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Conserved domains on  [gi|2566968170|ref|NP_001410896|]
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leucine-rich repeat transmembrane protein FLRT1 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-303 9.47e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 9.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  56 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 133
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 211
Cdd:COG4886   193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 212 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 290
Cdd:COG4886   263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                         250
                  ....*....|...
gi 2566968170 291 NLAQLLLRNNPWF 303
Cdd:COG4886   343 SLSLLALLTLLLL 355
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 272-378 1.59e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 64.72  E-value: 1.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  272 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 347
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2566968170  348 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 378
Cdd:TIGR00864   81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
LRRNT smart00013
Leucine rich repeat N-terminal domain;
26-56 2.20e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 2.20e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2566968170   26 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 56
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 413-477 1.33e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.33e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2566968170  413 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-303 9.47e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 9.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  56 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 133
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 211
Cdd:COG4886   193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 212 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 290
Cdd:COG4886   263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                         250
                  ....*....|...
gi 2566968170 291 NLAQLLLRNNPWF 303
Cdd:COG4886   343 SLSLLALLTLLLL 355
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-301 1.93e-23

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 105.55  E-value: 1.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  30 CRCDNGFIYCNDR-GLTSIPADIPDDATTLYLQNNQINNagIPQDLKTkvNVQVIYLYENDLDEFPINLPRSLRELHLQD 108
Cdd:PRK15370  175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 109 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 187
Cdd:PRK15370  251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 188 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 267
Cdd:PRK15370  322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2566968170 268 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 301
Cdd:PRK15370  393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-283 1.49e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 87.53  E-value: 1.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  56 TTLYLQNNQINnaGIPqDLKTKVNVQVIYLYENDLDEFPiNLP--RSLRELHLQDNNVRTIarDSLARIPLLEKLHLDDN 133
Cdd:cd21340     5 THLYLNDKNIT--KID-NLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNSLRRLVLDGNllanqriad 213
Cdd:cd21340    79 RISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN--------- 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2566968170 214 dtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDLSNNNLTTLPR 283
Cdd:cd21340   131 ----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
243-301 2.36e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 2.36e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 243 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 301
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 272-378 1.59e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 64.72  E-value: 1.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  272 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 347
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2566968170  348 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 378
Cdd:TIGR00864   81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-350 1.40e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 51.28  E-value: 1.40e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2566968170  300 NPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 350
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRRNT smart00013
Leucine rich repeat N-terminal domain;
26-56 2.20e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 2.20e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2566968170   26 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 56
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 26-52 1.04e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 1.04e-05
                          10        20
                  ....*....|....*....|....*..
gi 2566968170  26 CPSVCRCDNGFIYCNDRGLTSIPADIP 52
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 413-477 1.33e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.33e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2566968170  413 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
LRR smart00370
Leucine-rich repeats, outliers;
265-288 1.40e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 1.40e-04
                           10        20
                   ....*....|....*....|....
gi 2566968170  265 MRELERLDLSNNNLTTLPRGLFDD 288
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
fn3 pfam00041
Fibronectin type III domain;
413-481 1.83e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.83e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2566968170 413 IHVKALTADSIRITWKATLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 481
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-477 5.24e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 5.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 413 IHVKALTADSIRITWKA----TLPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-303 9.47e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.41  E-value: 9.47e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  56 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 133
Cdd:COG4886   116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 211
Cdd:COG4886   193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 212 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 290
Cdd:COG4886   263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                         250
                  ....*....|...
gi 2566968170 291 NLAQLLLRNNPWF 303
Cdd:COG4886   343 SLSLLALLTLLLL 355
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
40-300 3.15e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.79  E-value: 3.15e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  40 NDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArD 117
Cdd:COG4886    75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-E 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 118 SLARIPLLEKLHLDDNSVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGL--PHTLEELRLDDNRISTIPLhAFKGLNS 195
Cdd:COG4886   154 PLGNLTNLKSLDLSNNQLTDLP---EELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 196 LRRLVLDGNllanqRIAD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLS 274
Cdd:COG4886   230 LETLDLSNN-----QLTDlPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304

                         250       260
                  ....*....|....*....|....*.
gi 2566968170 275 NNNLTTLPRGLFDDLGNLAQLLLRNN 300
Cdd:COG4886   305 LLLLNLLELLILLLLLTTLLLLLLLL 330
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-301 1.93e-23

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 105.55  E-value: 1.93e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  30 CRCDNGFIYCNDR-GLTSIPADIPDDATTLYLQNNQINNagIPQDLKTkvNVQVIYLYENDLDEFPINLPRSLRELHLQD 108
Cdd:PRK15370  175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 109 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 187
Cdd:PRK15370  251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 188 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 267
Cdd:PRK15370  322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 2566968170 268 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 301
Cdd:PRK15370  393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-311 3.40e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 3.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  56 TTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSV 135
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 136 STVSIEEDAFADSKQLKLLFLSRN-HLSSIPSglphtLEELRLDDNRISTIPlHAFKGLNSLRRLVLDGNLLANqriADD 214
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTELDLSGNeELSNLTN-----LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD---LPE 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 215 TFSRLQNLTELSLVRN---SLAAPPLNLPsaHLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLTTLPRGLfDDLGN 291
Cdd:COG4886   154 PLGNLTNLKSLDLSNNqltDLPEELGNLT--NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTN 229

                         250       260
                  ....*....|....*....|....*.
gi 2566968170 292 LAQLLLRNN-----PWFCGC-NLMWL 311
Cdd:COG4886   230 LETLDLSNNqltdlPELGNLtNLEEL 255
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-283 1.49e-19

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 87.53  E-value: 1.49e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  56 TTLYLQNNQINnaGIPqDLKTKVNVQVIYLYENDLDEFPiNLP--RSLRELHLQDNNVRTIarDSLARIPLLEKLHLDDN 133
Cdd:cd21340     5 THLYLNDKNIT--KID-NLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNSLRRLVLDGNllanqriad 213
Cdd:cd21340    79 RISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN--------- 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2566968170 214 dtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDLSNNNLTTLPR 283
Cdd:cd21340   131 ----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-290 4.71e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 4.71e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  37 IYCNDRGLTSIPADIPDDA--TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINL--PRSLRELHLQDNNVR 112
Cdd:COG4886   141 LDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 113 TIArDSLARIPLLEKLHLDDNSVSTVSieedAFADSKQLKLLFLSRNHLSSIPSGLPHT-LEELRLDDNRISTIPLHAFK 191
Cdd:COG4886   219 DLP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELE 293

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 192 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERL 271
Cdd:COG4886   294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                         250
                  ....*....|....*....
gi 2566968170 272 DLSNNNLTTLPRGLFDDLG 290
Cdd:COG4886   374 LLEATLLTLALLLLTLLLL 392
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
75-292 2.53e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 76.66  E-value: 2.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  75 KTKVNVQVIY---LYENDLDEFPiNLPRSLRELH--LQDNNVR-TIARDSLARIPL-----LEKLHLDDNSVstVSIEED 143
Cdd:PRK15370  141 KDAVNYELIWsewVKEAPAKEAA-NREEAVQRMRdcLKNNKTElRLKILGLTTIPAcipeqITTLILDNNEL--KSLPEN 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 144 AFADskqLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSlrrLVLDGNLLAnqrIADDTFSrlQNLT 223
Cdd:PRK15370  218 LQGN---IKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKIS---CLPENLP--EELR 286

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 224 ELSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPyNTLAKmrELERLDLSNNNLTTLPRGLFDDLGNL 292
Cdd:PRK15370  287 YLSVYDNSIRTLPAHLPSG-ITHLNVQSNSLTALP-ETLPP--GLKTLEAGENALTSLPASLPPELQVL 351
LRR_8 pfam13855
Leucine rich repeat;
243-301 2.36e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.46  E-value: 2.36e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 243 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 301
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 47-299 8.84e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.25  E-value: 8.84e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  47 IPADI--PDDATTLYLQNNQINNAgIPQDLKTKVNVQVIYLYENDLD-EFPINLP--RSLRELHLQDNNVRTIARDSLAR 121
Cdd:PLN00113  348 IPKNLgkHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTK 426

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 122 IPLLEKLHLDDNSVSTvSIEEDAFaDSKQLKLLFLSRNHLSSipsGLPHT-----LEELRLDDNRIS-TIPLhAFKGLNS 195
Cdd:PLN00113  427 LPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRNQFSgAVPR-KLGSLSE 500

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 196 LRRLVLDGNLLANQriADDTFSRLQNLTELSLVRNSLAApplnlpsahlqklylqdnaisHIPyNTLAKMRELERLDLSN 275
Cdd:PLN00113  501 LMQLKLSENKLSGE--IPDELSSCKKLVSLDLSHNQLSG---------------------QIP-ASFSEMPVLSQLDLSQ 556

                         250       260
                  ....*....|....*....|....*
gi 2566968170 276 NNLT-TLPRglfdDLGNLAQLLLRN 299
Cdd:PLN00113  557 NQLSgEIPK----NLGNVESLVQVN 577
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 272-378 1.59e-10

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 64.72  E-value: 1.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  272 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 347
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 2566968170  348 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 378
Cdd:TIGR00864   81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
LRR_8 pfam13855
Leucine rich repeat;
150-206 3.03e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 3.03e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2566968170 150 QLKLLFLSRNHLSSIP----SGLPHtLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLL 206
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 99-304 6.85e-10

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 60.83  E-value: 6.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  99 RSLRELHLQDNNVRTIA----RDSLARIPLLEKLHLDDN----SVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGL-- 168
Cdd:cd00116    23 LCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVle 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 169 ----PHTLEELRLDDNRISTIPL-HAFKGLNS----LRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAAPPL 237
Cdd:cd00116   103 sllrSSSLQELKLNNNGLGDRGLrLLAKGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDAGI 182

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2566968170 238 NL------PSAHLQKLYLQDNAISHIPY----NTLAKMRELERLDLSNNNLTTLP-RGLFDDLGNLAQLLLRNNPWFC 304
Cdd:cd00116   183 RAlaeglkANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
34-279 7.30e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.02  E-value: 7.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  34 NGFIYCNDRGLTSIPADIPDDATTLYLQNNQINN-AGIPQDLKTkvnvqvIYLYENDLDEFPInLPRSLRELHLQDNNVR 112
Cdd:PRK15387  203 NAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELRT------LEVSGNQLTSLPV-LPPGLLELSIFSNPLT 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 113 T------------IARDSLARIPL----LEKLHLDDNSVSTVSieedafADSKQLKLLFLSRNHLSSIPSgLPHTLEELR 176
Cdd:PRK15387  276 HlpalpsglcklwIFGNQLTSLPVlppgLQELSVSDNQLASLP------ALPSELCKLWAYNNQLTSLPT-LPSGLQELS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 177 LDDNRISTIP---------------LHAFKGLNS-LRRLVLDGNLLANQRIADdtfsrlQNLTELSLVRNSLAAPPLnLP 240
Cdd:PRK15387  349 VSDNQLASLPtlpselyklwaynnrLTSLPALPSgLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LP 421

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 2566968170 241 SAhLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLT 279
Cdd:PRK15387  422 SG-LLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPLS 458
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-350 1.40e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 51.28  E-value: 1.40e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2566968170  300 NPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 350
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
99-161 3.26e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 3.26e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2566968170  99 RSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTvsIEEDAFADSKQLKLLFLSRNHL 161
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
195-278 6.54e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 195 SLRRLVLDGNLLanQRIADDTFSRLQNLTELslvrnslaapplnlpsahlqklYLQDNAISHIPYNTLAKMRELERLDLS 274
Cdd:pfam13855   2 NLRSLDLSNNRL--TSLDDGAFKGLSNLKVL----------------------DLSNNLLTTLSPGAFSGLPSLRYLDLS 57


                  ....
gi 2566968170 275 NNNL 278
Cdd:pfam13855  58 GNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 70-300 6.53e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.54  E-value: 6.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  70 IPQDLKTKVNVQVIYLYENDLD-EFPI---NLPRsLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVsTVSIEEDAF 145
Cdd:PLN00113  300 IPELVIQLQNLEILHLFSNNFTgKIPValtSLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL-TGEIPEGLC 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 146 ADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANqRIADDTFSrLQNLT 223
Cdd:PLN00113  378 SSGNLFKLILFSNSLEGEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQG-RINSRKWD-MPSLQ 455

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 224 ELSLVRNSLAApplNLP----SAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLT-TLPRGLfDDLGNLAQLLLR 298
Cdd:PLN00113  456 MLSLARNKFFG---GLPdsfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDEL-SSCKKLVSLDLS 531


                  ..
gi 2566968170 299 NN 300
Cdd:PLN00113  532 HN 533
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 101-287 8.72e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 8.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 101 LRELHLQDN-----NVRTIArdSLARIPLLEKLHLDDNSVST--VSIEEDAFADSK-QLKLLFLSRNHLSSIPS-----G 167
Cdd:cd00116    83 LQELDLSDNalgpdGCGVLE--SLLRSSSLQELKLNNNGLGDrgLRLLAKGLKDLPpALEKLVLGRNRLEGASCealakA 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 168 LPH--TLEELRLDDNRIST--IPL--HAFKGLNSLRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAapplNL 239
Cdd:cd00116   161 LRAnrDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLT----DA 236

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2566968170 240 PSAHLQKLYLQDNaishipyntlakmRELERLDLSNNNLT-----TLPRGLFD 287
Cdd:cd00116   237 GAAALASALLSPN-------------ISLLTLSLSCNDITddgakDLAEVLAE 276
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 57-300 2.11e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  57 TLYLQNNQINnAGIPQDLKTkvnvqviylyendldefpinLPRSLRELHLQDNNVR-TIARDSlarIPLLEKLHLDDNSV 135
Cdd:PLN00113   97 TINLSNNQLS-GPIPDDIFT--------------------TSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNML 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 136 STVSIEEDAFADSkqLKLLFLSRNHLSS-IPSGLPH--TLEELRLDDNR-ISTIPlHAFKGLNSLRRLVLDGNLLANQri 211
Cdd:PLN00113  153 SGEIPNDIGSFSS--LKVLDLGGNVLVGkIPNSLTNltSLEFLTLASNQlVGQIP-RELGQMKSLKWIYLGYNNLSGE-- 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 212 ADDTFSRLQNLTELSLVRNSLAAPplnLPSA-----HLQKLYLQDNAIS-HIPyNTLAKMRELERLDLSNNNLTTLPRGL 285
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLVYNNLTGP---IPSSlgnlkNLQYLFLYQNKLSgPIP-PSIFSLQKLISLDLSDNSLSGEIPEL 303

                         250
                  ....*....|....*
gi 2566968170 286 FDDLGNLAQLLLRNN 300
Cdd:PLN00113  304 VIQLQNLEILHLFSN 318
LRRNT smart00013
Leucine rich repeat N-terminal domain;
26-56 2.20e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 44.62  E-value: 2.20e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2566968170   26 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 56
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 26-52 1.04e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 42.61  E-value: 1.04e-05
                          10        20
                  ....*....|....*....|....*..
gi 2566968170  26 CPSVCRCDNGFIYCNDRGLTSIPADIP 52
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 413-477 1.33e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.06  E-value: 1.33e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2566968170  413 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:smart00060   7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
LRR smart00370
Leucine-rich repeats, outliers;
265-288 1.40e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 1.40e-04
                           10        20
                   ....*....|....*....|....
gi 2566968170  265 MRELERLDLSNNNLTTLPRGLFDD 288
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
265-288 1.40e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 39.26  E-value: 1.40e-04
                           10        20
                   ....*....|....*....|....
gi 2566968170  265 MRELERLDLSNNNLTTLPRGLFDD 288
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
fn3 pfam00041
Fibronectin type III domain;
413-481 1.83e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 40.48  E-value: 1.83e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2566968170 413 IHVKALTADSIRITWKATLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 481
Cdd:pfam00041   6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 56-182 1.86e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 1.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170  56 TTLYLQNNQINNAG---IPQDLKTKVNVQVIYLYENDL-DEFPINLPRSLR------ELHLQDNNVRTIARDSLARI--- 122
Cdd:COG5238   267 ETLYLSGNQIGAEGaiaLAKALQGNTTLTSLDLSVNRIgDEGAIALAEGLQgnktlhTLNLAYNGIGAQGAIALAKAlqe 346

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 123 -PLLEKLHLDDNSVSTVSIEE--DAFADSKQLKLLFLSRNHLSS------IPSGLPHTLEELRLDDNRI 182
Cdd:COG5238   347 nTTLHSLDLSDNQIGDEGAIAlaKYLEGNTTLRELNLGKNNIGKqgaealIDALQTNRLHTLILDGNLI 415
LRR_8 pfam13855
Leucine rich repeat;
266-300 3.47e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 3.47e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 2566968170 266 RELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNN 300
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 413-477 5.24e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.40  E-value: 5.24e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 413 IHVKALTADSIRITWKA----TLPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:cd00063     7 LRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 243-280 3.49e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 3.49e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 2566968170 243 HLQKLYLQDNAISHIPynTLAKMRELERLDLSNNNLTT 280
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 125-223 8.91e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 36.75  E-value: 8.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 125 LEKLHLDDNsvsTVSIEEDAFADSKQLKLLFLSRNhLSSIPSglpHT-----LEELRLDDNrISTIPLHAFKGLNSLRRL 199
Cdd:pfam13306  13 LTSITIPSS---LTSIGEYAFSNCTSLKSITLPSS-LTSIGS---YAfyncsLTSITIPSS-LTSIGEYAFSNCSNLKSI 84

                          90       100
                  ....*....|....*....|....*.
gi 2566968170 200 VLDGNLlanQRIADDTF--SRLQNLT 223
Cdd:pfam13306  85 TLPSNL---TSIGSYAFsnCSLKSIT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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