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Conserved domains on  [gi|4505681|ref|NP_002599|]
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platelet-derived growth factor subunit B isoform 1 preproprotein [Homo sapiens]

Protein Classification

PDGF_N and PDGF domain-containing protein( domain architecture ID 10520088)

PDGF_N and PDGF domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
97-180 1.31e-33

PDGF/VEGF domain;


:

Pssm-ID: 425620  Cd Length: 82  Bit Score: 116.23  E-value: 1.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681     97 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL 176
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 4505681    177 ACKC 180
Cdd:pfam00341  79 QCEC 82
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-93 9.18e-20

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


:

Pssm-ID: 461394  Cd Length: 78  Bit Score: 80.17  E-value: 9.18e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4505681     21 EGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARG------RRSLgSLTIAEPAM 93
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHRAHSDHSSSSVDLKrrqlhsRRKR-SIEEAVPAV 78
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
97-180 1.31e-33

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 116.23  E-value: 1.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681     97 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL 176
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 4505681    177 ACKC 180
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 95-182 3.75e-30

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 107.51  E-value: 3.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681      95 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLrpVQVRKIEIVRKKPIfKKATVTLED 174
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 4505681     175 HLACKCET 182
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 95-182 3.99e-28

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 102.45  E-value: 3.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681   95 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRkKPIFKKATVTLED 174
Cdd:cd00135   1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
gi 4505681  175 HLACKCET 182
Cdd:cd00135  78 HTECECRP 85
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-93 9.18e-20

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 80.17  E-value: 9.18e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4505681     21 EGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARG------RRSLgSLTIAEPAM 93
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHRAHSDHSSSSVDLKrrqlhsRRKR-SIEEAVPAV 78
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 97-193 1.52e-09

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 55.01  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681    97 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKK-ATVTLEDH 175
Cdd:PHA02661  48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTISVEEH 125

                         90       100
                 ....*....|....*....|
gi 4505681   176 LACKCETVAAARPVT--RSP 193
Cdd:PHA02661 126 TKCKCEFKTTPPPTTttREP 145
 
Name Accession Description Interval E-value
PDGF pfam00341
PDGF/VEGF domain;
97-180 1.31e-33

PDGF/VEGF domain;


Pssm-ID: 425620  Cd Length: 82  Bit Score: 116.23  E-value: 1.31e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681     97 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHL 176
Cdd:pfam00341   1 CKPRETLVEIRRELPDETNAFFK--PSCVEVQRCSGCCNDEGLECVPTETHNVTMQVLKIEYAPRRPSPELVEVSFEEHV 78


                  ....
gi 4505681    177 ACKC 180
Cdd:pfam00341  79 QCEC 82
PDGF smart00141
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived ...
 95-182 3.75e-30

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family; Platelet-derived growth factor is a potent activator for cells of mesenchymal origin. PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer. Members of the VEGF family are homologues of PDGF.


Pssm-ID: 197537  Cd Length: 83  Bit Score: 107.51  E-value: 3.75e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681      95 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLrpVQVRKIEIVRKKPIfKKATVTLED 174
Cdd:smart00141   1 SQCKPRETVVEVSREYPDETN--FLFKPPCVTVKRCGGCCNDEGLECVPTETSN--VTMQLLEISRPLSQ-HLVEVSFEE 75


                   ....*...
gi 4505681     175 HLACKCET 182
Cdd:smart00141  76 HTKCECRP 83
PDGF cd00135
Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a ...
 95-182 3.99e-28

Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and somatic angiogenesis with a unique specificity for vascular endothelial cells; VEGF forms homodimers and exists in 4 different isoforms; overall, the VEGF monomer resembles that of PDGF, but its N-terminal segment is helical rather than extended; the cysteine knot motif is a common feature of this domain


Pssm-ID: 238079  Cd Length: 86  Bit Score: 102.45  E-value: 3.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681   95 AECKTRTEVFEISRRLIDRTNanFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRkKPIFKKATVTLED 174
Cdd:cd00135   1 SSCKPRETLVEISEELPDETN--TIFKPPCVEVKRCGGCCNDESLECVPTETSNVTMQVLKISPKR-KPRSKLVEISFEE 77


                ....*...
gi 4505681  175 HLACKCET 182
Cdd:cd00135  78 HTECECRP 85
PDGF_N pfam04692
Platelet-derived growth factor, N terminal region; This family consists of the amino terminal ...
 21-93 9.18e-20

Platelet-derived growth factor, N terminal region; This family consists of the amino terminal regions of platelet-derived growth factor (PDGF, pfam00341) A and B chains.


Pssm-ID: 461394  Cd Length: 78  Bit Score: 80.17  E-value: 9.18e-20
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4505681     21 EGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARG------RRSLgSLTIAEPAM 93
Cdd:pfam04692   1 EEAPIPRELIERLSRSEIRSISDLQRLLEIDSVGNEDAEEVETKHRAHSDHSSSSVDLKrrqlhsRRKR-SIEEAVPAV 78
PHA02661 PHA02661
vascular endothelial growth factor like protein; Provisional
 97-193 1.52e-09

vascular endothelial growth factor like protein; Provisional


Pssm-ID: 177444  Cd Length: 146  Bit Score: 55.01  E-value: 1.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505681    97 CKTRTEVFEISRRLIDRTNANFLvwPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKK-ATVTLEDH 175
Cdd:PHA02661  48 CQPRDTVVQLSDEYPGNTNDRYN--PRCVTVRRCGGCCNDESQICTPTETSNVTVTVMLTSVSGSTGATSNfQTISVEEH 125

                         90       100
                 ....*....|....*....|
gi 4505681   176 LACKCETVAAARPVT--RSP 193
Cdd:PHA02661 126 TKCKCEFKTTPPPTTttREP 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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