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Conserved domains on  [gi|612407849|ref|NP_001278423|]
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integrin alpha-8 isoform 2 preproprotein [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192641)

integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 469-919 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 561.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   469 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 547
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   548 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 625
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   626 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 701
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   702 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPP 781
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   782 QIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEF-LLYIFHIQTLGPLQCQPNPNINP 860
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   861 QDIkpaaspEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNI-ECLQISC 919
Cdd:pfam08441  396 LNL------TQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 368-422 1.77e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.86  E-value: 1.77e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407849    368 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 422
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 302-350 1.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 1.17e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 612407849    302 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 350
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 54-112 2.31e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.31e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612407849     54 GSYFGYAVDFHI---PDaRTASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191    2 GSYFGYSVAGVGdvnGD-GYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 433-477 2.75e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 612407849    433 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 477
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1020-1034 8.94e-04

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


:

Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.48  E-value: 8.94e-04
                           10
                   ....*....|....*
gi 612407849  1020 KCGFFDRARPPQEDM 1034
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 469-919 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 561.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   469 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 547
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   548 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 625
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   626 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 701
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   702 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPP 781
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   782 QIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEF-LLYIFHIQTLGPLQCQPNPNINP 860
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   861 QDIkpaaspEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNI-ECLQISC 919
Cdd:pfam08441  396 LNL------TQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 368-422 1.77e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.86  E-value: 1.77e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407849    368 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 422
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 302-350 1.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 1.17e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 612407849    302 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 350
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 371-407 1.63e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 48.28  E-value: 1.63e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 612407849   371 FGSAMAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 407
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 54-112 2.31e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.31e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612407849     54 GSYFGYAVDFHI---PDaRTASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191    2 GSYFGYSVAGVGdvnGD-GYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-348 6.11e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 46.73  E-value: 6.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 612407849   306 FGYTVVVSDVNSDGLDDVLVGAPLFmerefesNPREVGQIYLY 348
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 433-477 2.75e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 612407849    433 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 477
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1020-1034 8.94e-04

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.48  E-value: 8.94e-04
                           10
                   ....*....|....*
gi 612407849  1020 KCGFFDRARPPQEDM 1034
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 469-919 0e+00

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 561.56  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   469 RPVVTVDAQLLLHPMIINLENKTCQVPDSMTSaaCFSLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNH 547
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKNCTLTGTPVS--CFTVRACFSYTGKPIPNpSLVLNYELELDRQKKKGLPPRVLFLDSQ 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   548 QAHRVFPLVIKRQKSHQCQDFIVYLRDEteFRDKLSPINISLNYSL--DESTFKEGLEVKPILNYYRENIVSEQAHILVD 625
Cdd:pfam08441   79 QPSLTGTLVLLSQGRKVCRTTKAYLRDE--FRDKLSPIVISLNYSLrvDPRAPSDLPGLKPILDQNQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   626 CGEDNLCVPDLKLSARPD----KHQVIIGDENHLMLIINARNEGEGAYEAELFVMIPEEADYVGIeRNNKGFRPLSCEYK 701
Cdd:pfam08441  157 CGEDNVCVPDLQLSAKFDsresDEPLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGV-RREGSEKQLSCTAK 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   702 MENVTRMVVCDLGNPMVSGTNYSLGLRFAVPRLEKTNMSINFDLQIRSSNKDNPDSNFVSLQINITAVAQVEIRGVSHPP 781
Cdd:pfam08441  236 KENSTRQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNSNSNPVSLKVPVVAEAQLSLSGVSKPD 315

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   782 QIVLPIHNWEPEEEPHKEEEVGPLVEHIYELHNIGPSTISDTILEVGWPFSARDEF-LLYIFHIQTLGPLQCQPNPNINP 860
Cdd:pfam08441  316 QVVGGSVKGESAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKwLLYLLDVQGQGKGECSPQNEINP 395

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407849   861 QDIkpaaspEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKILNCTNI-ECLQISC 919
Cdd:pfam08441  396 LNL------TQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTASVLLSCDSGaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 368-422 1.77e-13

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 65.86  E-value: 1.77e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 612407849    368 FGRFGSAMAHLGDLNQDGYNDIAIGVPFAGKDQR-GKVLIYNGNKDGLNTKPSQVL 422
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGEtGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 302-350 1.17e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 55.07  E-value: 1.17e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 612407849    302 MASYFGYTVV-VSDVNSDGLDDVLVGAPlfmereFESNPREVGQIYLYLQ 350
Cdd:smart00191    1 PGSYFGYSVAgVGDVNGDGYPDLLVGAP------RANDAGETGAVYVYFG 44
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 371-407 1.63e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 48.28  E-value: 1.63e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 612407849   371 FGSAMAhLGDLNQDGYNDIAIGVPFAGKDQRGKVLIY 407
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 54-112 2.31e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 48.53  E-value: 2.31e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 612407849     54 GSYFGYAVDFHI---PDaRTASVLVGAPKANTSQpdivEGGAVYYCPWPAEGSaQCRQIPFD 112
Cdd:smart00191    2 GSYFGYSVAGVGdvnGD-GYPDLLVGAPRANDAG----ETGAVYVYFGSSGGG-NSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-348 6.11e-07

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 46.73  E-value: 6.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 612407849   306 FGYTVVVSDVNSDGLDDVLVGAPLFmerefesNPREVGQIYLY 348
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGE-------GGAGAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 433-477 2.75e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 42.75  E-value: 2.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 612407849    433 SGFGFTLRGDSDIDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQ 477
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSG 47
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 314-391 5.37e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 41.83  E-value: 5.37e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 612407849   314 DVNSDGLDDVLVGAPlfmerefesnprevGQIYLYLQVSSLLFRDPQILTGTETFGRFGsamAHLGDLNQDGYNDIAI 391
Cdd:pfam13517    1 DLDGDGKLDLVVAND--------------GGLRLYLNNGDGTFTFITSVSLGGGGGGLS---VAVGDLDGDGRLDLLV 61
Integrin_alpha pfam00357
Integrin alpha cytoplasmic region; This family contains the short intracellular region of ...
 1020-1034 8.94e-04

Integrin alpha cytoplasmic region; This family contains the short intracellular region of integrin alpha chains.


Pssm-ID: 459778  Cd Length: 15  Bit Score: 37.48  E-value: 8.94e-04
                           10
                   ....*....|....*
gi 612407849  1020 KCGFFDRARPPQEDM 1034
Cdd:pfam00357    1 KCGFFKRNYPPQEEE 15
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 380-455 1.27e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 37.98  E-value: 1.27e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 612407849   380 DLNQDGYNDIaigvpFAGKDQRGKVLIYNGNKDGLNTKPSQVLQGVWASHAVpsgFGftlrgdsDIDKNDYPDLIV 455
Cdd:pfam13517    1 DLDGDGKLDL-----VVANDGGLRLYLNNGDGTFTFITSVSLGGGGGGLSVA---VG-------DLDGDGRLDLLV 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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