Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 914095695  529 HLTEHMKTHTGLKPYDCHGCGKKF 552
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|...
gi 914095695  503 DRHINMHLNLRPFHCPVCAKKFK 525
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFK 25

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695   33 LNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLK----NMSTVSIPAVmDPLAFESVLSCAYTGQLrMLRE 108
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDDV-SPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 914095695  109 DIVNYLTVGSVLQMWHIVDKCTELLKE 135
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 914095695  529 HLTEHMKTHTGLKPYDCHGCGKKF 552
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

zinc finger;

                           10        20
                   ....*....|....*....|...
gi 914095695   515 FHCPVCAKKFKMKHHLTEHMKTH 537
Cdd:smart00355   1 YRCPECGKVFKSKSALREHMRTH 23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  19 QVCFPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMSTVSIPAVMDPLAFESVLSCA 98
Cdd:cd18227    2 RVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSRRIVLPDVMNPRVFENILLSC 81

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 914095695  99 YTGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLK 134
Cdd:cd18227   82 YTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  18 VQVCFPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMSTVSIPAVMDPLAFESVLSC 97
Cdd:cd18222    1 IQLEIPDFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPTVFEQLLSF 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 914095695  98 AYTGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLK 134
Cdd:cd18222   81 CYTGRICLQLADIISYLTAASFLQMQHIIDKCTQILE 117

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695   33 LNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLK----NMSTVSIPAVmDPLAFESVLSCAYTGQLrMLRE 108
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQesesSVSEITLDDV-SPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 914095695  109 DIVNYLTVGSVLQMWHIVDKCTELLKE 135
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  17 VVQVCFPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMSTVSIPAVMDPLAFESVLS 96
Cdd:cd18289    4 MLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQILS 83

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 914095695  97 CAYTGQLRML-REDIVNYLTVGsVLQMWHIVDKCTELL 133
Cdd:cd18289   84 FCYTGKLTMAaSEQLVVMYTAG-FLQIQHIVERGTDLM 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  28 SVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLkNMSTVSIPAVMDPLAFESVLSCAYTGQLRMLR 107
Cdd:cd18208   11 SVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLL-GYSDIEIPSVVSVQSVQKLIDFMYSGVLRVSQ 89

                         90       100
                 ....*....|....*....|....*...
gi 914095695 108 EDIVNYLTVGSVLQMWHIVDKCTELLKE 135
Cdd:cd18208   90 SEALQILTAASILQIKTVIDECTRIVSQ 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  22 FPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMSTVSIPAVMDP-LAFESVLSCaYT 100
Cdd:cd18203    5 LPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMHSSrVVADLLLSC-YT 83

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 914095695 101 GQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLKE 135
Cdd:cd18203   84 GALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQ 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  30 LDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVL--LKNMSTVSIPA---VMD-----PLAFESVLSCAY 99
Cdd:cd18228    7 LGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVgqASPRLVLVSPAgkcVLDlhhvtVTGFAPLLEYAY 86

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 914095695 100 TGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLK 134
Cdd:cd18228   87 TSTLSINTENIIDVLAAASYMQMFNVANTCSEFMK 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  22 FPRAQTSVLDSLNRQreeGHLCDLSIHVQGQVFKAHRCVLAASSPYFH----DQVLLKNMSTVSIPAvMDPLAFESVLSC 97
Cdd:cd18247    2 LPSSGFPVMEEIRRQ---GKLCDVTLKVGDQKFSAHRIVLAATIPYFHamftHDMVESKQDEITMQG-IEPSALEALINF 77

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 914095695  98 AYTGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLKE 135
Cdd:cd18247   78 AYSGRIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  22 FPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFhdQVLLKNMSTVSIPAVMDPLAFESVLSCAYTG 101
Cdd:cd18206    2 FPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYF--RMLFVDQKDVVHLDISNAAGLGQVLEFMYTA 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 914095695 102 QLRMLREDIVNYLTVGSVLQMWHIVDKCTEL 132
Cdd:cd18206   80 KLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  26 QTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHdQVLLKNMSTVSIPA-----VMDPLAFESVLSCAYT 100
Cdd:cd18329    5 QSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFK-MLLSQNAKETGQPTvatfdVFSPDTFTIILDFVYS 83

                         90       100
                 ....*....|....*....|....*....
gi 914095695 101 GQLRMLREDIVNYLTVGSVLQMWHIVDKC 129
Cdd:cd18329   84 GKLSLTSQNVIEVMSAASYLQMTDVISVC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  27 TSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMS--TVSIPAVMDPLAFESVLSCAYTGQLR 104
Cdd:cd18277   12 TNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQADAelNITLPEEVTVKGFEPLIQFAYTAKLI 91

                         90       100
                 ....*....|....*....|....*....
gi 914095695 105 MLREDIVNYLTVGSVLQMWHIVDKCTELL 133
Cdd:cd18277   92 LSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  22 FPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFhdQVLLKNMSTVSIPAVMD-----PLAFESVLS 96
Cdd:cd18198    5 FPDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYF--KKLFTSGAVVDQQNVYEidfvsPEALTALLE 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 914095695  97 CAYTGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLK 134
Cdd:cd18198   83 FAYTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  25 AQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVL----LKNMSTVSIPAVmDPLAFESVLSCAYT 100
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSsdsdGESILTVKLDGL-DPDAVEVLVNYAYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 914095695 101 GQLRmlrediVNYLTVGSV------LQMWHIVDKCTELLKE 135
Cdd:cd18306   80 SRLE------VPADLVKSVysaakkLKMDRVKKACGDFLLE 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  18 VQVCFPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFH---------DQVLLKNMSTVSIPAVMDP 88
Cdd:cd18326    1 IGIPFPDHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKklftsgavvDQQNVYEIDFVSAEALTAL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 914095695  89 LAFesvlscAYTGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELL 133
Cdd:cd18326   81 LDF------AYTATLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  22 FPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFH----DQVLLKNMSTVSIPAVMDPlAFESVLSC 97
Cdd:cd18324    3 FPDHSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHlfykDQLDKRDIVHLNSDIVTAP-AFALLLEF 81

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 914095695  98 AYTGQLRMLREDIVNYLTVGSVLQMWHIVDKCTELLKE 135
Cdd:cd18324   82 MYEGKLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKE 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  29 VLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYF---HDQVL-LKNMSTVSIPAVMDPLAFESVLSCAYTGQLR 104
Cdd:cd18230    8 LLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFktlYCQVQkTSDQATVTHLDIVTAQGFKAIIDFMYSAHLA 87

                         90       100       110
                 ....*....|....*....|....*....|
gi 914095695 105 MLREDIVNYLTVGSVLQMWHIVDKCTELLK 134
Cdd:cd18230   88 LTSKNVIEVMSAASYLQMTDIVQACHNFIK 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  22 FPRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMSTVSIPAVmDPLAFESVLSCAYTG 101
Cdd:cd18334    1 LPNHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHDNLINLDTDMV-NPTVFRQILDFIYTG 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 914095695 102 QL----RMLREDIVNYLTVGSVLQMWHIVDKCTELLK 134
Cdd:cd18334   80 KLltsdQPGEQNFNALLTAASYLQLHDLAALCRKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  24 RAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHD---QVLLKNMSTVSIPAVMDPLAFESVLSCAYT 100
Cdd:cd18215    1 RHASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSiftDQLKNNVSVINLDPEIEPEGFRILLDFMYT 80

                         90       100
                 ....*....|....*....|....*....
gi 914095695 101 GQLRMLREDIVNYLTVGSVLQMWHIVDKC 129
Cdd:cd18215   81 SRLNLREGNIMAVMATAMYLQMEHVVDTC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  33 LNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFhdQVLLKN------MSTVSIPAVmDPLAFESVLSCAYTGQLRML 106
Cdd:cd18240    8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYF--RALFTNgwneteKKVYKIPGV-SPEMMELIIEYAYTRTVPIT 84

                         90       100
                 ....*....|....*....|....*....
gi 914095695 107 REDIVNYLTVGSVLQMWHIVDKCTELLKE 135
Cdd:cd18240   85 AENVEELLPAADQFNIMGIVKACCDFLED 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  26 QTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFH---DQVLLKNMSTVSIPAVMDPLaFESVLSCAYTGQ 102
Cdd:cd18204    2 KTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKklfKKLEVDSSSVIEIDFLRSDI-FEEVLNYMYTAK 80

                         90       100
                 ....*....|....*....|....*....
gi 914095695 103 LRMLREDIVNYLTVGSVLQMWHIVDKCTE 131
Cdd:cd18204   81 ISVKKEDVNLMMSSGQILGIRFLDKLCSQ 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  23 PRAQTSVLDSLNRQREEGHLCDLSIHVQGQVFKAHRCVLAASSPYFHDQVLLKNMSTVSiPAVMDPLAFESVLSCAYTGQ 102
Cdd:cd18216    1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHDNLIHLD-QDMVSPTVFQQILDFIYTGK 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 914095695 103 LRMLREDIVNY---LTVGSVLQMWHIVDKCTELLKE 135
Cdd:cd18216   80 LLDSLFEEPNLsevLAAANYLQLPDLAALCRSKLKR 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  33 LNRQREEGHLCDLSIHVQGQV----FKAHRCVLAASSPYF--------HDQvllkNMSTVSIPAVMdPLAFESVLSCAYT 100
Cdd:cd18248   12 MNELRLSQQLCDVTLKVKYQDpkeeFMAHKVVLASSSPYFkamftsglREC----GMEVVPIEGVH-PCVMSRLIEFAYT 86

                         90       100       110
                 ....*....|....*....|....*....|....
gi 914095695 101 GQLRMlREDIVNYLTVGSVL-QMWHIVDKCTELL 133
Cdd:cd18248   87 ASISV-GEKCVLHVLPGAVMyQMDSVVKACCDFL 119

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 914095695  42 LCDLSIHVQGQVFKAHRCVLAASSPYFhdQVLLKNMSTVSIPAVM----DPLAFESVLSCAYTGQLRMLREDIVNYLtvg 117
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYF--AALLKETPPDEHPVIIlpdvPYSELKALLDFIYTGEVNVSQEQLESLL--- 75

                 ....*...
gi 914095695 118 SVLQMWHI 125
Cdd:cd18315   76 KLAELLQI 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.