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Conserved domains on  [gi|4507435|ref|NP_003664|]
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telethonin [Homo sapiens]

Protein Classification

Telethonin domain-containing protein( domain architecture ID 10559676)

Telethonin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Telethonin pfam09470
Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle ...
 17-167 1.98e-72

Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerization of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles.


:

Pssm-ID: 462811  Cd Length: 150  Bit Score: 214.65  E-value: 1.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507435     17 RREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTP 96
Cdd:pfam09470   1 RRESYTADWQSVSLKTQPEDRQSLHMVDDSRRETLSRQWQARPLVQRCPSGVMRMGTLGRGVREYQLPYRNTLPLPIFKP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4507435     97 AKMGaTKEEReDTPIQLQELLALETAlGGQCVDRQEVAEITKQLPPVVPVS-----KPGalrRSLSRSMSQEAQRG 167
Cdd:pfam09470  81 AELG-TRLGR-GTPHTLEDLMPFETA-DGVCPDKREVSEITRDLPPVVQPTrmefaKPP---RSLGRSMSQEAQRG 150
 
Name Accession Description Interval E-value
Telethonin pfam09470
Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle ...
 17-167 1.98e-72

Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerization of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles.


Pssm-ID: 462811  Cd Length: 150  Bit Score: 214.65  E-value: 1.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507435     17 RREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTP 96
Cdd:pfam09470   1 RRESYTADWQSVSLKTQPEDRQSLHMVDDSRRETLSRQWQARPLVQRCPSGVMRMGTLGRGVREYQLPYRNTLPLPIFKP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4507435     97 AKMGaTKEEReDTPIQLQELLALETAlGGQCVDRQEVAEITKQLPPVVPVS-----KPGalrRSLSRSMSQEAQRG 167
Cdd:pfam09470  81 AELG-TRLGR-GTPHTLEDLMPFETA-DGVCPDKREVSEITRDLPPVVQPTrmefaKPP---RSLGRSMSQEAQRG 150
 
Name Accession Description Interval E-value
Telethonin pfam09470
Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle ...
 17-167 1.98e-72

Telethonin protein; Telethonin is a 167-residue protein which complexes with the large muscle protein, titin. The very N-terminus of titin, composed of two immunoglobulin-like (Ig) domains, referred to as Z1 and Z2, interacts with the N-terminal region (residues 1-53) of telethonin, mediating the antiparallel assembly of two Z1Z2 domains. The C-terminus of the telethonin appears to induce dimerization of this 2:1 titin/telethonin structure which thus forms a complex necessary for myofibril assembly and maintenance of the intact Z-disk of skeletal and cardiac muscles.


Pssm-ID: 462811  Cd Length: 150  Bit Score: 214.65  E-value: 1.98e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507435     17 RREAFWAEWKDLTLSTRPEEGCSLHEEDTQRHETYHQQGQCQVLVQRSPWLMMRMGILGRGLQEYQLPYQRVLPLPIFTP 96
Cdd:pfam09470   1 RRESYTADWQSVSLKTQPEDRQSLHMVDDSRRETLSRQWQARPLVQRCPSGVMRMGTLGRGVREYQLPYRNTLPLPIFKP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4507435     97 AKMGaTKEEReDTPIQLQELLALETAlGGQCVDRQEVAEITKQLPPVVPVS-----KPGalrRSLSRSMSQEAQRG 167
Cdd:pfam09470  81 AELG-TRLGR-GTPHTLEDLMPFETA-DGVCPDKREVSEITRDLPPVVQPTrmefaKPP---RSLGRSMSQEAQRG 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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