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Conserved domains on  [gi|6319366|ref|NP_009448|]
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Sft2p [Saccharomyces cerevisiae S288C]

Protein Classification

Got1/Sft2-like family vesicle transport protein( domain architecture ID 10009077)

Got1/Sft2-like family vesicle transport protein such as Homo sapiens vesicle transport protein GOT1A, which may be involved in fusion of ER-derived transport vesicles with the Golgi complex

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SFT2 COG5102
Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];
7-214 1.45e-95

Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];


:

Pssm-ID: 227433  Cd Length: 201  Bit Score: 277.18  E-value: 1.45e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366    7 SDQVNsLRDSLNRWNQTRQQNSQGFNESAKTLFSsWADSlntraqdiYQTLPVSRQDLVQDQEPSWFQLSRTERMVLFVC 86
Cdd:COG5102   4 SFQSR-LMDPLMRAFKTREESSKTFCSPIPTRYE-WSND--------YQMFPTRKYDLEHYFQSSEFGLSRFERAVLFSA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366   87 FLLGATACFTLCTFLFPVLAAKPRKFGLLWTMGSLLFVLAFGVLMGPLAYLKHLTARERLPFSMFFFATCFMTIYFAAFS 166
Cdd:COG5102  74 CLLGAGACSAFLYFMFPVLRLKPRKFILLWTMGSLLFVLMFGFLLGFRAYLEGLTSKERLPHSSWFFGTTLLTIYVVLKY 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 6319366  167 KNTVLTITCALLELVAVIYYAISYFPFGATGLRMLSSAGVNSARGVLR 214
Cdd:COG5102 154 KRTLLNIAFCFLQVVSFIMYSITFFPFGTSGVSSIISMFFKSLSNWLP 201
 
Name Accession Description Interval E-value
SFT2 COG5102
Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];
7-214 1.45e-95

Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227433  Cd Length: 201  Bit Score: 277.18  E-value: 1.45e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366    7 SDQVNsLRDSLNRWNQTRQQNSQGFNESAKTLFSsWADSlntraqdiYQTLPVSRQDLVQDQEPSWFQLSRTERMVLFVC 86
Cdd:COG5102   4 SFQSR-LMDPLMRAFKTREESSKTFCSPIPTRYE-WSND--------YQMFPTRKYDLEHYFQSSEFGLSRFERAVLFSA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366   87 FLLGATACFTLCTFLFPVLAAKPRKFGLLWTMGSLLFVLAFGVLMGPLAYLKHLTARERLPFSMFFFATCFMTIYFAAFS 166
Cdd:COG5102  74 CLLGAGACSAFLYFMFPVLRLKPRKFILLWTMGSLLFVLMFGFLLGFRAYLEGLTSKERLPHSSWFFGTTLLTIYVVLKY 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 6319366  167 KNTVLTITCALLELVAVIYYAISYFPFGATGLRMLSSAGVNSARGVLR 214
Cdd:COG5102 154 KRTLLNIAFCFLQVVSFIMYSITFFPFGTSGVSSIISMFFKSLSNWLP 201
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
81-192 6.47e-34

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 117.21  E-value: 6.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366     81 MVLFVCFLLGATACFTLCTFLFpvLAAKPRKFGLLWTMGSLLFVLAFGVLMGPLAYLKHLTARERLPFSMFFFATCFMTI 160
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFLF--VLAKPRKFALLYTLGNILFLGSTGFLIGPKKQLKHMFSKERLPFTIAYLGSLLLTL 78
                          90       100       110
                  ....*....|....*....|....*....|..
gi 6319366    161 YFAAFSKNTVLTITCALLELVAVIYYAISYFP 192
Cdd:pfam04178  79 YFALILKSYGLTLLFSIIQFLALVWYFLSYIP 110
 
Name Accession Description Interval E-value
SFT2 COG5102
Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];
7-214 1.45e-95

Membrane protein involved in ER to Golgi transport [Intracellular trafficking and secretion];


Pssm-ID: 227433  Cd Length: 201  Bit Score: 277.18  E-value: 1.45e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366    7 SDQVNsLRDSLNRWNQTRQQNSQGFNESAKTLFSsWADSlntraqdiYQTLPVSRQDLVQDQEPSWFQLSRTERMVLFVC 86
Cdd:COG5102   4 SFQSR-LMDPLMRAFKTREESSKTFCSPIPTRYE-WSND--------YQMFPTRKYDLEHYFQSSEFGLSRFERAVLFSA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366   87 FLLGATACFTLCTFLFPVLAAKPRKFGLLWTMGSLLFVLAFGVLMGPLAYLKHLTARERLPFSMFFFATCFMTIYFAAFS 166
Cdd:COG5102  74 CLLGAGACSAFLYFMFPVLRLKPRKFILLWTMGSLLFVLMFGFLLGFRAYLEGLTSKERLPHSSWFFGTTLLTIYVVLKY 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 6319366  167 KNTVLTITCALLELVAVIYYAISYFPFGATGLRMLSSAGVNSARGVLR 214
Cdd:COG5102 154 KRTLLNIAFCFLQVVSFIMYSITFFPFGTSGVSSIISMFFKSLSNWLP 201
Got1 pfam04178
Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the ...
81-192 6.47e-34

Got1/Sft2-like family; Traffic through the yeast Golgi complex depends on a member of the syntaxin family of SNARE proteins, Sed5, present in early Golgi cisternae. Got1 is thought to facilitate Sed5-dependent fusion events. This is a family of sequences derived from eukaryotic proteins. They are similar to a region of a SNARE-like protein required for traffic through the Golgi complex, SFT2 protein. This is a conserved protein with four putative transmembrane helices, thought to be involved in vesicular transport in later Golgi compartments.


Pssm-ID: 461210  Cd Length: 110  Bit Score: 117.21  E-value: 6.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319366     81 MVLFVCFLLGATACFTLCTFLFpvLAAKPRKFGLLWTMGSLLFVLAFGVLMGPLAYLKHLTARERLPFSMFFFATCFMTI 160
Cdd:pfam04178   1 LIGFGICLLLGVLCFFLSFFLF--VLAKPRKFALLYTLGNILFLGSTGFLIGPKKQLKHMFSKERLPFTIAYLGSLLLTL 78
                          90       100       110
                  ....*....|....*....|....*....|..
gi 6319366    161 YFAAFSKNTVLTITCALLELVAVIYYAISYFP 192
Cdd:pfam04178  79 YFALILKSYGLTLLFSIIQFLALVWYFLSYIP 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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