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Conserved domains on  [gi|2311270592|ref|NP_001399341|]
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zinc finger protein 626 isoform 3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.77e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.77e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2311270592    4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-516 4.60e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 264 -------KAFMSSSTLSKHEIIHTEKKPYK--------------------------------CEECGKAFNRSSTLTTHK 304
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLsisnlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 305 IIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDkPYKCEECGKAFK-------YSSTLTTHKRIHTGE----------- 366
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPksllsqsPSSLSSSDSSSSASEsprsslptass 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 367 -----------------KPYKCEECGKAFKRSSDLTTHK--IIHTGE--KPYKCEE--CGKAFKYSSNLTTHKKIHTGER 423
Cdd:COG5048   271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 424 PYKC--EECGKAFNQSSI------LTTHKRIHTGEKFYKCE-ECGKAFKRSSHLTTHKIIHTGEKF--YKCEECDKAFKH 492
Cdd:COG5048   351 PAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410       420
                  ....*....|....*....|....
gi 2311270592 493 FSNLTTHKKIHTGKKPYRCEECGK 516
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKS 454
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.77e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2311270592    4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 7.13e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.13e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2311270592   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 2.88e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.88e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2311270592   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFL 43
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-516 4.60e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 264 -------KAFMSSSTLSKHEIIHTEKKPYK--------------------------------CEECGKAFNRSSTLTTHK 304
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLsisnlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 305 IIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDkPYKCEECGKAFK-------YSSTLTTHKRIHTGE----------- 366
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPksllsqsPSSLSSSDSSSSASEsprsslptass 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 367 -----------------KPYKCEECGKAFKRSSDLTTHK--IIHTGE--KPYKCEE--CGKAFKYSSNLTTHKKIHTGER 423
Cdd:COG5048   271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 424 PYKC--EECGKAFNQSSI------LTTHKRIHTGEKFYKCE-ECGKAFKRSSHLTTHKIIHTGEKF--YKCEECDKAFKH 492
Cdd:COG5048   351 PAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410       420
                  ....*....|....*....|....
gi 2311270592 493 FSNLTTHKKIHTGKKPYRCEECGK 516
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 2311270592 215 SLTRHKKIHTGEKPYKCEECGKAFKH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 1.77e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 1.77e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2311270592    4 LQFRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLGITVSKPDLITCLEQGRKP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-44 7.13e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.60  E-value: 7.13e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 2311270592   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFLG 44
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 6-43 2.88e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 2.88e-18
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2311270592   6 FRDVAIEFSLEEWHCLDTAQRNLYRNVMLENYSNLVFL 43
Cdd:cd07765     3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-516 4.60e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 74.35  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 199 KPYKCEECGKAFNHSCSLTRHKKIHTGEKPYKC--EECGKAFKHSSTLTTHKRNHTGEKPYKCDKCG------------- 263
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 264 -------KAFMSSSTLSKHEIIHTEKKPYK--------------------------------CEECGKAFNRSSTLTTHK 304
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLsisnlrnnplpgnnsssvntpqsnslhpplpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 305 IIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDkPYKCEECGKAFK-------YSSTLTTHKRIHTGE----------- 366
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPksllsqsPSSLSSSDSSSSASEsprsslptass 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 367 -----------------KPYKCEECGKAFKRSSDLTTHK--IIHTGE--KPYKCEE--CGKAFKYSSNLTTHKKIHTGER 423
Cdd:COG5048   271 qssspnesdsssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 424 PYKC--EECGKAFNQSSI------LTTHKRIHTGEKFYKCE-ECGKAFKRSSHLTTHKIIHTGEKF--YKCEECDKAFKH 492
Cdd:COG5048   351 PAKEklLNSSSKFSPLLNneppqsLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410       420
                  ....*....|....*....|....
gi 2311270592 493 FSNLTTHKKIHTGKKPYRCEECGK 516
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-525 4.92e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 4.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 227 KPYKCEECGKAFKHSSTLTTHKRNHTGEKPYKC--DKCGKAFMSSSTLSKHEIIHTEKKPYKCE---------------- 288
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 289 ECGKAFNRSSTLTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHKRIHTEDKPYKC--------EECGKAFKYSSTLTTHK 360
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSlhpplpanSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 361 RIHTGEKPYKCEECGKAFKRSSDLTTHKIIHTgEKPYKCEECGKAFKYSSNLTTHKKIHTGERPYKCEECGKAFNQSSIL 440
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 441 TTHKRIHTGE-------KFYKCEECGKAFKRSSHLTTHK--IIHTGEKFYKCEE----CDKAFKHFSNLTTHKKIHTGKK 507
Cdd:COG5048   271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSIS 350

                         330
                  ....*....|....*...
gi 2311270592 508 PYRCEECGKAFKHSSKLT 525
Cdd:COG5048   351 PAKEKLLNSSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-444 4.16e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 283 KPYKCEECGKAFNRSSTLTTHK--IIHTGE--KPYKCEE--CDKAFKYSYTLTTHKRIHTEDKPYKCEEC-------GKA 349
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 350 FKYSSTLTTHKRIHTGEKPYKCE--ECGKAFKRSSDLTTHKIIHTGEKP--YKCEECGKAFKYSSNLTTHKKIHTGERPY 425
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*....
gi 2311270592 426 KCEECGKAFNQSSILTTHK 444
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
311-466 1.83e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 311 KPYKCEECDKAFKYSYTLTTHKR--IHT--EDKPYKCEE--CGKAFKYSSTLTTHKRIHTGEKPYKC--EECGKAFKRSS 382
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 383 D-----LTTHKIIHTGEKPYKCE--ECGKAFKYSSNLTTHKKIHTGERP--YKCEECGKAFNQSSILTTHKRIHTGEKFY 453
Cdd:COG5048   368 NneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|...
gi 2311270592 454 KCEECGKAFKRSS 466
Cdd:COG5048   448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
267-539 1.88e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 1.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 267 MSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTTHKIIHTGEKPYKC--EECDKAFKYSYTLTTHKRIHTEDKPYKCE 344
Cdd:COG5048    16 LSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 345 ----------------ECGKAF---------------KYSSTLTTHKRIHTGEKPYK---------------------CE 372
Cdd:COG5048    96 kslplsnskasssslsSSSSNSndnnllsshslppssRDPQLPDLLSISNLRNNPLPgnnsssvntpqsnslhpplpaNS 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 373 ECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKAFKYSSNLTTHKKIHTGErPYKCEECGKAFNQSSI----LTTHKRIHT 448
Cdd:COG5048   176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLsqspSSLSSSDSS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 449 GE--KFYKCEECGKAFKRSSHLTTHKIIHTG-EKFYKCEECDKAFKHFSNLTTHK--KIHTGK--KPYRCEE--CGKAFK 519
Cdd:COG5048   255 SSasESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFS 334

                         330       340
                  ....*....|....*....|
gi 2311270592 520 HSSKLTTHKRFHTGEKPYRC 539
Cdd:COG5048   335 RNDALKRHILLHTSISPAKE 354
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 225-304 9.63e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 48.18  E-value: 9.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 225 GEKPYKCE--ECGKAFKHSSTLTTHKRNhtgekpykcDKCGKAFMSSSTLSKHEIIHTEKKPYKCEECGKAFNRSSTLTT 302
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 2311270592 303 HK 304
Cdd:COG5189   417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 329-417 3.32e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 329 TTHKRIHTED-KPYKCE--ECGKAFKYSSTLTTHKrihtgekpyKCEECGKAFKRSSDLTTHKIIHTGEKPYKCEECGKA 405
Cdd:COG5189   337 TPSRMLKVKDgKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKR 407

                          90
                  ....*....|..
gi 2311270592 406 FKYSSNLTTHKK 417
Cdd:COG5189   408 YKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 435-532 6.45e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 6.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 435 NQSSILTTHKRIHT-GEKFYKCE--ECGKAFKRSSHLTTHKII-HTGEKFYKCEECDKafkhfsnlttHKKIHTGKKPYR 510
Cdd:COG5189   331 GERNIDTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYR 400

                          90       100
                  ....*....|....*....|..
gi 2311270592 511 CEECGKAFKHSSKLTTHKRFHT 532
Cdd:COG5189   401 CEVCDKRYKNLNGLKYHRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 226-338 1.57e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 226 EKPYKCEECGKAFKHSSTLT--THKRNH--TGEKPYKCD--KCGKAFMSSSTLSKHEiihtekkpyKCEECGKAFNRSST 299
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNidTPSRMLkvKDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPS 385

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 2311270592 300 LTTHKIIHTGEKPYKCEECDKAFKYSYTLTTHkRIHTED 338
Cdd:COG5189   386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
215-240 1.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 2311270592 215 SLTRHKKIHTGEKPYKCEECGKAFKH 240
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-252 3.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2311270592 197 GGKPYKCE--ECGKAFNHSCSLTRHKK-------------------IHTGEKPYKCEECGKAFKHSSTLTTHKRNHT 252
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-380 5.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.62e-04
                          10        20
                  ....*....|....*....|....*
gi 2311270592 356 LTTHKRIHTGEKPYKCEECGKAFKR 380
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
495-520 7.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.40e-04
                          10        20
                  ....*....|....*....|....*.
gi 2311270592 495 NLTTHKKIHTGKKPYRCEECGKAFKH 520
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
411-436 8.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.08e-04
                          10        20
                  ....*....|....*....|....*.
gi 2311270592 411 NLTTHKKIHTGERPYKCEECGKAFNQ 436
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 1.94e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|....*.
gi 2311270592 383 DLTTHKIIHTGEKPYKCEECGKAFKY 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 334-444 2.04e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2311270592 334 IHTEDKPYKCEECGKAFKYSSTL---TTHKRIHT-GEKPYKCE--ECGKAFKRSSDLTTHKiihtgekpyKCEECGKAFK 407
Cdd:COG5189   311 IDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLH 381

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2311270592 408 YSSNLTTHKKIHTGERPYKCEECGKAFNQSSILTTHK 444
Cdd:COG5189   382 ENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 2.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.05e-03
                          10        20
                  ....*....|....*....|....*
gi 2311270592 300 LTTHKIIHTGEKPYKCEECDKAFKY 324
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-464 3.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.20e-03
                          10        20
                  ....*....|....*....|....*
gi 2311270592 440 LTTHKRIHTGEKFYKCEECGKAFKR 464
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
328-352 3.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.39e-03
                          10        20
                  ....*....|....*....|....*
gi 2311270592 328 LTTHKRIHTEDKPYKCEECGKAFKY 352
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-266 3.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.78e-03
                          10        20
                  ....*....|....*....|...
gi 2311270592 244 LTTHKRNHTGEKPYKCDKCGKAF 266
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-492 5.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.28e-03
                          10        20
                  ....*....|....*....|....*.
gi 2311270592 467 HLTTHKIIHTGEKFYKCEECDKAFKH 492
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-212 5.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|....*
gi 2311270592 188 LTTHKKIHTGGKPYKCEECGKAFNH 212
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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