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Conserved domains on  [gi|1015809700|ref|NP_001309109|]
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contactin-associated protein-like 4 isoform 5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 692-810 5.96e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 5.96e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  692 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 770
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809700  771 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 810
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 83-212 5.03e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   83 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 162
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809700  163 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 212
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 269-395 7.95e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 7.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  269 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 347
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809700  348 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 395
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 917-1047 1.05e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  917 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 996
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809700  997 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1047
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
FA58C super family cl25480
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 3-47 1.34e-08

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


The actual alignment was detected with superfamily member cd00057:

Pssm-ID: 330301 [Multi-domain]  Cd Length: 143  Bit Score: 54.67  E-value: 1.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1015809700    3 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 47
Cdd:cd00057    101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 464-505 2.63e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 51.02  E-value: 2.63e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809700  464 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 505
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 424-455 1.05e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809700  424 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
COLFI super family cl02436
Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 475-558 4.37e-04

Fibrillar collagen C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1 alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


The actual alignment was detected with superfamily member smart00038:

Pssm-ID: 470578  Cd Length: 232  Bit Score: 43.23  E-value: 4.37e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   475 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 541
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809700   542 NR--AEHCEQEFTYYCKKS 558
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 833-867 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809700  833 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 867
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 692-810 5.96e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 5.96e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  692 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 770
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809700  771 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 810
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 665-809 6.86e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 6.86e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  665 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 741
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809700  742 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 809
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 83-212 5.03e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   83 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 162
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809700  163 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 212
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
687-811 1.57e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.66  E-value: 1.57e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   687 DVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRVERNMKEASLQVD 764
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809700   765 QLTPKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 811
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 269-395 7.95e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 7.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  269 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 347
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809700  348 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 395
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 65-210 2.92e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.10  E-value: 2.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   65 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 143
Cdd:cd00110     10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809700  144 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 210
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 242-392 9.78e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.56  E-value: 9.78e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  242 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNlYQPGKLPSDITAGVELN 320
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015809700  321 DGQWHSVSLSAKKNHLSVAVDG-QMASAAPLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 392
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
79-212 1.82e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.33  E-value: 1.82e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700    79 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 155
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809700   156 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 212
Cdd:smart00282   74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
264-395 3.10e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.78  E-value: 3.10e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   264 SATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQ 343
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1015809700   344 MASAAPLLGPEQIY-SGGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISISGK 395
Cdd:smart00282   81 NRVSGESPGGLTILnLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 917-1047 1.05e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  917 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 996
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809700  997 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1047
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 913-1044 4.93e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 67.83  E-value: 4.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  913 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLNKyqEPDVVNFDfKNMADGQLHHIMINREEGVVFIEID 991
Cdd:cd00110     24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGS--GSLVLSSK-TPLNDGQWHSVSVERNGRSVTLSVD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809700  992 DNRRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqdTALAGAQGFTGCLSAVQL 1044
Cdd:cd00110    100 GERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
913-1047 1.20e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.20e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   913 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNkyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 991
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809700   992 DNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDTAlagAQGFTGCLSAVQLSHV 1047
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 3-47 1.34e-08

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 54.67  E-value: 1.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1015809700    3 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 47
Cdd:cd00057    101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 464-505 2.63e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 51.02  E-value: 2.63e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809700  464 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 505
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 3-48 4.53e-08

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 53.28  E-value: 4.53e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1015809700     3 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 48
Cdd:smart00231   96 FPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 2-45 1.30e-06

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 48.60  E-value: 1.30e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1015809700    2 GFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 45
Cdd:pfam00754   84 KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 424-455 1.05e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809700  424 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 463-510 1.75e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 44.15  E-value: 1.75e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1015809700  463 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTET--AWTIIQH--NGS 510
Cdd:cd00087      4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDggGWTVIQRrgDGS 54
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 466-514 2.77e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.42  E-value: 2.77e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1015809700   466 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETA--WTIIQH--NGS-DLTR 514
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 475-558 4.37e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 43.23  E-value: 4.37e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   475 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 541
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809700   542 NR--AEHCEQEFTYYCKKS 558
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 833-867 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809700  833 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 867
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 422-456 2.37e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1015809700  422 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 456
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 692-810 5.96e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 115.21  E-value: 5.96e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  692 FKTTASSGVFLEN-LGIADFIRIELRSPTVVtFSFDVGNGPFEISVqSPTHFNDNQWHHVRVERNMKEASLQVDQLTPKT 770
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLV-LRYDLGSGPESLLS-SGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVS 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809700  771 QPAPADGHvLLQLNSQLFVGG--------TATRQRGFLGCIRSLQLNG 810
Cdd:pfam02210   79 SLPPGESL-LLNLNGPLYLGGlppllllpALPVRAGFVGCIRDVRVNG 125
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 665-809 6.86e-30

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 115.98  E-value: 6.86e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  665 SASFDTEaSYLHFPTFHGEL-SADVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtfsFDVGNGPFEISVQSPTH 741
Cdd:cd00110      1 GVSFSGS-SYVRLPTLPAPRtRLSISFSFRTTSPNGLllYAGSQNGGDFLALELEDGRLV---LRYDLGSGSLVLSSKTP 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809700  742 FNDNQWHHVRVERNMKEASLQVDQLTPKTQPAPaDGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLN 809
Cdd:cd00110     77 LNDGQWHSVSVERNGRSVTLSVDGERVVESGSP-GGSALLNLDGPLYLGGLpedlkspgLPVSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 83-212 5.03e-29

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 112.90  E-value: 5.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   83 FKTMQSDGILLHREGPNGDHITLQLRRARLFLLINSGeaklpsTSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVDEH 162
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLG------SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809700  163 RHHFHARGEFNL-MNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 212
Cdd:pfam02210   75 TVVSSLPPGESLlLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
687-811 1.57e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 111.66  E-value: 1.57e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   687 DVSFFFKTTASSGV--FLENLGIADFIRIELRSPTVVtFSFDVGNGPFEISVQsPTHFNDNQWHHVRVERNMKEASLQVD 764
Cdd:smart00282    1 SISFSFRTTSPNGLllYAGSKGGGDYLALELRDGRLV-LRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1015809700   765 QLTPKTQPAPAdGHVLLQLNSQLFVGGT--------ATRQRGFLGCIRSLQLNGM 811
Cdd:smart00282   79 GGNRVSGESPG-GLTILNLDGPLYLGGLpedlklppLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 269-395 7.95e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 97.88  E-value: 7.95e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  269 FRTWNKAGLLLFSElQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMA-SA 347
Cdd:pfam02210    1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVvSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1015809700  348 APLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISISGK 395
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLL-LLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 65-210 2.92e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.10  E-value: 2.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   65 YRFDQKSLSPIKDIISLKFKTMQSDGILLHREG-PNGDHITLQLRRARLFLLINSGEAKLPststlvnLTLGSLLDDQHW 143
Cdd:cd00110     10 VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSqNGGDFLALELEDGRLVLRYDLGSGSLV-------LSSKTPLNDGQW 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809700  144 HSVLIQRLGKQVNFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFPHRN-FHGCLENLYYN 210
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPgFVGCIRDLKVN 151
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 242-392 9.78e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 95.56  E-value: 9.78e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  242 PVTFlSSRSYLALPDFSGEE-EVSATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNlYQPGKLPSDITAGVELN 320
Cdd:cd00110      1 GVSF-SGSSYVRLPTLPAPRtRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1015809700  321 DGQWHSVSLSAKKNHLSVAVDG-QMASAAPLLGPEQIYSGGTYYFGGCPDKSfGSKCKSPLGGFQGCMRLISI 392
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGeRVVESGSPGGSALLNLDGPLYLGGLPEDL-KSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
79-212 1.82e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 94.33  E-value: 1.82e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700    79 ISLKFKTMQSDGILLHREGPNG-DHITLQLRRARLFLLIN--SGEAKLPSTSTLVNltlgslldDQHWHSVLIQRLGKQV 155
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALELRDGRLVLRYDlgSGPARLTSDPTPLN--------DGQWHRVAVERNGRSV 73

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809700   156 NFTVDEHRH-HFHARGEFNLMNLDYEISFGGIPAPGKSVSFP-HRNFHGCLENLYYNGV 212
Cdd:smart00282   74 TLSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
692-814 9.37e-21

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 89.30  E-value: 9.37e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  692 FKTTASSGVFLENLGIA--DFIRIELRSPTVvTFSFDVGNGPfeISVQSPTHFNDNQWHHVRVERNMKEASLQVDQLTPK 769
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTerDFLALELRDGRL-EVSYDLGSGA--AVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARP 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1015809700  770 T--QPAPADGHvlLQLNSQLFVGGT---------ATRQRGFLGCIRSLQLNGMTLD 814
Cdd:pfam00054   78 TgeSPLGATTD--LDVDGPLYVGGLpslgvkkrrLAISPSFDGCIRDVIVNGKPLD 131
LamG smart00282
Laminin G domain;
264-395 3.10e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 87.78  E-value: 3.10e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   264 SATFQFRTWNKAGLLLFSELQLISGGILLFLSDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQ 343
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1015809700   344 MASAAPLLGPEQIY-SGGTYYFGGCPDkSFGSKCKSPLGGFQGCMRLISISGK 395
Cdd:smart00282   81 NRVSGESPGGLTILnLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
269-398 1.02e-17

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 80.44  E-value: 1.02e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  269 FRTWNKAGLLLFSELQLISGGILLFLSDGKLKSnLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDG-QMASA 347
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEV-SYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGeARPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809700  348 APLLGPEQIYS-GGTYYFGGCPDKSFGSKCKSPLGGFQGCMRLISISGKVVD 398
Cdd:pfam00054   80 ESPLGATTDLDvDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 917-1047 1.05e-17

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 80.54  E-value: 1.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  917 FRTTRTPSLLLFVSSFYKEYLSVIIaKNGSLQIRYKLNKYQEPDVVNFdfKNMADGQLHHIMINREEGVVFIEIDDNRRR 996
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALEL-VNGRLVLRYDLGSGPESLLSSG--KNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1015809700  997 QVHLSSGTE-FSAVKSLVLGRileHSDVDQDTALAGAQGFTGCLSAVQLSHV 1047
Cdd:pfam02210   78 SSLPPGESLlLNLNGPLYLGG---LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 913-1044 4.93e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 67.83  E-value: 4.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  913 IKFSFRTTRTPSLLLFVSSF-YKEYLSVIIaKNGSLQIRYKLNKyqEPDVVNFDfKNMADGQLHHIMINREEGVVFIEID 991
Cdd:cd00110     24 ISFSFRTTSPNGLLLYAGSQnGGDFLALEL-EDGRLVLRYDLGS--GSLVLSSK-TPLNDGQWHSVSVERNGRSVTLSVD 99

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1015809700  992 DNRRRQVHLSSGTEF-SAVKSLVLGRILEHSDVdqdTALAGAQGFTGCLSAVQL 1044
Cdd:cd00110    100 GERVVESGSPGGSALlNLDGPLYLGGLPEDLKS---PGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
913-1047 1.20e-12

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 66.21  E-value: 1.20e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   913 IKFSFRTTRTPSLLLFVSSFYK-EYLSVIIaKNGSLQIRYKLNkyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEID 991
Cdd:smart00282    2 ISFSFRTTSPNGLLLYAGSKGGgDYLALEL-RDGRLVLRYDLG--SGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1015809700   992 DNRRRQVHLSSGTEFSAVKS-LVLGRILEHSDVDQDTAlagAQGFTGCLSAVQLSHV 1047
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGpLYLGGLPEDLKLPPLPV---TPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
83-212 1.76e-10

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 1.76e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   83 FKTMQSDGILLHREGPN-GDHITLQLRRARLFLLINSGeaklpstSTLVNLTLGSLLDDQHWHSVLIQRLGKQVNFTVD- 160
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTeRDFLALELRDGRLEVSYDLG-------SGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDg 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1015809700  161 EHRHHfharGEFNL-----MNLDYEISFGGIPAPGKSVS-FPHR-NFHGCLENLYYNGV 212
Cdd:pfam00054   74 EARPT----GESPLgattdLDVDGPLYVGGLPSLGVKKRrLAISpSFDGCIRDVIVNGK 128
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 3-47 1.34e-08

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 54.67  E-value: 1.34e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1015809700    3 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFG 47
Cdd:cd00057    101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 464-505 2.63e-08

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 51.02  E-value: 2.63e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1015809700  464 SCEAYKHRGNT--SGFYYIDSDGSGPLEPFLLYCNMTET--AWTII 505
Cdd:NF040941     1 SCWEILQAGPSapSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 3-48 4.53e-08

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 53.28  E-value: 4.53e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1015809700     3 FSGNANADSVVYYRLQPSIKARFLRFIPLEWNpkGRIGMRIEVFGC 48
Cdd:smart00231   96 FPGNSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 2-45 1.30e-06

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 48.60  E-value: 1.30e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1015809700    2 GFSGNANADSVVYYRLQPSIKARFLRFIPLEWNPKGRIGMRIEV 45
Cdd:pfam00754   84 KIPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 424-455 1.05e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.44  E-value: 1.05e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1015809700  424 CLPNYCEHGGECSQSWSTFHCNCTnTGYRGAT 455
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 463-510 1.75e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 44.15  E-value: 1.75e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1015809700  463 QSC-EAYKHRGNTSGFYYIDSDGSgpLEPFLLYCNMTET--AWTIIQH--NGS 510
Cdd:cd00087      4 RDCsEVLQRGGRTSGVYTIQPPGS--NEPFQVYCDMDTDggGWTVIQRrgDGS 54
TSPN smart00210
Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...
 878-1000 2.03e-04

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin


Pssm-ID: 214560  Cd Length: 184  Bit Score: 43.50  E-value: 2.03e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   878 GSSVIYNFQENyllsKNSSSHAASFHgDMKLSREM-IKFSFRTTRTPSLLLF--VSSFYKEYLSVIIakNGSLQI---RY 951
Cdd:smart00210   25 PGSPAYRLGDP----ALVPQPTRDLF-PSGLPEDFsLLTTFRQTPKSRGVLFaiYDAQNVRQFGLEV--DGRANTlllRY 97

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*....
gi 1015809700   952 KLNKyQEPDVVNFDFKNMADGQLHHIMINREEGVVFIEIDDNRRRQVHL 1000
Cdd:smart00210   98 QGVD-GKQHTVSFRNLPLADGQWHKLALSVSGSSATLYVDCNEIDSRPL 145
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 466-514 2.77e-04

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 43.42  E-value: 2.77e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1015809700   466 EAYKHRGNTSGFYYIDSDGSGplEPFLLYCNMTETA--WTIIQH--NGS-DLTR 514
Cdd:smart00186    7 DVLQNGGKTSGLYTIYPDGSS--RPLKVYCDMETDGggWTVIQRrmDGSvDFYR 58
COLFI smart00038
Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia ...
 475-558 4.37e-04

Fibrillar collagens C-terminal domain; Found at C-termini of fibrillar collagens: Ephydatia muelleri procollagen EMF1alpha, vertebrate collagens alpha(1)III, alpha(1)II, alpha(2)V etc.


Pssm-ID: 197483  Cd Length: 232  Bit Score: 43.23  E-value: 4.37e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700   475 SGFYYIDSDGSGPLEPFLLYCNMtETAWTIIQHNGSDLTRVRNTNPENPYAGF---------FEYVAS----MEQLQATI 541
Cdd:smart00038   44 SGEYWVDPNQGCIRDAIKVFCNF-ETGETCVSPSPSSIPRKTWYSGKSKHVWFgetmnggfkFSYGDSegppVGVVQLTF 122

                            90
                    ....*....|....*....
gi 1015809700   542 NR--AEHCEQEFTYYCKKS 558
Cdd:smart00038  123 LRllSTEAHQNITYHCKNS 141
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 287-366 4.64e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 41.99  E-value: 4.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1015809700  287 SGGILLFL-SDGKLKSNLYQPGKLPSDITAGVELNDGQWHSVSLSAKKNHLSVAVDGQMASAAPLLGPEQIYSGGTYYFG 365
Cdd:pfam13385   43 GGGYSLGLdGDGRLRFAVNGGNGGWDTVTSGASVPLGQWTHVAVTYDGGTLRLYVNGVLVGSSTLTGGPPPGTGGPLYIG 122


                   .
gi 1015809700  366 G 366
Cdd:pfam13385  123 R 123
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 833-867 1.83e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.83e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1015809700  833 CSSYGkLCRNGGKCRERPIGFFCDCTfSAYTGPFC 867
Cdd:cd00054      5 CASGN-PCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 422-456 2.37e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 2.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1015809700  422 DRCL-PNYCEHGGECSQSWSTFHCNCTNtGYRGATC 456
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPP-GYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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