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Conserved domains on  [gi|46094079|ref|NP_006839|]
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coiled-coil domain-containing protein 85B [Homo sapiens]

Protein Classification

CCDC85 superfamily-containing protein( domain architecture ID 5248)

CCDC85 superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC85 super family cl10913
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
 5-148 5.59e-55

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


The actual alignment was detected with superfamily member pfam10226:

Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 173.05  E-value: 5.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094079     5 AGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFL 84
Cdd:pfam10226   1 AEDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46094079    85 DSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEW 148
Cdd:pfam10226  81 DDDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEER 144
 
Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
 5-148 5.59e-55

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 173.05  E-value: 5.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094079     5 AGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFL 84
Cdd:pfam10226   1 AEDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46094079    85 DSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEW 148
Cdd:pfam10226  81 DDDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEER 144
 
Name Accession Description Interval E-value
CCDC85 pfam10226
CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 ...
 5-148 5.59e-55

CCDC85 family; This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.


Pssm-ID: 463009 [Multi-domain]  Cd Length: 192  Bit Score: 173.05  E-value: 5.59e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46094079     5 AGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQAENRELRDLCCFL 84
Cdd:pfam10226   1 AEDLSKLTDEELLRWSKEELVRRLRRAEAEKMSLLVEHGRLMREVNRRLQQHLLEIRGLKDVNQKLQEDNQELRDLCCFL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 46094079    85 DSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEW 148
Cdd:pfam10226  81 DDDRQKGKKVAREWQRFGRYAAGVMRKEVAGYLQKLKELEARQEELVRENLELKELCLMLDEER 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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