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Conserved domains on  [gi|2327432583|ref|NP_001400606|]
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tumor suppressor candidate 3 isoform 10 [Homo sapiens]

Protein Classification

OST3/OST6 family protein( domain architecture ID 10520659)

OST3/OST6 family protein similar to Homo sapiens magnesium transporter protein 1 and tumor suppressor candidate 3, which are required for cellular magnesium uptake and vertebrate embryonic development

Gene Ontology:  GO:0022857
PubMed:  10358084
SCOP:  4005064

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
OST3_OST6 pfam04756
OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of ...
 1-198 2.60e-66

OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.


:

Pssm-ID: 461420  Cd Length: 294  Bit Score: 205.56  E-value: 2.60e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327432583   1 MNSAPTFMHFPPKGRPKRA----DTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRN 76
Cdd:pfam04756  93 LQTAPHLLLFPPTGGPKISdsepDQYDFTRGGFSAEQLAAFLSRHTGVPIPIKRPINYSKIIITFIIVLGVVTLLKKARP 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327432583  77 NL-EFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPhNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLN 155
Cdd:pfam04756 173 YLlPILQNRNLWAALSLIFILLFTSGYMFNHIRGVPYVARDG-KGGISYFAGGSQNQFGIETQIVAALYGLLALLVILLT 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2327432583 156 EAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 198
Cdd:pfam04756 252 IKVPRIKDPKVQRVAVIVWAGVLFLFFSFLLSVFRIKNPGYPF 294
 
Name Accession Description Interval E-value
OST3_OST6 pfam04756
OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of ...
 1-198 2.60e-66

OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.


Pssm-ID: 461420  Cd Length: 294  Bit Score: 205.56  E-value: 2.60e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327432583   1 MNSAPTFMHFPPKGRPKRA----DTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRN 76
Cdd:pfam04756  93 LQTAPHLLLFPPTGGPKISdsepDQYDFTRGGFSAEQLAAFLSRHTGVPIPIKRPINYSKIIITFIIVLGVVTLLKKARP 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327432583  77 NL-EFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPhNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLN 155
Cdd:pfam04756 173 YLlPILQNRNLWAALSLIFILLFTSGYMFNHIRGVPYVARDG-KGGISYFAGGSQNQFGIETQIVAALYGLLALLVILLT 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2327432583 156 EAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 198
Cdd:pfam04756 252 IKVPRIKDPKVQRVAVIVWAGVLFLFFSFLLSVFRIKNPGYPF 294
 
Name Accession Description Interval E-value
OST3_OST6 pfam04756
OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of ...
 1-198 2.60e-66

OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.


Pssm-ID: 461420  Cd Length: 294  Bit Score: 205.56  E-value: 2.60e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327432583   1 MNSAPTFMHFPPKGRPKRA----DTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRN 76
Cdd:pfam04756  93 LQTAPHLLLFPPTGGPKISdsepDQYDFTRGGFSAEQLAAFLSRHTGVPIPIKRPINYSKIIITFIIVLGVVTLLKKARP 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2327432583  77 NL-EFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPhNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLN 155
Cdd:pfam04756 173 YLlPILQNRNLWAALSLIFILLFTSGYMFNHIRGVPYVARDG-KGGISYFAGGSQNQFGIETQIVAALYGLLALLVILLT 251

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2327432583 156 EAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 198
Cdd:pfam04756 252 IKVPRIKDPKVQRVAVIVWAGVLFLFFSFLLSVFRIKNPGYPF 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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