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Conserved domains on  [gi|2758982210|ref|NP_001418271|]
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ankyrin and armadillo repeat containing isoform 1 [Rattus norvegicus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-705 2.05e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 2.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQRrfimftqesskmdmkkERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----------------DKDGETPLHLAAYNGNLEIVKLLLEAG 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666    144 ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                          170       180
                   ....*....|....*....|
gi 2758982210  686 NIIHLSVLTFHTEVLKYIIE 705
Cdd:COG0666    221 TALDLAAENGNLEIVKLLLE 240
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 717-1130 8.66e-10

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 63.97  E-value: 8.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  717 LVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNISIHVSVVHALVE-AG 795
Cdd:PLN03200   451 LISLLGLSSEQQQEYAVALLAILTDEVDESKWAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAG 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  796 GIPALISLLASDEPELHSRCAVILYDIAKCENKDVIAKYNGIpaLINLLSLNKENVLvNVMNCirVLCMGNEGN--QKAM 873
Cdd:PLN03200   531 AVPALLWLLKNGGPKGQEIAAKTLTKLVRTADAATISQLTAL--LLGDLPESKVHVL-DVLGH--VLSVASLEDlvREGS 605

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  874 RDYNGIHYLIQFLSSDSDVLKAVSSATIAEVGRDNKQVQDAIAMEGAIPPLVALFKGKQLSVQVKGAMAVESLANRNPSI 953
Cdd:PLN03200   606 AANDALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAALSRSIKEN 685

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  954 QK-AFLERKLTKDLLKLLKAFQIDVKEQgaiALWALAgqtlkqqkymaeqigynfiiNMLLSPSAKMQYVGGEAVIALSK 1032
Cdd:PLN03200   686 RKvSYAAEDAIKPLIKLAKSSSIEVAEQ---AVCALA--------------------NLLSDPEVAAEALAEDIILPLTR 742

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 1033 DSRkhqyqicEG------NGIAPLIRLLRISKIAE---------GTLLSVIRAVGSICIGVAHTSnpmsqqcvveeNAFP 1097
Cdd:PLN03200   743 VLR-------EGtlegkrNAARALAQLLKHFPVDDvlkdsvqcrGTVLALVDLLNSTDLDSSATS-----------EALE 804

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2758982210 1098 VLIQLLR-------SHPSINIKVEVAFSLA----CIVLGNDSLQ 1130
Cdd:PLN03200   805 ALALLARtkgganfSHPPWAVLAEVPSSLEplvrCLAEGHPLVQ 848
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-705 2.05e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 2.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQRrfimftqesskmdmkkERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----------------DKDGETPLHLAAYNGNLEIVKLLLEAG 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666    144 ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                          170       180
                   ....*....|....*....|
gi 2758982210  686 NIIHLSVLTFHTEVLKYIIE 705
Cdd:COG0666    221 TALDLAAENGNLEIVKLLLE 240
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 717-1130 8.66e-10

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 63.97  E-value: 8.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  717 LVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNISIHVSVVHALVE-AG 795
Cdd:PLN03200   451 LISLLGLSSEQQQEYAVALLAILTDEVDESKWAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAG 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  796 GIPALISLLASDEPELHSRCAVILYDIAKCENKDVIAKYNGIpaLINLLSLNKENVLvNVMNCirVLCMGNEGN--QKAM 873
Cdd:PLN03200   531 AVPALLWLLKNGGPKGQEIAAKTLTKLVRTADAATISQLTAL--LLGDLPESKVHVL-DVLGH--VLSVASLEDlvREGS 605

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  874 RDYNGIHYLIQFLSSDSDVLKAVSSATIAEVGRDNKQVQDAIAMEGAIPPLVALFKGKQLSVQVKGAMAVESLANRNPSI 953
Cdd:PLN03200   606 AANDALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAALSRSIKEN 685

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  954 QK-AFLERKLTKDLLKLLKAFQIDVKEQgaiALWALAgqtlkqqkymaeqigynfiiNMLLSPSAKMQYVGGEAVIALSK 1032
Cdd:PLN03200   686 RKvSYAAEDAIKPLIKLAKSSSIEVAEQ---AVCALA--------------------NLLSDPEVAAEALAEDIILPLTR 742

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 1033 DSRkhqyqicEG------NGIAPLIRLLRISKIAE---------GTLLSVIRAVGSICIGVAHTSnpmsqqcvveeNAFP 1097
Cdd:PLN03200   743 VLR-------EGtlegkrNAARALAQLLKHFPVDDvlkdsvqcrGTVLALVDLLNSTDLDSSATS-----------EALE 804

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2758982210 1098 VLIQLLR-------SHPSINIKVEVAFSLA----CIVLGNDSLQ 1130
Cdd:PLN03200   805 ALALLARtkgganfSHPPWAVLAEVPSSLEplvrCLAEGHPLVQ 848
Ank_2 pfam12796
Ankyrin repeats (3 copies);
586-681 1.16e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  586 LHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 665
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 2758982210  666 TIQYLFSLGANWRKTD 681
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
698-865 1.62e-07

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 55.67  E-value: 1.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  698 EVLKYIIELHIPelpvwKTLVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGL 777
Cdd:COG5064    276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  778 LSNISI-HVSVVHALVEAGGIPALISLLASDEPELHSR-CAVILYDIAKCENKDVIAKY---NG-IPALINLLSLNKENV 851
Cdd:COG5064    351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430

                          170
                   ....*....|....*
gi 2758982210  852 LVNVMNCIR-VLCMG 865
Cdd:COG5064    431 IEVALDAIEnILKVG 445
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 743-782 3.81e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.75  E-value: 3.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2758982210  743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 743-782 2.16e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.80  E-value: 2.16e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2758982210   743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 580-676 2.86e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  580 RNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIialcrkdPSLLEAEATAENQ----CTPL 655
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI-------ELLIDHKACLDIEdccgCTPL 172

                           90       100
                   ....*....|....*....|.
gi 2758982210  656 LLAATSGALDTIQYLFSLGAN 676
Cdd:PHA02875   173 IIAMAKGDIAICKMLLDSGAN 193
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 582-706 8.70e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 8.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  582 GPTPLHLAAQACSLEATICLLcfKADYTLTEK-------RGWMPIHFAAFYDNICIIIALCRKDPSLLEAEAT------- 647
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATgtffrpg 128

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2758982210  648 AENQCT----PLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIEL 706
Cdd:cd22192    129 PKNLIYygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDL 191
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-705 2.05e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.62  E-value: 2.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQRrfimftqesskmdmkkERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666     80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----------------DKDGETPLHLAAYNGNLEIVKLLLEAG 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666    144 ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220

                          170       180
                   ....*....|....*....|
gi 2758982210  686 NIIHLSVLTFHTEVLKYIIE 705
Cdd:COG0666    221 TALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-708 4.39e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 74.61  E-value: 4.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQrrfimftqesskmdmkKERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666    113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA----------------QDNDGNTPLHLAAANGNLEIVKLLLEAG 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666    177 ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV---NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253

                          170       180
                   ....*....|....*....|...
gi 2758982210  686 NIIHLSVLTFHTEVLKYIIELHI 708
Cdd:COG0666    254 TALLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
526-688 7.94e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.89  E-value: 7.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQRrfimftqesskmdmkkERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666    146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR----------------DNDGETPLHLAAENGHLEIVKLLLEAG 209

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKdpsLLEAEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666    210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEA---GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286


                   ...
gi 2758982210  686 NII 688
Cdd:COG0666    287 TLL 289
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 717-1130 8.66e-10

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 63.97  E-value: 8.66e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  717 LVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNISIHVSVVHALVE-AG 795
Cdd:PLN03200   451 LISLLGLSSEQQQEYAVALLAILTDEVDESKWAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAG 530

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  796 GIPALISLLASDEPELHSRCAVILYDIAKCENKDVIAKYNGIpaLINLLSLNKENVLvNVMNCirVLCMGNEGN--QKAM 873
Cdd:PLN03200   531 AVPALLWLLKNGGPKGQEIAAKTLTKLVRTADAATISQLTAL--LLGDLPESKVHVL-DVLGH--VLSVASLEDlvREGS 605

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  874 RDYNGIHYLIQFLSSDSDVLKAVSSATIAEVGRDNKQVQDAIAMEGAIPPLVALFKGKQLSVQVKGAMAVESLANRNPSI 953
Cdd:PLN03200   606 AANDALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAALSRSIKEN 685

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  954 QK-AFLERKLTKDLLKLLKAFQIDVKEQgaiALWALAgqtlkqqkymaeqigynfiiNMLLSPSAKMQYVGGEAVIALSK 1032
Cdd:PLN03200   686 RKvSYAAEDAIKPLIKLAKSSSIEVAEQ---AVCALA--------------------NLLSDPEVAAEALAEDIILPLTR 742

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 1033 DSRkhqyqicEG------NGIAPLIRLLRISKIAE---------GTLLSVIRAVGSICIGVAHTSnpmsqqcvveeNAFP 1097
Cdd:PLN03200   743 VLR-------EGtlegkrNAARALAQLLKHFPVDDvlkdsvqcrGTVLALVDLLNSTDLDSSATS-----------EALE 804

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....
gi 2758982210 1098 VLIQLLR-------SHPSINIKVEVAFSLA----CIVLGNDSLQ 1130
Cdd:PLN03200   805 ALALLARtkgganfSHPPWAVLAEVPSSLEplvrCLAEGHPLVQ 848
Ank_2 pfam12796
Ankyrin repeats (3 copies);
586-681 1.16e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 1.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  586 LHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 665
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75

                           90
                   ....*....|....*.
gi 2758982210  666 TIQYLFSLGANWRKTD 681
Cdd:pfam12796   76 IVKLLLEKGADINVKD 91
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
698-865 1.62e-07

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 55.67  E-value: 1.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  698 EVLKYIIELHIPelpvwKTLVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGL 777
Cdd:COG5064    276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  778 LSNISI-HVSVVHALVEAGGIPALISLLASDEPELHSR-CAVILYDIAKCENKDVIAKY---NG-IPALINLLSLNKENV 851
Cdd:COG5064    351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430

                          170
                   ....*....|....*
gi 2758982210  852 LVNVMNCIR-VLCMG 865
Cdd:COG5064    431 IEVALDAIEnILKVG 445
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 756-956 2.70e-06

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 52.41  E-value: 2.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  756 IPALVNLLK--CPKIKLQ-CKIVGLL---SNISIHVSVvhalveAGGIPALISLLASDEPELHSRCAVILYDIAKCENKD 829
Cdd:PLN03200    60 MPLLVSLLRsgTLGAKVNaAAVLGVLckeEDLRVKVLL------GGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSD 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  830 -----VIAKYNGIPALINLLS--LNKENVLVN-VMNCIRVLCMGNEGNQKAMRDYNGIHYLIQFLSSDSDVLKAVSSATI 901
Cdd:PLN03200   134 hvgskIFSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLL 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2758982210  902 AEVGRDNKQVQDAIAMEGAIPPLVALF-KGKQLSVQVKGAMAVESLANRNPSIQKA 956
Cdd:PLN03200   214 ARLMMAFESSISKVLDAGAVKQLLKLLgQGNEVSVRAEAAGALEALSSQSKEAKQA 269
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 743-782 3.81e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.75  E-value: 3.81e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 2758982210  743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
573-705 7.13e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.57  E-value: 7.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  573 KMDMKKERNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDpslLEAEATAENQC 652
Cdd:COG0666     12 LAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGN 88

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2758982210  653 TPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIE 705
Cdd:COG0666     89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141
Ank_4 pfam13637
Ankyrin repeats (many copies);
653-704 1.40e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 43.80  E-value: 1.40e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 2758982210  653 TPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYII 704
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 743-782 2.16e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 42.80  E-value: 2.16e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 2758982210   743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 735-929 2.95e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 48.95  E-value: 2.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  735 SLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSN-ISIHVSVVHALVEAGGIPALISLLAS-DEPELH 812
Cdd:PLN03200   170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARlMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVR 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  813 SRCAVILYDI-AKC-ENKDVIAKYNGIPALIN-LLSLNKEnvlvnvmncirvlCMGNEGNQkAMRDY---------NGIH 880
Cdd:PLN03200   250 AEAAGALEALsSQSkEAKQAIADAGGIPALINaTVAPSKE-------------FMQGEFAQ-ALQENamgalanicGGMS 315

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  881 YLIQFL--SSDS--------DVLKAVSSA-TIAEVGRDNKQVQDAIAMEGAippLVALFK 929
Cdd:PLN03200   316 ALILYLgeLSESprspapiaDTLGALAYAlMVFDSSAESTRAFDPTVIEQI---LVKLLK 372
Ank_2 pfam12796
Ankyrin repeats (3 copies);
655-705 1.66e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 1.66e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2758982210  655 LLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIE 705
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
HEAT COG1413
HEAT repeat [General function prediction only];
713-845 6.28e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.54  E-value: 6.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  713 VWKTLVEMLQCESFKRRMMAVMSLEVIClandeywqnilDAGTIPALVNLLKCPKIKLQCKIVGLLSNISihvsvvhalv 792
Cdd:COG1413     17 AVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIG---------- 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2758982210  793 EAGGIPALISLLASDEPELHSRCAVILYDIAKCEnkdviakynGIPALINLLS 845
Cdd:COG1413     76 DPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA---------AVPALLEALK 119
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 580-676 2.86e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 41.90  E-value: 2.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  580 RNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIialcrkdPSLLEAEATAENQ----CTPL 655
Cdd:PHA02875   100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI-------ELLIDHKACLDIEdccgCTPL 172

                           90       100
                   ....*....|....*....|.
gi 2758982210  656 LLAATSGALDTIQYLFSLGAN 676
Cdd:PHA02875   173 IIAMAKGDIAICKMLLDSGAN 193
Ank_4 pfam13637
Ankyrin repeats (many copies);
584-634 2.98e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 2.98e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2758982210  584 TPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIAL 634
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
578-622 3.86e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 3.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 2758982210  578 KERNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFA 622
Cdd:pfam13857   12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 754-883 4.17e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.01  E-value: 4.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  754 GTIPALVNLLKcPKIKLQCKIVGLLSNISIHVSVVH-----ALVEAGGIPALISLLASDEPELHSRCAVILYDIAKcENK 828
Cdd:PLN03200   144 GVVPSLWDQLQ-PGNKQDKVVEGLLTGALRNLCGSTdgfwsATLEAGGVDILVKLLSSGNSDAQANAASLLARLMM-AFE 221

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2758982210  829 DVIAKY---NGIPALINLLSLNKE-NVLVNVMNCIRVLCMGNEGNQKAMRDYNGIHYLI 883
Cdd:PLN03200   222 SSISKVldaGAVKQLLKLLGQGNEvSVRAEAAGALEALSSQSKEAKQAIADAGGIPALI 280
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 521-648 4.42e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 4.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  521 TSSSTINVSDEAGYAIFHHAALHNRVPIICQLCNANFNVnqrrfimftqesskmdmkKERNGPTPLHLAAQ-ACSLEATI 599
Cdd:PHA02874   211 DHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASIND------------------QDIDGSTPLHHAINpPCDIDIID 272

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 2758982210  600 CLLCFKADYTLTEKRGWMPIHFAAFYDNiciiialcrKDPSLLEAEATA 648
Cdd:PHA02874   273 ILLYHKADISIKDNKGENPIDTAFKYIN---------KDPVIKDIIANA 312
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 582-706 8.70e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 8.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210  582 GPTPLHLAAQACSLEATICLLcfKADYTLTEK-------RGWMPIHFAAFYDNICIIIALCRKDPSLLEAEAT------- 647
Cdd:cd22192     51 GETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATgtffrpg 128

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2758982210  648 AENQCT----PLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIEL 706
Cdd:cd22192    129 PKNLIYygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDL 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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