHEDAVYGLSVSPvNDNIFASSSDDGRVLIWDIRESPhgEPFCLANYPSAFHSVMFNPvEPRLLATAN 206
Cdd:COG2319  190 DLATgKLLRTLtGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 207 SKEGVGLWDIRKPQsSLLRYGGNLSlqSAMSVRFNSNGTQLLA------LRrrlppvLYDIHSRLPVFQFdnQGYFNSCT 280
Cdd:COG2319  266 ADGTVRLWDLATGE-LLRTLTGHSG--GVNSVAFSPDGKLLASgsddgtVR------LWDLATGKLLRTL--TGHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 281 mkSCCFAGDrDQYILSGSDDFNLYMWripaDPEAGGIGRvvngafmVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 360
Cdd:COG2319  335 --SVAFSPD-GKTLASGSDDGTVRLW----DLATGELLR-------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                 .
gi 545746355 361 P 361
Cdd:COG2319  401 L 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
49-361 2.99e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 2.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWHMEQAihsrvKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILH 128
Cdd:COG2319  116 LTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATG-----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 129 DVES-ETLDVF-AHEDAVYGLSVSPvNDNIFASSSDDGRVLIWDIRESPhgEPFCLANYPSAFHSVMFNPvEPRLLATAN 206
Cdd:COG2319  190 DLATgKLLRTLtGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 207 SKEGVGLWDIRKPQsSLLRYGGNLSlqSAMSVRFNSNGTQLLA------LRrrlppvLYDIHSRLPVFQFdnQGYFNSCT 280
Cdd:COG2319  266 ADGTVRLWDLATGE-LLRTLTGHSG--GVNSVAFSPDGKLLASgsddgtVR------LWDLATGKLLRTL--TGHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 281 mkSCCFAGDrDQYILSGSDDFNLYMWripaDPEAGGIGRvvngafmVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 360
Cdd:COG2319  335 --SVAFSPD-GKTLASGSDDGTVRLW----DLATGELLR-------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                 .
gi 545746355 361 P 361
Cdd:COG2319  401 L 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-360 1.17e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 1.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWHMEQAIHSRvkpiQLKGeHHSNIFCLAFNSGNTKVFSGGNDEQVILH 128
Cdd:cd00200    5 LKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLR----TLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 129 DVESETL--DVFAHEDAVYGLSVSPvNDNIFASSSDDGRVLIWDIRESPhgepfCLANYPSAFHSVM---FNPvEPRLLA 203
Cdd:cd00200   79 DLETGECvrTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK-----CLTTLRGHTDWVNsvaFSP-DGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 204 TAnSKEG-VGLWDIRKPQSSLLRYGGNLSLQSamsVRFNSNGTQLLA------LRrrlppvLYDIHSRLPVFQFD-NQGY 275
Cdd:cd00200  152 SS-SQDGtIKLWDLRTGKCVATLTGHTGEVNS---VAFSPDGEKLLSsssdgtIK------LWDLSTGKCLGTLRgHENG 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 276 FNSCtmkscCFAGDRDqYILSGSDDFNLYMWRIpadpeagGIGRVVngafMVLKGHRSIVNQVRFNPHTYMICSSGVEKI 355
Cdd:cd00200  222 VNSV-----AFSPDGY-LLASGSEDGTIRVWDL-------RTGECV----QTLSGHTNSVTSLAWSPDGKRLASGSADGT 284


                 ....*
gi 545746355 356 IKIWS 360
Cdd:cd00200  285 IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-170 2.90e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.90e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 545746355   139 AHEDAVYGLSVSPvNDNIFASSSDDGRVLIWD 170
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 285-359 1.20e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 1.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545746355 285 CFAgdrdQYILSGSDDFNLYMWRIPADPEAGgigRVVNGAFMVLKGHRSIVNQVRFNPHTYMI-CSSGVEKIIKIW 359
Cdd:PTZ00420  85 CFS----EILASGSEDLTIRVWEIPHNDESV---KEIKDPQCILKGHKKKISIIDWNPMNYYImCSSGFDSFVNIW 153
WD40 pfam00400
WD domain, G-beta repeat;
49-81 1.55e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.55e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 545746355   49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLW 81
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
49-361 2.99e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 130.42  E-value: 2.99e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWHMEQAihsrvKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILH 128
Cdd:COG2319  116 LTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATG-----KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 129 DVES-ETLDVF-AHEDAVYGLSVSPvNDNIFASSSDDGRVLIWDIRESPhgEPFCLANYPSAFHSVMFNPvEPRLLATAN 206
Cdd:COG2319  190 DLATgKLLRTLtGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSP-DGRLLASGS 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 207 SKEGVGLWDIRKPQsSLLRYGGNLSlqSAMSVRFNSNGTQLLA------LRrrlppvLYDIHSRLPVFQFdnQGYFNSCT 280
Cdd:COG2319  266 ADGTVRLWDLATGE-LLRTLTGHSG--GVNSVAFSPDGKLLASgsddgtVR------LWDLATGKLLRTL--TGHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 281 mkSCCFAGDrDQYILSGSDDFNLYMWripaDPEAGGIGRvvngafmVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 360
Cdd:COG2319  335 --SVAFSPD-GKTLASGSDDGTVRLW----DLATGELLR-------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400


                 .
gi 545746355 361 P 361
Cdd:COG2319  401 L 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-360 1.17e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 1.17e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWHMEQAIHSRvkpiQLKGeHHSNIFCLAFNSGNTKVFSGGNDEQVILH 128
Cdd:cd00200    5 LKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLR----TLKG-HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 129 DVESETL--DVFAHEDAVYGLSVSPvNDNIFASSSDDGRVLIWDIRESPhgepfCLANYPSAFHSVM---FNPvEPRLLA 203
Cdd:cd00200   79 DLETGECvrTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK-----CLTTLRGHTDWVNsvaFSP-DGTFVA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 204 TAnSKEG-VGLWDIRKPQSSLLRYGGNLSLQSamsVRFNSNGTQLLA------LRrrlppvLYDIHSRLPVFQFD-NQGY 275
Cdd:cd00200  152 SS-SQDGtIKLWDLRTGKCVATLTGHTGEVNS---VAFSPDGEKLLSsssdgtIK------LWDLSTGKCLGTLRgHENG 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 276 FNSCtmkscCFAGDRDqYILSGSDDFNLYMWRIpadpeagGIGRVVngafMVLKGHRSIVNQVRFNPHTYMICSSGVEKI 355
Cdd:cd00200  222 VNSV-----AFSPDGY-LLASGSEDGTIRVWDL-------RTGECV----QTLSGHTNSVTSLAWSPDGKRLASGSADGT 284


                 ....*
gi 545746355 356 IKIWS 360
Cdd:cd00200  285 IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-361 3.83e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.17  E-value: 3.83e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355   3 RRAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGcRNLYKKDLLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWH 82
Cdd:COG2319   29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAA-AGALLATLLGHTAAVLSVAFSPDG-RLLASASADGTVRLWD 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  83 MEQAihsrvKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILHDVES-ETLDVF-AHEDAVYGLSVSPvNDNIFASS 160
Cdd:COG2319  107 LATG-----LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgKLLRTLtGHSGAVTSVAFSP-DGKLLASG 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 161 SDDGRVLIWDIREsphGEPFC-LANYPSAFHSVMFNPvEPRLLATANSKEGVGLWDIRKPQsSLLRYGGNLSlqSAMSVR 239
Cdd:COG2319  181 SDDGTVRLWDLAT---GKLLRtLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGK-LLRTLTGHSG--SVRSVA 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355 240 FNSNGTQLLA------LRrrlppvLYDIHSRLPVFQFDNQgyfnSCTMKSCCFAGDrDQYILSGSDDFNLYMWRIPAdpe 313
Cdd:COG2319  254 FSPDGRLLASgsadgtVR------LWDLATGELLRTLTGH----SGGVNSVAFSPD-GKLLASGSDDGTVRLWDLAT--- 319

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 545746355 314 aggiGRVVNGafmvLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWSP 361
Cdd:COG2319  320 ----GKLLRT----LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-170 1.69e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 1.69e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  46 KKDLLGHFGCVNAIEFSNNGGQwLVSGGDDRRVLLW--HMEQAIHsrvkpiQLKGeHHSNIFCLAFNSGNTKVFSGGNDE 123
Cdd:cd00200  170 VATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKLWdlSTGKCLG------TLRG-HENGVNSVAFSPDGYLLASGSEDG 241

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 545746355 124 QVILHDVESETLD--VFAHEDAVYGLSVSPvNDNIFASSSDDGRVLIWD 170
Cdd:cd00200  242 TIRVWDLRTGECVqtLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
49-132 3.17e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.92  E-value: 3.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWHMEQAihsrvKPIQLKGEHHSNIFCLAFNSGNTKVFSGGNDEQVILH 128
Cdd:COG2319  326 LTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATG-----ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                 ....
gi 545746355 129 DVES 132
Cdd:COG2319  400 DLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 139-170 2.90e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.90e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 545746355   139 AHEDAVYGLSVSPvNDNIFASSSDDGRVLIWD 170
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 285-359 1.20e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 45.71  E-value: 1.20e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545746355 285 CFAgdrdQYILSGSDDFNLYMWRIPADPEAGgigRVVNGAFMVLKGHRSIVNQVRFNPHTYMI-CSSGVEKIIKIW 359
Cdd:PTZ00420  85 CFS----EILASGSEDLTIRVWEIPHNDESV---KEIKDPQCILKGHKKKISIIDWNPMNYYImCSSGFDSFVNIW 153
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 326-360 1.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 1.48e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 545746355   326 MVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 360
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
49-81 1.55e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.55e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 545746355   49 LLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLW 81
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
139-170 2.21e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.21e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 545746355  139 AHEDAVYGLSVSPvNDNIFASSSDDGRVLIWD 170
Cdd:pfam00400   9 GHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 19-223 3.00e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.69  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  19 SQRGLHGDPLLTQ-----DFQRRRLRGcrNLYKKDLLGHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWHME------QAI 87
Cdd:PLN00181 446 SRQGGWIDPFLEGlckylSFSKLRVKA--DLKQGDLLNSSNLVCAIGFDRDG-EFFATAGVNKKIKIFECEsiikdgRDI 522

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  88 HSRVkpIQLKGEhhSNIFCLAFNSG-NTKVFSGGNDEQVILHDVESETL--DVFAHEDAVYGLSVSPVNDNIFASSSDDG 164
Cdd:PLN00181 523 HYPV--VELASR--SKLSGICWNSYiKSQVASSNFEGVVQVWDVARSQLvtEMKEHEKRVWSIDYSSADPTLLASGSDDG 598

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 545746355 165 RVLIWDIREsphGEPFCLANYPSAFHSVMFNPVEPRLLATANSKEGVGLWDIRKPQSSL 223
Cdd:PLN00181 599 SVKLWSINQ---GVSIGTIKTKANICCVQFPSESGRSLAFGSADHKVYYYDLRNPKLPL 654
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 51-82 8.88e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.88e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 545746355    51 GHFGCVNAIEFSNNGgQWLVSGGDDRRVLLWH 82
Cdd:smart00320  10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
326-360 1.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.34e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 545746355  326 MVLKGHRSIVNQVRFNPHTYMICSSGVEKIIKIWS 360
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 42-177 1.39e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746355  42 RNLYKKDLLGHFGCVNAIEFSNNGGQWLVSGGDDRRVLLWHMEQAIhsRVKPIQLKgehhSNIFCLAF--NSGNTKVFsG 119
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGV--SIGTIKTK----ANICCVQFpsESGRSLAF-G 636

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 545746355 120 GNDEQVILHDVESETL---DVFAHEDAVYglSVSPVNDNIFASSSDDGRVLIWDIRESPHG 177
Cdd:PLN00181 637 SADHKVYYYDLRNPKLplcTMIGHSKTVS--YVRFVDSSTLVSSSTDNTLKLWDLSMSISG 695
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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