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Conserved domains on  [gi|7110681|ref|NP_032809|]
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pre-B-cell leukemia transcription factor 1 isoform b [Mus musculus]

Protein Classification

TALE/PBX homeobox family transcription factor( domain architecture ID 10510321)

TALE/PBX homeobox family transcription factor similar to human pre-B-cell leukemia transcription factor 1 (PBX1) that binds the sequence 5'-ATCAATCAA-3'

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
42-232 2.19e-109

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


:

Pssm-ID: 461052  Cd Length: 181  Bit Score: 316.63  E-value: 2.19e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681     42 DIGDILQQIMTITDQSLDEA--QARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAG 119
Cdd:pfam03792   1 DISDLLQQIMKITDMSLDEAavNKLKHALNCHPMYPALFSVLCEIKEKTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681    120 PEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIER 199
Cdd:pfam03792  81 PEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEFRPITPKEIER 148
                         170       180       190
                  ....*....|....*....|....*....|...
gi 7110681    200 MVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 232
Cdd:pfam03792 149 MVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
234-294 1.99e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 72.66  E-value: 1.99e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7110681  234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKN 294
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
42-232 2.19e-109

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 316.63  E-value: 2.19e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681     42 DIGDILQQIMTITDQSLDEA--QARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAG 119
Cdd:pfam03792   1 DISDLLQQIMKITDMSLDEAavNKLKHALNCHPMYPALFSVLCEIKEKTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681    120 PEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIER 199
Cdd:pfam03792  81 PEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEFRPITPKEIER 148
                         170       180       190
                  ....*....|....*....|....*....|...
gi 7110681    200 MVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 232
Cdd:pfam03792 149 MVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
234-294 1.99e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 72.66  E-value: 1.99e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7110681  234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKN 294
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
234-293 4.92e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 71.38  E-value: 4.92e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681    234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKK 293
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
234-292 5.62e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 68.43  E-value: 5.62e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 7110681     234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYK 292
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
191-293 7.02e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.20  E-value: 7.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681  191 PISPKEIERMVSIIHRKFSSIQMQLKQStcEAVMILrSRFLD----ARRKRRNFNKQATEILNEYFyshLSNPYPSEEAK 266
Cdd:COG5576   8 PLSALESQRMPQIRTIKTTKNKREVEAA--DSEMKL-ERKQDgsspPKSKRRRTTDEQLMVLEREF---EINPYPSSITR 81
                        90       100
                ....*....|....*....|....*..
gi 7110681  267 EELAKKCGITVSQVSNWFGNKRIRYKK 293
Cdd:COG5576  82 IKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
PBC pfam03792
PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) ...
42-232 2.19e-109

PBC domain; The PBC domain is a member of the TALE (three-amino-acid loop extension) superclass of homeodomain proteins.


Pssm-ID: 461052  Cd Length: 181  Bit Score: 316.63  E-value: 2.19e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681     42 DIGDILQQIMTITDQSLDEA--QARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAG 119
Cdd:pfam03792   1 DISDLLQQIMKITDMSLDEAavNKLKHALNCHPMYPALFSVLCEIKEKTVLSIRMIKEEEPPDNQLMRLDNMLLAEGVAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681    120 PEKGGGSAAAaaaaaasggagsDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIER 199
Cdd:pfam03792  81 PEKSGSAEAE------------DNGIDQSDYRAKLAQIRQIYHSELEKYEQACNEFTEHVRNLLREQSEFRPITPKEIER 148
                         170       180       190
                  ....*....|....*....|....*....|...
gi 7110681    200 MVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLD 232
Cdd:pfam03792 149 MVSIISKKFNKIQEQLKQSTCEAVMILRSRFLD 181
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
234-294 1.99e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 72.66  E-value: 1.99e-16
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7110681  234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKN 294
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEF---EKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
Homeodomain pfam00046
Homeodomain;
234-293 4.92e-16

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 71.38  E-value: 4.92e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681    234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKK 293
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEF---QENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeobox_KN pfam05920
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ...
252-290 8.91e-16

Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.


Pssm-ID: 428673  Cd Length: 39  Bit Score: 70.24  E-value: 8.91e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 7110681    252 FYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIR 290
Cdd:pfam05920   1 LYEHLHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
234-292 5.62e-15

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 68.43  E-value: 5.62e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 7110681     234 RRKRRNFNKQATEILNEYFyshLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYK 292
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEF---QKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
191-293 7.02e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.20  E-value: 7.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7110681  191 PISPKEIERMVSIIHRKFSSIQMQLKQStcEAVMILrSRFLD----ARRKRRNFNKQATEILNEYFyshLSNPYPSEEAK 266
Cdd:COG5576   8 PLSALESQRMPQIRTIKTTKNKREVEAA--DSEMKL-ERKQDgsspPKSKRRRTTDEQLMVLEREF---EINPYPSSITR 81
                        90       100
                ....*....|....*....|....*..
gi 7110681  267 EELAKKCGITVSQVSNWFGNKRIRYKK 293
Cdd:COG5576  82 IKLSLLLNMPPKSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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