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Conserved domains on  [gi|635372947|ref|NP_001278964|]
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TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform b [Homo sapiens]

Protein Classification

zinc finger Ran-binding domain-containing protein( domain architecture ID 18754769)

zinc finger Ran-binding domain-containing protein; similar to human zinc finger Ran-binding domain-containing protein 2 (ZRANB2) which is a splice factor required for alternative splicing of TRA2B/SFRS10 transcripts and whose zinc finger domains bind single-stranded RNA, and to the zinc finger domain of human TAK1-binding protein 2 (TAB2) which binds Lys 63-linked polyubiquitin chains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 635-658 7.67e-07

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


:

Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 45.77  E-value: 7.67e-07
                           10        20
                   ....*....|....*....|....
gi 635372947   635 QWNCTACTFLNHPALIRCEQCEMP 658
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
508-587 3.67e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


:

Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.43  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635372947 508 QKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLE-EMQQLRSCNRQLQIDIDCLTKEIDLFQA 586
Cdd:COG4372   71 ARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQkERQDLEQQRKQLEAQIAELQSEIAEREE 150


                 .
gi 635372947 587 R 587
Cdd:COG4372  151 E 151
 
Name Accession Description Interval E-value
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 635-658 7.67e-07

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 45.77  E-value: 7.67e-07
                           10        20
                   ....*....|....*....|....
gi 635372947   635 QWNCTACTFLNHPALIRCEQCEMP 658
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
508-587 3.67e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.43  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635372947 508 QKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLE-EMQQLRSCNRQLQIDIDCLTKEIDLFQA 586
Cdd:COG4372   71 ARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQkERQDLEQQRKQLEAQIAELQSEIAEREE 150


                 .
gi 635372947 587 R 587
Cdd:COG4372  151 E 151
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 505-582 2.90e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.24  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635372947  505 LVHQKARMERLQRELEIQKK----KLDKLKSEVNEMENNLTRRRLKRS-NSISQipSLEEMQQ----LRSCNRQLQIDID 575
Cdd:TIGR04523 515 LTKKISSLKEKIEKLESEKKekesKISDLEDELNKDDFELKKENLEKEiDEKNK--EIEELKQtqksLKKKQEEKQELID 592


                  ....*..
gi 635372947  576 CLTKEID 582
Cdd:TIGR04523 593 QKEKEKK 599
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
635-659 9.52e-04

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 36.95  E-value: 9.52e-04
                          10        20
                  ....*....|....*....|....*
gi 635372947  635 QWNCTACTFLNHPALIRCEQCEMPR 659
Cdd:pfam00641   4 DWDCSKCLVQNFATSTKCVACQAPK 28
HR1_ROCK2 cd11638
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated ...
 502-570 1.38e-03

Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2; ROCK2 is a serine/threonine protein kinase and was the first identified target of activated RhoA. It plays a role in stress fiber and focal adhesion formation, and is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK2 contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a Rho-binding HR1 domain and a pleckstrin homology (PH) domain. ROCK2 is auto-inhibited by HR1 and PH domains interacting with the catalytic domain. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family.


Pssm-ID: 212028 [Multi-domain]  Cd Length: 67  Bit Score: 37.60  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 635372947 502 QALLVHQKARMERlQRELEIQKKKLdkLKSEVNEMENNLtrRRLKRSNSISQIpSLEEMQQLRscnRQL 570
Cdd:cd11638    1 KALLQHKNTEYQR-KAEHEADRKRN--LENEVNSLKDQL--EDLKKKNQNSQI-SNEKNIQLQ---RQL 60
 
Name Accession Description Interval E-value
ZnF_RBZ smart00547
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ...
 635-658 7.67e-07

Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.


Pssm-ID: 197784 [Multi-domain]  Cd Length: 25  Bit Score: 45.77  E-value: 7.67e-07
                           10        20
                   ....*....|....*....|....
gi 635372947   635 QWNCTACTFLNHPALIRCEQCEMP 658
Cdd:smart00547   2 DWECPACTFLNFASRSKCFACGAP 25
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
508-587 3.67e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 46.43  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635372947 508 QKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLE-EMQQLRSCNRQLQIDIDCLTKEIDLFQA 586
Cdd:COG4372   71 ARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQkERQDLEQQRKQLEAQIAELQSEIAEREE 150


                 .
gi 635372947 587 R 587
Cdd:COG4372  151 E 151
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 505-582 2.90e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 44.24  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635372947  505 LVHQKARMERLQRELEIQKK----KLDKLKSEVNEMENNLTRRRLKRS-NSISQipSLEEMQQ----LRSCNRQLQIDID 575
Cdd:TIGR04523 515 LTKKISSLKEKIEKLESEKKekesKISDLEDELNKDDFELKKENLEKEiDEKNK--EIEELKQtqksLKKKQEEKQELID 592


                  ....*..
gi 635372947  576 CLTKEID 582
Cdd:TIGR04523 593 QKEKEKK 599
zf-RanBP pfam00641
Zn-finger in Ran binding protein and others;
635-659 9.52e-04

Zn-finger in Ran binding protein and others;


Pssm-ID: 395516 [Multi-domain]  Cd Length: 30  Bit Score: 36.95  E-value: 9.52e-04
                          10        20
                  ....*....|....*....|....*
gi 635372947  635 QWNCTACTFLNHPALIRCEQCEMPR 659
Cdd:pfam00641   4 DWDCSKCLVQNFATSTKCVACQAPK 28
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
491-548 9.64e-04

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 441447 [Multi-domain]  Cd Length: 217  Bit Score: 40.96  E-value: 9.64e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 635372947 491 LSMGSDDAAyTQAL--LVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRS 548
Cdd:COG1842   78 LEKGREDLA-REALerKAELEAQAEALEAQLAQLEEQVEKLKEALRQLESKLEELKAKKD 136
HR1_ROCK2 cd11638
Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated ...
 502-570 1.38e-03

Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 2; ROCK2 is a serine/threonine protein kinase and was the first identified target of activated RhoA. It plays a role in stress fiber and focal adhesion formation, and is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK2 contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a Rho-binding HR1 domain and a pleckstrin homology (PH) domain. ROCK2 is auto-inhibited by HR1 and PH domains interacting with the catalytic domain. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family.


Pssm-ID: 212028 [Multi-domain]  Cd Length: 67  Bit Score: 37.60  E-value: 1.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 635372947 502 QALLVHQKARMERlQRELEIQKKKLdkLKSEVNEMENNLtrRRLKRSNSISQIpSLEEMQQLRscnRQL 570
Cdd:cd11638    1 KALLQHKNTEYQR-KAEHEADRKRN--LENEVNSLKDQL--EDLKKKNQNSQI-SNEKNIQLQ---RQL 60
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 484-589 6.54e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.36  E-value: 6.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 635372947 484 RISETRKLSMGSDDAAYTQALLVHQKARMERLQRELEIQKKKLDKLKSEVNEMENNLTRRRLKRSnsisqipslEEMQQL 563
Cdd:COG4942  148 RREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELA---------AELAEL 218

                         90       100
                 ....*....|....*....|....*.
gi 635372947 564 RSCNRQLQIDIDCLTKEIDLFQARGP 589
Cdd:COG4942  219 QQEAEELEALIARLEAEAAAAAERTP 244
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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