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Conserved domains on  [gi|1100818968|ref|NP_001333843|]
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zinc finger protein 429 isoform c [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-592 7.54e-18

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.67  E-value: 7.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 197 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 273
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 274 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 353
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 354 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 428
Cdd:COG5048   194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 429 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 501
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 502 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 570
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420
                  ....*....|....*....|..
gi 1100818968 571 NRSSRLTQHKKIHTREKPYKCE 592
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCS 450
KRAB super family cl42959
krueppel associated box;
1-31 1.74e-11

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.53  E-value: 1.74e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1100818968    1 MLENYRNLVFLGIAVSKPDLITCLEKEKEPC 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-592 7.54e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.67  E-value: 7.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 197 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 273
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 274 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 353
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 354 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 428
Cdd:COG5048   194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 429 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 501
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 502 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 570
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420
                  ....*....|....*....|..
gi 1100818968 571 NRSSRLTQHKKIHTREKPYKCE 592
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCS 450
KRAB smart00349
krueppel associated box;
1-31 1.74e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.53  E-value: 1.74e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1100818968    1 MLENYRNLVFLGIAVSKPDLITCLEKEKEPC 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 3.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818968 435 HLTSHRRIHTGEKPYKCEECGKAFKQ 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
197-592 7.54e-18

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 86.67  E-value: 7.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 197 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 273
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 274 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 353
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 354 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 428
Cdd:COG5048   194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 429 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 501
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 502 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 570
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420
                  ....*....|....*....|..
gi 1100818968 571 NRSSRLTQHKKIHTREKPYKCE 592
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
251-611 9.77e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 9.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 251 KPYKCDECGKTFSISSTFTKHKIIHTEEKPYKC--KECGKAFNRSSTLTSHKRIHTGEKPYKCE-ECGKAFNWSSTLTKH 327
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 328 KVIHTGEKPYKCEECGKAFNQSSRLTRHKKIHTGEEPYKFEKCGRVFT-----------------------CSSTLTQDK 384
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpssNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 385 KIHTGEKPYNCEECGKVFTYSSTLTRHKRIHTEEkPYKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQSSNL 464
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 465 NSHKKIHSGE-------KPYKCEECGKAFILSSRLTQHK--KIHTGE--KPYKCEE--CGKAFNRSSRLTQHKKIHTGEK 531
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 532 PYKCK--QCDKAFTHSSN-----LSSHKKIHSGEKPYKCE--ECGKAFNRSSRLTQHKKIHTREKP--YKCEECAKAFTR 600
Cdd:COG5048   351 PAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410
                  ....*....|.
gi 1100818968 601 SSRLTQHKKIH 611
Cdd:COG5048   431 HYNLIPHKKIH 441
KRAB smart00349
krueppel associated box;
1-31 1.74e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 59.53  E-value: 1.74e-11
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1100818968    1 MLENYRNLVFLGIAVSKPDLITCLEKEKEPC 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPW 60
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 501-581 1.97e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 501 GEKPYKCE--ECGKAFNRSSRLTQHKKiHtgekpykcKQCDKAFTHSSNLSSHKKIHSGEKPYKCEECGKAFNRSSRLTQ 578
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1100818968 579 HKK 581
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 529-609 2.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 529 GEKPYKCK--QCDKAFTHSSNLSSHKKiHSGEKPYKCEECGKafnrssrlTQHKKIHTREKPYKCEECAKAFTRSSRLTQ 606
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1100818968 607 HKK 609
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 3.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818968 435 HLTSHRRIHTGEKPYKCEECGKAFKQ 460
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 405-497 3.87e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 405 SSTLTRHKRIHTEEKPYKCNECGKAFNRSSHL---TSHRRIHT-GEKPYKCE--ECGKAFKQSSNLNSHKK--------- 469
Cdd:COG5189   302 RGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklh 381

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1100818968 470 ----------IHSGEKPYKCEECGKAFILSSRLTQHKK 497
Cdd:COG5189   382 enpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 389-472 4.61e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 389 GEKPYNCE--ECGKVFTYSSTLTRHKrihteekpyKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQSSNLNS 466
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1100818968 467 HKKiHS 472
Cdd:COG5189   417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
519-544 5.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.47e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818968 519 RLTQHKKIHTGEKPYKCKQCDKAFTH 544
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
547-572 5.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.98e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818968 547 NLSSHKKIHSGEKPYKCEECGKAFNR 572
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
491-516 6.73e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.73e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818968 491 RLTQHKKIHTGEKPYKCEECGKAFNR 516
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
212-236 7.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.57e-04
                          10        20
                  ....*....|....*....|....*
gi 1100818968 212 LTNHKRIHTGEKPYKCKECGKAFSR 236
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-432 8.43e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.43e-04
                          10        20
                  ....*....|....*....|....*
gi 1100818968 408 LTRHKRIHTEEKPYKCNECGKAFNR 432
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
537-614 9.53e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 537 QCDKAFTHSSNlSSHKKIHSGEKPYKCEECGKAFNRSSRLTQHKKIHTREKPYKC--EECAKAFTRSSRLTQHKKIHRMG 614
Cdd:COG5048    11 SNNSVLSSTPK-STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNN 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-319 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|....
gi 1100818968 296 LTSHKRIHTGEKPYKCEECGKAFN 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-486 1.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.12e-03
                          10        20
                  ....*....|....*....|....
gi 1100818968 463 NLNSHKKIHSGEKPYKCEECGKAF 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 264-357 3.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 264 ISSTFTKHKIIHTEEKPYKCKECGKAFNRSSTL---TSHKRIHT-GEKPYKCE--ECGKAFNWSSTLTKHK--------- 328
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqkl 380

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1100818968 329 ----------VIHTGEKPYKCEECGKAFNQSSRLTRHKK 357
Cdd:COG5189   381 henpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-348 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....*
gi 1100818968 324 LTKHKVIHTGEKPYKCEECGKAFNQ 348
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-263 3.75e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|....
gi 1100818968 240 LTTHKRIHSGEKPYKCDECGKTFS 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-300 5.64e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818968 221 GEKPYKCK--ECGKAFSRYSTLTTHKrihsgekpyKCDECGKTFSISSTFTKHKIIHTEEKPYKCKECGKAFNRSSTLTS 298
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1100818968 299 HK 300
Cdd:COG5189   417 HR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 421-443 5.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.75e-03
                          10        20
                  ....*....|....*....|...
gi 1100818968 421 YKCNECGKAFNRSSHLTSHRRIH 443
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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