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Conserved domains on  [gi|2287780843|ref|NP_001397863|]
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zinc finger homeobox protein 4 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2201-2257 1.49e-20

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.56  E-value: 1.49e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2201 RSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARK 2257
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2580-2636 1.58e-20

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.17  E-value: 1.58e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2580 KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERK 2636
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2904-2960 4.64e-19

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 83.32  E-value: 4.64e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2904 KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKK 2960
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2104-2159 2.89e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.28  E-value: 2.89e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287780843  2104 KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKER 2159
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 super family cl35021
Homeodomain-containing transcription factor [Transcription];
2516-2638 2.26e-08

Homeodomain-containing transcription factor [Transcription];


The actual alignment was detected with superfamily member COG5576:

Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.91  E-value: 2.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2516 PNNPLmtgQLLGSSLTQMPPQASSSHTTapttvaaSLKRKLDDKEDNNCSEKEGGNSGEDqhRDKRLRTTitPEQLEILY 2595
Cdd:COG5576      2 PVQPM---QPLSALESQRMPQIRTIKTT-------KNKREVEAADSEMKLERKQDGSSPP--KSKRRRTT--DEQLMVLE 67

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2287780843 2596 EKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQ 2638
Cdd:COG5576     68 REFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
PHA02682 super family cl31817
ORF080 virion core protein; Provisional
 2324-2480 1.13e-04

ORF080 virion core protein; Provisional


The actual alignment was detected with superfamily member PHA02682:

Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.16  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2324 EDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAekPKQSDPSPpsqgtKPAL 2403
Cdd:PHA02682    44 DADVDPLDKYSVKEAGRYYQSRLKANSACMQRPSGQSPLAPSPACAAPAPACPACAPAAPA--PAVTCPAP-----APAC 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2404 PLASTSSDPPQASTAQPQPQPQPPkqpqligrPPSASQTPvPSSPLQISMTS-------LQNSLPPQllQYQCDQCtvaf 2476
Cdd:PHA02682   117 PPATAPTCPPPAVCPAPARPAPAC--------PPSTRQCP-PAPPLPTPKPApaakpifLHNQLPPP--DYPAASC---- 181


                   ....
gi 2287780843 2477 PTLE 2480
Cdd:PHA02682   182 PTIE 185
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2201-2257 1.49e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.56  E-value: 1.49e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2201 RSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARK 2257
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2580-2636 1.58e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.17  E-value: 1.58e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2580 KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERK 2636
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2904-2960 4.64e-19

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 83.32  E-value: 4.64e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2904 KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKK 2960
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2200-2256 1.93e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 81.53  E-value: 1.93e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843  2200 KRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKAR 2256
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2201-2258 8.09e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 79.59  E-value: 8.09e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2287780843 2201 RSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARKS 2258
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2580-2635 5.52e-17

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 77.29  E-value: 5.52e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287780843  2580 KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARER 2635
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2580-2638 7.18e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 76.90  E-value: 7.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2287780843 2580 KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQ 2638
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2104-2159 2.89e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.28  E-value: 2.89e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287780843  2104 KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKER 2159
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2904-2959 3.88e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 71.90  E-value: 3.88e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287780843  2904 KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEK 2959
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2904-2960 4.71e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.89  E-value: 4.71e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2904 KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKK 2960
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2104-2162 1.31e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 70.74  E-value: 1.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2287780843 2104 KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKERQRN 2162
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
2104-2163 4.88e-14

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 69.07  E-value: 4.88e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2104 KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTlfkeRQRNK 2163
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR----RAKWK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2193-2282 1.53e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.85  E-value: 1.53e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2193 KSDASFSKRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARKSYEnqaetKDNEKRE 2272
Cdd:COG5576     44 KQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS-----GKVEQRP 118

                           90
                   ....*....|
gi 2287780843 2273 LTNERYIRTS 2282
Cdd:COG5576    119 GEEEADLAKI 128
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2894-2962 8.90e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.14  E-value: 8.90e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2287780843 2894 KSKSNDRPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKKFK 2962
Cdd:COG5576     42 ERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2516-2638 2.26e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.91  E-value: 2.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2516 PNNPLmtgQLLGSSLTQMPPQASSSHTTapttvaaSLKRKLDDKEDNNCSEKEGGNSGEDqhRDKRLRTTitPEQLEILY 2595
Cdd:COG5576      2 PVQPM---QPLSALESQRMPQIRTIKTT-------KNKREVEAADSEMKLERKQDGSSPP--KSKRRRTT--DEQLMVLE 67

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2287780843 2596 EKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQ 2638
Cdd:COG5576     68 REFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 2324-2480 1.13e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.16  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2324 EDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAekPKQSDPSPpsqgtKPAL 2403
Cdd:PHA02682    44 DADVDPLDKYSVKEAGRYYQSRLKANSACMQRPSGQSPLAPSPACAAPAPACPACAPAAPA--PAVTCPAP-----APAC 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2404 PLASTSSDPPQASTAQPQPQPQPPkqpqligrPPSASQTPvPSSPLQISMTS-------LQNSLPPQllQYQCDQCtvaf 2476
Cdd:PHA02682   117 PPATAPTCPPPAVCPAPARPAPAC--------PPSTRQCP-PAPPLPTPKPApaakpifLHNQLPPP--DYPAASC---- 181


                   ....
gi 2287780843 2477 PTLE 2480
Cdd:PHA02682   182 PTIE 185
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2367-2448 4.22e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.16  E-value: 4.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2367 PSPKPEPEKTSPKPEYPAEKPKQSDPSPPsqgtKPALPLASTSSDPPQASTAQpqpqpqppkqpqligRPPSASQTPVPS 2446
Cdd:NF033838   422 PAPAPQPEKPAPKPEKPAEQPKAEKPADQ----QAEEDYARRSEEEYNRLTQQ---------------QPPKTEKPAQPS 482


                   ..
gi 2287780843 2447 SP 2448
Cdd:NF033838   483 TP 484
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2361-2546 3.71e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2361 TSTPLIPSPKPEPEKTS------PKPEYPAEKPKQSDPS--PPSQGTKPALPLASTSSDPpqasTAQPQPQPQPPKQPQL 2432
Cdd:pfam03154  176 AQSGAASPPSPPPPGTTqaatagPTPSAPSVPPQGSPATsqPPNQTQSTAAPHTLIQQTP----TLHPQRLPSPHPPLQP 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2433 IGRPPSASQTPVPSSP--------------LQISMTSLQNSLPPQ--LLQYQCDQCTVAFP--TLELWQEHQHMHFLAAQ 2494
Cdd:pfam03154  252 MTQPPPPSQVSPQPLPqpslhgqmppmphsLQTGPSHMQHPVPPQpfPLTPQSSQSQVPPGpsPAAPGQSQQRIHTPPSQ 331

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2287780843 2495 NQF------LHSPFLERPMDMPYMIFDPNNPlmtgqllgssLTQMP-PQASS--SHTTAPT 2546
Cdd:pfam03154  332 SQLqsqqppREQPLPPAPLSMPHIKPPPTTP----------IPQLPnPQSHKhpPHLSGPS 382
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
2201-2257 1.49e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.56  E-value: 1.49e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2201 RSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARK 2257
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2580-2636 1.58e-20

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 87.17  E-value: 1.58e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2580 KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERK 2636
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
2904-2960 4.64e-19

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 83.32  E-value: 4.64e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2904 KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKK 2960
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2200-2256 1.93e-18

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 81.53  E-value: 1.93e-18
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843  2200 KRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKAR 2256
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2201-2258 8.09e-18

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 79.59  E-value: 8.09e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2287780843 2201 RSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARKS 2258
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2580-2635 5.52e-17

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 77.29  E-value: 5.52e-17
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287780843  2580 KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARER 2635
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2580-2638 7.18e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 76.90  E-value: 7.18e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2287780843 2580 KRLRTTITPEQLEILYEKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQ 2638
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2104-2159 2.89e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.28  E-value: 2.89e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287780843  2104 KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKER 2159
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 2904-2959 3.88e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 71.90  E-value: 3.88e-15
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 2287780843  2904 KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEK 2959
Cdd:smart00389    2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2904-2960 4.71e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.89  E-value: 4.71e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 2287780843 2904 KRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKK 2960
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 2104-2162 1.31e-14

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 70.74  E-value: 1.31e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2287780843 2104 KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTLFKERQRN 2162
Cdd:cd00086      1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
2104-2163 4.88e-14

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 69.07  E-value: 4.88e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2104 KRPRTRITDDQLKILRAYFDINNSPSEEQIQEMAEKSGLSQKVIKHWFRNTlfkeRQRNK 2163
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNR----RAKWK 56
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2193-2282 1.53e-12

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 67.85  E-value: 1.53e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2193 KSDASFSKRSSRTRFTDYQLRVLQDFFDTNAYPKDDEIEQLSTVLNLPTRVIVVWFQNARQKARKSYEnqaetKDNEKRE 2272
Cdd:COG5576     44 KQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKRS-----GKVEQRP 118

                           90
                   ....*....|
gi 2287780843 2273 LTNERYIRTS 2282
Cdd:COG5576    119 GEEEADLAKI 128
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2894-2962 8.90e-10

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.14  E-value: 8.90e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2287780843 2894 KSKSNDRPGHKRFRTQMSNLQLKVLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKKFK 2962
Cdd:COG5576     42 ERKQDGSSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2516-2638 2.26e-08

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 55.91  E-value: 2.26e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2516 PNNPLmtgQLLGSSLTQMPPQASSSHTTapttvaaSLKRKLDDKEDNNCSEKEGGNSGEDqhRDKRLRTTitPEQLEILY 2595
Cdd:COG5576      2 PVQPM---QPLSALESQRMPQIRTIKTT-------KNKREVEAADSEMKLERKQDGSSPP--KSKRRRTT--DEQLMVLE 67

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2287780843 2596 EKYLLDSNPTRKMLDHIAREVGLKKRVVQVWFQNTRARERKGQ 2638
Cdd:COG5576     68 REFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR 110
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
2075-2214 1.55e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 53.59  E-value: 1.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2075 QMDALSADLTQLCQQQLGLDPNFLRH------------------SQFKRPRTRITDDQLKILRAYFDINNSPSEEQIQEM 2136
Cdd:COG5576      5 PMQPLSALESQRMPQIRTIKTTKNKReveaadsemklerkqdgsSPPKSKRRRTTDEQLMVLEREFEINPYPSSITRIKL 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2137 AEKSGLSQKVIKHWFRNtlfkERQRNKDSpYNFSN---PPITVLEDIRIDpqptSLEHYKSDASFSKRSSRTRFTDYQLR 2213
Cdd:COG5576     85 SLLLNMPPKSVQIWFQN----KRAKEKKK-RSGKVeqrPGEEEADLAKIG----SLSTGQISIIETLEFSRTSYEEGGLQ 155


                   .
gi 2287780843 2214 V 2214
Cdd:COG5576    156 Y 156
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 2324-2480 1.13e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 47.16  E-value: 1.13e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2324 EDSMDATDQVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPEKTSPKPEYPAekPKQSDPSPpsqgtKPAL 2403
Cdd:PHA02682    44 DADVDPLDKYSVKEAGRYYQSRLKANSACMQRPSGQSPLAPSPACAAPAPACPACAPAAPA--PAVTCPAP-----APAC 116

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2404 PLASTSSDPPQASTAQPQPQPQPPkqpqligrPPSASQTPvPSSPLQISMTS-------LQNSLPPQllQYQCDQCtvaf 2476
Cdd:PHA02682   117 PPATAPTCPPPAVCPAPARPAPAC--------PPSTRQCP-PAPPLPTPKPApaakpifLHNQLPPP--DYPAASC---- 181


                   ....
gi 2287780843 2477 PTLE 2480
Cdd:PHA02682   182 PTIE 185
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 2367-2448 4.22e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 46.16  E-value: 4.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2367 PSPKPEPEKTSPKPEYPAEKPKQSDPSPPsqgtKPALPLASTSSDPPQASTAQpqpqpqppkqpqligRPPSASQTPVPS 2446
Cdd:NF033838   422 PAPAPQPEKPAPKPEKPAEQPKAEKPADQ----QAEEDYARRSEEEYNRLTQQ---------------QPPKTEKPAQPS 482


                   ..
gi 2287780843 2447 SP 2448
Cdd:NF033838   483 TP 484
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
 2128-2153 1.47e-03

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 38.65  E-value: 1.47e-03
                           10        20
                   ....*....|....*....|....*.
gi 2287780843 2128 PSEEQIQEMAEKSGLSQKVIKHWFRN 2153
Cdd:pfam05920   10 PSEEEKAELAKETGLSRKQISNWFIN 35
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 2361-2546 3.71e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 3.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2361 TSTPLIPSPKPEPEKTS------PKPEYPAEKPKQSDPS--PPSQGTKPALPLASTSSDPpqasTAQPQPQPQPPKQPQL 2432
Cdd:pfam03154  176 AQSGAASPPSPPPPGTTqaatagPTPSAPSVPPQGSPATsqPPNQTQSTAAPHTLIQQTP----TLHPQRLPSPHPPLQP 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2433 IGRPPSASQTPVPSSP--------------LQISMTSLQNSLPPQ--LLQYQCDQCTVAFP--TLELWQEHQHMHFLAAQ 2494
Cdd:pfam03154  252 MTQPPPPSQVSPQPLPqpslhgqmppmphsLQTGPSHMQHPVPPQpfPLTPQSSQSQVPPGpsPAAPGQSQQRIHTPPSQ 331

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2287780843 2495 NQF------LHSPFLERPMDMPYMIFDPNNPlmtgqllgssLTQMP-PQASS--SHTTAPT 2546
Cdd:pfam03154  332 SQLqsqqppREQPLPPAPLSMPHIKPPPTTP----------IPQLPnPQSHKhpPHLSGPS 382
PRK10819 PRK10819
transport protein TonB; Provisional
 2367-2418 4.53e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 41.98  E-value: 4.53e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2287780843 2367 PSPKPEPEKTSPKPEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTA 2418
Cdd:PRK10819   103 PKPKPKPVKKVEEQPKREVKPVEPRPASPFENTAPARPTSSTATAAASKPVT 154
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2356-2448 9.82e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 9.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2287780843 2356 SSGSGTSTPLIP--SPKPEPEKTSPKPEY------PAEKPKQSDPSPPSQGTKPALPLASTSSDPPQASTAQPQPQPQPP 2427
Cdd:PHA03247  2545 SDDAGDPPPPLPpaAPPAAPDRSVPPPRPaprpsePAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAP 2624

                           90       100
                   ....*....|....*....|.
gi 2287780843 2428 kqpqligRPPSASQTPVPSSP 2448
Cdd:PHA03247  2625 -------DPPPPSPSPAANEP 2638
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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