|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
526-705 |
2.05e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 84.62 E-value: 2.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQRrfimftqesskmdmkkERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----------------DKDGETPLHLAAYNGNLEIVKLLLEAG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666 144 ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220
|
170 180
....*....|....*....|
gi 2758982210 686 NIIHLSVLTFHTEVLKYIIE 705
Cdd:COG0666 221 TALDLAAENGNLEIVKLLLE 240
|
|
| PLN03200 |
PLN03200 |
cellulose synthase-interactive protein; Provisional |
717-1130 |
8.66e-10 |
|
cellulose synthase-interactive protein; Provisional
Pssm-ID: 215629 [Multi-domain] Cd Length: 2102 Bit Score: 63.97 E-value: 8.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 717 LVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNISIHVSVVHALVE-AG 795
Cdd:PLN03200 451 LISLLGLSSEQQQEYAVALLAILTDEVDESKWAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAG 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 796 GIPALISLLASDEPELHSRCAVILYDIAKCENKDVIAKYNGIpaLINLLSLNKENVLvNVMNCirVLCMGNEGN--QKAM 873
Cdd:PLN03200 531 AVPALLWLLKNGGPKGQEIAAKTLTKLVRTADAATISQLTAL--LLGDLPESKVHVL-DVLGH--VLSVASLEDlvREGS 605
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 874 RDYNGIHYLIQFLSSDSDVLKAVSSATIAEVGRDNKQVQDAIAMEGAIPPLVALFKGKQLSVQVKGAMAVESLANRNPSI 953
Cdd:PLN03200 606 AANDALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAALSRSIKEN 685
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 954 QK-AFLERKLTKDLLKLLKAFQIDVKEQgaiALWALAgqtlkqqkymaeqigynfiiNMLLSPSAKMQYVGGEAVIALSK 1032
Cdd:PLN03200 686 RKvSYAAEDAIKPLIKLAKSSSIEVAEQ---AVCALA--------------------NLLSDPEVAAEALAEDIILPLTR 742
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 1033 DSRkhqyqicEG------NGIAPLIRLLRISKIAE---------GTLLSVIRAVGSICIGVAHTSnpmsqqcvveeNAFP 1097
Cdd:PLN03200 743 VLR-------EGtlegkrNAARALAQLLKHFPVDDvlkdsvqcrGTVLALVDLLNSTDLDSSATS-----------EALE 804
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2758982210 1098 VLIQLLR-------SHPSINIKVEVAFSLA----CIVLGNDSLQ 1130
Cdd:PLN03200 805 ALALLARtkgganfSHPPWAVLAEVPSSLEplvrCLAEGHPLVQ 848
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
586-681 |
1.16e-09 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 56.66 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 586 LHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 665
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75
|
90
....*....|....*.
gi 2758982210 666 TIQYLFSLGANWRKTD 681
Cdd:pfam12796 76 IVKLLLEKGADINVKD 91
|
|
| SRP1 |
COG5064 |
Karyopherin (importin) alpha [Intracellular trafficking and secretion]; |
698-865 |
1.62e-07 |
|
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
Pssm-ID: 227396 [Multi-domain] Cd Length: 526 Bit Score: 55.67 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 698 EVLKYIIELHIPelpvwKTLVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGL 777
Cdd:COG5064 276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 778 LSNISI-HVSVVHALVEAGGIPALISLLASDEPELHSR-CAVILYDIAKCENKDVIAKY---NG-IPALINLLSLNKENV 851
Cdd:COG5064 351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430
|
170
....*....|....*
gi 2758982210 852 LVNVMNCIR-VLCMG 865
Cdd:COG5064 431 IEVALDAIEnILKVG 445
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
743-782 |
3.81e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 44.75 E-value: 3.81e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2758982210 743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
743-782 |
2.16e-05 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 42.80 E-value: 2.16e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2758982210 743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
580-676 |
2.86e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 41.90 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 580 RNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIialcrkdPSLLEAEATAENQ----CTPL 655
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI-------ELLIDHKACLDIEdccgCTPL 172
|
90 100
....*....|....*....|.
gi 2758982210 656 LLAATSGALDTIQYLFSLGAN 676
Cdd:PHA02875 173 IIAMAKGDIAICKMLLDSGAN 193
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
582-706 |
8.70e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 40.38 E-value: 8.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 582 GPTPLHLAAQACSLEATICLLcfKADYTLTEK-------RGWMPIHFAAFYDNICIIIALCRKDPSLLEAEAT------- 647
Cdd:cd22192 51 GETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATgtffrpg 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2758982210 648 AENQCT----PLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIEL 706
Cdd:cd22192 129 PKNLIYygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDL 191
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
526-705 |
2.05e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 84.62 E-value: 2.05e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQRrfimftqesskmdmkkERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR----------------DKDGETPLHLAAYNGNLEIVKLLLEAG 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666 144 ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV---NARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGK 220
|
170 180
....*....|....*....|
gi 2758982210 686 NIIHLSVLTFHTEVLKYIIE 705
Cdd:COG0666 221 TALDLAAENGNLEIVKLLLE 240
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
526-708 |
4.39e-14 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 74.61 E-value: 4.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQrrfimftqesskmdmkKERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666 113 VNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA----------------QDNDGNTPLHLAAANGNLEIVKLLLEAG 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLleaEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666 177 ADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADV---NAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGL 253
|
170 180
....*....|....*....|...
gi 2758982210 686 NIIHLSVLTFHTEVLKYIIELHI 708
Cdd:COG0666 254 TALLLAAAAGAALIVKLLLLALL 276
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
526-688 |
7.94e-10 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 61.89 E-value: 7.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 526 INVSDEAGYAIFHHAALHNRVPIICQLCNANFNVNQRrfimftqesskmdmkkERNGPTPLHLAAQACSLEATICLLCFK 605
Cdd:COG0666 146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNAR----------------DNDGETPLHLAAENGHLEIVKLLLEAG 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 606 ADYTLTEKRGWMPIHFAAFYDNICIIIALCRKdpsLLEAEATAENQCTPLLLAATSGALDTIQYLFSLGANWRKTDTKGN 685
Cdd:COG0666 210 ADVNAKDNDGKTALDLAAENGNLEIVKLLLEA---GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286
|
...
gi 2758982210 686 NII 688
Cdd:COG0666 287 TLL 289
|
|
| PLN03200 |
PLN03200 |
cellulose synthase-interactive protein; Provisional |
717-1130 |
8.66e-10 |
|
cellulose synthase-interactive protein; Provisional
Pssm-ID: 215629 [Multi-domain] Cd Length: 2102 Bit Score: 63.97 E-value: 8.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 717 LVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNISIHVSVVHALVE-AG 795
Cdd:PLN03200 451 LISLLGLSSEQQQEYAVALLAILTDEVDESKWAITAAGGIPPLVQLLETGSQKAKEDSATVLWNLCCHSEDIRACVEsAG 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 796 GIPALISLLASDEPELHSRCAVILYDIAKCENKDVIAKYNGIpaLINLLSLNKENVLvNVMNCirVLCMGNEGN--QKAM 873
Cdd:PLN03200 531 AVPALLWLLKNGGPKGQEIAAKTLTKLVRTADAATISQLTAL--LLGDLPESKVHVL-DVLGH--VLSVASLEDlvREGS 605
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 874 RDYNGIHYLIQFLSSDSDVLKAVSSATIAEVGRDNKQVQDAIAMEGAIPPLVALFKGKQLSVQVKGAMAVESLANRNPSI 953
Cdd:PLN03200 606 AANDALRTLIQLLSSSKEETQEKAASVLADIFSSRQDLCESLATDEIINPCIKLLTNNTEAVATQSARALAALSRSIKEN 685
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 954 QK-AFLERKLTKDLLKLLKAFQIDVKEQgaiALWALAgqtlkqqkymaeqigynfiiNMLLSPSAKMQYVGGEAVIALSK 1032
Cdd:PLN03200 686 RKvSYAAEDAIKPLIKLAKSSSIEVAEQ---AVCALA--------------------NLLSDPEVAAEALAEDIILPLTR 742
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 1033 DSRkhqyqicEG------NGIAPLIRLLRISKIAE---------GTLLSVIRAVGSICIGVAHTSnpmsqqcvveeNAFP 1097
Cdd:PLN03200 743 VLR-------EGtlegkrNAARALAQLLKHFPVDDvlkdsvqcrGTVLALVDLLNSTDLDSSATS-----------EALE 804
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 2758982210 1098 VLIQLLR-------SHPSINIKVEVAFSLA----CIVLGNDSLQ 1130
Cdd:PLN03200 805 ALALLARtkgganfSHPPWAVLAEVPSSLEplvrCLAEGHPLVQ 848
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
586-681 |
1.16e-09 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 56.66 E-value: 1.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 586 LHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDPSLLEaeataENQCTPLLLAATSGALD 665
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK-----DNGRTALHYAARSGHLE 75
|
90
....*....|....*.
gi 2758982210 666 TIQYLFSLGANWRKTD 681
Cdd:pfam12796 76 IVKLLLEKGADINVKD 91
|
|
| SRP1 |
COG5064 |
Karyopherin (importin) alpha [Intracellular trafficking and secretion]; |
698-865 |
1.62e-07 |
|
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
Pssm-ID: 227396 [Multi-domain] Cd Length: 526 Bit Score: 55.67 E-value: 1.62e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 698 EVLKYIIELHIPelpvwKTLVEMLQCESFKRRMMAVMSLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGL 777
Cdd:COG5064 276 EKIQAVLDVGIP-----GRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWT 350
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 778 LSNISI-HVSVVHALVEAGGIPALISLLASDEPELHSR-CAVILYDIAKCENKDVIAKY---NG-IPALINLLSLNKENV 851
Cdd:COG5064 351 ISNITAgNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEaCWAISNATSGGLNRPDIIRYlvsQGfIKPLCDLLDVVDNKI 430
|
170
....*....|....*
gi 2758982210 852 LVNVMNCIR-VLCMG 865
Cdd:COG5064 431 IEVALDAIEnILKVG 445
|
|
| PLN03200 |
PLN03200 |
cellulose synthase-interactive protein; Provisional |
756-956 |
2.70e-06 |
|
cellulose synthase-interactive protein; Provisional
Pssm-ID: 215629 [Multi-domain] Cd Length: 2102 Bit Score: 52.41 E-value: 2.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 756 IPALVNLLK--CPKIKLQ-CKIVGLL---SNISIHVSVvhalveAGGIPALISLLASDEPELHSRCAVILYDIAKCENKD 829
Cdd:PLN03200 60 MPLLVSLLRsgTLGAKVNaAAVLGVLckeEDLRVKVLL------GGCIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSD 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 830 -----VIAKYNGIPALINLLS--LNKENVLVN-VMNCIRVLCMGNEGNQKAMRDYNGIHYLIQFLSSDSDVLKAVSSATI 901
Cdd:PLN03200 134 hvgskIFSTEGVVPSLWDQLQpgNKQDKVVEGlLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLL 213
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 2758982210 902 AEVGRDNKQVQDAIAMEGAIPPLVALF-KGKQLSVQVKGAMAVESLANRNPSIQKA 956
Cdd:PLN03200 214 ARLMMAFESSISKVLDAGAVKQLLKLLgQGNEVSVRAEAAGALEALSSQSKEAKQA 269
|
|
| Arm |
pfam00514 |
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ... |
743-782 |
3.81e-06 |
|
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.
Pssm-ID: 425727 [Multi-domain] Cd Length: 41 Bit Score: 44.75 E-value: 3.81e-06
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2758982210 743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:pfam00514 1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
573-705 |
7.13e-06 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 49.57 E-value: 7.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 573 KMDMKKERNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIALCRKDpslLEAEATAENQC 652
Cdd:COG0666 12 LAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAG---ADINAKDDGGN 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2758982210 653 TPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIE 705
Cdd:COG0666 89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE 141
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
653-704 |
1.40e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 43.80 E-value: 1.40e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 2758982210 653 TPLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYII 704
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| ARM |
smart00185 |
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ... |
743-782 |
2.16e-05 |
|
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.
Pssm-ID: 214547 [Multi-domain] Cd Length: 41 Bit Score: 42.80 E-value: 2.16e-05
10 20 30 40
....*....|....*....|....*....|....*....|
gi 2758982210 743 NDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSNIS 782
Cdd:smart00185 1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
|
|
| PLN03200 |
PLN03200 |
cellulose synthase-interactive protein; Provisional |
735-929 |
2.95e-05 |
|
cellulose synthase-interactive protein; Provisional
Pssm-ID: 215629 [Multi-domain] Cd Length: 2102 Bit Score: 48.95 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 735 SLEVICLANDEYWQNILDAGTIPALVNLLKCPKIKLQCKIVGLLSN-ISIHVSVVHALVEAGGIPALISLLAS-DEPELH 812
Cdd:PLN03200 170 ALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARlMMAFESSISKVLDAGAVKQLLKLLGQgNEVSVR 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 813 SRCAVILYDI-AKC-ENKDVIAKYNGIPALIN-LLSLNKEnvlvnvmncirvlCMGNEGNQkAMRDY---------NGIH 880
Cdd:PLN03200 250 AEAAGALEALsSQSkEAKQAIADAGGIPALINaTVAPSKE-------------FMQGEFAQ-ALQENamgalanicGGMS 315
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 881 YLIQFL--SSDS--------DVLKAVSSA-TIAEVGRDNKQVQDAIAMEGAippLVALFK 929
Cdd:PLN03200 316 ALILYLgeLSESprspapiaDTLGALAYAlMVFDSSAESTRAFDPTVIEQI---LVKLLK 372
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
655-705 |
1.66e-04 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 42.03 E-value: 1.66e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2758982210 655 LLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIE 705
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE 51
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
713-845 |
6.28e-04 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 41.54 E-value: 6.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 713 VWKTLVEMLQCESFKRRMMAVMSLEVIClandeywqnilDAGTIPALVNLLKCPKIKLQCKIVGLLSNISihvsvvhalv 792
Cdd:COG1413 17 AVPALIAALADEDPDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIG---------- 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 2758982210 793 EAGGIPALISLLASDEPELHSRCAVILYDIAKCEnkdviakynGIPALINLLS 845
Cdd:COG1413 76 DPEAVPALIAALKDEDPEVRRAAAEALGRLGDPA---------AVPALLEALK 119
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
580-676 |
2.86e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 41.90 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 580 RNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIialcrkdPSLLEAEATAENQ----CTPL 655
Cdd:PHA02875 100 KDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGI-------ELLIDHKACLDIEdccgCTPL 172
|
90 100
....*....|....*....|.
gi 2758982210 656 LLAATSGALDTIQYLFSLGAN 676
Cdd:PHA02875 173 IIAMAKGDIAICKMLLDSGAN 193
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
584-634 |
2.98e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.25 E-value: 2.98e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 2758982210 584 TPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFAAFYDNICIIIAL 634
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
578-622 |
3.86e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.94 E-value: 3.86e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 2758982210 578 KERNGPTPLHLAAQACSLEATICLLCFKADYTLTEKRGWMPIHFA 622
Cdd:pfam13857 12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PLN03200 |
PLN03200 |
cellulose synthase-interactive protein; Provisional |
754-883 |
4.17e-03 |
|
cellulose synthase-interactive protein; Provisional
Pssm-ID: 215629 [Multi-domain] Cd Length: 2102 Bit Score: 42.01 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 754 GTIPALVNLLKcPKIKLQCKIVGLLSNISIHVSVVH-----ALVEAGGIPALISLLASDEPELHSRCAVILYDIAKcENK 828
Cdd:PLN03200 144 GVVPSLWDQLQ-PGNKQDKVVEGLLTGALRNLCGSTdgfwsATLEAGGVDILVKLLSSGNSDAQANAASLLARLMM-AFE 221
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 2758982210 829 DVIAKY---NGIPALINLLSLNKE-NVLVNVMNCIRVLCMGNEGNQKAMRDYNGIHYLI 883
Cdd:PLN03200 222 SSISKVldaGAVKQLLKLLGQGNEvSVRAEAAGALEALSSQSKEAKQAIADAGGIPALI 280
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
521-648 |
4.42e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 41.10 E-value: 4.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 521 TSSSTINVSDEAGYAIFHHAALHNRVPIICQLCNANFNVnqrrfimftqesskmdmkKERNGPTPLHLAAQ-ACSLEATI 599
Cdd:PHA02874 211 DHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNASIND------------------QDIDGSTPLHHAINpPCDIDIID 272
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 2758982210 600 CLLCFKADYTLTEKRGWMPIHFAAFYDNiciiialcrKDPSLLEAEATA 648
Cdd:PHA02874 273 ILLYHKADISIKDNKGENPIDTAFKYIN---------KDPVIKDIIANA 312
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
582-706 |
8.70e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 40.38 E-value: 8.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2758982210 582 GPTPLHLAAQACSLEATICLLcfKADYTLTEK-------RGWMPIHFAAFYDNICIIIALCRKDPSLLEAEAT------- 647
Cdd:cd22192 51 GETALHVAALYDNLEAAVVLM--EAAPELVNEpmtsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATgtffrpg 128
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2758982210 648 AENQCT----PLLLAATSGALDTIQYLFSLGANWRKTDTKGNNIIHLSVLTFHTEVLKYIIEL 706
Cdd:cd22192 129 PKNLIYygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDL 191
|
|
|