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Conserved domains on  [gi|109633044|ref|NP_003887|]
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lactosylceramide alpha-2,3-sialyltransferase isoform 1 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 191-401 1.10e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 438.02  E-value: 1.10e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 271 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 350
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633044 351 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 191-401 1.10e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 438.02  E-value: 1.10e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 271 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 350
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633044 351 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 156-406 7.11e-93

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 280.26  E-value: 7.11e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044  156 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 235
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044  236 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFR 307
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044  308 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQT 387
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 109633044  388 MHNVTTETKFLLKLVKEGV 406
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 191-401 1.10e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 438.02  E-value: 1.10e-155
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23983    1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 271 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 350
Cdd:cd23983   81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633044 351 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd23983  161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 191-401 1.20e-120

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 348.90  E-value: 1.20e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 271 FNWLQAMVKKETLPFWVrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQsrfwGRDKNVPTIGVIAVVLAT 350
Cdd:cd23967   81 LLWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG----KQGKNVPTTGIIAIVMAL 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633044 351 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd23967  155 HYCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 156-406 7.11e-93

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 280.26  E-value: 7.11e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044  156 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 235
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044  236 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFR 307
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044  308 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQT 387
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 109633044  388 MHNVTTETKFLLKLVKEGV 406
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 191-401 9.98e-70

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 219.02  E-value: 9.98e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 270
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 271 FNWLQAMVKKETlpfwVRLF--FWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpQSRFWGRDkNVPTIGVIAVVL 348
Cdd:cd23981   81 FKWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPF-NNGLMGRG-NIPTLGSVAITM 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 109633044 349 ATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd23981  155 ALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 191-401 1.36e-65

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 208.36  E-value: 1.36e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 191 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSND-LFVAVLFKSV 269
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDtLLVLVPFKPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 270 DFNWLQAMVKKETLpfwVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSrfwgrDKNVPTIGVIAVVLA 349
Cdd:cd23982   81 DFYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRK-----KKQKPTTGLLAITLA 152

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 109633044 350 THLCDEVSLAGFGYDLNQ-PRTPLHYFDSQCMAAM-NFQtmHNVTTETKFLLKL 401
Cdd:cd23982  153 LHLCDEVHIAGFGYPDNGnSNQPIHYYNQITLKSMaNSG--HNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 192-401 2.13e-58

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 189.96  E-value: 2.13e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDF 271
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 272 NWL-QAMVKKETLPFWvrlfFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpqsRFWGRDKNV-PTIGVIAVVLA 349
Cdd:cd23984   82 RWLlDLLMGKKVSAKG----FWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPK---RFPKEKKPKhPTTGIIAITLA 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 109633044 350 THLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd23984  155 LHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 156-408 1.43e-38

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 140.47  E-value: 1.43e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 156 SKYDPPFGFRKFS-SKVQTLLELL--PEHDLPEHLKA--KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGY 230
Cdd:cd23964   41 SHYKLPFGWGGLNrEVVERLLRNLnlTSSRYMFVLRGgrPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 231 SEHVGNKTTIRMTYPEGAPLSDLEYYSND---LFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFR 307
Cdd:cd23964  121 EKDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVR 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 308 ILNPviiketafDILQYSEpqsRFWGRDKNV--PTIGVIAVVLATHLCDEVSLAGFGYDlnqPRTPLHYFDSQCMAAMNF 385
Cdd:cd23964  201 LLHP--------DFIRYLF---NRWLNSSTSyrPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVF 266

                        250       260
                 ....*....|....*....|...
gi 109633044 386 QTMHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23964  267 YANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 195-401 7.63e-30

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 114.38  E-value: 7.63e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 195 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 274
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAG----FYLRGPRCGCHPLPLEEEVVL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 275 QAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNpviiketAFDILQYSEpqSRFWGRDKNVPTIGVIAVVLATHLCD 354
Cdd:cd19952   77 ILSRAAAADFKRLKRRKKRHDNAVLLLTDPAPDLLS-------YVRKRLEKL--GLKSFFGGNAPSSGLLAVLLALQLCD 147

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 109633044 355 EVSLAGFGYD-LNQPRTPLHYFDsqCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd19952  148 SVDLYGFGVDsGHAPKVPYHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 171-408 6.30e-29

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 113.91  E-value: 6.30e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 171 VQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 250
Cdd:cd23966   56 LEKLFQVVPGENPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVD 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 251 SDLEYYsndlFVAVLFKSVDFNWLQAMVKKETLpfwvrLFFWKQVAEKIPLQPKHFRILNPVIIKETAFdilQYSEPQSR 330
Cdd:cd23966  136 LDPGVH----LVLVPFKVLDLQWLISALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKYVHD---NWTEHHGR 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 331 FwgrdknvPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTplHYFDSQcMAAMNFQ--TMHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23966  204 Y-------PSTGFLALIFALHICDEVSVFGFGADSKGNWH--HYWEKN-RSAGAFRktGVHDADFESDIIKKLAKEGKIR 273
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 120-408 3.12e-23

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 98.40  E-value: 3.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 120 CRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKY-----DPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRR 194
Cdd:cd23979    3 CRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYwwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 195 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 274
Cdd:cd23979   83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAK----NLPANVSFVLVPFKTLDLLWI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 275 QAMVKKETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKetaFDILQYSEPQSRFwgrdknvPTIGVIAVVLATHLCD 354
Cdd:cd23979  159 TSALSTGQIR-----FTYAPVKQFLRVDKDKVQIYNPAFFK---YIHDRWTEHHGRY-------PSTGMLVLFFALHVCD 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109633044 355 EVSLAGFGYDlnqPRTPLHYFDSQCMAAMNFQT--MHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23979  224 EVNVYGFGAD---SRGNWHHYWENNRYAGEFRKtgVHDADFEAHIIDMLAKAGKIK 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 172-408 1.17e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 96.56  E-value: 1.17e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 172 QTLLELLPEHDLPEHlkaKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKT--------TIRMT 243
Cdd:cd23963   46 KSLYELLPKTSPFSH---KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRR 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 244 YPEGAP-------LSDLEYYSNDLFVAVLFKsvdFNWLQAMVKKetlpfwvrlffwkqVAEKIPLQPKHFRIlnpviike 316
Cdd:cd23963  123 YNSLKKnrdrdkfLNRLKEYNGSILWYPKFS---FKSSTNLLLK--------------AARALKKNGLNLTV-------- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 317 tAFDILQYSEPQSRFWGRDKN--VPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSqcMAAMNFQTMHNV 391
Cdd:cd23963  178 -VYSNPEHFLAVQKFWKRRGLekRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYDD--LSPSTKNKVHNM 254

                        250
                 ....*....|....*..
gi 109633044 392 TTETKFLLKLVKEGVVK 408
Cdd:cd23963  255 PEEFKLLRELHKKGVLK 271
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 171-364 1.36e-21

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 93.79  E-value: 1.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 171 VQTLLELLP-EHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgap 249
Cdd:cd23980   59 IRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE--- 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 250 lSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSepqs 329
Cdd:cd23980  136 -SFRELAQNVSMILVPFKTLDLEWVISATTTGTIS-----HTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGH---- 205

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 109633044 330 rfwGRdknVPTIGVIAVVLATHLCDEVSLAGFGYD 364
Cdd:cd23980  206 ---GR---YPSTGILSVIFSLHVCDEVDLYGFGAD 234
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 138-401 2.33e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 90.02  E-value: 2.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 138 SVDLLPFVQKAPKDSEAEsKYDPPFGFRKFSskvqtlLELLPEHDLpehLKAKTCRRCVVIGSGGILHGLELGHTLNQFD 217
Cdd:cd23968    1 SEDLLCRLKKAAPFSTLR-KTTSPFKDLLSL------RYPFPESSL---ENTKRYNTCAVVSSSGALLGSKLGKEIDSHD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 218 VVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLSDLEYYSNDLFV--AVLFKSVDFNWLqamvKKETLPFWVRL 289
Cdd:cd23968   71 AVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEFNFLTDPLYRNVTLLVwdPSSYNVNLEKWY----KKPDFDFFPNY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 290 FFWKQVaekIPLQPkhFRILNPVIIKEtAFDILQYSEPQSRFwgrdKNVPTIGVIAVVLATHLCDEVSLagFGYDLNQPR 369
Cdd:cd23968  147 IKYRRR---HPEEP--FYLIDPRFLWR-LWDILQEYTPEKIK----PNPPSSGFIGIVLMLHLCDWVDV--YEYVPSVRQ 214

                        250       260       270
                 ....*....|....*....|....*....|...
gi 109633044 370 TPL-HYFDSQCMAAMNFQTMHNVTTETKFLLKL 401
Cdd:cd23968  215 TDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 173-408 1.13e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 88.60  E-value: 1.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 173 TLLELLPEHdlpEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplSD 252
Cdd:cd23970   52 NLRSLLPEV---SPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 253 LEYYSNDLFVavlfKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKiplqpkhFRILNPVIIK-------ETAF--DILQ 323
Cdd:cd23970  124 LEKYYNNLLT----IQDRNNFFLSLKKLDGAILWIPAFFFHTSATV-------TRTLVDFFVEhrgqlkvQLAWpgNIMQ 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 324 YSepqSRFWGRDKNVP---TIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSQ-CMAAMNFQTMHNVTTETK 396
Cdd:cd23970  193 HV---NRYWKTKHLSPkrlSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEFV 269

                        250
                 ....*....|..
gi 109633044 397 FLLKLVKEGVVK 408
Cdd:cd23970  270 LLYKMHGAGVLK 281
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 158-408 3.83e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 87.50  E-value: 3.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 158 YDPPFGFRKFS-SKVQTLLELLPEHDLPEHLKA-----KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYS 231
Cdd:cd23973   43 FNPPFGFMGLNyTLVKEVVELIPKPKEQQLLALsppggDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 232 EHVGNKTTIrmtYPEGAP--LSDLEYYSNDLF-----------VAVLFKSVDFNWLQAMVKKETLPfwvRLFFWKQVAEK 298
Cdd:cd23973  123 EDVGTRTSF---YVHTAHsiTSSLMILQKRGFknipqdkdikyILFPEGPRDYQWLEALLKNKTIP---SGAYYGRRPRS 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 299 I---PLQPKHFRILNPviiketafDILQYSepQSRFWgRDKNV---------PTIGVIAVVLATHLCDEVSLAGF---GY 363
Cdd:cd23973  197 YfsgDFTEDKYLVLHP--------DFLRYV--KNRFL-RSKTLkgkywaiyrPTTGAFLLLTALHLCDTVSAYGFiteDY 265

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 109633044 364 DlnqpRTPLHYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23973  266 R----KYPDHYYDKK-KTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 172-408 8.13e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 79.98  E-value: 8.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 172 QTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplS 251
Cdd:cd23987   47 QNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-----S 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 252 DLEYYSNDLfvavlfksVDFNWLQAMVKK-ETLP---FWVRLFFWKQVAEKIplqpkhfRILNPVIIK-----ETAFDIL 322
Cdd:cd23987  119 VVQRAFEDL--------VNETWKEKFLQRlQSLNgsiLWIPAFMAKGGEERV-------EWVNDLILKhhinvRTAYPSL 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 323 QYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETK 396
Cdd:cd23987  184 RLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263

                        250
                 ....*....|..
gi 109633044 397 FLLKLVKEGVVK 408
Cdd:cd23987  264 ALKNLHQQGALK 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 165-408 4.33e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 78.07  E-value: 4.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 165 RKFSSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG--------N 236
Cdd:cd23988   40 RRTLNISQNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdfitmN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 237 KTTIRMTYPEGAPLSDLEYYSNDLfvAVLFKSVdfnwlqamvkketlpFWVRLFFWKQvaekiplQPKHFRILNPVIIK- 315
Cdd:cd23988  117 PSVVQRAFGGFRNESDREKFVHRL--SMLNDSV---------------LWIPAFMVKG-------GEKHVEWVNALILKn 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 316 ----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNF 385
Cdd:cd23988  173 klkvRTAYPSLRLIHAVRGYWLTNKvniKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSN 252

                        250       260
                 ....*....|....*....|...
gi 109633044 386 QTMHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23988  253 AGPHRMPLEFKTLNVLHNRGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 172-408 7.73e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 77.07  E-value: 7.73e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 172 QTLLELLPEHDlPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPls 251
Cdd:cd23969   47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIP-- 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 252 dlEYYSNDLFVAVLFKSVDfnwlqamvkketlpfwvRLffwKQVAEKIPLQP--------KHFRILNPVIIKE-----TA 318
Cdd:cd23969  122 --HAYGDLVNATDKEKFVE-----------------RL---RQLGDSILWIPafvskggeEHVQWTNEIILKHklnvkTA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 319 FDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQtmHNVT 392
Cdd:cd23969  180 YPPLRLNHAIRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMP 257

                        250
                 ....*....|....*.
gi 109633044 393 TETKFLLKLVKEGVVK 408
Cdd:cd23969  258 EEFRALRSLHQRGALR 273
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 178-379 1.15e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 76.67  E-value: 1.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 178 LPEHDLPEhlKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLS 251
Cdd:cd23985   33 LPKKSLRE--EVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKFLK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 252 DLEYYSNDLFVavlfksvdfnWLQAMVKKEtLPFWVRL----FF--WKQVAEKIPLQPkhFRILNPVIIKETaFDILQYS 325
Cdd:cd23985  111 DSLYNEGILIV----------WDPAPYHSD-IPEWYKNpdynFFenYKTYRRLNPNQP--FYILHPQMQWEL-WDIIQEN 176

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 326 EPQSrfwgRDKNVPTIGVIAVVLATHLCDEVSLAGFgydL-NQPRTPL-----HYFDSQC 379
Cdd:cd23985  177 SPEE----IQPNPPSSGMLGIILMMTLCDQVDVYEF---LpSKRKTDVchyyqKFFDRAC 229
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 156-408 1.68e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.62  E-value: 1.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 156 SKYDPPFGFRKFSSK-VQTLLELLPEHD----LPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGY 230
Cdd:cd23972   41 SQRKVPYGWKGLSHQvVASTLSLLNDSAnaklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 231 SEHVGNKTTIR-----------MTY--------PEGaplSDLEYysndLFVAVLFKsvDFNWLQAMVKKETLPF------ 285
Cdd:cd23972  121 EEDVGTKTSFYgftvntmknslISYwnlgftrtPQG---QDLQY----IFIPSDIR--DYVMLRSAILGVPVPEgldkgd 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 286 -WVRLFFWKQVAEKiplqpkhFRILNPVIIKETAFDILQySEPQSRFWGrDKNVPTIGVIAVVLATHLCDEVSLAGFGYD 364
Cdd:cd23972  192 rPHKYFGPEASAKK-------FKLLHPDFISYLTDRFLK-SKLLNTHYG-HLYMPSTGALMLLTALHTCDQVSAYGFITS 262

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 109633044 365 lNQPRTPLHYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23972  263 -NYWKFSDHYYERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 159-410 1.70e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 70.25  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 159 DPPF---GFRKFSSKVQtlLELLPEHDLpehlkaKTCrrCVVIGSGGILHGlELGHTLNQFDVVIRLNSAPVEGYSEHVG 235
Cdd:cd23986   24 EAPFsalGWEKYVPKIP--LSKLHLRGF------RSC--AVVTSAGAILNS-SLGKEIDSHDAVLRFNSAPTRGYEKDVG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 236 NKTTIRMTYPEgaPLSDLEYYSNDlfvAVLFKSVdfnwlqAMVKKETLPFWVRLFFW------------KQVAEKIPLQP 303
Cdd:cd23986   93 NKTTIRIINSQ--ILTNPNHHFID---SSLYKDV------ILVAWDPAPYSANLHKWykkpdynlftpyVQYRKRNPNQP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 304 khFRILNPVIIKETaFDILQYSEPQSrfwgRDKNVPTIGVIAVVLATHLCDEVSLAGFGYDLNQprTPL-HYFDSQCMAA 382
Cdd:cd23986  162 --FYILHPKFIWQL-WDIIQENTQEK----IQPNPPSSGFIGILIMMSMCREVHVYEYIPSVRQ--TDLcHYHERYYDAA 232

                        250       260
                 ....*....|....*....|....*...
gi 109633044 383 MNFQTMHNVTTEtKFLLKLVKEGVVKDL 410
Cdd:cd23986  233 CTLGAYHPLLYE-KLLIQRMNKGTEDDL 259
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 157-408 3.33e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 69.21  E-value: 3.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 157 KYDppfGFRKFSSKV-QTLLELLPEhDLPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEgYSEHVG 235
Cdd:cd23971   34 HYE---GERKKTITVnEKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVG 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 236 NKT----------TIRMTYPEGAPLS---DLEYYSNDLFvavlfksvdfnWLQAMVKKETLPFWVRLFFwkqVAEKIPLQ 302
Cdd:cd23971  107 SKTnlvtanpsilREKFHNLKKRRRPfveRMKVYGNALL-----------LLPAFSYTSNTEPSLRALY---TLEDFGSP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 303 PKHFrILNPviiketafdilQYSEPQSRFWgRDKNVPTI----GVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYF 375
Cdd:cd23971  173 QKVL-FFNP-----------EYLRNLSRYW-KSKGLKARrlstGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYY 239

                        250       260       270
                 ....*....|....*....|....*....|...
gi 109633044 376 DsQCMAAMNFqtmHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23971  240 D-NVLPKKGV---HAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 192-243 3.69e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 65.34  E-value: 3.69e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 109633044 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMT 243
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV 52
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 192-408 2.21e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 64.39  E-value: 2.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMtypegaplsdleYYSNDLFVAVL-FKSVD 270
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYT------------FSTNTLMNSLRaYAGVG 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 271 FNWLQamVKKET----LPFWVRLFFWKQVA------EKIP-------------LQPKHFRILNPviiketafDILQYSep 327
Cdd:cd23974  152 FNGPP--QSKETryifLPDHDRDYLLVKAAlthtpiDRGRdkskrpskyfgkdVTAEKFKIYHP--------DFIRYL-- 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 328 QSRF-WG-------RDKNVPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPrtplHYFDSQcMAAMNFQTMHNVTTETK 396
Cdd:cd23974  220 RNRFlWSpilntkqRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD----HYYDKT-YHKVVFYANHDLRLEMQ 294

                        250
                 ....*....|..
gi 109633044 397 FLLKLVKEGVVK 408
Cdd:cd23974  295 LWQKLHKAGLIK 306
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 185-376 2.38e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.65  E-value: 2.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 185 EHLKAKT-CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTypegaPLSDLEYysndlfva 263
Cdd:cd23976    7 DHKPLKMhCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-----AHSSIQR-------- 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 264 VLFKSvdfNWLQAMVKKETLPFWVRLFFWKQVAEKipLQPKHFRILNPVIIKETAFDI-----LQYSEPQSRFWGRDKNV 338
Cdd:cd23976   74 ILRNR---NELLNVSQGTVFIFWGPSNYMRRDGKG--LVYNNLQLMNQILPKLKVYTItrhkmLQFDELFKRETGKDRKI 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 109633044 339 P----TIGVIAVVLATHLCDEVSLAG-----FGYDLNQPRTPLHYFD 376
Cdd:cd23976  149 SntwlSTGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 192-242 6.14e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.10  E-value: 6.14e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 109633044 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 242
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 192-250 1.06e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 58.33  E-value: 1.06e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 109633044 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 250
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 193-408 2.19e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 52.06  E-value: 2.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 193 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEG-YSEHVGNKTT--------IRMTYPE----GAP-LSDLEYYSN 258
Cdd:cd23991   65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNlvtanpsiISIKYAKlnerRKPfLETVSVYGD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 259 DLFvavLFKSVDFNWLQAMVKK--ETLpfwvRLFFWKQvaekiplQPKHFrilNPVIIKETAfdilqysepqsRFWgRDK 336
Cdd:cd23991  145 AFL---LLPAFSYRSNTALSFKvyYTL----EDFKAKQ-------KVIFF---HPIYLKHLA-----------QFW-RSK 195

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109633044 337 NVP----TIGVIAVVLATHLCDEVSLAGF-GYDLNQPRTPL--HYFDSQcMAAMNFqtmHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23991  196 GVQvyrlSTGLMITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDNQ-LPKPGF---HSMPKEFYQLLQLHSKGILK 270
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 192-250 2.47e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.09  E-value: 2.47e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 109633044 192 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 250
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPL 59
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 172-389 2.22e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 48.68  E-value: 2.22e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 172 QTLLELLPEhDLPEHlkAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapl 250
Cdd:cd23990   47 SEIFKMFPK-DMPYS--RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPS---- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 251 sdleyysndlFVAVLFKSVDfnwlqamvkKETLPFWVRLffwkQVAEKIP-LQPKHFRILNPVIIKETAFDILQYSEPQ- 328
Cdd:cd23990  120 ----------IITERFHKLE---------KWRRPFYEVL----QVYENASvVLPAFYNTRNTDVSIRVKYVLDDFESQQa 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 329 ------------SRFWGRD---KNVPTIGVIAVVLATHLCDEVSLAGFG---------------YDLNQPRTPLHYFDSQ 378
Cdd:cd23990  177 vyyfhpqyllnvSRFWLRQgvrAKRISSGLMLVTAALELCEEVHLYGFWafpmnpsgifithhyYDNVKPRPGFHAMPSE 256

                        250
                 ....*....|.
gi 109633044 379 CmaaMNFQTMH 389
Cdd:cd23990  257 I---FNFLHMH 264
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 193-408 5.74e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 44.44  E-value: 5.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 193 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapLSDLEYYSNDLFVAVLFKSV-- 269
Cdd:cd23989   64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPS---IIDKRFQNLLWSRKSFVESMkv 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 109633044 270 ---DFNWLQAM-VKKETLP-FWVrlffWKQVAEKIPLQPKHFRilNPVIIKETafdilqysepqSRFW-GRD---KNVPT 340
Cdd:cd23989  141 ygrSYIYMPAFsMKTGTDPsLRV----YYTLADVGANQTVLFA--NPNFLRNV-----------GKFWkSKGvhaKRLST 203

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 109633044 341 iGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQcmaaMNFQTMHNVTTETKFLLKLVKEGVVK 408
Cdd:cd23989  204 -GLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVLR 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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