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Conserved domains on  [gi|751247070|ref|NP_001291396|]
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EEF1A lysine methyltransferase 2 isoform 2 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Methyltransf_31 super family cl48233
Methyltransferase domain; This family appears to have methyltransferase activity.
 25-141 7.42e-12

Methyltransferase domain; This family appears to have methyltransferase activity.


The actual alignment was detected with superfamily member pfam13847:

Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.89  E-value: 7.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070   25 SNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGTFDAISlNPDNAIEKrkqyvksLSRV 102
Cdd:pfam13847  29 AEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCVLNHIP-DPDKVLQE-------ILRV 100

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 751247070  103 LKVKGFFLITSCNWtKEELLNEFSEGWSTVAGFWLTAAL 141
Cdd:pfam13847 101 LKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCVGGAIL 138
 
Name Accession Description Interval E-value
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 25-141 7.42e-12

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.89  E-value: 7.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070   25 SNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGTFDAISlNPDNAIEKrkqyvksLSRV 102
Cdd:pfam13847  29 AEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCVLNHIP-DPDKVLQE-------ILRV 100

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 751247070  103 LKVKGFFLITSCNWtKEELLNEFSEGWSTVAGFWLTAAL 141
Cdd:pfam13847 101 LKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCVGGAIL 138
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 15-113 1.89e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 55.31  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070  15 WLNLLAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTqlsgfhicIDKGTFDAISLNpdNAI----- 89
Cdd:COG0500   40 NLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP--------LPAESFDLVVAF--GVLhhlpp 109

                         90       100
                 ....*....|....*....|....
gi 751247070  90 EKRKQYVKSLSRVLKVKGFFLITS 113
Cdd:COG0500  110 EEREALLRELARALKPGGVLLLSA 133
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 15-112 1.04e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.80  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070  15 WLNLLAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLstqlsgfhICIDKGTFDAISLNP--DNAIEKR 92
Cdd:cd02440   12 LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL--------PPEADESFDVIISDPplHHLVEDL 83

                         90       100
                 ....*....|....*....|
gi 751247070  93 KQYVKSLSRVLKVKGFFLIT 112
Cdd:cd02440   84 ARFLEEARRLLKPGGVLVLT 103
 
Name Accession Description Interval E-value
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 25-141 7.42e-12

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 60.89  E-value: 7.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070   25 SNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTQLS--GFHICIDKGTFDAISlNPDNAIEKrkqyvksLSRV 102
Cdd:pfam13847  29 AEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEELPELLEddKFDVVISNCVLNHIP-DPDKVLQE-------ILRV 100

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 751247070  103 LKVKGFFLITSCNWtKEELLNEFSEGWSTVAGFWLTAAL 141
Cdd:pfam13847 101 LKPGGRLIISDPDS-LAELPAHVKEDSTYYAGCVGGAIL 138
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 15-113 1.89e-09

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 55.31  E-value: 1.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070  15 WLNLLAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLSTqlsgfhicIDKGTFDAISLNpdNAI----- 89
Cdd:COG0500   40 NLLALAARFGGRVIGIDLSPEAIALARARAAKAGLGNVEFLVADLAELDP--------LPAESFDLVVAF--GVLhhlpp 109

                         90       100
                 ....*....|....*....|....
gi 751247070  90 EKRKQYVKSLSRVLKVKGFFLITS 113
Cdd:COG0500  110 EEREALLRELARALKPGGVLLLSA 133
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 15-104 1.35e-06

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 45.25  E-value: 1.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070   15 WLNLLAKFGFSNITGIDYSPSAIQLSGSIIEKEGLsNIKLKVEDFLNLStqlsgfhicIDKGTFDAISLNpdNAI----- 89
Cdd:pfam13649  11 LTLALARRGGARVTGVDLSPEMLERARERAAEAGL-NVEFVQGDAEDLP---------FPDGSFDLVVSS--GVLhhlpd 78

                          90
                  ....*....|....*
gi 751247070   90 EKRKQYVKSLSRVLK 104
Cdd:pfam13649  79 PDLEAALREIARVLK 93
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 15-112 1.04e-05

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 42.80  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070  15 WLNLLAKFGFSNITGIDYSPSAIQLSGSIIEKEGLSNIKLKVEDFLNLstqlsgfhICIDKGTFDAISLNP--DNAIEKR 92
Cdd:cd02440   12 LALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEEL--------PPEADESFDVIISDPplHHLVEDL 83

                         90       100
                 ....*....|....*....|
gi 751247070  93 KQYVKSLSRVLKVKGFFLIT 112
Cdd:cd02440   84 ARFLEEARRLLKPGGVLVLT 103
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 18-113 3.03e-05

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 42.61  E-value: 3.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070  18 LLAKFGFsNITGIDYSPSAIQLSGSIIEKEGLSN-IKLKVEDFLNLSTQlsgfhicidkGTFDAISLNpdNAIE-----K 91
Cdd:COG2230   69 LARRYGV-RVTGVTLSPEQLEYARERAAEAGLADrVEVRLADYRDLPAD----------GQFDAIVSI--GMFEhvgpeN 135

                         90       100
                 ....*....|....*....|..
gi 751247070  92 RKQYVKSLSRVLKVKGFFLITS 113
Cdd:COG2230  136 YPAYFAKVARLLKPGGRLLLHT 157
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 19-115 7.12e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 41.16  E-value: 7.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070  19 LAKFGFsNITGIDYSPSAIQLSgsiIEKEGLSNIKLKVEDFLNLStqlsgfhicIDKGTFDAISLNpdNAIE---KRKQY 95
Cdd:COG2227   42 LARRGA-DVTGVDISPEALEIA---RERAAELNVDFVQGDLEDLP---------LEDGSFDLVICS--EVLEhlpDPAAL 106

                         90       100
                 ....*....|....*....|
gi 751247070  96 VKSLSRVLKVKGFFLITSCN 115
Cdd:COG2227  107 LRELARLLKPGGLLLLSTPN 126
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 18-135 1.12e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 40.75  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070  18 LLAKFGFSnITGIDYSPSAIQLSGSIIEKEGLsNIKLKVEDFLNLStqlsgfhicIDKGTFDAI-SLNPDNAIEKRKQYV 96
Cdd:COG2226   39 ALAERGAR-VTGVDISPEMLELARERAAEAGL-NVEFVVGDAEDLP---------FPDGSFDLViSSFVLHHLPDPERAL 107

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 751247070  97 KSLSRVLKVKGFFLITSCNW-TKEELLNEFSEgwstvAGF 135
Cdd:COG2226  108 AEIARVLKPGGRLVVVDFSPpDLAELEELLAE-----AGF 142
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 16-111 7.08e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 37.64  E-value: 7.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070   16 LNLLAKFGfSNITGIDYSPSAIQLSGSIIEKEGLSNIklkVEDFLNLStqlsgfhicIDKGTFDAISLNpdNAIE---KR 92
Cdd:pfam08241  11 TELLARLG-ARVTGVDISPEMLELAREKAPREGLTFV---VGDAEDLP---------FPDNSFDLVLSS--EVLHhveDP 75

                          90
                  ....*....|....*....
gi 751247070   93 KQYVKSLSRVLKVKGFFLI 111
Cdd:pfam08241  76 ERALREIARVLKPGGILII 94
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 18-109 3.91e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.42  E-value: 3.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 751247070   18 LLAKFGFSNITGIDYSPSAIQlsgsiIEKEGLSNIKLKVEDFLNLSTQLSGFHiciDKGTFDAISLNpdNAIE---KRKQ 94
Cdd:pfam08242  14 LLEALPGLEYTGLDISPAALE-----AARERLAALGLLNAVRVELFQLDLGEL---DPGSFDVVVAS--NVLHhlaDPRA 83

                          90
                  ....*....|....*
gi 751247070   95 YVKSLSRVLKVKGFF 109
Cdd:pfam08242  84 VLRNIRRLLKPGGVL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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