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Conserved domains on  [gi|222136575|ref|NP_001549|]
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interleukin-10 receptor subunit alpha precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 19-111 3.86e-30

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


:

Pssm-ID: 460067  Cd Length: 107  Bit Score: 114.02  E-value: 3.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136575   19 SDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQT--LSYDLTAVTLDLYHSngY 96
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNItrTECDLTDETSDLTET--Y 92

                          90
                  ....*....|....*
gi 222136575   97 RARVRAVDGSRHSNW 111
Cdd:pfam01108  93 YARVRAVSGGGTSSW 107
JAK1bd_box_IFNLR1-like super family cl45915
JAK1 binding box domain found in interferon lambda receptor 1 (IFNLR1), interleukin-10 ...
 262-303 2.57e-23

JAK1 binding box domain found in interferon lambda receptor 1 (IFNLR1), interleukin-10 receptor subunit alpha (IL10RA) and similar proteins; This family includes two class II cytokine receptors, IFNLR1 and IL10RA. IFNLR1 (also called IFN-lambda receptor 1, IFN-lambda-R1, cytokine receptor class-II member 12, cytokine receptor family 2 member 12, CRF2-12, interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, likely interleukin, cytokine receptor 2 or LICR2), together with IL10RB, forms a dimer. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3, and mediates their antiviral activity. The ligand/receptor complex stimulates the activation of the JAK/STAT signaling pathway, leading to expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. IFNLR1 determines the cell type specificity of the lambda interferon action. It plays a significant role in the antiviral immune defense in the intestinal epithelium. IL10RA (also called IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, interleukin-10 receptor subunit 1, IL-10R subunit 1, or IL-10R1) is a cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Both, IFNLR1 and IL10RA, contain a box domain consisting of box1 and box2. The cytokine receptor box1 motif is critical for JAK kinase binding and activation.


The actual alignment was detected with superfamily member cd21909:

Pssm-ID: 459260  Cd Length: 52  Bit Score: 92.92  E-value: 2.57e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 222136575 262 RRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 303
Cdd:cd21909   11 RRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 52
Interfer-bind super family cl46366
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 116-227 8.40e-03

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


The actual alignment was detected with superfamily member pfam09294:

Pssm-ID: 480706  Cd Length: 103  Bit Score: 36.17  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136575  116 TRFSVDEVTLTVGSVNLEIHngfilgkIQLPRPKMaPANDTYESIFSHFrEYEIAIRKVPGNFTFTHKKVKHENFSL--L 193
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVT-------VKDPETRE-GKNLSLRDLYGSL-QYRVSYWKNSSNGEKKNTTSTNSFVVLsdL 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 222136575  194 TSGEvgEFCVQVKPSVASRSNKGMWSKEECISLT 227
Cdd:pfam09294  72 EPGT--TYCVSVQAFSPLDNKSSQRSPPQCIRTT 103
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 19-111 3.86e-30

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 114.02  E-value: 3.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136575   19 SDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQT--LSYDLTAVTLDLYHSngY 96
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNItrTECDLTDETSDLTET--Y 92

                          90
                  ....*....|....*
gi 222136575   97 RARVRAVDGSRHSNW 111
Cdd:pfam01108  93 YARVRAVSGGGTSSW 107
JAK1bd_box_IL10RA cd21909
JAK1 binding box domain found in interleukin-10 receptor subunit alpha (IL10RA) and similar ...
 262-303 2.57e-23

JAK1 binding box domain found in interleukin-10 receptor subunit alpha (IL10RA) and similar proteins; IL10RA, also called IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, interleukin-10 receptor subunit 1, IL-10R subunit 1, or IL-10R1, is a cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. This model corresponds to IL10RA box domain which consists of box1 and box2.


Pssm-ID: 439314  Cd Length: 52  Bit Score: 92.92  E-value: 2.57e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 222136575 262 RRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 303
Cdd:cd21909   11 RRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 52
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 116-227 8.40e-03

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 36.17  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136575  116 TRFSVDEVTLTVGSVNLEIHngfilgkIQLPRPKMaPANDTYESIFSHFrEYEIAIRKVPGNFTFTHKKVKHENFSL--L 193
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVT-------VKDPETRE-GKNLSLRDLYGSL-QYRVSYWKNSSNGEKKNTTSTNSFVVLsdL 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 222136575  194 TSGEvgEFCVQVKPSVASRSNKGMWSKEECISLT 227
Cdd:pfam09294  72 EPGT--TYCVSVQAFSPLDNKSSQRSPPQCIRTT 103
 
Name Accession Description Interval E-value
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 19-111 3.86e-30

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 114.02  E-value: 3.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136575   19 SDAHGTELPSPPSVWFEAEFFHHILHWTPIPNQSESTCYEVALLRYGIESWNSISNCSQT--LSYDLTAVTLDLYHSngY 96
Cdd:pfam01108  15 SAAGGPSLPAPQNVTFQSTNFKNILTWEPGPNSPPDVVYTVQYKIYGSGDWKNVPNCTNItrTECDLTDETSDLTET--Y 92

                          90
                  ....*....|....*
gi 222136575   97 RARVRAVDGSRHSNW 111
Cdd:pfam01108  93 YARVRAVSGGGTSSW 107
JAK1bd_box_IL10RA cd21909
JAK1 binding box domain found in interleukin-10 receptor subunit alpha (IL10RA) and similar ...
 262-303 2.57e-23

JAK1 binding box domain found in interleukin-10 receptor subunit alpha (IL10RA) and similar proteins; IL10RA, also called IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, interleukin-10 receptor subunit 1, IL-10R subunit 1, or IL-10R1, is a cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. This model corresponds to IL10RA box domain which consists of box1 and box2.


Pssm-ID: 439314  Cd Length: 52  Bit Score: 92.92  E-value: 2.57e-23
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 222136575 262 RRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 303
Cdd:cd21909   11 RRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAFLK 52
JAK1bd_box_IFNLR1-like cd21844
JAK1 binding box domain found in interferon lambda receptor 1 (IFNLR1), interleukin-10 ...
 253-301 5.26e-16

JAK1 binding box domain found in interferon lambda receptor 1 (IFNLR1), interleukin-10 receptor subunit alpha (IL10RA) and similar proteins; This family includes two class II cytokine receptors, IFNLR1 and IL10RA. IFNLR1 (also called IFN-lambda receptor 1, IFN-lambda-R1, cytokine receptor class-II member 12, cytokine receptor family 2 member 12, CRF2-12, interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, likely interleukin, cytokine receptor 2 or LICR2), together with IL10RB, forms a dimer. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3, and mediates their antiviral activity. The ligand/receptor complex stimulates the activation of the JAK/STAT signaling pathway, leading to expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. IFNLR1 determines the cell type specificity of the lambda interferon action. It plays a significant role in the antiviral immune defense in the intestinal epithelium. IL10RA (also called IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, interleukin-10 receptor subunit 1, IL-10R subunit 1, or IL-10R1) is a cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Both, IFNLR1 and IL10RA, contain a box domain consisting of box1 and box2. The cytokine receptor box1 motif is critical for JAK kinase binding and activation.


Pssm-ID: 439313  Cd Length: 49  Bit Score: 72.07  E-value: 5.26e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 222136575 253 CLALQLYVRRRKKLPSVLLFKKPSPFIFISQRPSPETQDTIHPLDEEAF 301
Cdd:cd21844    1 KNLLGNPWFQRAKMPQALDFSGYRHPVATLQPSRPESQDDLFLCPQKEL 49
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 116-227 8.40e-03

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 36.17  E-value: 8.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222136575  116 TRFSVDEVTLTVGSVNLEIHngfilgkIQLPRPKMaPANDTYESIFSHFrEYEIAIRKVPGNFTFTHKKVKHENFSL--L 193
Cdd:pfam09294   1 TIIGPPEVELEVEGGSLNVT-------VKDPETRE-GKNLSLRDLYGSL-QYRVSYWKNSSNGEKKNTTSTNSFVVLsdL 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 222136575  194 TSGEvgEFCVQVKPSVASRSNKGMWSKEECISLT 227
Cdd:pfam09294  72 EPGT--TYCVSVQAFSPLDNKSSQRSPPQCIRTT 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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