NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|597517993|ref|NP_001277954|]
View 

phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 1 [Mus musculus]

Protein Classification

phosphatidylinositol N-acetylglucosaminyltransferase subunit Q/GPI1( domain architecture ID 10523437)

phosphatidylinositol N-acetylglucosaminyltransferase subunit Q/GPI1 is part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Gpi1 pfam05024
N-acetylglucosaminyl transferase component (Gpi1); Glycosylphosphatidylinositol (GPI) ...
 370-569 4.15e-96

N-acetylglucosaminyl transferase component (Gpi1); Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.


:

Pssm-ID: 461527  Cd Length: 273  Bit Score: 296.01  E-value: 4.15e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597517993  370 ELGERRVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIHLMSPFIEHILWHVGLSACLGLTVALSIFS 449
Cdd:pfam05024  72 KLLREYLVDLLKKLLEWLMGNPAGLKLNTELNSFLGDLFLWIIDLWSTFLFILTPFLPLLLRLLGFSGFLGASFALSLLS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597517993  450 DIIALLTFHIYCFYVYGARLYCLKIYGLSSLWRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILVFLLPTTALYYLV 529
Cdd:pfam05024 152 DLLSLLTLHIYCFYVISARLYRWQLQILGSLFRLFRGKKRNVLRNRVDSCDYDLDQLLLGTLLFTILLFLLPTVLVFYLV 231

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 597517993  530 FTLLRLLVITVQGLIHLLVDLINSLPLYSLGLRLCRPYRL 569
Cdd:pfam05024 232 FALLRLAIILVQALLETLLALLNHFPLFALLLRLKDPKRL 271
 
Name Accession Description Interval E-value
Gpi1 pfam05024
N-acetylglucosaminyl transferase component (Gpi1); Glycosylphosphatidylinositol (GPI) ...
 370-569 4.15e-96

N-acetylglucosaminyl transferase component (Gpi1); Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.


Pssm-ID: 461527  Cd Length: 273  Bit Score: 296.01  E-value: 4.15e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597517993  370 ELGERRVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIHLMSPFIEHILWHVGLSACLGLTVALSIFS 449
Cdd:pfam05024  72 KLLREYLVDLLKKLLEWLMGNPAGLKLNTELNSFLGDLFLWIIDLWSTFLFILTPFLPLLLRLLGFSGFLGASFALSLLS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597517993  450 DIIALLTFHIYCFYVYGARLYCLKIYGLSSLWRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILVFLLPTTALYYLV 529
Cdd:pfam05024 152 DLLSLLTLHIYCFYVISARLYRWQLQILGSLFRLFRGKKRNVLRNRVDSCDYDLDQLLLGTLLFTILLFLLPTVLVFYLV 231

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 597517993  530 FTLLRLLVITVQGLIHLLVDLINSLPLYSLGLRLCRPYRL 569
Cdd:pfam05024 232 FALLRLAIILVQALLETLLALLNHFPLFALLLRLKDPKRL 271
 
Name Accession Description Interval E-value
Gpi1 pfam05024
N-acetylglucosaminyl transferase component (Gpi1); Glycosylphosphatidylinositol (GPI) ...
 370-569 4.15e-96

N-acetylglucosaminyl transferase component (Gpi1); Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively.


Pssm-ID: 461527  Cd Length: 273  Bit Score: 296.01  E-value: 4.15e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597517993  370 ELGERRVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIHLMSPFIEHILWHVGLSACLGLTVALSIFS 449
Cdd:pfam05024  72 KLLREYLVDLLKKLLEWLMGNPAGLKLNTELNSFLGDLFLWIIDLWSTFLFILTPFLPLLLRLLGFSGFLGASFALSLLS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597517993  450 DIIALLTFHIYCFYVYGARLYCLKIYGLSSLWRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILVFLLPTTALYYLV 529
Cdd:pfam05024 152 DLLSLLTLHIYCFYVISARLYRWQLQILGSLFRLFRGKKRNVLRNRVDSCDYDLDQLLLGTLLFTILLFLLPTVLVFYLV 231

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 597517993  530 FTLLRLLVITVQGLIHLLVDLINSLPLYSLGLRLCRPYRL 569
Cdd:pfam05024 232 FALLRLAIILVQALLETLLALLNHFPLFALLLRLKDPKRL 271
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH