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Conserved domains on  [gi|1861099407|ref|NP_001371579|]
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PR domain-containing protein 11 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET super family cl40432
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 109-235 5.36e-50

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


The actual alignment was detected with superfamily member cd19195:

Pssm-ID: 394802  Cd Length: 127  Bit Score: 167.73  E-value: 5.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRNVA 188
Cdd:cd19195     1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1861099407 189 hlaerkrkpkFSKEELDILVTEVTHHEAVLFgRETMRLSHADRDKIW 235
Cdd:cd19195    81 ----------ISREEREQNLLAFQHSEQIYF-RACRDIRPGEKLRVW 116
zf_PR_Knuckle super family cl39781
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 9.80e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


The actual alignment was detected with superfamily member pfam18445:

Pssm-ID: 375871  Cd Length: 38  Bit Score: 36.89  E-value: 9.80e-04
                          10        20
                  ....*....|....*....|....*..
gi 1861099407  75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445  12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 334-404 2.99e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.99e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1861099407  334 GPSRQPLRVPLQRSPEEEAHLARPALLRSSSSSDQ---SETVGPKPEALPHPSPQAQAAcRTPRPHPSPPTTGL 404
Cdd:PHA03247  2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppdQPERPPQPQAPPPPQPQPQPP-PPPQPQPPPPPPPR 2938
 
Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 5.36e-50

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 167.73  E-value: 5.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRNVA 188
Cdd:cd19195     1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1861099407 189 hlaerkrkpkFSKEELDILVTEVTHHEAVLFgRETMRLSHADRDKIW 235
Cdd:cd19195    81 ----------ISREEREQNLLAFQHSEQIYF-RACRDIRPGEKLRVW 116
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 195-271 1.31e-18

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 80.02  E-value: 1.31e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1861099407 195 RKPKFSKEELDILVTEVTHHEAVLFGRETMRLSHADRDKIWEGIARKITSVSQVPRSVKDIKHRWDDMKRRTKDKLA 271
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLA 77
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 9.80e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 36.89  E-value: 9.80e-04
                          10        20
                  ....*....|....*....|....*..
gi 1861099407  75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445  12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 334-404 2.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.99e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1861099407  334 GPSRQPLRVPLQRSPEEEAHLARPALLRSSSSSDQ---SETVGPKPEALPHPSPQAQAAcRTPRPHPSPPTTGL 404
Cdd:PHA03247  2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppdQPERPPQPQAPPPPQPQPQPP-PPPQPQPPPPPPPR 2938
 
Name Accession Description Interval E-value
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 109-235 5.36e-50

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 167.73  E-value: 5.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 109 AALTIPQGMEVVKDTSGESDVRCVNEVIPKGHIFGPYEGQISTQDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRNVA 188
Cdd:cd19195     1 AALTAPQGIEVVKDTSGESDVRCVDEVIPKGHIFGPYEGQICTQDKSSGFFSWLIVDKNNRYKSIDGSDETKANWMRYVV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1861099407 189 hlaerkrkpkFSKEELDILVTEVTHHEAVLFgRETMRLSHADRDKIW 235
Cdd:cd19195    81 ----------ISREEREQNLLAFQHSEQIYF-RACRDIRPGEKLRVW 116
Myb_DNA-bind_5 pfam13873
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT ...
 195-271 1.31e-18

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT like DNA binding domains. This family is greatly expanded in arthropods and higher eukaryotes.


Pssm-ID: 433544  Cd Length: 78  Bit Score: 80.02  E-value: 1.31e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1861099407 195 RKPKFSKEELDILVTEVTHHEAVLFGRETMRLSHADRDKIWEGIARKITSVSQVPRSVKDIKHRWDDMKRRTKDKLA 271
Cdd:pfam13873   1 RKKNFSEEEKEVLVELVEKRKHILEGKKSDAATWKAKNRAWKEIAARVNAIGGVHRTAEELKKKWRDLKRRTKRKLA 77
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 111-187 3.37e-15

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 72.27  E-value: 3.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 111 LTIPQGMEVvkdtsGESDVR------CVNEVIPKGHIFGPYEGQISTQDKSAGF-FSWLIVDKNNRYKSIDGSDETKANW 183
Cdd:cd19193     2 LTLPPGLSI-----KRSSIPgaglgvWAEAPIPKGMVFGPYEGEIVEDEEAADSgYSWQIYKGGKLSHYIDAKDESKSNW 76


                  ....
gi 1861099407 184 MRNV 187
Cdd:cd19193    77 MRYV 80
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 112-188 1.27e-10

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 58.88  E-value: 1.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 112 TIPQGMeVVKDTSGESDVRCV--NEVIPKGHIFGPYEGQISTQDK-----SAGFFsWLIVDKNNRYKSIDGSDETKANWM 184
Cdd:cd19187     2 SLPRNL-TLKYSSVGREVLGVwsSDYIPRGTRFGPLVGEIYTNDPvpkgaNRKYF-WRIYSNGEFYHYIDGFDPSKSNWM 79


                  ....
gi 1861099407 185 RNVA 188
Cdd:cd19187    80 RYVN 83
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 131-185 4.45e-07

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 49.01  E-value: 4.45e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1861099407 131 CVNEVIPKGHIFGPYEGQISTQDKSAGFFS-----WLIVDKNNRYKS-IDGSDETKANWMR 185
Cdd:cd19191    20 CAAQRIPQGTWIGPFEGVLVSPEKQIGAVRntqhlWEIYDQEGTLQHfIDGGDPSKSSWMR 80
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 136-187 4.98e-07

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 48.59  E-value: 4.98e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1861099407 136 IPKGHIFGPYEGQIST-QDKSAGFFSWLIVDKNNRYKSIDGSDETKANWMRNV 187
Cdd:cd19188    28 IPKGRKFGPFVGEKKKrSQVKNNVYMWEIYGPKRGWMCVDASDPTKGNWLRYV 80
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 111-192 3.97e-05

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 43.54  E-value: 3.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 111 LTIPQGMEVVKDTSGE---SDVRCvNEVIPKGHIFGPYEG------QISTQDKSAgfFSWLIVDKNNRYKSIDGSDETkA 181
Cdd:cd19198     1 LDLPEGLRVLQTSFGGtphYGVFC-KKTIPKGTRFGPFRGrvvntsEIKTYDDNS--FMWEIFEDGKLSHFIDGRGST-G 76

                          90
                  ....*....|...
gi 1861099407 182 NWMR--NVAHLAE 192
Cdd:cd19198    77 NWMSyvNCARYAE 89
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 136-187 1.83e-04

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 41.58  E-value: 1.83e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1861099407 136 IPKGHIFGPYEGQISTQDKSAGFfSWLIVDKNNRYKS-IDGSDETKANWMRNV 187
Cdd:cd19200    34 IEVGEKFGPFVGVQRSSVKDPTY-AWEIVDEFGKVKFwIDASEPGTGNWMKYI 85
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 108-194 3.79e-04

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 40.48  E-value: 3.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 108 RAALTIPQGMEVVKDTSGESDVRCVNEvIPKGHIFGPYEGQI-STQDKSAgFFSWLIVDKNNRYKSIDGSDETKANWMRN 186
Cdd:cd19199     2 RARSSLPDNLEIRQLEDGSEGVFALVP-LVKRTQFGPFEAKRvARLDGFA-VFPLKVFEKDGSVVYLDTSNEDDCNWMMF 79


                  ....*...
gi 1861099407 187 VAHLAERK 194
Cdd:cd19199    80 VRPATDVE 87
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 108-184 4.65e-04

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 40.41  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 108 RAALTIPQGMEVVKdtSGESDVRCVNE-VIPKGHIFGPYEGQISTQDKSAG--FFSWLIVDKNNRYKSIDGSDETKANWM 184
Cdd:cd19194     1 RARASLPLILQIFR--FGETLGGVFAKrRIPKRTQFGPLEGPLVKKSELKDnkIHPLELEEDDGEDLYFDLSDENKCNWM 78
zf_PR_Knuckle pfam18445
PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, ...
 75-101 9.80e-04

PR zinc knuckle motif; This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a beta-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two beta-hairpins, each providing two zinc ligands).


Pssm-ID: 375871  Cd Length: 38  Bit Score: 36.89  E-value: 9.80e-04
                          10        20
                  ....*....|....*....|....*..
gi 1861099407  75 FCESCQEYFVDECPNHGPPVFVSDTPV 101
Cdd:pfam18445  12 WCTLCERSYPSDCPEHGPVTFIPDTPI 38
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 113-150 2.05e-03

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 37.18  E-value: 2.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1861099407 113 IPQGMEVVKDTSGESDVR-CVNEVIPKGHIFGPYEGQIS 150
Cdd:cd10534     1 LPAGLELVLSSIPEGGLGvFARRTIPAGTRFGPLEGVVN 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 334-404 2.99e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.99e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1861099407  334 GPSRQPLRVPLQRSPEEEAHLARPALLRSSSSSDQ---SETVGPKPEALPHPSPQAQAAcRTPRPHPSPPTTGL 404
Cdd:PHA03247  2866 PPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALppdQPERPPQPQAPPPPQPQPQPP-PPPQPQPPPPPPPR 2938
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 196-265 7.20e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 35.70  E-value: 7.20e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1861099407 196 KPKFSKEELDILVTEVTHHEAVLFGRETMRlshadRDKIWEGIARKITSVSqVPRSVKDIKHRWDDMKRR 265
Cdd:pfam13837   1 RNKWTEEETLALIEIWGERLELRFQESKKR-----NKKLWEEIAEKMAELG-YNRSPEQCKEKWENLKKK 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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