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Conserved domains on  [gi|2180230550|ref|NP_001386805|]
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DNA damage-binding protein 2 isoform D1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
95-221 1.47e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180230550  95 LHTLDSYRILQKAAPFDRRATSLAWHPTHpSTVAVGSKGGDIMLWNFGIKDKPTFIKG-------AAWHPRYNLIVVGRY 167
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLATGELLRTLTGhsggvnsVAFSPDGKLLASGSD 308

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2180230550 168 pDpnfksctpyelRTIDVFDGNSGKMMCQLyDPESSGISSLNeFNPMGDTLASA 221
Cdd:COG2319   309 -D-----------GTVRLWDLATGKLLRTL-TGHTGAVRSVA-FSPDGKTLASG 348
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
95-221 1.47e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180230550  95 LHTLDSYRILQKAAPFDRRATSLAWHPTHpSTVAVGSKGGDIMLWNFGIKDKPTFIKG-------AAWHPRYNLIVVGRY 167
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLATGELLRTLTGhsggvnsVAFSPDGKLLASGSD 308

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2180230550 168 pDpnfksctpyelRTIDVFDGNSGKMMCQLyDPESSGISSLNeFNPMGDTLASA 221
Cdd:COG2319   309 -D-----------GTVRLWDLATGKLLRTL-TGHTGAVRSVA-FSPDGKTLASG 348
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
95-221 1.47e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180230550  95 LHTLDSYRILQKAAPFDRRATSLAWHPTHpSTVAVGSKGGDIMLWNFGIKDKPTFIKG-------AAWHPRYNLIVVGRY 167
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSPDG-RLLASGSADGTVRLWDLATGELLRTLTGhsggvnsVAFSPDGKLLASGSD 308

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 2180230550 168 pDpnfksctpyelRTIDVFDGNSGKMMCQLyDPESSGISSLNeFNPMGDTLASA 221
Cdd:COG2319   309 -D-----------GTVRLWDLATGKLLRTL-TGHTGAVRSVA-FSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
111-230 1.48e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180230550 111 DRRATSLAWHPTHpSTVAVGSKGGDIMLWNFG-------IKDKPTFIKGAAWHPRYNLIVVGRYpDpnfksctpyelRTI 183
Cdd:COG2319   204 TGAVRSVAFSPDG-KLLASGSADGTVRLWDLAtgkllrtLTGHSGSVRSVAFSPDGRLLASGSA-D-----------GTV 270

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 2180230550 184 DVFDGNSGKMMcQLYDPESSGISSLnEFNPMGDTLASA-MGYHILIWS 230
Cdd:COG2319   271 RLWDLATGELL-RTLTGHSGGVNSV-AFSPDGKLLASGsDDGTVRLWD 316
WD40 COG2319
WD40 repeat [General function prediction only];
95-230 5.05e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 37.58  E-value: 5.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2180230550  95 LHTLDSYRILQKAAPFDRRATSLAWHPTHpSTVAVGSKGGDIMLWNFG-------IKDKPTFIKGAAWHPRYNLIVVGRY 167
Cdd:COG2319   146 LWDLATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLAtgkllrtLTGHTGAVRSVAFSPDGKLLASGSA 224

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2180230550 168 PdpnfksctpyelRTIDVFDGNSGKMMcQLYDPESSGISSLnEFNPMGDTLASAMGYH-ILIWS 230
Cdd:COG2319   225 D------------GTVRLWDLATGKLL-RTLTGHSGSVRSV-AFSPDGRLLASGSADGtVRLWD 274
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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