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Conserved domains on  [gi|557440858|ref|NP_001273498|]
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DNA annealing helicase and endonuclease ZRANB3 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 557-595 8.01e-08

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


:

Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 8.01e-08
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 557440858 557 PGEGHFWQVDHIKPVYGGGgQCSLDNLQTLCTVCHKERT 595
Cdd:cd00085   20 PGGTEGLEVDHIIPLSDGG-NNDLDNLVLLCRKCHRKKH 57
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
171-193 3.28e-04

Zn-finger in Ran binding protein and others;


:

Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.10  E-value: 3.28e-04
                          10        20
                  ....*....|....*....|...
gi 557440858  171 WQCSLCTYINNSELPYCEMCETP 193
Cdd:pfam00641   5 WDCSKCLVQNFATSTKCVACQAP 27
 
Name Accession Description Interval E-value
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 557-595 8.01e-08

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 8.01e-08
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 557440858 557 PGEGHFWQVDHIKPVYGGGgQCSLDNLQTLCTVCHKERT 595
Cdd:cd00085   20 PGGTEGLEVDHIIPLSDGG-NNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 562-597 4.56e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 41.18  E-value: 4.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 557440858  562 FWQVDHIKPVYGGGGQcSLDNLQTLCTVCHKERTAR 597
Cdd:pfam01844  13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
557-592 4.79e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.51  E-value: 4.79e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 557440858 557 PGEGHFWQVDHIKPVYGGGGQcSLDNLQTLCTVCHK 592
Cdd:COG1403   28 PFSGDALEVDHIIPRSRGGTD-TWENLVLLCRRCNR 62
HNHc smart00507
HNH nucleases;
563-591 2.40e-04

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 39.36  E-value: 2.40e-04
                           10        20
                   ....*....|....*....|....*....
gi 557440858   563 WQVDHIKPvYGGGGQCSLDNLQTLCTVCH 591
Cdd:smart00507  24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
171-193 3.28e-04

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.10  E-value: 3.28e-04
                          10        20
                  ....*....|....*....|...
gi 557440858  171 WQCSLCTYINNSELPYCEMCETP 193
Cdd:pfam00641   5 WDCSKCLVQNFATSTKCVACQAP 27
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 171-193 3.56e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 35.37  E-value: 3.56e-03
                           10        20
                   ....*....|....*....|...
gi 557440858   171 WQCSLCTYINNSELPYCEMCETP 193
Cdd:smart00547   3 WECPACTFLNFASRSKCFACGAP 25
 
Name Accession Description Interval E-value
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 557-595 8.01e-08

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 49.01  E-value: 8.01e-08
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 557440858 557 PGEGHFWQVDHIKPVYGGGgQCSLDNLQTLCTVCHKERT 595
Cdd:cd00085   20 PGGTEGLEVDHIIPLSDGG-NNDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 562-597 4.56e-05

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 41.18  E-value: 4.56e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 557440858  562 FWQVDHIKPVYGGGGQcSLDNLQTLCTVCHKERTAR 597
Cdd:pfam01844  13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
557-592 4.79e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 41.51  E-value: 4.79e-05
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 557440858 557 PGEGHFWQVDHIKPVYGGGGQcSLDNLQTLCTVCHK 592
Cdd:COG1403   28 PFSGDALEVDHIIPRSRGGTD-TWENLVLLCRRCNR 62
HNHc smart00507
HNH nucleases;
563-591 2.40e-04

HNH nucleases;


Pssm-ID: 214702 [Multi-domain]  Cd Length: 52  Bit Score: 39.36  E-value: 2.40e-04
                           10        20
                   ....*....|....*....|....*....
gi 557440858   563 WQVDHIKPvYGGGGQCSLDNLQTLCTVCH 591
Cdd:smart00507  24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
171-193 3.28e-04

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 38.10  E-value: 3.28e-04
                          10        20
                  ....*....|....*....|...
gi 557440858  171 WQCSLCTYINNSELPYCEMCETP 193
Cdd:pfam00641   5 WDCSKCLVQNFATSTKCVACQAP 27
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 171-193 3.56e-03

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 35.37  E-value: 3.56e-03
                           10        20
                   ....*....|....*....|...
gi 557440858   171 WQCSLCTYINNSELPYCEMCETP 193
Cdd:smart00547   3 WECPACTFLNFASRSKCFACGAP 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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