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Conserved domains on  [gi|58331216|ref|NP_065202|]
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histo-blood group ABO system transferase isoform A1.01 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 11142430)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_transf_6 pfam03414
Glycosyltransferase family 6;
64-353 0e+00

Glycosyltransferase family 6;


:

Pssm-ID: 427285  Cd Length: 289  Bit Score: 540.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216    64 VSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMV 143
Cdd:pfam03414   1 PQLPRWFYPKPKLLEPKRPDVLTVTPWLAPIVWEGTFDPAILEDYYRPQNLTIGLTVFAVGKYVRFLELFLESAEKYFMV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216   144 GHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVE 223
Cdd:pfam03414  81 GHRVIYYVFTDDPAAVPRVPLGPGRQLSVFEIGRYKRWQDISMRRMETISEHIAQRIQHEVDYLFCVDVDMVFRDHFGVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216   224 ILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDE 303
Cdd:pfam03414 161 TLGPLVAQLHPWWYAADRQKFTYERRPLSAAYIPFGEGDFYYHGAIFGGTVARVYNLTRACHKAILADKANGIEAAWHDE 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 58331216   304 SHLNKYLLRHKPTKVLSPEYLWDQQlLGWPAVLRKLRFTAVPKNHQAVRN 353
Cdd:pfam03414 241 SHLNKYFLSHKPTKVLSPEYLWDYQ-IGRPSDLRLVRFAWVPKNYNWVRN 289
 
Name Accession Description Interval E-value
Glyco_transf_6 pfam03414
Glycosyltransferase family 6;
64-353 0e+00

Glycosyltransferase family 6;


Pssm-ID: 427285  Cd Length: 289  Bit Score: 540.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216    64 VSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMV 143
Cdd:pfam03414   1 PQLPRWFYPKPKLLEPKRPDVLTVTPWLAPIVWEGTFDPAILEDYYRPQNLTIGLTVFAVGKYVRFLELFLESAEKYFMV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216   144 GHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVE 223
Cdd:pfam03414  81 GHRVIYYVFTDDPAAVPRVPLGPGRQLSVFEIGRYKRWQDISMRRMETISEHIAQRIQHEVDYLFCVDVDMVFRDHFGVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216   224 ILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDE 303
Cdd:pfam03414 161 TLGPLVAQLHPWWYAADRQKFTYERRPLSAAYIPFGEGDFYYHGAIFGGTVARVYNLTRACHKAILADKANGIEAAWHDE 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 58331216   304 SHLNKYLLRHKPTKVLSPEYLWDQQlLGWPAVLRKLRFTAVPKNHQAVRN 353
Cdd:pfam03414 241 SHLNKYFLSHKPTKVLSPEYLWDYQ-IGRPSDLRLVRFAWVPKNYNWVRN 289
Glyco_transf_6 cd02515
Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO ...
81-352 5.02e-177

Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens; Glycosyltransferase family 6, GT_6, comprises enzymes with three known activities: alpha-1,3-galactosyltransferase, alpha-1,3 N-acetylgalactosaminyltransferase, and alpha-galactosyltransferase. UDP-galactose:beta-galactosyl alpha-1,3-galactosyltransferase (alpha3GT) catalyzes the transfer of galactose from UDP-alpha-d-galactose into an alpha-1,3 linkage with beta-galactosyl groups in glycoconjugates. The enzyme exists in most mammalian species but is absent from humans, apes, and old world monkeys as a result of the mutational inactivation of the gene. The alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase are responsible for the production of the human ABO blood group antigens. A N-acetylgalactosaminyltransferases use a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase uses a UDP-galactose donor to convert the H-antigen acceptor to the B antigen. Alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase differ only in the identity of four critical amino acid residues.


Pssm-ID: 133008  Cd Length: 271  Bit Score: 491.84  E-value: 5.02e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216  81 RKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVP 160
Cdd:cd02515   1 RPDVLTVTPWLAPIVWEGTFNPDVLDEYYRKQNITIGLTVFAVGKYTEFLERFLESAEKHFMVGYRVIYYIFTDKPAAVP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216 161 RVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSS 240
Cdd:cd02515  81 EVELGPGRRLTVLKIAEESRWQDISMRRMKTLADHIADRIGHEVDYLFCMDVDMVFQGPFGVETLGDSVAQLHPWWYGKP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216 241 REAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLS 320
Cdd:cd02515 161 RKQFPYERRPSSAAYIPEGEGDFYYHGAVFGGSVEEVYRLTRACHEGILADKANGIEARWHDESHLNKYFLLHKPTKVLS 240
                       250       260       270
                ....*....|....*....|....*....|..
gi 58331216 321 PEYLWDQQlLGWPAVLRKLRFTAVPKNHQAVR 352
Cdd:cd02515 241 PEYLWDDR-IGQAAEIRLPRLSWLPKNYQEVR 271
Gltr_6 NF041524
family 6 glucosyltransferase;
115-333 2.74e-51

family 6 glucosyltransferase;


Pssm-ID: 469409  Cd Length: 226  Bit Score: 170.11  E-value: 2.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216  115 TIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDqPAAVPRVTLGtgrqlsvlEVRAYKR----WQDVSMRRME 190
Cdd:NF041524   2 KIGILYICTGKYSIFWKDFYLSCEKYFLPGAEKEYFVFTD-PDDLYFKKNN--------NVHVIYQenlgWPLNTLLRFS 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216  191 MISDFCERrfLSEVDYLVCVDVDMEFRDHVGVEILTP-----LFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYY 265
Cdd:NF041524  73 MFLKIKEE--LKEFDYLFFFNANALFVKPISAEILPTeeengLVGVIHPGYYNKPPIEYPYERRKKSTAYIPYGKGGYYF 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58331216  266 LGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPtKVLSPEYLWDQqllGWP 333
Cdd:NF041524 151 QGGLNGGKTKAYLKLIETCSLNIEKDLKNNIIAIWHDESHLNKYFLDKKP-KILSPAYGYPE---GWN 214
 
Name Accession Description Interval E-value
Glyco_transf_6 pfam03414
Glycosyltransferase family 6;
64-353 0e+00

Glycosyltransferase family 6;


Pssm-ID: 427285  Cd Length: 289  Bit Score: 540.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216    64 VSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMV 143
Cdd:pfam03414   1 PQLPRWFYPKPKLLEPKRPDVLTVTPWLAPIVWEGTFDPAILEDYYRPQNLTIGLTVFAVGKYVRFLELFLESAEKYFMV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216   144 GHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVE 223
Cdd:pfam03414  81 GHRVIYYVFTDDPAAVPRVPLGPGRQLSVFEIGRYKRWQDISMRRMETISEHIAQRIQHEVDYLFCVDVDMVFRDHFGVE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216   224 ILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDE 303
Cdd:pfam03414 161 TLGPLVAQLHPWWYAADRQKFTYERRPLSAAYIPFGEGDFYYHGAIFGGTVARVYNLTRACHKAILADKANGIEAAWHDE 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 58331216   304 SHLNKYLLRHKPTKVLSPEYLWDQQlLGWPAVLRKLRFTAVPKNHQAVRN 353
Cdd:pfam03414 241 SHLNKYFLSHKPTKVLSPEYLWDYQ-IGRPSDLRLVRFAWVPKNYNWVRN 289
Glyco_transf_6 cd02515
Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO ...
81-352 5.02e-177

Glycosyltransferase family 6 comprises enzymes responsible for the production of the human ABO blood group antigens; Glycosyltransferase family 6, GT_6, comprises enzymes with three known activities: alpha-1,3-galactosyltransferase, alpha-1,3 N-acetylgalactosaminyltransferase, and alpha-galactosyltransferase. UDP-galactose:beta-galactosyl alpha-1,3-galactosyltransferase (alpha3GT) catalyzes the transfer of galactose from UDP-alpha-d-galactose into an alpha-1,3 linkage with beta-galactosyl groups in glycoconjugates. The enzyme exists in most mammalian species but is absent from humans, apes, and old world monkeys as a result of the mutational inactivation of the gene. The alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase are responsible for the production of the human ABO blood group antigens. A N-acetylgalactosaminyltransferases use a UDP-GalNAc donor to convert the H-antigen acceptor to the A antigen, whereas a galactosyltransferase uses a UDP-galactose donor to convert the H-antigen acceptor to the B antigen. Alpha-1,3 N-acetylgalactosaminyltransferase and alpha-galactosyltransferase differ only in the identity of four critical amino acid residues.


Pssm-ID: 133008  Cd Length: 271  Bit Score: 491.84  E-value: 5.02e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216  81 RKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVP 160
Cdd:cd02515   1 RPDVLTVTPWLAPIVWEGTFNPDVLDEYYRKQNITIGLTVFAVGKYTEFLERFLESAEKHFMVGYRVIYYIFTDKPAAVP 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216 161 RVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSS 240
Cdd:cd02515  81 EVELGPGRRLTVLKIAEESRWQDISMRRMKTLADHIADRIGHEVDYLFCMDVDMVFQGPFGVETLGDSVAQLHPWWYGKP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216 241 REAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLS 320
Cdd:cd02515 161 RKQFPYERRPSSAAYIPEGEGDFYYHGAVFGGSVEEVYRLTRACHEGILADKANGIEARWHDESHLNKYFLLHKPTKVLS 240
                       250       260       270
                ....*....|....*....|....*....|..
gi 58331216 321 PEYLWDQQlLGWPAVLRKLRFTAVPKNHQAVR 352
Cdd:cd02515 241 PEYLWDDR-IGQAAEIRLPRLSWLPKNYQEVR 271
Gltr_6 NF041524
family 6 glucosyltransferase;
115-333 2.74e-51

family 6 glucosyltransferase;


Pssm-ID: 469409  Cd Length: 226  Bit Score: 170.11  E-value: 2.74e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216  115 TIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDqPAAVPRVTLGtgrqlsvlEVRAYKR----WQDVSMRRME 190
Cdd:NF041524   2 KIGILYICTGKYSIFWKDFYLSCEKYFLPGAEKEYFVFTD-PDDLYFKKNN--------NVHVIYQenlgWPLNTLLRFS 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 58331216  191 MISDFCERrfLSEVDYLVCVDVDMEFRDHVGVEILTP-----LFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYY 265
Cdd:NF041524  73 MFLKIKEE--LKEFDYLFFFNANALFVKPISAEILPTeeengLVGVIHPGYYNKPPIEYPYERRKKSTAYIPYGKGGYYF 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 58331216  266 LGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPtKVLSPEYLWDQqllGWP 333
Cdd:NF041524 151 QGGLNGGKTKAYLKLIETCSLNIEKDLKNNIIAIWHDESHLNKYFLDKKP-KILSPAYGYPE---GWN 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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