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Conserved domains on  [gi|4503165|ref|NP_003581|]
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cullin-3 isoform 1 [Homo sapiens]

Protein Classification

cullin family protein( domain architecture ID 12011692)

cullin family protein, similar to cullins that are core components of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
34-665 0e+00

Cullin family;


:

Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 832.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165     34 WDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSL-NNNFLQTLNQAWNDH 112
Cdd:pfam00888   1 WAKLEDAIDEILNKNVSSLSYEELYRAVYNLCLHKQGEKLYDKLKEYLEEHLKKLVKPLIKEASsGEEFLKAYVKEWEDH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    113 QTAMVMIRDILMYMDRVYVQqnNVENVYNLGLIIFRDQVVRYGcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI 192
Cdd:pfam00888  81 TISMKMIRDIFMYLDRVYVK--RLPSIYDLGLELFRDHVFRIP-LKDKLIDALLDLIEKERNGEVIDRSLIKSVIDMLVS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    193 LGL--EGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELIS 270
Cdd:pfam00888 158 LGEdeKKDNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEERVRHYLHSSTKKKLLDVLEEVLIS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    271 KHMKTIVEMEnsgLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEG-KNPVDYIQGLLDLK 349
Cdd:pfam00888 238 DHLEELLEEE---LQNLLDDNKTEDLKRLYRLLSRVPDGLEPLRKAFEEYIKKEGKAIVKDAKEQtTDAKKYVEDLLELK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    350 SRFDRFLLESFNNDRLFKQTIAGDFEYFLNL---NSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKD 426
Cdd:pfam00888 315 DKFDKIVKDAFSNDELFVKALDEAFEEFINKntsNSKSPELLAKYIDDLLKKGLKGKSEEELEEKLDKVITLFRYIQDKD 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    427 VFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVR 506
Cdd:pfam00888 395 VFEAFYKKHLAKRLLLGKSASDDAERSMISKLKEECGSEFTSKLEGMFKDMELSKDLMKEFKEHLSENKSSKKGIDLSVN 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    507 VLTTGYWPTQSaTPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYgpvkkedgsevgvggaqvtgsN 586
Cdd:pfam00888 475 VLTSGAWPTYL-TSDFILPPELEKAIERFEKFYLSKHSGRKLTWLHSLGTAELKATFP---------------------K 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    587 TRKHILQVSTFQMTILMLFNN-REKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEIENGHIFTVNDQF 665
Cdd:pfam00888 533 GKKHELNVSTYQMAILLLFNDdGDSLSYEEIQEATGLPDEELKRTLQSLACAK--AKVLLKEPMSKDINPTDTFSFNEDF 610
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
698-760 1.88e-30

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


:

Pssm-ID: 463146  Cd Length: 63  Bit Score: 114.09  E-value: 1.88e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503165    698 DRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPED 760
Cdd:pfam10557   1 DRKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDEDD 63
 
Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
34-665 0e+00

Cullin family;


Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 832.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165     34 WDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSL-NNNFLQTLNQAWNDH 112
Cdd:pfam00888   1 WAKLEDAIDEILNKNVSSLSYEELYRAVYNLCLHKQGEKLYDKLKEYLEEHLKKLVKPLIKEASsGEEFLKAYVKEWEDH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    113 QTAMVMIRDILMYMDRVYVQqnNVENVYNLGLIIFRDQVVRYGcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI 192
Cdd:pfam00888  81 TISMKMIRDIFMYLDRVYVK--RLPSIYDLGLELFRDHVFRIP-LKDKLIDALLDLIEKERNGEVIDRSLIKSVIDMLVS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    193 LGL--EGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELIS 270
Cdd:pfam00888 158 LGEdeKKDNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEERVRHYLHSSTKKKLLDVLEEVLIS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    271 KHMKTIVEMEnsgLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEG-KNPVDYIQGLLDLK 349
Cdd:pfam00888 238 DHLEELLEEE---LQNLLDDNKTEDLKRLYRLLSRVPDGLEPLRKAFEEYIKKEGKAIVKDAKEQtTDAKKYVEDLLELK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    350 SRFDRFLLESFNNDRLFKQTIAGDFEYFLNL---NSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKD 426
Cdd:pfam00888 315 DKFDKIVKDAFSNDELFVKALDEAFEEFINKntsNSKSPELLAKYIDDLLKKGLKGKSEEELEEKLDKVITLFRYIQDKD 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    427 VFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVR 506
Cdd:pfam00888 395 VFEAFYKKHLAKRLLLGKSASDDAERSMISKLKEECGSEFTSKLEGMFKDMELSKDLMKEFKEHLSENKSSKKGIDLSVN 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    507 VLTTGYWPTQSaTPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYgpvkkedgsevgvggaqvtgsN 586
Cdd:pfam00888 475 VLTSGAWPTYL-TSDFILPPELEKAIERFEKFYLSKHSGRKLTWLHSLGTAELKATFP---------------------K 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    587 TRKHILQVSTFQMTILMLFNN-REKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEIENGHIFTVNDQF 665
Cdd:pfam00888 533 GKKHELNVSTYQMAILLLFNDdGDSLSYEEIQEATGLPDEELKRTLQSLACAK--AKVLLKEPMSKDINPTDTFSFNEDF 610
COG5647 COG5647
Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, ...
15-768 1.38e-157

Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227934 [Multi-domain]  Cd Length: 773  Bit Score: 476.60  E-value: 1.38e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165   15 KMRIRAFPMTMDEKYVNSIWDLLKNAIQEIqrknnsglsFEELYRNAYTMVLHKHGEKLYTGLREV-------------- 80
Cdd:COG5647   5 AIKIDVPRKTLSEEDFESTWEFIERAIGQI---------FERLYDSMAILSLMEVYTKIYNYCTNKtrslesdlrwkidf 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165   81 --VTEHLINKV---REDVLNSLNN--------NFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNN-----VENVYNL 142
Cdd:COG5647  76 iyLGSRLIQKLvdyAKNYIEEYNRgrsqenmeEFLDELVKFWNRFTKGATMINHLFLYMDRVYLKKARydktlVFEVYSL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  143 GLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGL------EGRSVYEEDFEAPFLEMSAEF 216
Cdd:COG5647 156 CLVKEKIESFRL--IVDSLINPLLYYVERYRALQSIDRKYIEDAKDMLESLERpsdykkENLSYYKSVFEPIFLEETWEF 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  217 FQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEmENSGLVHMLKNGKTEDL 296
Cdd:COG5647 234 YEMESSEVIELLSVTEYLEKAHKILEREEELVEIYLKVSTKKPLLEVLEDVLITRHLDDLEE-QGSGFREALDASNLEKL 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  297 GCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSE-----EGEGKN---------PVDYIQGLLDLKSRFDRFLLESFNN 362
Cdd:COG5647 313 QVLYRLLSETKYGVQPLQEVFERYVKDEGVLINIEtnyifHCKVDVgflgsreclPKLYVQKLLSCHDLFPSLVNESFEG 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  363 DRLFKQTIAGDFEYFLNLN----SRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLAR 438
Cdd:COG5647 393 DGSIVKALGNAFKTFINGNesadSGPSEYLAKYIDGLLKKDGKQSFIGKIKDLLQDIITLFRYVEEKDVFEKYYKKLLAK 472
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  439 RLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQAtgvSLGGVDLTVRVLTTGYWPTQSA 518
Cdd:COG5647 473 RLLNGRSASAQAELKMISMLKKVCGQEFTSKLEGMFRDISLSSEFTEAFQHSPQS---YNKYLDLFVWVLTQAYWPLSPE 549
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  519 TPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFyGPVKKEdgsevgvggaqvtgsntrKHILQVSTFQ 598
Cdd:COG5647 550 EVSIRLPKELVPILEGFKKFYSSKHNGRKLKWYWHLGSGEVKARF-NEGQKY------------------LEISTFSVYQ 610
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  599 MTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVltkePKSKEIENGHIFTVNDQFTSKLHRVKIQTVA 678
Cdd:COG5647 611 LLVFLLFNDHEELTFEEILELTKLSTDDLKRVLQSLSCAKLVVLL----KDDKLVSPNTKFYVNENFSSKLERIKINYIA 686
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  679 AKQGESDPERkeTRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTp 758
Cdd:COG5647 687 ESECMQDNLD--THETVEEDRQAELQACIVRIMKARKKLKHGDLVKEVIAQHKSRFEPKVSMVKRAIETLIEKEYLERQ- 763
                       810
                ....*....|
gi 4503165  759 EDRKVYTYVA 768
Cdd:COG5647 764 ADDEIYVYLA 773
CULLIN smart00182
Cullin;
421-563 3.67e-69

Cullin;


Pssm-ID: 214545 [Multi-domain]  Cd Length: 143  Bit Score: 223.74  E-value: 3.67e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165     421 FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGG 500
Cdd:smart00182   1 YIQDKDVFEKYYKKHLAKRLILNRSASDDAEENMITKLKQECGYEFTSKLERMFRDISLSKDLNQSFKDMLENNPSAKPI 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503165     501 VDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATF 563
Cdd:smart00182  81 IDLNVRVLTSGYWPTSSTEVEINLPQELEDALEEFEEFYLAKHSGRKLTWLHSLGRGEVKANF 143
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
698-760 1.88e-30

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 463146  Cd Length: 63  Bit Score: 114.09  E-value: 1.88e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503165    698 DRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPED 760
Cdd:pfam10557   1 DRKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDEDD 63
Cullin_Nedd8 smart00884
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
695-762 1.29e-28

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 214883 [Multi-domain]  Cd Length: 68  Bit Score: 108.78  E-value: 1.29e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503165     695 VDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRK 762
Cdd:smart00884   1 VEEDRKLEIQAAIVRIMKSRKTLSHSELVSEVIEQLKKRFKPSVSDIKKRIESLIEREYLERDEDDPN 68
 
Name Accession Description Interval E-value
Cullin pfam00888
Cullin family;
34-665 0e+00

Cullin family;


Pssm-ID: 459983 [Multi-domain]  Cd Length: 610  Bit Score: 832.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165     34 WDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSL-NNNFLQTLNQAWNDH 112
Cdd:pfam00888   1 WAKLEDAIDEILNKNVSSLSYEELYRAVYNLCLHKQGEKLYDKLKEYLEEHLKKLVKPLIKEASsGEEFLKAYVKEWEDH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    113 QTAMVMIRDILMYMDRVYVQqnNVENVYNLGLIIFRDQVVRYGcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMI 192
Cdd:pfam00888  81 TISMKMIRDIFMYLDRVYVK--RLPSIYDLGLELFRDHVFRIP-LKDKLIDALLDLIEKERNGEVIDRSLIKSVIDMLVS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    193 LGL--EGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELIS 270
Cdd:pfam00888 158 LGEdeKKDNVYEEDFEPPFLEATEEYYRAESQELLAENVAPEYLKKAERRLEEEEERVRHYLHSSTKKKLLDVLEEVLIS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    271 KHMKTIVEMEnsgLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEG-KNPVDYIQGLLDLK 349
Cdd:pfam00888 238 DHLEELLEEE---LQNLLDDNKTEDLKRLYRLLSRVPDGLEPLRKAFEEYIKKEGKAIVKDAKEQtTDAKKYVEDLLELK 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    350 SRFDRFLLESFNNDRLFKQTIAGDFEYFLNL---NSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKD 426
Cdd:pfam00888 315 DKFDKIVKDAFSNDELFVKALDEAFEEFINKntsNSKSPELLAKYIDDLLKKGLKGKSEEELEEKLDKVITLFRYIQDKD 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    427 VFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVR 506
Cdd:pfam00888 395 VFEAFYKKHLAKRLLLGKSASDDAERSMISKLKEECGSEFTSKLEGMFKDMELSKDLMKEFKEHLSENKSSKKGIDLSVN 474
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    507 VLTTGYWPTQSaTPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYgpvkkedgsevgvggaqvtgsN 586
Cdd:pfam00888 475 VLTSGAWPTYL-TSDFILPPELEKAIERFEKFYLSKHSGRKLTWLHSLGTAELKATFP---------------------K 532
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165    587 TRKHILQVSTFQMTILMLFNN-REKYTFEEIQQETDIPERELVRALQSLACGKptQRVLTKEPKSKEIENGHIFTVNDQF 665
Cdd:pfam00888 533 GKKHELNVSTYQMAILLLFNDdGDSLSYEEIQEATGLPDEELKRTLQSLACAK--AKVLLKEPMSKDINPTDTFSFNEDF 610
COG5647 COG5647
Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, ...
15-768 1.38e-157

Cullin, a subunit of E3 ubiquitin ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227934 [Multi-domain]  Cd Length: 773  Bit Score: 476.60  E-value: 1.38e-157
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165   15 KMRIRAFPMTMDEKYVNSIWDLLKNAIQEIqrknnsglsFEELYRNAYTMVLHKHGEKLYTGLREV-------------- 80
Cdd:COG5647   5 AIKIDVPRKTLSEEDFESTWEFIERAIGQI---------FERLYDSMAILSLMEVYTKIYNYCTNKtrslesdlrwkidf 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165   81 --VTEHLINKV---REDVLNSLNN--------NFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNN-----VENVYNL 142
Cdd:COG5647  76 iyLGSRLIQKLvdyAKNYIEEYNRgrsqenmeEFLDELVKFWNRFTKGATMINHLFLYMDRVYLKKARydktlVFEVYSL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  143 GLIIFRDQVVRYgcIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGL------EGRSVYEEDFEAPFLEMSAEF 216
Cdd:COG5647 156 CLVKEKIESFRL--IVDSLINPLLYYVERYRALQSIDRKYIEDAKDMLESLERpsdykkENLSYYKSVFEPIFLEETWEF 233
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  217 FQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEmENSGLVHMLKNGKTEDL 296
Cdd:COG5647 234 YEMESSEVIELLSVTEYLEKAHKILEREEELVEIYLKVSTKKPLLEVLEDVLITRHLDDLEE-QGSGFREALDASNLEKL 312
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  297 GCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSE-----EGEGKN---------PVDYIQGLLDLKSRFDRFLLESFNN 362
Cdd:COG5647 313 QVLYRLLSETKYGVQPLQEVFERYVKDEGVLINIEtnyifHCKVDVgflgsreclPKLYVQKLLSCHDLFPSLVNESFEG 392
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  363 DRLFKQTIAGDFEYFLNLN----SRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLAR 438
Cdd:COG5647 393 DGSIVKALGNAFKTFINGNesadSGPSEYLAKYIDGLLKKDGKQSFIGKIKDLLQDIITLFRYVEEKDVFEKYYKKLLAK 472
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  439 RLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQAtgvSLGGVDLTVRVLTTGYWPTQSA 518
Cdd:COG5647 473 RLLNGRSASAQAELKMISMLKKVCGQEFTSKLEGMFRDISLSSEFTEAFQHSPQS---YNKYLDLFVWVLTQAYWPLSPE 549
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  519 TPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFyGPVKKEdgsevgvggaqvtgsntrKHILQVSTFQ 598
Cdd:COG5647 550 EVSIRLPKELVPILEGFKKFYSSKHNGRKLKWYWHLGSGEVKARF-NEGQKY------------------LEISTFSVYQ 610
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  599 MTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVltkePKSKEIENGHIFTVNDQFTSKLHRVKIQTVA 678
Cdd:COG5647 611 LLVFLLFNDHEELTFEEILELTKLSTDDLKRVLQSLSCAKLVVLL----KDDKLVSPNTKFYVNENFSSKLERIKINYIA 686
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165  679 AKQGESDPERkeTRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTp 758
Cdd:COG5647 687 ESECMQDNLD--THETVEEDRQAELQACIVRIMKARKKLKHGDLVKEVIAQHKSRFEPKVSMVKRAIETLIEKEYLERQ- 763
                       810
                ....*....|
gi 4503165  759 EDRKVYTYVA 768
Cdd:COG5647 764 ADDEIYVYLA 773
CULLIN smart00182
Cullin;
421-563 3.67e-69

Cullin;


Pssm-ID: 214545 [Multi-domain]  Cd Length: 143  Bit Score: 223.74  E-value: 3.67e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503165     421 FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGG 500
Cdd:smart00182   1 YIQDKDVFEKYYKKHLAKRLILNRSASDDAEENMITKLKQECGYEFTSKLERMFRDISLSKDLNQSFKDMLENNPSAKPI 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503165     501 VDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATF 563
Cdd:smart00182  81 IDLNVRVLTSGYWPTSSTEVEINLPQELEDALEEFEEFYLAKHSGRKLTWLHSLGRGEVKANF 143
Cullin_Nedd8 pfam10557
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
698-760 1.88e-30

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognizes and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 463146  Cd Length: 63  Bit Score: 114.09  E-value: 1.88e-30
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4503165    698 DRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPED 760
Cdd:pfam10557   1 DRKHEIQAAIVRIMKSRKTLSHNELVNEVIEQLKSRFKPSVSDIKKRIESLIEKEYLERDEDD 63
Cullin_Nedd8 smart00884
Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a ...
695-762 1.29e-28

Cullin protein neddylation domain; This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue.


Pssm-ID: 214883 [Multi-domain]  Cd Length: 68  Bit Score: 108.78  E-value: 1.29e-28
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4503165     695 VDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRK 762
Cdd:smart00884   1 VEEDRKLEIQAAIVRIMKSRKTLSHSELVSEVIEQLKKRFKPSVSDIKKRIESLIEREYLERDEDDPN 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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