|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
56-303 |
9.47e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 110.41 E-value: 9.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 56 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 133
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 211
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 212 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 290
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
|
250
....*....|...
gi 2566968170 291 NLAQLLLRNNPWF 303
Cdd:COG4886 343 SLSLLALLTLLLL 355
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
30-301 |
1.93e-23 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 105.55 E-value: 1.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 30 CRCDNGFIYCNDR-GLTSIPADIPDDATTLYLQNNQINNagIPQDLKTkvNVQVIYLYENDLDEFPINLPRSLRELHLQD 108
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 109 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 187
Cdd:PRK15370 251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 188 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 267
Cdd:PRK15370 322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392
|
250 260 270
....*....|....*....|....*....|....*..
gi 2566968170 268 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 301
Cdd:PRK15370 393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
56-283 |
1.49e-19 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 87.53 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 56 TTLYLQNNQINnaGIPqDLKTKVNVQVIYLYENDLDEFPiNLP--RSLRELHLQDNNVRTIarDSLARIPLLEKLHLDDN 133
Cdd:cd21340 5 THLYLNDKNIT--KID-NLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNSLRRLVLDGNllanqriad 213
Cdd:cd21340 79 RISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN--------- 130
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2566968170 214 dtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDLSNNNLTTLPR 283
Cdd:cd21340 131 ----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
243-301 |
2.36e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.46 E-value: 2.36e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 243 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 301
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
272-378 |
1.59e-10 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 64.72 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 272 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 347
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 2566968170 348 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 378
Cdd:TIGR00864 81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
300-350 |
1.40e-08 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 51.28 E-value: 1.40e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2566968170 300 NPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 350
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
26-56 |
2.20e-06 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 44.62 E-value: 2.20e-06
10 20 30
....*....|....*....|....*....|.
gi 2566968170 26 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 56
Cdd:smart00013 2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
26-52 |
1.04e-05 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 42.61 E-value: 1.04e-05
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
413-477 |
1.33e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 41.06 E-value: 1.33e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2566968170 413 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
265-288 |
1.40e-04 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 39.26 E-value: 1.40e-04
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
413-481 |
1.83e-04 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 40.48 E-value: 1.83e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2566968170 413 IHVKALTADSIRITWKATLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 481
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
413-477 |
5.24e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.40 E-value: 5.24e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 413 IHVKALTADSIRITWKA----TLPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
56-303 |
9.47e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 110.41 E-value: 9.47e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 56 TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 133
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 211
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 212 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 290
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
|
250
....*....|...
gi 2566968170 291 NLAQLLLRNNPWF 303
Cdd:COG4886 343 SLSLLALLTLLLL 355
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
40-300 |
3.15e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 105.79 E-value: 3.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 40 NDRGLTSIPADIPDDATTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArD 117
Cdd:COG4886 75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-E 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 118 SLARIPLLEKLHLDDNSVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGL--PHTLEELRLDDNRISTIPLhAFKGLNS 195
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLP---EELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 196 LRRLVLDGNllanqRIAD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLS 274
Cdd:COG4886 230 LETLDLSNN-----QLTDlPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLL 304
|
250 260
....*....|....*....|....*.
gi 2566968170 275 NNNLTTLPRGLFDDLGNLAQLLLRNN 300
Cdd:COG4886 305 LLLLNLLELLILLLLLTTLLLLLLLL 330
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
30-301 |
1.93e-23 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 105.55 E-value: 1.93e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 30 CRCDNGFIYCNDR-GLTSIPADIPDDATTLYLQNNQINNagIPQDLKTkvNVQVIYLYENDLDEFPINLPRSLRELHLQD 108
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQG--NIKTLYANSNQLTSIPATLPDTIQEMELSI 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 109 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 187
Cdd:PRK15370 251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 188 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 267
Cdd:PRK15370 322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392
|
250 260 270
....*....|....*....|....*....|....*..
gi 2566968170 268 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 301
Cdd:PRK15370 393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
56-311 |
3.40e-21 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 96.54 E-value: 3.40e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 56 TTLYLQNNQINNAGIPQDLKTKVNVQVIYLYENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSV 135
Cdd:COG4886 3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 136 STVSIEEDAFADSKQLKLLFLSRN-HLSSIPSglphtLEELRLDDNRISTIPlHAFKGLNSLRRLVLDGNLLANqriADD 214
Cdd:COG4886 83 SLLLLGLTDLGDLTNLTELDLSGNeELSNLTN-----LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD---LPE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 215 TFSRLQNLTELSLVRN---SLAAPPLNLPsaHLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLTTLPRGLfDDLGN 291
Cdd:COG4886 154 PLGNLTNLKSLDLSNNqltDLPEELGNLT--NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTN 229
|
250 260
....*....|....*....|....*.
gi 2566968170 292 LAQLLLRNN-----PWFCGC-NLMWL 311
Cdd:COG4886 230 LETLDLSNNqltdlPELGNLtNLEEL 255
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
56-283 |
1.49e-19 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 87.53 E-value: 1.49e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 56 TTLYLQNNQINnaGIPqDLKTKVNVQVIYLYENDLDEFPiNLP--RSLRELHLQDNNVRTIarDSLARIPLLEKLHLDDN 133
Cdd:cd21340 5 THLYLNDKNIT--KID-NLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 134 SVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNSLRRLVLDGNllanqriad 213
Cdd:cd21340 79 RISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN--------- 130
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2566968170 214 dtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDLSNNNLTTLPR 283
Cdd:cd21340 131 ----NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPK 185
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
37-290 |
4.71e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 89.99 E-value: 4.71e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 37 IYCNDRGLTSIPADIPDDA--TTLYLQNNQINNagIPQDLKTKVNVQVIYLYENDLDEFPINL--PRSLRELHLQDNNVR 112
Cdd:COG4886 141 LDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 113 TIArDSLARIPLLEKLHLDDNSVSTVSieedAFADSKQLKLLFLSRNHLSSIPSGLPHT-LEELRLDDNRISTIPLHAFK 191
Cdd:COG4886 219 DLP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELE 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 192 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERL 271
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
|
250
....*....|....*....
gi 2566968170 272 DLSNNNLTTLPRGLFDDLG 290
Cdd:COG4886 374 LLEATLLTLALLLLTLLLL 392
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
75-292 |
2.53e-14 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 76.66 E-value: 2.53e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 75 KTKVNVQVIY---LYENDLDEFPiNLPRSLRELH--LQDNNVR-TIARDSLARIPL-----LEKLHLDDNSVstVSIEED 143
Cdd:PRK15370 141 KDAVNYELIWsewVKEAPAKEAA-NREEAVQRMRdcLKNNKTElRLKILGLTTIPAcipeqITTLILDNNEL--KSLPEN 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 144 AFADskqLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPLHAFKGLNSlrrLVLDGNLLAnqrIADDTFSrlQNLT 223
Cdd:PRK15370 218 LQGN---IKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKIS---CLPENLP--EELR 286
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 224 ELSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPyNTLAKmrELERLDLSNNNLTTLPRGLFDDLGNL 292
Cdd:PRK15370 287 YLSVYDNSIRTLPAHLPSG-ITHLNVQSNSLTALP-ETLPP--GLKTLEAGENALTSLPASLPPELQVL 351
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
243-301 |
2.36e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.46 E-value: 2.36e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 243 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 301
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
47-299 |
8.84e-11 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 65.25 E-value: 8.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 47 IPADI--PDDATTLYLQNNQINNAgIPQDLKTKVNVQVIYLYENDLD-EFPINLP--RSLRELHLQDNNVRTIARDSLAR 121
Cdd:PLN00113 348 IPKNLgkHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTK 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 122 IPLLEKLHLDDNSVSTvSIEEDAFaDSKQLKLLFLSRNHLSSipsGLPHT-----LEELRLDDNRIS-TIPLhAFKGLNS 195
Cdd:PLN00113 427 LPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRNQFSgAVPR-KLGSLSE 500
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 196 LRRLVLDGNLLANQriADDTFSRLQNLTELSLVRNSLAApplnlpsahlqklylqdnaisHIPyNTLAKMRELERLDLSN 275
Cdd:PLN00113 501 LMQLKLSENKLSGE--IPDELSSCKKLVSLDLSHNQLSG---------------------QIP-ASFSEMPVLSQLDLSQ 556
|
250 260
....*....|....*....|....*
gi 2566968170 276 NNLT-TLPRglfdDLGNLAQLLLRN 299
Cdd:PLN00113 557 NQLSgEIPK----NLGNVESLVQVN 577
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
272-378 |
1.59e-10 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 64.72 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 272 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVKARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 347
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 2566968170 348 DE----CFETGPQGGVANAAAKTT-ASNHASATTPQ 378
Cdd:TIGR00864 81 DEeyvaCLKDNSSGGGAARSELVIfSAAHEGLFQPE 116
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
150-206 |
3.03e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.99 E-value: 3.03e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2566968170 150 QLKLLFLSRNHLSSIP----SGLPHtLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLL 206
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
99-304 |
6.85e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 60.83 E-value: 6.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 99 RSLRELHLQDNNVRTIA----RDSLARIPLLEKLHLDDN----SVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGL-- 168
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVle 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 169 ----PHTLEELRLDDNRISTIPL-HAFKGLNS----LRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAAPPL 237
Cdd:cd00116 103 sllrSSSLQELKLNNNGLGDRGLrLLAKGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDAGI 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2566968170 238 NL------PSAHLQKLYLQDNAISHIPY----NTLAKMRELERLDLSNNNLTTLP-RGLFDDLGNLAQLLLRNNPWFC 304
Cdd:cd00116 183 RAlaeglkANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
34-279 |
7.30e-09 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 59.02 E-value: 7.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 34 NGFIYCNDRGLTSIPADIPDDATTLYLQNNQINN-AGIPQDLKTkvnvqvIYLYENDLDEFPInLPRSLRELHLQDNNVR 112
Cdd:PRK15387 203 NAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELRT------LEVSGNQLTSLPV-LPPGLLELSIFSNPLT 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 113 T------------IARDSLARIPL----LEKLHLDDNSVSTVSieedafADSKQLKLLFLSRNHLSSIPSgLPHTLEELR 176
Cdd:PRK15387 276 HlpalpsglcklwIFGNQLTSLPVlppgLQELSVSDNQLASLP------ALPSELCKLWAYNNQLTSLPT-LPSGLQELS 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 177 LDDNRISTIP---------------LHAFKGLNS-LRRLVLDGNLLANQRIADdtfsrlQNLTELSLVRNSLAAPPLnLP 240
Cdd:PRK15387 349 VSDNQLASLPtlpselyklwaynnrLTSLPALPSgLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LP 421
|
250 260 270
....*....|....*....|....*....|....*....
gi 2566968170 241 SAhLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLT 279
Cdd:PRK15387 422 SG-LLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPLS 458
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
300-350 |
1.40e-08 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 51.28 E-value: 1.40e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2566968170 300 NPWFCGCNLMWLRDWVKARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 350
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
99-161 |
3.26e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.22 E-value: 3.26e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2566968170 99 RSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTvsIEEDAFADSKQLKLLFLSRNHL 161
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
195-278 |
6.54e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.45 E-value: 6.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 195 SLRRLVLDGNLLanQRIADDTFSRLQNLTELslvrnslaapplnlpsahlqklYLQDNAISHIPYNTLAKMRELERLDLS 274
Cdd:pfam13855 2 NLRSLDLSNNRL--TSLDDGAFKGLSNLKVL----------------------DLSNNLLTTLSPGAFSGLPSLRYLDLS 57
|
....
gi 2566968170 275 NNNL 278
Cdd:pfam13855 58 GNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
70-300 |
6.53e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 52.54 E-value: 6.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 70 IPQDLKTKVNVQVIYLYENDLD-EFPI---NLPRsLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVsTVSIEEDAF 145
Cdd:PLN00113 300 IPELVIQLQNLEILHLFSNNFTgKIPValtSLPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL-TGEIPEGLC 377
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 146 ADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLLANqRIADDTFSrLQNLT 223
Cdd:PLN00113 378 SSGNLFKLILFSNSLEGEIPKSLGacRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQG-RINSRKWD-MPSLQ 455
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 224 ELSLVRNSLAApplNLP----SAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLT-TLPRGLfDDLGNLAQLLLR 298
Cdd:PLN00113 456 MLSLARNKFFG---GLPdsfgSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDEL-SSCKKLVSLDLS 531
|
..
gi 2566968170 299 NN 300
Cdd:PLN00113 532 HN 533
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
101-287 |
8.72e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.20 E-value: 8.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 101 LRELHLQDN-----NVRTIArdSLARIPLLEKLHLDDNSVST--VSIEEDAFADSK-QLKLLFLSRNHLSSIPS-----G 167
Cdd:cd00116 83 LQELDLSDNalgpdGCGVLE--SLLRSSSLQELKLNNNGLGDrgLRLLAKGLKDLPpALEKLVLGRNRLEGASCealakA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 168 LPH--TLEELRLDDNRIST--IPL--HAFKGLNSLRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAapplNL 239
Cdd:cd00116 161 LRAnrDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLT----DA 236
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 2566968170 240 PSAHLQKLYLQDNaishipyntlakmRELERLDLSNNNLT-----TLPRGLFD 287
Cdd:cd00116 237 GAAALASALLSPN-------------ISLLTLSLSCNDITddgakDLAEVLAE 276
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
57-300 |
2.11e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.00 E-value: 2.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 57 TLYLQNNQINnAGIPQDLKTkvnvqviylyendldefpinLPRSLRELHLQDNNVR-TIARDSlarIPLLEKLHLDDNSV 135
Cdd:PLN00113 97 TINLSNNQLS-GPIPDDIFT--------------------TSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNML 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 136 STVSIEEDAFADSkqLKLLFLSRNHLSS-IPSGLPH--TLEELRLDDNR-ISTIPlHAFKGLNSLRRLVLDGNLLANQri 211
Cdd:PLN00113 153 SGEIPNDIGSFSS--LKVLDLGGNVLVGkIPNSLTNltSLEFLTLASNQlVGQIP-RELGQMKSLKWIYLGYNNLSGE-- 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 212 ADDTFSRLQNLTELSLVRNSLAAPplnLPSA-----HLQKLYLQDNAIS-HIPyNTLAKMRELERLDLSNNNLTTLPRGL 285
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLVYNNLTGP---IPSSlgnlkNLQYLFLYQNKLSgPIP-PSIFSLQKLISLDLSDNSLSGEIPEL 303
|
250
....*....|....*
gi 2566968170 286 FDDLGNLAQLLLRNN 300
Cdd:PLN00113 304 VIQLQNLEILHLFSN 318
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
26-56 |
2.20e-06 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 44.62 E-value: 2.20e-06
10 20 30
....*....|....*....|....*....|.
gi 2566968170 26 CPSVCRCDNGFIYCNDRGLTSIPADIPDDAT 56
Cdd:smart00013 2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
26-52 |
1.04e-05 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 42.61 E-value: 1.04e-05
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
413-477 |
1.33e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 41.06 E-value: 1.33e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2566968170 413 IHVKALTADSIRITWKATLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
265-288 |
1.40e-04 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 39.26 E-value: 1.40e-04
|
| LRR_TYP |
smart00369 |
Leucine-rich repeats, typical (most populated) subfamily; |
265-288 |
1.40e-04 |
|
Leucine-rich repeats, typical (most populated) subfamily;
Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 39.26 E-value: 1.40e-04
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
413-481 |
1.83e-04 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 40.48 E-value: 1.83e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2566968170 413 IHVKALTADSIRITWKATLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 481
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
56-182 |
1.86e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 56 TTLYLQNNQINNAG---IPQDLKTKVNVQVIYLYENDL-DEFPINLPRSLR------ELHLQDNNVRTIARDSLARI--- 122
Cdd:COG5238 267 ETLYLSGNQIGAEGaiaLAKALQGNTTLTSLDLSVNRIgDEGAIALAEGLQgnktlhTLNLAYNGIGAQGAIALAKAlqe 346
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 123 -PLLEKLHLDDNSVSTVSIEE--DAFADSKQLKLLFLSRNHLSS------IPSGLPHTLEELRLDDNRI 182
Cdd:COG5238 347 nTTLHSLDLSDNQIGDEGAIAlaKYLEGNTTLRELNLGKNNIGKqgaealIDALQTNRLHTLILDGNLI 415
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
266-300 |
3.47e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 3.47e-04
10 20 30
....*....|....*....|....*....|....*
gi 2566968170 266 RELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNN 300
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
413-477 |
5.24e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.40 E-value: 5.24e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2566968170 413 IHVKALTADSIRITWKA----TLPASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 477
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPpeddGGPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
243-280 |
3.49e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.68 E-value: 3.49e-03
10 20 30
....*....|....*....|....*....|....*...
gi 2566968170 243 HLQKLYLQDNAISHIPynTLAKMRELERLDLSNNNLTT 280
Cdd:pfam12799 2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
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| LRR_5 |
pfam13306 |
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
125-223 |
8.91e-03 |
|
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.
Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 36.75 E-value: 8.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2566968170 125 LEKLHLDDNsvsTVSIEEDAFADSKQLKLLFLSRNhLSSIPSglpHT-----LEELRLDDNrISTIPLHAFKGLNSLRRL 199
Cdd:pfam13306 13 LTSITIPSS---LTSIGEYAFSNCTSLKSITLPSS-LTSIGS---YAfyncsLTSITIPSS-LTSIGEYAFSNCSNLKSI 84
|
90 100
....*....|....*....|....*.
gi 2566968170 200 VLDGNLlanQRIADDTF--SRLQNLT 223
Cdd:pfam13306 85 TLPSNL---TSIGSYAFsnCSLKSIT 107
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