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DNA repair protein XRCC1 [Homo sapiens]
XRCC1_N and BRCT_XRCC1_rpt2 domain-containing protein( domain architecture ID 13667286)
protein containing domains XRCC1_N, BRCT_XRCC1_rpt1, Herpes_pp85, and BRCT_XRCC1_rpt2
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
XRCC1_N | pfam01834 | XRCC1 N terminal domain; |
1-149 | 1.97e-92 | ||||
XRCC1 N terminal domain; : Pssm-ID: 460356 Cd Length: 148 Bit Score: 281.82 E-value: 1.97e-92
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BRCT_XRCC1_rpt2 | cd17707 | Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ... |
538-631 | 3.94e-63 | ||||
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain. : Pssm-ID: 349340 Cd Length: 94 Bit Score: 203.27 E-value: 3.94e-63
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BRCT_XRCC1_rpt1 | cd17725 | First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ... |
322-401 | 7.65e-53 | ||||
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one. : Pssm-ID: 349357 [Multi-domain] Cd Length: 80 Bit Score: 175.54 E-value: 7.65e-53
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PRK13700 super family | cl32925 | conjugal transfer protein TraD; Provisional |
412-512 | 1.24e-03 | ||||
conjugal transfer protein TraD; Provisional The actual alignment was detected with superfamily member PRK13700: Pssm-ID: 184256 [Multi-domain] Cd Length: 732 Bit Score: 41.87 E-value: 1.24e-03
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PHA03307 super family | cl33723 | transcriptional regulator ICP4; Provisional |
94-321 | 8.38e-03 | ||||
transcriptional regulator ICP4; Provisional The actual alignment was detected with superfamily member PHA03307: Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 39.38 E-value: 8.38e-03
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Name | Accession | Description | Interval | E-value | ||||
XRCC1_N | pfam01834 | XRCC1 N terminal domain; |
1-149 | 1.97e-92 | ||||
XRCC1 N terminal domain; Pssm-ID: 460356 Cd Length: 148 Bit Score: 281.82 E-value: 1.97e-92
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BRCT_XRCC1_rpt2 | cd17707 | Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ... |
538-631 | 3.94e-63 | ||||
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain. Pssm-ID: 349340 Cd Length: 94 Bit Score: 203.27 E-value: 3.94e-63
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BRCT_XRCC1_rpt1 | cd17725 | First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ... |
322-401 | 7.65e-53 | ||||
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one. Pssm-ID: 349357 [Multi-domain] Cd Length: 80 Bit Score: 175.54 E-value: 7.65e-53
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BRCT_2 | pfam16589 | BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ... |
539-627 | 3.37e-21 | ||||
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown. Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 88.19 E-value: 3.37e-21
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BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
318-389 | 1.35e-15 | ||||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 71.94 E-value: 1.35e-15
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BRCT | smart00292 | breast cancer carboxy-terminal domain; |
318-389 | 1.06e-11 | ||||
breast cancer carboxy-terminal domain; Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 60.85 E-value: 1.06e-11
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BRCT | smart00292 | breast cancer carboxy-terminal domain; |
540-615 | 4.47e-08 | ||||
breast cancer carboxy-terminal domain; Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 50.45 E-value: 4.47e-08
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PRK13700 | PRK13700 | conjugal transfer protein TraD; Provisional |
412-512 | 1.24e-03 | ||||
conjugal transfer protein TraD; Provisional Pssm-ID: 184256 [Multi-domain] Cd Length: 732 Bit Score: 41.87 E-value: 1.24e-03
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
258-473 | 1.98e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 1.98e-03
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NOP7 | COG5163 | Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure ... |
423-629 | 2.38e-03 | ||||
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227492 [Multi-domain] Cd Length: 591 Bit Score: 40.83 E-value: 2.38e-03
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PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
94-321 | 8.38e-03 | ||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 39.38 E-value: 8.38e-03
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Name | Accession | Description | Interval | E-value | ||||
XRCC1_N | pfam01834 | XRCC1 N terminal domain; |
1-149 | 1.97e-92 | ||||
XRCC1 N terminal domain; Pssm-ID: 460356 Cd Length: 148 Bit Score: 281.82 E-value: 1.97e-92
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BRCT_XRCC1_rpt2 | cd17707 | Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and ... |
538-631 | 3.94e-63 | ||||
Second (C-terminal) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This model corresponds to the second BRCT domain. Pssm-ID: 349340 Cd Length: 94 Bit Score: 203.27 E-value: 3.94e-63
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BRCT_XRCC1_rpt1 | cd17725 | First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar ... |
322-401 | 7.65e-53 | ||||
First (central) BRCT domain in X-ray repair cross-complementing protein 1 (XRCC1) and similar proteins; XRCC1 is a DNA repair protein that corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. It forms homodimers and interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB), DNA ligase III (LIG3), APTX, APLF, and APEX1. XRCC1 contains an N-terminal XRCC1-specific domain and two BRCT domains. This family corresponds to the first one. Pssm-ID: 349357 [Multi-domain] Cd Length: 80 Bit Score: 175.54 E-value: 7.65e-53
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BRCT_2 | pfam16589 | BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ... |
539-627 | 3.37e-21 | ||||
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown. Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 88.19 E-value: 3.37e-21
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BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
318-389 | 1.35e-15 | ||||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 71.94 E-value: 1.35e-15
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BRCT | cd00027 | C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ... |
323-389 | 1.61e-14 | ||||
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage. Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 68.54 E-value: 1.61e-14
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BRCT_DNA_ligase_III | cd18431 | BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ... |
539-623 | 3.06e-13 | ||||
BRCT domain of DNA ligase 3 (LIG3) and similar proteins; LIG3 (EC 6.5.1.1), also termed DNA ligase III, or polydeoxyribonucleotide synthase [ATP] 3, functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Pssm-ID: 349384 [Multi-domain] Cd Length: 78 Bit Score: 65.03 E-value: 3.06e-13
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BRCT | smart00292 | breast cancer carboxy-terminal domain; |
318-389 | 1.06e-11 | ||||
breast cancer carboxy-terminal domain; Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 60.85 E-value: 1.06e-11
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BRCT_TopBP1_rpt2_like | cd17731 | second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
318-389 | 1.07e-11 | ||||
second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the second BRCT domain. Pssm-ID: 349363 [Multi-domain] Cd Length: 77 Bit Score: 60.63 E-value: 1.07e-11
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BRCT_CTDP1 | cd17729 | BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar ... |
313-394 | 1.06e-10 | ||||
BRCT domain of RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1) and similar proteins; CTDP1 (EC 3.1.3.16), also termed TFIIF-associating CTD phosphatase, or TFIIF- associating RNA polymerase C-terminal domain phosphatase (FCP1), promotes the activity of RNA polymerase II through processively dephosphorylating 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. It plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. Pssm-ID: 349361 [Multi-domain] Cd Length: 97 Bit Score: 58.70 E-value: 1.06e-10
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PTCB-BRCT | pfam12738 | twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. ... |
323-385 | 5.13e-10 | ||||
twin BRCT domain; This is a BRCT domain that appears in duplicate in most member sequences. BRCT domains are peptide- and phosphopeptide-binding modules. BRCT domains are present in a number of proteins involved in DNA checkpoint controls and DNA repair. Pssm-ID: 463687 [Multi-domain] Cd Length: 63 Bit Score: 55.67 E-value: 5.13e-10
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BRCT_Rev1 | cd17719 | BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha ... |
319-403 | 2.83e-09 | ||||
BRCT domain of DNA repair protein Rev1 and similar proteins; REV1, also termed alpha integrin-binding protein 80, or AIBP80, or Rev1-like terminal deoxycytidyl transferase, is a DNA template-dependent dCMP transferase required for mutagenesis induced by UV light. Pssm-ID: 349351 [Multi-domain] Cd Length: 87 Bit Score: 54.11 E-value: 2.83e-09
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BRCT_Rad4_rpt2 | cd17746 | second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and ... |
325-385 | 1.17e-08 | ||||
second BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the second one. Pssm-ID: 349377 [Multi-domain] Cd Length: 91 Bit Score: 52.62 E-value: 1.17e-08
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BRCT | smart00292 | breast cancer carboxy-terminal domain; |
540-615 | 4.47e-08 | ||||
breast cancer carboxy-terminal domain; Pssm-ID: 214602 [Multi-domain] Cd Length: 78 Bit Score: 50.45 E-value: 4.47e-08
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BRCT | pfam00533 | BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in ... |
540-615 | 1.37e-07 | ||||
BRCA1 C Terminus (BRCT) domain; The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage. The BRCT domain of XRCC1 forms a homodimer in the crystal structure. This suggests that pairs of BRCT domains associate as homo- or heterodimers. BRCT domains are often found as tandem-repeat pairs. Structures of the BRCA1 BRCT domains revealed a basis for a widely utilized head-to-tail BRCT-BRCT oligomerization mode. This conserved tandem BRCT architecture facilitates formation of the canonical BRCT phospho-peptide interaction cleft at a groove between the BRCT domains. Disease associated missense and nonsense mutations in the BRCA1 BRCT domains disrupt peptide binding by directly occluding this peptide binding groove, or by disrupting key conserved BRCT core folding determinants. Pssm-ID: 425736 [Multi-domain] Cd Length: 75 Bit Score: 49.21 E-value: 1.37e-07
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BRCT_Rad4_rpt1 | cd17740 | first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar ... |
318-390 | 1.46e-07 | ||||
first BRCT domain of Schizosaccharomyces pombe S-M checkpoint control protein Rad4 and similar proteins; Rad4, also termed P74, or protein cut5, is an essential component for DNA replication and the checkpoint control system which couples the S and M phases. It may directly or indirectly interact with chromatin proteins to form the complex required for the initiation and/or progression of DNA synthesis. Rad4 contains four BRCT repeats. The family corresponds to the first one. Pssm-ID: 349371 Cd Length: 82 Bit Score: 49.40 E-value: 1.46e-07
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BRCT_PAXIP1_rpt4 | cd17730 | fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ... |
323-389 | 1.14e-06 | ||||
fourth BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the fourth BRCT domain. Pssm-ID: 349362 [Multi-domain] Cd Length: 73 Bit Score: 46.47 E-value: 1.14e-06
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BRCT_BRC1_like_rpt4 | cd18438 | fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ... |
324-389 | 2.18e-06 | ||||
fourth BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. Members in this family contains six BRCT domains. This family corresponds to the fourth repeat. Pssm-ID: 349391 [Multi-domain] Cd Length: 68 Bit Score: 45.45 E-value: 2.18e-06
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BRCT_BRC1_like_rpt2 | cd18436 | second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar ... |
321-391 | 2.99e-06 | ||||
second BRCT domain of Schizosaccharomyces pombe BRCT-containing protein 1 (BRC1) and similar proteins; Schizosaccharomyces pombe BRC1 is required for mitotic fidelity, specifically in the G2 phase of the cell cycle. It plays a role in chromatin organization. The family also includes Cryptococcus neoformans DNA ligase 4 (LIG4, also known as DNA ligase IV or polydeoxyribonucleotide synthase [ATP] 4), which is involved in dsDNA break repair, and plays a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologus end-joining. Members in this family contains six BRCT domains. This family corresponds to the second repeat. Pssm-ID: 349389 [Multi-domain] Cd Length: 75 Bit Score: 45.30 E-value: 2.99e-06
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BRCT_CHS5_like | cd17742 | BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed ... |
335-394 | 6.41e-06 | ||||
BRCT domain of yeast chitin biosynthesis protein CHS5 and similar proteins; CHS5, also termed protein CAL3, is a component of the CHS5/6 complex which mediates export of specific cargo proteins, including chitin synthase CHS3. It is also involved in targeting FUS1 to sites of polarized growth. Pssm-ID: 349373 [Multi-domain] Cd Length: 77 Bit Score: 44.25 E-value: 6.41e-06
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BRCT_TopBP1_rpt6 | cd17727 | sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
320-391 | 6.76e-06 | ||||
sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the sixth BRCT domain. Pssm-ID: 349359 [Multi-domain] Cd Length: 75 Bit Score: 44.12 E-value: 6.76e-06
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LIG3_BRCT | pfam16759 | DNA ligase 3 BRCT domain; The BRCT domain of DNA ligase 3 (LIG3) binds to the C-terminal BRCT ... |
539-615 | 1.34e-05 | ||||
DNA ligase 3 BRCT domain; The BRCT domain of DNA ligase 3 (LIG3) binds to the C-terminal BRCT domain of the scaffolding protein X-ray repair cross-complementing protein 1 (XRCC1) and mediates homo- and heterodimerization. Pssm-ID: 465260 Cd Length: 77 Bit Score: 43.51 E-value: 1.34e-05
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BRCT_2 | pfam16589 | BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found ... |
316-401 | 2.77e-05 | ||||
BRCT domain, a BRCA1 C-terminus domain; This BRCT domain, a BRCA1 C-terminus region, is found on many RAP1 proteins, usually at the very N-terminus. The function in human at least of a BRCT is to contribute to the heterogeneity of the telomere DNA length, but that may not be its general function, which remains unknown. Pssm-ID: 465186 [Multi-domain] Cd Length: 84 Bit Score: 42.74 E-value: 2.77e-05
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BRCT_TopBP1_rpt5 | cd18434 | fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; ... |
319-397 | 4.17e-05 | ||||
fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the fifth BRCT domain. Pssm-ID: 349387 Cd Length: 89 Bit Score: 42.29 E-value: 4.17e-05
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BRCT_nibrin | cd17741 | BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ... |
323-385 | 5.10e-05 | ||||
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group. Pssm-ID: 349372 [Multi-domain] Cd Length: 74 Bit Score: 41.82 E-value: 5.10e-05
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BRCT_PAXIP1_rpt3 | cd17711 | third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ... |
322-397 | 1.05e-04 | ||||
third BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the third BRCT domain. Pssm-ID: 349343 Cd Length: 81 Bit Score: 41.10 E-value: 1.05e-04
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BRCT | cd00027 | C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ... |
548-615 | 5.00e-04 | ||||
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage. Pssm-ID: 349339 [Multi-domain] Cd Length: 68 Bit Score: 38.88 E-value: 5.00e-04
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BRCT_microcephalin_rpt1 | cd17716 | first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA ... |
322-396 | 5.04e-04 | ||||
first (N-terminal) BRCT domain of microcephalin and similar proteins; Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1. It has been implicated in chromosome condensation and DNA damage induced cellular responses. It may play a role in neurogenesis and regulation of the size of the cerebral cortex. Microcephalin contains three BRCT repeats. This family corresponds to the first repeat. Pssm-ID: 349348 [Multi-domain] Cd Length: 78 Bit Score: 39.10 E-value: 5.04e-04
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BRCT_PAXIP1_rpt2 | cd17710 | second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also ... |
346-397 | 1.09e-03 | ||||
second BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the second BRCT domain. Pssm-ID: 349342 [Multi-domain] Cd Length: 81 Bit Score: 38.37 E-value: 1.09e-03
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PRK13700 | PRK13700 | conjugal transfer protein TraD; Provisional |
412-512 | 1.24e-03 | ||||
conjugal transfer protein TraD; Provisional Pssm-ID: 184256 [Multi-domain] Cd Length: 732 Bit Score: 41.87 E-value: 1.24e-03
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PHA03247 | PHA03247 | large tegument protein UL36; Provisional |
258-473 | 1.98e-03 | ||||
large tegument protein UL36; Provisional Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 1.98e-03
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BRCT_PAXIP1_rpt1 | cd17714 | first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; ... |
543-623 | 2.27e-03 | ||||
first (N-terminal) BRCT domain of PAX-interacting protein 1 (PAXIP1) and similar proteins; PAXIP1, also termed PAX transactivation activation domain-interacting protein (PTIP), is involved in DNA damage response and in transcriptional regulation through histone methyltransferase (HMT) complexes. It also facilitates ATM-mediated activation of p53 and promotes cellular resistance to ionizing radiation. PAXIP1 contains six BRCT repeats. This family corresponds to the first BRCT domain. Pssm-ID: 349346 Cd Length: 76 Bit Score: 37.30 E-value: 2.27e-03
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NOP7 | COG5163 | Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure ... |
423-629 | 2.38e-03 | ||||
Protein required for biogenesis of the 60S ribosomal subunit [Translation, ribosomal structure and biogenesis]; Pssm-ID: 227492 [Multi-domain] Cd Length: 591 Bit Score: 40.83 E-value: 2.38e-03
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BRCT_TopBP1_rpt7 | cd17738 | seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA ... |
324-391 | 3.68e-03 | ||||
seventh BRCT domain of DNA topoisomerase 2-binding protein 1; TopBP1, also termed DNA topoisomerase II-beta-binding protein 1, or DNA topoisomerase II-binding protein 1, functions in DNA replication and damage response. It binds double-stranded DNA breaks and nicks as well as single-stranded DNA. TopBP1 contains six copies of BRCT domain. The family corresponds to the seventh BRCT domain. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is missing in this group. Pssm-ID: 349370 [Multi-domain] Cd Length: 75 Bit Score: 36.39 E-value: 3.68e-03
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PHA03169 | PHA03169 | hypothetical protein; Provisional |
405-538 | 6.90e-03 | ||||
hypothetical protein; Provisional Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 39.18 E-value: 6.90e-03
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PHA03307 | PHA03307 | transcriptional regulator ICP4; Provisional |
94-321 | 8.38e-03 | ||||
transcriptional regulator ICP4; Provisional Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 39.38 E-value: 8.38e-03
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Blast search parameters | ||||
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